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- PDB-1fsb: STRUCTURE OF THE EGF DOMAIN OF P-SELECTIN, NMR, 19 STRUCTURES -

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Basic information

Entry
Database: PDB / ID: 1fsb
TitleSTRUCTURE OF THE EGF DOMAIN OF P-SELECTIN, NMR, 19 STRUCTURES
ComponentsP-SELECTIN
KeywordsCELL ADHESION PROTEIN / EGF-LIKE DOMAIN / TRANSMEMBRANE / GLYCOPROTEIN
Function / homology
Function and homology information


regulation of integrin activation / fucose binding / glycosphingolipid binding / platelet dense granule membrane / positive regulation of leukocyte tethering or rolling / sialic acid binding / oligosaccharide binding / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / platelet alpha granule membrane / leukocyte tethering or rolling ...regulation of integrin activation / fucose binding / glycosphingolipid binding / platelet dense granule membrane / positive regulation of leukocyte tethering or rolling / sialic acid binding / oligosaccharide binding / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / platelet alpha granule membrane / leukocyte tethering or rolling / positive regulation of platelet activation / positive regulation of leukocyte migration / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / leukocyte cell-cell adhesion / response to cytokine / Cell surface interactions at the vascular wall / lipopolysaccharide binding / cell-cell adhesion / calcium-dependent protein binding / integrin binding / Platelet degranulation / heparin binding / defense response to Gram-negative bacterium / response to lipopolysaccharide / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cell adhesion / inflammatory response / external side of plasma membrane / calcium ion binding / extracellular space / plasma membrane
Similarity search - Function
Selectin superfamily / Selectin, C-type lectin-like domain / : / C-type lectin, conserved site / C-type lectin domain signature. / Sushi repeat (SCR repeat) / Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR) / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily ...Selectin superfamily / Selectin, C-type lectin-like domain / : / C-type lectin, conserved site / C-type lectin domain signature. / Sushi repeat (SCR repeat) / Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR) / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily / Lectin C-type domain / C-type lectin domain profile. / C-type lectin-like / C-type lectin (CTL) or carbohydrate-recognition domain (CRD) / Laminin / Laminin / C-type lectin-like/link domain superfamily / C-type lectin fold / EGF-like domain profile. / EGF-like domain signature 1. / EGF-like domain signature 2. / EGF-like domain / Ribbon / Mainly Beta
Similarity search - Domain/homology
Biological speciesHomo sapiens (human)
MethodSOLUTION NMR
AuthorsFreedman, S.J. / Sanford, D.G. / Bachovchin, W.W. / Furie, B.C. / Baleja, J.D. / Furie, B.
CitationJournal: Biochemistry / Year: 1996
Title: Structure and function of the epidermal growth factor domain of P-selectin.
Authors: Freedman, S.J. / Sanford, D.G. / Bachovchin, W.W. / Furie, B.C. / Baleja, J.D. / Furie, B.
History
DepositionMar 25, 1996Processing site: BNL
Revision 1.0Apr 1, 1997Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Nov 29, 2017Group: Derived calculations / Other
Category: pdbx_database_status / pdbx_struct_assembly ...pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_conf
Item: _pdbx_database_status.process_site
Revision 1.4Nov 6, 2024Group: Data collection / Database references / Structure summary
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: P-SELECTIN


Theoretical massNumber of molelcules
Total (without water)4,4561
Polymers4,4561
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_5551
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)19 / 19
Representative

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Components

#1: Protein/peptide P-SELECTIN


Mass: 4455.910 Da / Num. of mol.: 1 / Fragment: EGF DOMAIN, RESIDUES 119 - 158
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / References: UniProt: P16109
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Sample conditionspH: 6 / Temperature: 298 K
Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

NMR ensembleConformers calculated total number: 19 / Conformers submitted total number: 19

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