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Open data
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Basic information
Entry | Database: PDB / ID: 1lit | ||||||
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Title | HUMAN LITHOSTATHINE | ||||||
![]() | LITHOSTATHINE | ||||||
![]() | PANCREATIC STONE INHIBITOR / LECTIN | ||||||
Function / homology | ![]() disruption of cell wall in another organism / oligosaccharide binding / peptidoglycan binding / molecular function inhibitor activity / growth factor activity / response to peptide hormone / antimicrobial humoral immune response mediated by antimicrobial peptide / signaling receptor activity / collagen-containing extracellular matrix / positive regulation of cell population proliferation ...disruption of cell wall in another organism / oligosaccharide binding / peptidoglycan binding / molecular function inhibitor activity / growth factor activity / response to peptide hormone / antimicrobial humoral immune response mediated by antimicrobial peptide / signaling receptor activity / collagen-containing extracellular matrix / positive regulation of cell population proliferation / extracellular space / extracellular exosome Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Bertrand, J.A. / Pignol, D. / Bernard, J.-P. / Verdier, J.-M. / Dagorn, J.-C. / Fontacilla-Camps, J.C. | ||||||
![]() | ![]() Title: Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation. Authors: Bertrand, J.A. / Pignol, D. / Bernard, J.P. / Verdier, J.M. / Dagorn, J.C. / Fontecilla-Camps, J.C. #1: ![]() Title: Crystallization and Preliminary Crystallographic Study of Human Lithostathine Authors: Pignol, D. / Bertrand, J.A. / Bernard, J.P. / Verdier, J.M. / Dagorn, J.C. / Fontacilla-Camps, J.C. #2: ![]() Title: Inhibition of Nucleation and Crystal Growth of Calcium Carbonate Crystals by Human Lithostathine Authors: Bernard, J.P. / Adrich, Z. / Montalto, G. / Decaro, A. / De Reggi, M. / Sarles, H. / Dagorn, J-C. #3: ![]() Title: Homology of Human Pancreatic Stone Protein with Animal Lectins Authors: Patthy, L. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 37.4 KB | Display | ![]() |
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PDB format | ![]() | 29.2 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 369.9 KB | Display | ![]() |
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Full document | ![]() | 370.7 KB | Display | |
Data in XML | ![]() | 4.1 KB | Display | |
Data in CIF | ![]() | 6.6 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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1 |
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Unit cell |
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Components
#1: Protein | Mass: 16291.037 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) ![]() |
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#2: Water | ChemComp-HOH / |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.14 Å3/Da / Density % sol: 39 % | ||||||||||||||||||||||||||||||
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Crystal grow | *PLUS Temperature: 20 ℃ / Method: vapor diffusion, hanging dropDetails: Pignol, D., (1995) Proteins: Struct.,Funct., Genet., 23, 604. | ||||||||||||||||||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Diffraction source | Source: ![]() ![]() |
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Detector | Type: MARRESEARCH / Detector: IMAGE PLATE / Date: 1994 |
Radiation | Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 0.9 Å / Relative weight: 1 |
Reflection | Num. obs: 19356 / % possible obs: 98.2 % / Redundancy: 6.3 % / Rmerge(I) obs: 0.042 |
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Processing
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Refinement | Resolution: 1.55→8 Å
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Displacement parameters | Biso mean: 23.6 Å2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine analyze | Luzzati coordinate error obs: 0.1 Å | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 1.55→8 Å
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Refine LS restraints |
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Software | *PLUS Name: ![]() | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement | *PLUS Num. reflection obs: 19532 / Rfactor obs: 0.186 / Rfactor Rfree: 0.244 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Solvent computation | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine LS restraints | *PLUS Type: x_bond_d / Dev ideal: 0.01 |