Entry Database : PDB / ID : 1mg8 Structure visualization Downloads & linksTitle NMR structure of ubiquitin-like domain in murine Parkin ComponentsParkin Details Keywords APOPTOSIS / parkinson disease / RIKEN Structural Genomics/Proteomics Initiative / RSGI / Structural GenomicsFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of neurotransmitter uptake / negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway / mitochondrion-derived vesicle / negative regulation of spontaneous neurotransmitter secretion / negative regulation of intralumenal vesicle formation / regulation protein catabolic process at presynapse / Josephin domain DUBs / PINK1-PRKN Mediated Mitophagy / cellular response to L-glutamine / negative regulation of exosomal secretion ... positive regulation of neurotransmitter uptake / negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway / mitochondrion-derived vesicle / negative regulation of spontaneous neurotransmitter secretion / negative regulation of intralumenal vesicle formation / regulation protein catabolic process at presynapse / Josephin domain DUBs / PINK1-PRKN Mediated Mitophagy / cellular response to L-glutamine / negative regulation of exosomal secretion / mitochondrion to lysosome vesicle-mediated transport / Regulation of necroptotic cell death / Aggrephagy / type 2 mitophagy / response to curcumin / cellular response to hydrogen sulfide / negative regulation of mitochondrial fusion / Parkin-FBXW7-Cul1 ubiquitin ligase complex / free ubiquitin chain polymerization / positive regulation of protein linear polyubiquitination / negative regulation of actin filament bundle assembly / host-mediated suppression of viral genome replication / RBR-type E3 ubiquitin transferase / F-box domain binding / positive regulation of mitochondrial fusion / regulation of cellular response to oxidative stress / mitochondrial fragmentation involved in apoptotic process / mitochondrion localization / regulation of dopamine metabolic process / positive regulation of dendrite extension / negative regulation of excitatory postsynaptic potential / negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator / regulation of neurotransmitter secretion / protein K6-linked ubiquitination / dopaminergic synapse / norepinephrine metabolic process / autophagy of mitochondrion / positive regulation of type 2 mitophagy / protein localization to mitochondrion / cellular response to L-glutamate / synaptic transmission, dopaminergic / positive regulation of protein localization to membrane / cellular response to toxic substance / mitochondrial fission / negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / positive regulation of tumor necrosis factor-mediated signaling pathway / Antigen processing: Ubiquitination & Proteasome degradation / aggresome assembly / protein K11-linked ubiquitination / negative regulation of synaptic transmission, glutamatergic / regulation of mitochondrion organization / ubiquitin conjugating enzyme binding / positive regulation of mitochondrial membrane potential / negative regulation of JNK cascade / aggresome / response to corticosterone / positive regulation of mitochondrial fission / dopamine uptake involved in synaptic transmission / ubiquitin-specific protease binding / response to muscle activity / negative regulation of release of cytochrome c from mitochondria / startle response / dopamine metabolic process / positive regulation of ATP biosynthetic process / cullin family protein binding / protein K63-linked ubiquitination / regulation of synaptic vesicle endocytosis / protein monoubiquitination / cellular response to manganese ion / negative regulation of mitochondrial fission / response to unfolded protein / positive regulation of insulin secretion involved in cellular response to glucose stimulus / regulation of postsynaptic membrane neurotransmitter receptor levels / protein K48-linked ubiquitination / negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / phospholipase binding / mitophagy / protein autoubiquitination / negative regulation of reactive oxygen species biosynthetic process / regulation of mitochondrial membrane potential / Hsp70 protein binding / tubulin binding / response to endoplasmic reticulum stress / adult locomotory behavior / ubiquitin binding / learning / mitochondrion organization / synaptic transmission, glutamatergic / PDZ domain binding / locomotory behavior / protein catabolic process / G protein-coupled receptor binding / negative regulation of insulin secretion / negative regulation of canonical Wnt signaling pathway / protein destabilization / modulation of chemical synaptic transmission / beta-catenin binding / kinase binding / histone deacetylase binding / neuron cellular homeostasis Similarity search - Function : / E3 ubiquitin-protein ligase parkin / RING/Ubox-like zinc-binding domain / Parkin, RING/Ubox like zinc-binding domain / : / : / : / RING/Ubox like zinc-binding domain / RING/Ubox like zinc-binding domain / IBR domain ... : / E3 ubiquitin-protein ligase parkin / RING/Ubox-like zinc-binding domain / Parkin, RING/Ubox like zinc-binding domain / : / : / : / RING/Ubox like zinc-binding domain / RING/Ubox like zinc-binding domain / IBR domain / : / IBR domain / In Between Ring fingers / TRIAD supradomain / TRIAD supradomain profile. / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Ubiquitin-like (UB roll) / Ubiquitin family / Ubiquitin homologues / Ubiquitin domain profile. / Ubiquitin-like domain / Ubiquitin-like domain superfamily / Roll / Alpha Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method SOLUTION NMR / simulated annealing DetailsAuthors Tashiro, M. / Okubo, S. / Shimotakahara, S. / Hatanaka, H. / Yasuda, H. / Kainosho, M. / Yokoyama, S. / Shindo, H. / RIKEN Structural Genomics/Proteomics Initiative (RSGI) Citation Show more 1 items Show lessHistory Deposition Aug 15, 2002 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Apr 8, 2003 Provider : repository / Type : Initial releaseRevision 1.1 Apr 28, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Feb 23, 2022 Group : Database references / Derived calculationsCategory : database_2 / pdbx_struct_assembly ... database_2 / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.detailsRevision 1.4 Dec 21, 2022 Group : Database references / Category : struct_ref_seq_dif / Item : _struct_ref_seq_dif.detailsRevision 1.5 May 29, 2024 Group : Data collection / Category : chem_comp_atom / chem_comp_bond
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