登録情報 | データベース: PDB / ID: 1jsp |
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タイトル | NMR Structure of CBP Bromodomain in complex with p53 peptide |
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要素 | - CREB-BINDING PROTEIN
- tumor protein p53
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キーワード | DNA BINDING PROTEIN / Bromodomain / CBP / NMR structure. |
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機能・相同性 | 機能・相同性情報
protein N-acetyltransferase activity / peptide lactyltransferase (CoA-dependent) activity / NFE2L2 regulating ER-stress associated genes / Activation of the TFAP2 (AP-2) family of transcription factors / NFE2L2 regulating inflammation associated genes / N-terminal peptidyl-lysine acetylation / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / NFE2L2 regulates pentose phosphate pathway genes / regulation of smoothened signaling pathway / NFE2L2 regulating MDR associated enzymes ...protein N-acetyltransferase activity / peptide lactyltransferase (CoA-dependent) activity / NFE2L2 regulating ER-stress associated genes / Activation of the TFAP2 (AP-2) family of transcription factors / NFE2L2 regulating inflammation associated genes / N-terminal peptidyl-lysine acetylation / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / NFE2L2 regulates pentose phosphate pathway genes / regulation of smoothened signaling pathway / NFE2L2 regulating MDR associated enzymes / MRF binding / negative regulation of helicase activity / Loss of function of TP53 in cancer due to loss of tetramerization ability / Regulation of TP53 Expression / signal transduction by p53 class mediator / negative regulation of G1 to G0 transition / negative regulation of glucose catabolic process to lactate via pyruvate / Transcriptional activation of cell cycle inhibitor p21 / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / regulation of intrinsic apoptotic signaling pathway by p53 class mediator / negative regulation of pentose-phosphate shunt / ATP-dependent DNA/DNA annealing activity / Activation of NOXA and translocation to mitochondria / regulation of cell cycle G2/M phase transition / regulation of fibroblast apoptotic process / intrinsic apoptotic signaling pathway in response to hypoxia / oligodendrocyte apoptotic process / negative regulation of miRNA processing / positive regulation of thymocyte apoptotic process / oxidative stress-induced premature senescence / regulation of tissue remodeling / positive regulation of mitochondrial membrane permeability / Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells / Regulation of FOXO transcriptional activity by acetylation / mRNA transcription / positive regulation of programmed necrotic cell death / RUNX3 regulates NOTCH signaling / bone marrow development / circadian behavior / T cell proliferation involved in immune response / NOTCH4 Intracellular Domain Regulates Transcription / Nuclear events mediated by NFE2L2 / regulation of mitochondrial membrane permeability involved in apoptotic process / germ cell nucleus / Regulation of NFE2L2 gene expression / RUNX3 regulates CDKN1A transcription / Regulation of gene expression by Hypoxia-inducible Factor / glucose catabolic process to lactate via pyruvate / TP53 Regulates Transcription of Death Receptors and Ligands / TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain / Activation of PUMA and translocation to mitochondria / regulation of DNA damage response, signal transduction by p53 class mediator / NOTCH3 Intracellular Domain Regulates Transcription / negative regulation of transcription by RNA polymerase I / TRAF6 mediated IRF7 activation / histone deacetylase regulator activity / NFE2L2 regulating tumorigenic genes / embryonic digit morphogenesis / NFE2L2 regulating anti-oxidant/detoxification enzymes / negative regulation of glial cell proliferation / Regulation of TP53 Activity through Association with Co-factors / protein-lysine-acetyltransferase activity / negative regulation of neuroblast proliferation / T cell lineage commitment / histone H2AK5 acetyltransferase activity / histone H2AK9 acetyltransferase activity / histone H2BK5 acetyltransferase activity / histone H2BK12 acetyltransferase activity / histone H3K36 acetyltransferase activity / mitochondrial DNA repair / histone H3K4 acetyltransferase activity / Formation of Senescence-Associated Heterochromatin Foci (SAHF) / protein acetylation / ER overload response / histone H3K56 acetyltransferase activity / histone H3K23 acetyltransferase activity / homeostatic process / thymocyte apoptotic process / B cell lineage commitment / Notch-HLH transcription pathway / histone H4K12 acetyltransferase activity / TP53 Regulates Transcription of Caspase Activators and Caspases / histone H3K14 acetyltransferase activity / negative regulation of mitophagy / histone H4K16 acetyltransferase activity / cardiac septum morphogenesis / Formation of paraxial mesoderm / histone H3K9 acetyltransferase activity / histone H4K5 acetyltransferase activity / histone H4K8 acetyltransferase activity / histone H3K122 acetyltransferase activity / negative regulation of DNA replication / entrainment of circadian clock by photoperiod / positive regulation of transforming growth factor beta receptor signaling pathway / acetyltransferase activity / FOXO-mediated transcription of cell death genes / PI5P Regulates TP53 Acetylation / stimulatory C-type lectin receptor signaling pathway / negative regulation of telomere maintenance via telomerase / Zygotic genome activation (ZGA)類似検索 - 分子機能 Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily / TAZ zinc finger / Zinc finger TAZ-type profile. / TAZ zinc finger, present in p300 and CBP / : / Histone acetyltransferase p300-like, PHD domain ...Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily / TAZ zinc finger / Zinc finger TAZ-type profile. / TAZ zinc finger, present in p300 and CBP / : / Histone acetyltransferase p300-like, PHD domain / Coactivator CBP, KIX domain / CREB-binding protein/p300, atypical RING domain / CBP/p300-type histone acetyltransferase domain / CBP/p300, atypical RING domain superfamily / KIX domain / CREB-binding protein/p300, atypical RING domain / KIX domain profile. / CBP/p300-type histone acetyltransferase (HAT) domain profile. / Histone acetyltransferase Rtt109/CBP / Histone acetylation protein / Histone acetylation protein / Coactivator CBP, KIX domain superfamily / Cellular tumor antigen p53, transactivation domain 2 / Transactivation domain 2 / p53 transactivation domain / P53 transactivation motif / Zinc finger ZZ-type signature. / p53 family signature. / p53, tetramerisation domain / P53 tetramerisation motif / p53, DNA-binding domain / P53 DNA-binding domain / p53 tumour suppressor family / Zinc-binding domain, present in Dystrophin, CREB-binding protein. / Zinc finger, ZZ type / Zinc finger, ZZ-type / Zinc finger, ZZ-type superfamily / Zinc finger ZZ-type profile. / p53-like tetramerisation domain superfamily / p53/RUNT-type transcription factor, DNA-binding domain superfamily / p53-like transcription factor, DNA-binding / Nuclear receptor coactivator, interlocking / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / bromo domain / Bromodomain (BrD) profile. / Bromodomain / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Cellular tumor antigen p53 / CREB-binding protein類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / distance geometry simulated annealing |
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データ登録者 | He, Y. / Mujtaba, S. / Zeng, L. / Yan, S. / Zhou, M.-M. |
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引用 | ジャーナル: Mol.Cell / 年: 2004 タイトル: Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. 著者: Mujtaba, S. / He, Y. / Zeng, L. / Yan, S. / Plotnikova, O. / Sachchidanand / Sanchez, R. / Zeleznik-Le, N.J. / Ronai, Z. / Zhou, M.M. |
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履歴 | 登録 | 2001年8月17日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2002年8月17日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月27日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2022年2月23日 | Group: Database references / Derived calculations カテゴリ: database_2 / pdbx_struct_assembly ...database_2 / pdbx_struct_assembly / pdbx_struct_oper_list / struct_conn / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details |
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改定 2.0 | 2023年11月15日 | Group: Atomic model / Data collection / カテゴリ: atom_site / chem_comp_atom / chem_comp_bond / Item: _atom_site.auth_atom_id / _atom_site.label_atom_id |
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改定 2.1 | 2024年10月16日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature |
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