登録情報 | データベース: PDB / ID: 1fyv |
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タイトル | CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR1 |
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要素 | TOLL-LIKE RECEPTOR 1 |
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キーワード | SIGNALING PROTEIN / beta-alpha-beta fold parallel beta sheet |
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機能・相同性 | 機能・相同性情報
Toll-like receptor 1-Toll-like receptor 2 protein complex / detection of triacyl bacterial lipopeptide / cellular response to triacyl bacterial lipopeptide / positive regulation of toll-like receptor 2 signaling pathway / Toll Like Receptor TLR1:TLR2 Cascade / Beta defensins / Toll-like receptor 2 binding / macrophage activation / Regulation of TLR by endogenous ligand / lipopeptide binding ...Toll-like receptor 1-Toll-like receptor 2 protein complex / detection of triacyl bacterial lipopeptide / cellular response to triacyl bacterial lipopeptide / positive regulation of toll-like receptor 2 signaling pathway / Toll Like Receptor TLR1:TLR2 Cascade / Beta defensins / Toll-like receptor 2 binding / macrophage activation / Regulation of TLR by endogenous ligand / lipopeptide binding / NAD+ nucleotidase, cyclic ADP-ribose generating / MyD88 deficiency (TLR2/4) / IRAK4 deficiency (TLR2/4) / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / toll-like receptor signaling pathway / positive regulation of interleukin-8 production / positive regulation of interleukin-6 production / phagocytic vesicle membrane / transmembrane signaling receptor activity / positive regulation of tumor necrosis factor production / signaling receptor activity / ER-Phagosome pathway / receptor complex / inflammatory response / immune response / membrane raft / innate immune response / SARS-CoV-2 activates/modulates innate and adaptive immune responses / Golgi apparatus / signal transduction / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 Leucine rich repeat C-terminal domain / Toll/interleukin-1 receptor homology (TIR) domain / Toll-like receptor / TIR domain / Leucine-rich repeats, bacterial type / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Toll - interleukin 1 - resistance / TIR domain profile. / Toll/interleukin-1 receptor homology (TIR) domain ...Leucine rich repeat C-terminal domain / Toll/interleukin-1 receptor homology (TIR) domain / Toll-like receptor / TIR domain / Leucine-rich repeats, bacterial type / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Toll - interleukin 1 - resistance / TIR domain profile. / Toll/interleukin-1 receptor homology (TIR) domain / Toll/interleukin-1 receptor homology (TIR) domain superfamily / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Leucine-rich repeat domain superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 2.9 Å |
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データ登録者 | Xu, Y. / Tao, X. / Shen, B. / Horng, T. / Medzhitov, R. / Manley, J.L. / Tong, L. |
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引用 | ジャーナル: Nature / 年: 2000 タイトル: Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. 著者: Xu, Y. / Tao, X. / Shen, B. / Horng, T. / Medzhitov, R. / Manley, J.L. / Tong, L. |
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履歴 | 登録 | 2000年10月3日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2000年11月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月27日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2018年1月31日 | Group: Advisory / Experimental preparation カテゴリ: exptl_crystal_grow / pdbx_unobs_or_zero_occ_atoms / pdbx_unobs_or_zero_occ_residues Item: _exptl_crystal_grow.pdbx_details / _exptl_crystal_grow.temp |
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