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Open data
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Basic information
Entry | Database: PDB / ID: 1jun | ||||||
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Title | NMR STUDY OF C-JUN HOMODIMER | ||||||
![]() | C-JUN HOMODIMER | ||||||
![]() | TRANSCRIPTION REGULATION / DNA-BINDING REGULATORY PROTEIN / ONCOGENE PROTEIN / TRANSCRIPTION ACTIVATION | ||||||
Function / homology | ![]() cAMP response element binding / transcription factor AP-1 complex / integrated stress response signaling / positive regulation of DNA-templated transcription initiation / release from viral latency / WNT5:FZD7-mediated leishmania damping / SMAD protein signal transduction / positive regulation by host of viral transcription / nuclear chromosome / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models ...cAMP response element binding / transcription factor AP-1 complex / integrated stress response signaling / positive regulation of DNA-templated transcription initiation / release from viral latency / WNT5:FZD7-mediated leishmania damping / SMAD protein signal transduction / positive regulation by host of viral transcription / nuclear chromosome / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / negative regulation of DNA binding / Activation of the AP-1 family of transcription factors / ubiquitin-like protein ligase binding / R-SMAD binding / general transcription initiation factor binding / negative regulation by host of viral transcription / positive regulation of vascular associated smooth muscle cell proliferation / cellular response to cadmium ion / response to endoplasmic reticulum stress / GTPase activator activity / transforming growth factor beta receptor signaling pathway / Regulation of PTEN gene transcription / TP53 Regulates Transcription of DNA Repair Genes / FCERI mediated MAPK activation / MAPK6/MAPK4 signaling / euchromatin / DNA-binding transcription repressor activity, RNA polymerase II-specific / Pre-NOTCH Transcription and Translation / positive regulation of miRNA transcription / Activation of anterior HOX genes in hindbrain development during early embryogenesis / cellular response to reactive oxygen species / RNA polymerase II transcription regulator complex / sequence-specific double-stranded DNA binding / Signaling by ALK fusions and activated point mutants / regulation of cell population proliferation / Senescence-Associated Secretory Phenotype (SASP) / DNA-binding transcription activator activity, RNA polymerase II-specific / Oxidative Stress Induced Senescence / Estrogen-dependent gene expression / RNA polymerase II-specific DNA-binding transcription factor binding / transcription regulator complex / regulation of cell cycle / DNA-binding transcription factor activity, RNA polymerase II-specific / transcription cis-regulatory region binding / positive regulation of apoptotic process / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / ubiquitin protein ligase binding / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / enzyme binding / positive regulation of transcription by RNA polymerase II / DNA binding / RNA binding / nucleoplasm / identical protein binding / nucleus Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | SOLUTION NMR | ||||||
![]() | Junius, F.K. / O'Donoghue, S.I. / Nilges, M. / King, G.F. | ||||||
![]() | ![]() Title: High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer. Authors: Junius, F.K. / O'Donoghue, S.I. / Nilges, M. / Weiss, A.S. / King, G.F. #1: ![]() Title: Calculation of Symmetric Multimer Structures from NMR Data Using a Priori Knowledge of the Monomer Structure, Co-Monomer Restraints, and Interface Mapping: The Case of Leucine Zippers Authors: O'Donoghue, S.I. / King, G.F. / Nilges, M. #2: ![]() Title: Structural Studies of the Leucine Zipper Domain of the Oncoprotein C-Jun Authors: Junius, F.K. #3: ![]() Title: Nuclear Magnetic Resonance Characterization of the Jun Leucine Zipper Domain: Unusual Properties of Coiled-Coil Interfacial Polar Residues Authors: Junius, F.K. / Mackay, J.P. / Bubb, W.A. / Jensen, S.A. / Weiss, A.S. / King, G.F. #4: ![]() Title: The Solution Structure of the Leucine Zipper Motif of the Jun Oncoprotein Homodimer Authors: Junius, F.K. / Weiss, A.S. / King, G.F. #5: ![]() Title: Determination of the Structure of Symmetric Coiled-Coil Proteins from NMR Data: Application of the Leucine Zipper Proteins Jun and GCN4 Authors: O'Donoghue, S.I. / Junius, F.K. / King, G.F. #6: ![]() Title: Preferential Heterodimer Formation by Isolated Leucine Zippers from Fos and Jun Authors: O'Shea, E.K. / Rutkowski, R. / Stafford III, W.F. / Kim, P.S. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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PDBx/mmCIF format | ![]() | 195.5 KB | Display | ![]() |
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PDB format | ![]() | 169.9 KB | Display | ![]() |
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-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Similar structure data |
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein/peptide | Mass: 4883.714 Da / Num. of mol.: 2 / Fragment: LEUCINE ZIPPER DOMAIN, RESIDUES 272 - 315 / Mutation: INS(272-275), INS(315) Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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Sample preparation
Sample conditions | pH: 3.6 / Temperature: 310 K |
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Crystal grow | *PLUS Method: other |
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Processing
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NMR software | Name: ![]() | ||||||||||||
NMR ensemble | Conformers submitted total number: 7 |