登録情報 | データベース: PDB / ID: 1li4 |
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タイトル | Human S-adenosylhomocysteine hydrolase complexed with neplanocin |
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要素 | S-adenosylhomocysteine hydrolase |
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キーワード | HYDROLASE / alpha-beta structure / inhibitor complex |
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機能・相同性 | 機能・相同性情報
Defective AHCY causes HMAHCHD / Sulfur amino acid metabolism / Metabolism of ingested SeMet, Sec, MeSec into H2Se / adenosylhomocysteinase / adenosylhomocysteinase activity / S-adenosylmethionine cycle / Methylation / melanosome / one-carbon metabolic process / endoplasmic reticulum ...Defective AHCY causes HMAHCHD / Sulfur amino acid metabolism / Metabolism of ingested SeMet, Sec, MeSec into H2Se / adenosylhomocysteinase / adenosylhomocysteinase activity / S-adenosylmethionine cycle / Methylation / melanosome / one-carbon metabolic process / endoplasmic reticulum / extracellular exosome / nucleus / cytosol類似検索 - 分子機能 Adenosylhomocysteinase-like / Adenosylhomocysteinase-like / S-adenosyl-L-homocysteine hydrolase, conserved site / Adenosylhomocysteinase-like superfamily / S-adenosyl-L-homocysteine hydrolase, NAD binding domain / S-adenosyl-L-homocysteine hydrolase / S-adenosyl-L-homocysteine hydrolase signature 1. / S-adenosyl-L-homocysteine hydrolase signature 2. / S-adenosyl-L-homocysteine hydrolase / S-adenosyl-L-homocysteine hydrolase, NAD binding domain ...Adenosylhomocysteinase-like / Adenosylhomocysteinase-like / S-adenosyl-L-homocysteine hydrolase, conserved site / Adenosylhomocysteinase-like superfamily / S-adenosyl-L-homocysteine hydrolase, NAD binding domain / S-adenosyl-L-homocysteine hydrolase / S-adenosyl-L-homocysteine hydrolase signature 1. / S-adenosyl-L-homocysteine hydrolase signature 2. / S-adenosyl-L-homocysteine hydrolase / S-adenosyl-L-homocysteine hydrolase, NAD binding domain / S-adenosyl-L-homocysteine hydrolase, NAD binding domain / NAD(P)-binding Rossmann-like Domain / NAD(P)-binding domain superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 ISOPROPYL ALCOHOL / NICOTINAMIDE-ADENINE-DINUCLEOTIDE / Chem-NOC / Adenosylhomocysteinase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.01 Å |
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データ登録者 | Yang, X. / Hu, Y. / Yin, D.H. / Turner, M.A. / Wang, M. / Borchardt, R.T. / Howell, P.L. / Kuczera, K. / Schowen, R.L. |
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引用 | ジャーナル: Biochemistry / 年: 2003 タイトル: Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: Transition-state stabilization and the avoidance of abortive reactions 著者: Yang, X. / Hu, Y. / Yin, D.H. / Turner, M.A. / Wang, M. / Borchardt, R.T. / Howell, P.L. / Kuczera, K. / Schowen, R.L. |
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履歴 | 登録 | 2002年4月17日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2003年5月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月28日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Derived calculations / Version format compliance |
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改定 1.3 | 2023年8月16日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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