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基本情報
登録情報 | データベース: PDB / ID: 1jun | ||||||
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タイトル | NMR STUDY OF C-JUN HOMODIMER | ||||||
![]() | C-JUN HOMODIMER | ||||||
![]() | TRANSCRIPTION REGULATION / DNA-BINDING REGULATORY PROTEIN / ONCOGENE PROTEIN / TRANSCRIPTION ACTIVATION | ||||||
機能・相同性 | ![]() cAMP response element binding / transcription factor AP-1 complex / integrated stress response signaling / positive regulation of DNA-templated transcription initiation / release from viral latency / WNT5:FZD7-mediated leishmania damping / SMAD protein signal transduction / positive regulation by host of viral transcription / nuclear chromosome / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models ...cAMP response element binding / transcription factor AP-1 complex / integrated stress response signaling / positive regulation of DNA-templated transcription initiation / release from viral latency / WNT5:FZD7-mediated leishmania damping / SMAD protein signal transduction / positive regulation by host of viral transcription / nuclear chromosome / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / negative regulation of DNA binding / Activation of the AP-1 family of transcription factors / ubiquitin-like protein ligase binding / R-SMAD binding / general transcription initiation factor binding / negative regulation by host of viral transcription / positive regulation of vascular associated smooth muscle cell proliferation / cellular response to cadmium ion / response to endoplasmic reticulum stress / GTPase activator activity / transforming growth factor beta receptor signaling pathway / Regulation of PTEN gene transcription / TP53 Regulates Transcription of DNA Repair Genes / FCERI mediated MAPK activation / MAPK6/MAPK4 signaling / euchromatin / Pre-NOTCH Transcription and Translation / DNA-binding transcription repressor activity, RNA polymerase II-specific / positive regulation of miRNA transcription / Activation of anterior HOX genes in hindbrain development during early embryogenesis / cellular response to reactive oxygen species / RNA polymerase II transcription regulator complex / sequence-specific double-stranded DNA binding / Signaling by ALK fusions and activated point mutants / regulation of cell population proliferation / Senescence-Associated Secretory Phenotype (SASP) / DNA-binding transcription activator activity, RNA polymerase II-specific / Oxidative Stress Induced Senescence / Estrogen-dependent gene expression / RNA polymerase II-specific DNA-binding transcription factor binding / transcription regulator complex / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / regulation of cell cycle / positive regulation of apoptotic process / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / ubiquitin protein ligase binding / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / DNA binding / RNA binding / nucleoplasm / identical protein binding / nucleus 類似検索 - 分子機能 | ||||||
生物種 | ![]() | ||||||
手法 | 溶液NMR | ||||||
![]() | Junius, F.K. / O'Donoghue, S.I. / Nilges, M. / King, G.F. | ||||||
![]() | ![]() タイトル: High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer. 著者: Junius, F.K. / O'Donoghue, S.I. / Nilges, M. / Weiss, A.S. / King, G.F. #1: ![]() タイトル: Calculation of Symmetric Multimer Structures from NMR Data Using a Priori Knowledge of the Monomer Structure, Co-Monomer Restraints, and Interface Mapping: The Case of Leucine Zippers 著者: O'Donoghue, S.I. / King, G.F. / Nilges, M. #2: ![]() タイトル: Structural Studies of the Leucine Zipper Domain of the Oncoprotein C-Jun 著者: Junius, F.K. #3: ![]() タイトル: Nuclear Magnetic Resonance Characterization of the Jun Leucine Zipper Domain: Unusual Properties of Coiled-Coil Interfacial Polar Residues 著者: Junius, F.K. / Mackay, J.P. / Bubb, W.A. / Jensen, S.A. / Weiss, A.S. / King, G.F. #4: ![]() タイトル: The Solution Structure of the Leucine Zipper Motif of the Jun Oncoprotein Homodimer 著者: Junius, F.K. / Weiss, A.S. / King, G.F. #5: ![]() タイトル: Determination of the Structure of Symmetric Coiled-Coil Proteins from NMR Data: Application of the Leucine Zipper Proteins Jun and GCN4 著者: O'Donoghue, S.I. / Junius, F.K. / King, G.F. #6: ![]() タイトル: Preferential Heterodimer Formation by Isolated Leucine Zippers from Fos and Jun 著者: O'Shea, E.K. / Rutkowski, R. / Stafford III, W.F. / Kim, P.S. | ||||||
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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-検証レポート
文書・要旨 | ![]() | 357 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 425.8 KB | 表示 | |
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-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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NMR アンサンブル |
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要素
#1: タンパク質・ペプチド | 分子量: 4883.714 Da / 分子数: 2 / 断片: LEUCINE ZIPPER DOMAIN, RESIDUES 272 - 315 / 変異: INS(272-275), INS(315) / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() |
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-実験情報
-実験
実験 | 手法: 溶液NMR |
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試料調製
試料状態 | pH: 3.6 / 温度: 310 K |
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結晶化 | *PLUS 手法: other |
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解析
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NMR software | 名称: ![]() | ||||||||||||
NMRアンサンブル | 登録したコンフォーマーの数: 7 |