negative regulation of peptide secretion / macrophage migration inhibitory factor signaling pathway / NOS2-CD74 complex / MHC class II protein binding, via antigen binding groove / antigen processing and presentation of endogenous antigen / positive regulation of dendritic cell antigen processing and presentation / negative regulation of T cell differentiation / macrophage migration inhibitory factor binding / positive regulation of macrophage migration inhibitory factor signaling pathway / protein trimerization ...negative regulation of peptide secretion / macrophage migration inhibitory factor signaling pathway / NOS2-CD74 complex / MHC class II protein binding, via antigen binding groove / antigen processing and presentation of endogenous antigen / positive regulation of dendritic cell antigen processing and presentation / negative regulation of T cell differentiation / macrophage migration inhibitory factor binding / positive regulation of macrophage migration inhibitory factor signaling pathway / protein trimerization / macrophage migration inhibitory factor receptor complex / positive regulation of cytokine-mediated signaling pathway / T cell activation involved in immune response / positive regulation of prostaglandin biosynthetic process / T cell selection / positive regulation of type 2 immune response / host-mediated suppression of symbiont invasion / negative thymic T cell selection / MHC class II protein binding / negative regulation of mature B cell apoptotic process / positive regulation of kinase activity / positive regulation of monocyte differentiation / positive thymic T cell selection / vacuole / CD4 receptor binding / cytokine receptor activity / positive regulation of neutrophil chemotaxis / positive regulation of chemokine (C-X-C motif) ligand 2 production / prostaglandin biosynthetic process / positive regulation of macrophage cytokine production / positive regulation of T cell differentiation / regulation of macrophage activation / transport vesicle membrane / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / nitric-oxide synthase binding / antigen processing and presentation / cytokine binding / negative regulation of DNA damage response, signal transduction by p53 class mediator / immunoglobulin mediated immune response / : / response to type II interferon / positive regulation of chemokine production / positive regulation of B cell proliferation / multivesicular body / protein folding chaperone / MHC class II antigen presentation / lysosomal lumen / negative regulation of cell migration / trans-Golgi network membrane / lumenal side of endoplasmic reticulum membrane / positive regulation of interleukin-8 production / Cell surface interactions at the vascular wall / intracellular protein transport / MHC class II protein complex / clathrin-coated endocytic vesicle membrane / ER to Golgi transport vesicle membrane / antigen processing and presentation of exogenous peptide antigen via MHC class II / positive regulation of interleukin-6 production / positive regulation of fibroblast proliferation / MHC class II protein complex binding / endocytic vesicle membrane / late endosome / positive regulation of protein phosphorylation / amyloid-beta binding / protein-containing complex assembly / positive regulation of viral entry into host cell / lysosome / positive regulation of canonical NF-kappaB signal transduction / positive regulation of ERK1 and ERK2 cascade / positive regulation of MAPK cascade / protein stabilization / external side of plasma membrane / Golgi membrane / lysosomal membrane / positive regulation of gene expression / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / cell surface / protein-containing complex / extracellular exosome / identical protein binding / nucleus / membrane / plasma membrane / cytoplasm 類似検索 - 分子機能
Thyroglobulin type-1 / Invariant Chain; Chain I / MHC class II-associated invariant chain, trimerisation / MHC class II-associated invariant chain/CLIP, MHC II-interacting / MHC class II-associated invariant chain / MHC class II-associated invariant chain, trimerisation domain superfamily / HLA class II histocompatibility antigen, gamma subunit / Class II MHC-associated invariant chain trimerisation domain / CLIP, MHC2 interacting / : ...Thyroglobulin type-1 / Invariant Chain; Chain I / MHC class II-associated invariant chain, trimerisation / MHC class II-associated invariant chain/CLIP, MHC II-interacting / MHC class II-associated invariant chain / MHC class II-associated invariant chain, trimerisation domain superfamily / HLA class II histocompatibility antigen, gamma subunit / Class II MHC-associated invariant chain trimerisation domain / CLIP, MHC2 interacting / : / Thyroglobulin type-1 repeat signature. / Thyroglobulin type-1 / Thyroglobulin type-1 superfamily / Thyroglobulin type-1 repeat / Thyroglobulin type-1 domain profile. / Thyroglobulin type I repeats. / Few Secondary Structures / Irregular 類似検索 - ドメイン・相同性
HLA class II histocompatibility antigen gamma chain 類似検索 - 構成要素
手法: torsion angle dynamics, simulated annealing with restrained molecular dynamics ソフトェア番号: 1 詳細: the structures are based on a total of 981 restraints, 925 are NOE-derived distance constraints, 56 dihedral angle restraints
代表構造
選択基準: fewest violations
NMRアンサンブル
コンフォーマー選択の基準: structures with the lowest energy,target function 計算したコンフォーマーの数: 600 / 登録したコンフォーマーの数: 30