|Entry||Database: PDB / ID: 1hiq|
|Title||PARADOXICAL STRUCTURE AND FUNCTION IN A MUTANT HUMAN INSULIN ASSOCIATED WITH DIABETES MELLITUS|
|Components||(INSULIN) x 2|
|Function / homology|
Function and homology information
Signaling by Insulin receptor / negative regulation of glycogen catabolic process / alpha-beta T cell activation / Insulin processing / IRS activation / Insulin receptor recycling / negative regulation of NAD(P)H oxidase activity / nitric oxide-cGMP-mediated signaling pathway / negative regulation of feeding behavior / negative regulation of fatty acid metabolic process ...Signaling by Insulin receptor / negative regulation of glycogen catabolic process / alpha-beta T cell activation / Insulin processing / IRS activation / Insulin receptor recycling / negative regulation of NAD(P)H oxidase activity / nitric oxide-cGMP-mediated signaling pathway / negative regulation of feeding behavior / negative regulation of fatty acid metabolic process / regulation of protein secretion / Regulation of gene expression in beta cells / positive regulation of peptide hormone secretion / positive regulation of respiratory burst / negative regulation of respiratory burst involved in inflammatory response / positive regulation of dendritic spine maintenance / negative regulation of gluconeogenesis / negative regulation of reactive oxygen species biosynthetic process / positive regulation of lipid biosynthetic process / positive regulation of cellular protein metabolic process / Regulation of insulin secretion / negative regulation of protein secretion / COPI-mediated anterograde transport / Synthesis, secretion, and deacylation of Ghrelin / regulation of protein localization to plasma membrane / fatty acid homeostasis / positive regulation of glycogen biosynthetic process / regulation of cellular amino acid metabolic process / positive regulation of nitric oxide mediated signal transduction / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / Signal attenuation / negative regulation of lipid catabolic process / endosome lumen / transport vesicle / positive regulation of insulin receptor signaling pathway / endoplasmic reticulum-Golgi intermediate compartment membrane / neuron projection maintenance / insulin-like growth factor receptor binding / positive regulation of protein autophosphorylation / regulation of transmembrane transporter activity / negative regulation of acute inflammatory response / positive regulation of glycolytic process / positive regulation of cell differentiation / Insulin receptor signalling cascade / regulation of synaptic plasticity / positive regulation of mitotic nuclear division / cognition / positive regulation of brown fat cell differentiation / regulation of protein localization / positive regulation of long-term synaptic potentiation / positive regulation of cytokine production / vasodilation / activation of protein kinase B activity / acute-phase response / positive regulation of glucose import / hormone activity / negative regulation of proteolysis / negative regulation of protein catabolic process / positive regulation of protein localization to nucleus / insulin receptor binding / insulin receptor signaling pathway / positive regulation of nitric-oxide synthase activity / glucose metabolic process / Golgi lumen / cell-cell signaling / glucose homeostasis / wound healing / endoplasmic reticulum to Golgi vesicle-mediated transport / positive regulation of MAPK cascade / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / positive regulation of cell growth / positive regulation of phosphatidylinositol 3-kinase signaling / secretory granule lumen / protease binding / positive regulation of NF-kappaB transcription factor activity / positive regulation of cell migration / positive regulation of protein kinase B signaling / Amyloid fiber formation / Golgi membrane / G protein-coupled receptor signaling pathway / amyloid fibril formation / endoplasmic reticulum lumen / regulation of transcription, DNA-templated / positive regulation of gene expression / positive regulation of cell population proliferation / extracellular space / extracellular region / identical protein binding
Similarity search - Function
Insulin / Insulin family / Insulin-like / Insulin / insulin-like growth factor / relaxin family. / Insulin/IGF/Relaxin family / Insulin, conserved site / Insulin-like superfamily / Insulin family signature.
Similarity search - Domain/homology
|Biological species||Homo sapiens (human)|
|Authors||Hua, Q.X. / Shoelson, S.E. / Inouye, K. / Weiss, M.A.|
Journal: Proc.Natl.Acad.Sci.USA / Year: 1993
Title: Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.
Authors: Hua, Q.X. / Shoelson, S.E. / Inouye, K. / Weiss, M.A.
#1: Journal: Proc.Natl.Acad.Sci.USA / Year: 1992
Title: Structure and Dynamics of Des-Pentapeptide-Insulin in Solution: The Molten-Globule Hypothesis
Authors: Hua, Q.-X. / Kochoyan, M. / Weiss, M.A.
|Structure viewer||Molecule: |
Downloads & links
|Atom site foot note||1: THR B 27 - PRO B 28 MODEL 2 OMEGA =213.93 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION|
2: THR B 27 - PRO B 28 MODEL 9 OMEGA =213.50 PEPTIDE BOND DEVIATES SIGNIFICANTLY FROM TRANS CONFORMATION
|#1: Protein/peptide|| |
Mass: 2383.698 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / References: UniProt: P01308
|#2: Protein/peptide|| |
Mass: 3373.857 Da / Num. of mol.: 1 / Mutation: F24S
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Organ: PANCREAS / References: UniProt: P01308
|Experiment||Method: SOLUTION NMR|
*PLUSMethod: other / Details: NMR
|NMR ensemble||Conformers submitted total number: 10|
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