negative regulation of DNA recombination at telomere / negative regulation of telomere maintenance / protection from non-homologous end joining at telomere / telomere maintenance via telomere lengthening / shelterin complex / Telomere C-strand synthesis initiation / Telomere C-strand (Lagging Strand) Synthesis / positive regulation of telomere maintenance / nuclear telomere cap complex / Processive synthesis on the C-strand of the telomere ...negative regulation of DNA recombination at telomere / negative regulation of telomere maintenance / protection from non-homologous end joining at telomere / telomere maintenance via telomere lengthening / shelterin complex / Telomere C-strand synthesis initiation / Telomere C-strand (Lagging Strand) Synthesis / positive regulation of telomere maintenance / nuclear telomere cap complex / Processive synthesis on the C-strand of the telomere / Polymerase switching on the C-strand of the telomere / Removal of the Flap Intermediate from the C-strand / G-rich strand telomeric DNA binding / telomere capping / regulation of telomere maintenance / protein localization to chromosome, telomeric region / regulation of double-strand break repair via homologous recombination / nuclear chromosome / telomeric DNA binding / Telomere Extension By Telomerase / telomere maintenance via telomerase / phosphatase binding / Packaging Of Telomere Ends / Recognition and association of DNA glycosylase with site containing an affected purine / Cleavage of the damaged purine / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine / Inhibition of DNA recombination at telomere / Meiotic synapsis / telomere maintenance / negative regulation of protein phosphorylation / male germ cell nucleus / DNA Damage/Telomere Stress Induced Senescence / positive regulation of non-canonical NF-kappaB signal transduction / positive regulation of NF-kappaB transcription factor activity / positive regulation of canonical NF-kappaB signal transduction / chromosome, telomeric region / nuclear body / intracellular signal transduction / regulation of DNA-templated transcription / nucleoplasm / nucleus / cytoplasm Similarity search - Function
The submitted conformer models are 25 structure with the lowest energy in those with the fewest number of constraint violations.
Representative
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Components
#1: Protein
TRF2-INTERACTINGTELOMERICRAP1PROTEIN
Mass: 6660.511 Da / Num. of mol.: 1 / Fragment: MYB-DOMAIN / Mutation: 25MDR / Source method: obtained synthetically Details: THIS PEPTIDE WAS CHEMICALLY SYNTHESIZED. THE SEQUENCE OF THIS PEPTIDE OCCURS NATURALLY IN HUMANS (HOMO SAPIENS). References: UniProt: Q9NYB0
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Experimental details
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Experiment
Experiment
Method: SOLUTION NMR
NMR experiment
Conditions-ID
Experiment-ID
Solution-ID
Type
1
1
1
2D NOESY
1
2
1
DQF-COSY
NMR details
Text: This structure was determined using standard 2D homonuclear techniques.
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Sample preparation
Details
Contents: 1.0mM protein concentration in 100mM potassium phosphate buffer pH5.5, 1mM NaN3 ; 90%H2O, 10%D2O Solvent system: 90% H2O/10% D2O
Sample conditions
pH: 5.5 / Pressure: 1 atm / Temperature: 300 K
Crystal grow
*PLUS
Method: other / Details: NMR
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NMR measurement
Radiation
Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M
Radiation wavelength
Relative weight: 1
NMR spectrometer
Type: Bruker DMX / Manufacturer: Bruker / Model: DMX / Field strength: 600 MHz
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Processing
NMR software
Name
Version
Developer
Classification
NMRPipe
4.2.5
Delaglio, F., Grzesiek, S., Vuister, G.W., Zhu,G., Pfeifer, J. andBax,A.
processing
X-PLOR
3.851
Brnger,A.T.
structuresolution
X-PLOR
3.851
Brnger,A.T.
refinement
Refinement
Method: distance geometry simulated annealing / Software ordinal: 1 Details: the structures are based on a total of 884 restraints, 838 are NOE-derived distance constraints, 39 dihedral angle restraints, 7 distance restraints from hydrogen bonds.
NMR ensemble
Conformer selection criteria: The submitted conformer models are 25 structure with the lowest energy in those with the fewest number of constraint violations. Conformers calculated total number: 100 / Conformers submitted total number: 25
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