+Open data
-Basic information
Entry | Database: PDB / ID: 1ldr | ||||||
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Title | SECOND REPEAT OF THE LDL RECEPTOR LIGAND-BINDING DOMAIN | ||||||
Components | LOW-DENSITY LIPOPROTEIN RECEPTOR | ||||||
Keywords | BINDING PROTEIN / LDL RECEPTOR CYSTEINE-RICH REPEAT | ||||||
Function / homology | Function and homology information regulation of phosphatidylcholine catabolic process / plasma lipoprotein particle clearance / positive regulation of lysosomal protein catabolic process / very-low-density lipoprotein particle receptor activity / negative regulation of astrocyte activation / receptor-mediated endocytosis involved in cholesterol transport / negative regulation of microglial cell activation / PCSK9-LDLR complex / cholesterol import / negative regulation of receptor recycling ...regulation of phosphatidylcholine catabolic process / plasma lipoprotein particle clearance / positive regulation of lysosomal protein catabolic process / very-low-density lipoprotein particle receptor activity / negative regulation of astrocyte activation / receptor-mediated endocytosis involved in cholesterol transport / negative regulation of microglial cell activation / PCSK9-LDLR complex / cholesterol import / negative regulation of receptor recycling / low-density lipoprotein particle clearance / clathrin heavy chain binding / low-density lipoprotein particle receptor activity / positive regulation of triglyceride biosynthetic process / negative regulation of low-density lipoprotein particle clearance / intestinal cholesterol absorption / low-density lipoprotein particle binding / Chylomicron clearance / response to caloric restriction / amyloid-beta clearance by cellular catabolic process / LDL clearance / regulation of protein metabolic process / high-density lipoprotein particle clearance / lipoprotein catabolic process / phospholipid transport / cholesterol transport / low-density lipoprotein particle / endolysosome membrane / negative regulation of amyloid fibril formation / negative regulation of protein metabolic process / artery morphogenesis / cellular response to fatty acid / regulation of cholesterol metabolic process / amyloid-beta clearance / sorting endosome / lipoprotein particle binding / cellular response to low-density lipoprotein particle stimulus / long-term memory / phagocytosis / Retinoid metabolism and transport / clathrin-coated pit / somatodendritic compartment / cholesterol metabolic process / receptor-mediated endocytosis / cholesterol homeostasis / clathrin-coated endocytic vesicle membrane / lipid metabolic process / positive regulation of inflammatory response / endocytosis / Cargo recognition for clathrin-mediated endocytosis / late endosome / apical part of cell / Clathrin-mediated endocytosis / virus receptor activity / amyloid-beta binding / basolateral plasma membrane / protease binding / molecular adaptor activity / lysosome / early endosome / receptor complex / endosome membrane / external side of plasma membrane / negative regulation of gene expression / calcium ion binding / positive regulation of gene expression / Golgi apparatus / cell surface / identical protein binding / membrane / plasma membrane Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Daly, N.L. / Djordjevic, J.T. / Kroon, P.A. / Smith, R. | ||||||
Citation | Journal: Biochemistry / Year: 1995 Title: Three-dimensional structure of the second cysteine-rich repeat from the human low-density lipoprotein receptor. Authors: Daly, N.L. / Djordjevic, J.T. / Kroon, P.A. / Smith, R. #1: Journal: Proc.Natl.Acad.Sci.USA / Year: 1995 Title: Three-Dimensional Structure of a Cysteine-Rich Repeat of the Low-Density Lipoprotein Receptor Authors: Daly, N.L. / Scanlon, M.J. / Djordjevic, J.T. / Kroon, P.A. / Smith, R. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1ldr.cif.gz | 117.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1ldr.ent.gz | 99 KB | Display | PDB format |
PDBx/mmJSON format | 1ldr.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1ldr_validation.pdf.gz | 341.9 KB | Display | wwPDB validaton report |
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Full document | 1ldr_full_validation.pdf.gz | 413.3 KB | Display | |
Data in XML | 1ldr_validation.xml.gz | 9.6 KB | Display | |
Data in CIF | 1ldr_validation.cif.gz | 14.8 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ld/1ldr ftp://data.pdbj.org/pub/pdb/validation_reports/ld/1ldr | HTTPS FTP |
-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein/peptide | Mass: 4592.014 Da / Num. of mol.: 1 / Fragment: LIGAND-BINDING DOMAIN, SECOND REPEAT Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: HUMAN / Plasmid: PGEX-2T / Gene (production host): HUMAN / Production host: Escherichia coli (E. coli) / References: UniProt: P01130 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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-Sample preparation
Crystal grow | *PLUS Method: other |
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-Processing
Software |
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NMR software | Name: X-PLOR / Version: 3.1 / Developer: BRUNGER / Classification: refinement | ||||||||||||
NMR ensemble | Conformers submitted total number: 10 |