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データを開く
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基本情報
登録情報 | データベース: PDB / ID: 1fos | ||||||
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タイトル | TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES | ||||||
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![]() | TRANSCRIPTION/DNA / COILED-COIL / DNA-BINDING PROTEIN / HETERODIMER / TRANSCRIPTION-DNA COMPLEX | ||||||
機能・相同性 | ![]() cAMP response element binding / transcription factor AP-1 complex / integrated stress response signaling / positive regulation of DNA-templated transcription initiation / release from viral latency / mononuclear cell differentiation / cellular response to prolactin / response to gravity / skeletal muscle cell proliferation / cellular response to zinc ion starvation ...cAMP response element binding / transcription factor AP-1 complex / integrated stress response signaling / positive regulation of DNA-templated transcription initiation / release from viral latency / mononuclear cell differentiation / cellular response to prolactin / response to gravity / skeletal muscle cell proliferation / cellular response to zinc ion starvation / cellular response to phorbol 13-acetate 12-myristate / WNT5:FZD7-mediated leishmania damping / conditioned taste aversion / SMAD protein signal transduction / NGF-stimulated transcription / positive regulation of osteoclast differentiation / positive regulation by host of viral transcription / cellular response to parathyroid hormone stimulus / myoblast proliferation / nuclear chromosome / response to corticosterone / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / negative regulation of DNA binding / Activation of the AP-1 family of transcription factors / ubiquitin-like protein ligase binding / skeletal muscle cell differentiation / R-SMAD binding / general transcription initiation factor binding / response to immobilization stress / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / response to light stimulus / negative regulation by host of viral transcription / RNA polymerase II core promoter sequence-specific DNA binding / cellular response to epidermal growth factor stimulus / positive regulation of vascular associated smooth muscle cell proliferation / response to cAMP / response to muscle stretch / cellular response to cadmium ion / cellular response to calcium ion / NPAS4 regulates expression of target genes / response to endoplasmic reticulum stress / GTPase activator activity / transforming growth factor beta receptor signaling pathway / osteoclast differentiation / response to activity / Regulation of PTEN gene transcription / transcription coregulator binding / response to progesterone / female pregnancy / protein-DNA complex / TP53 Regulates Transcription of DNA Repair Genes / FCERI mediated MAPK activation / MAPK6/MAPK4 signaling / response to insulin / euchromatin / response to toxic substance / Pre-NOTCH Transcription and Translation / DNA-binding transcription repressor activity, RNA polymerase II-specific / positive regulation of miRNA transcription / Activation of anterior HOX genes in hindbrain development during early embryogenesis / cellular response to reactive oxygen species / RNA polymerase II transcription regulator complex / sequence-specific double-stranded DNA binding / Signaling by ALK fusions and activated point mutants / cellular response to tumor necrosis factor / nervous system development / regulation of cell population proliferation / cellular response to hypoxia / Senescence-Associated Secretory Phenotype (SASP) / DNA-binding transcription activator activity, RNA polymerase II-specific / Interleukin-4 and Interleukin-13 signaling / Oxidative Stress Induced Senescence / response to ethanol / Estrogen-dependent gene expression / RNA polymerase II-specific DNA-binding transcription factor binding / transcription regulator complex / transcription by RNA polymerase II / response to lipopolysaccharide / regulation of cell cycle / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / response to xenobiotic stimulus / inflammatory response / positive regulation of apoptotic process / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / ubiquitin protein ligase binding / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / negative regulation of transcription by RNA polymerase II / endoplasmic reticulum / positive regulation of transcription by RNA polymerase II / DNA binding / RNA binding / nucleoplasm / identical protein binding 類似検索 - 分子機能 | ||||||
生物種 | ![]() | ||||||
手法 | ![]() | ||||||
![]() | Glover, J.N.M. / Harrison, S.C. | ||||||
![]() | ![]() タイトル: Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. 著者: Glover, J.N. / Harrison, S.C. | ||||||
履歴 |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
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ダウンロード
PDBx/mmCIF形式 | ![]() | 102.6 KB | 表示 | ![]() |
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PDB形式 | ![]() | 74.6 KB | 表示 | ![]() |
PDBx/mmJSON形式 | ![]() | ツリー表示 | ![]() | |
その他 | ![]() |
-検証レポート
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
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-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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2 | ![]()
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単位格子 |
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要素
#1: DNA鎖 | 分子量: 6271.092 Da / 分子数: 2 / 由来タイプ: 合成 #2: DNA鎖 | 分子量: 5994.890 Da / 分子数: 2 / 由来タイプ: 合成 #3: タンパク質 | 分子量: 7379.443 Da / 分子数: 2 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() ![]() ![]() #4: タンパク質 | 分子量: 7321.695 Da / 分子数: 2 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() ![]() ![]() 配列の詳細 | FOS SEQUENCE EXPRESSED CORRESPONDS TO RESIDUES 139 - 200 OF HUMAN P55-C-FOS PROTO-ONCOGENE PROTEIN. ...FOS SEQUENCE EXPRESSED CORRESPOND | |
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-実験情報
-実験
実験 | 手法: ![]() |
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試料調製
結晶 | マシュー密度: 3.53 Å3/Da / 溶媒含有率: 65.18 % | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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結晶化 | 温度: 293 K / 手法: 蒸気拡散法, ハンギングドロップ法 / pH: 6.7 詳細: pH 6.70, VAPOR DIFFUSION, HANGING DROP, temperature 293.00K | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
溶液の組成 |
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結晶化 | *PLUS 温度: 20 ℃ / pH: 6.7 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
溶液の組成 | *PLUS
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-データ収集
放射光源 | 波長: 1.54 |
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検出器 | タイプ: MARRESEARCH / 検出器: IMAGE PLATE |
放射 | プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray |
放射波長 | 波長: 1.54 Å / 相対比: 1 |
反射 | Num. obs: 14316 / % possible obs: 91.1 % / Observed criterion σ(I): 1 |
反射 | *PLUS % possible obs: 91.1 % / Observed criterion σ(I): 0 / Num. measured all: 76796 / Rmerge(I) obs: 0.09 |
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解析
ソフトウェア |
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精密化 | 解像度: 3.05→10 Å / Rfactor Rfree: 0.321 / Rfactor Rwork: 0.23 / Rfactor obs: 0.23 / σ(F): 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
精密化ステップ | サイクル: LAST / 解像度: 3.05→10 Å
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拘束条件 |
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ソフトウェア | *PLUS 名称: ![]() | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
精密化 | *PLUS 最高解像度: 3.05 Å / 最低解像度: 10 Å / σ(F): 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
溶媒の処理 | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
原子変位パラメータ | *PLUS |