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- PDB-1f3v: Crystal structure of the complex between the N-terminal domain of... -
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Basic information
Entry | Database: PDB / ID: 1f3v | ||||||
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Title | Crystal structure of the complex between the N-terminal domain of TRADD and the TRAF domain of TRAF2 | ||||||
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![]() | APOPTOSIS / a-b sandwich | ||||||
Function / homology | ![]() CD40 receptor binding / tumor necrosis factor receptor superfamily complex / death domain binding / sphingolipid binding / IRE1-TRAF2-ASK1 complex / Defective RIPK1-mediated regulated necrosis / TRAF2-GSTP1 complex / positive regulation of hair follicle development / negative regulation of glial cell apoptotic process / Regulation by c-FLIP ...CD40 receptor binding / tumor necrosis factor receptor superfamily complex / death domain binding / sphingolipid binding / IRE1-TRAF2-ASK1 complex / Defective RIPK1-mediated regulated necrosis / TRAF2-GSTP1 complex / positive regulation of hair follicle development / negative regulation of glial cell apoptotic process / Regulation by c-FLIP / CASP8 activity is inhibited / Dimerization of procaspase-8 / tumor necrosis factor binding / TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway / interleukin-17-mediated signaling pathway / programmed necrotic cell death / TNF signaling / Caspase activation via Death Receptors in the presence of ligand / CD40 receptor complex / signal transduction involved in regulation of gene expression / activation of NF-kappaB-inducing kinase activity / death-inducing signaling complex / vesicle membrane / mitogen-activated protein kinase kinase kinase binding / positive regulation of tumor necrosis factor-mediated signaling pathway / mRNA stabilization / transmembrane receptor protein tyrosine kinase adaptor activity / thioesterase binding / tumor necrosis factor receptor binding / positive regulation of extrinsic apoptotic signaling pathway / regulation of immunoglobulin production / TNFR1-induced proapoptotic signaling / RIPK1-mediated regulated necrosis / TRAF6 mediated IRF7 activation / non-canonical NF-kappaB signal transduction / TRAF6 mediated NF-kB activation / protein K63-linked ubiquitination / regulation of JNK cascade / extrinsic apoptotic signaling pathway via death domain receptors / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / cellular response to nitric oxide / regulation of protein-containing complex assembly / canonical NF-kappaB signal transduction / protein autoubiquitination / signaling adaptor activity / extrinsic apoptotic signaling pathway / ubiquitin ligase complex / positive regulation of JUN kinase activity / tumor necrosis factor-mediated signaling pathway / positive regulation of interleukin-2 production / response to endoplasmic reticulum stress / TNFR1-induced NF-kappa-B signaling pathway / Regulation of NF-kappa B signaling / TNFR2 non-canonical NF-kB pathway / Regulation of TNFR1 signaling / protein catabolic process / RING-type E3 ubiquitin transferase / Regulation of necroptotic cell death / cytoplasmic side of plasma membrane / positive regulation of T cell cytokine production / kinase binding / positive regulation of DNA-binding transcription factor activity / positive regulation of inflammatory response / ubiquitin-protein transferase activity / protein-macromolecule adaptor activity / cellular response to tumor necrosis factor / positive regulation of NF-kappaB transcription factor activity / cell cortex / protein-containing complex assembly / regulation of apoptotic process / protein phosphatase binding / positive regulation of canonical NF-kappaB signal transduction / molecular adaptor activity / cytoskeleton / receptor complex / Ub-specific processing proteases / positive regulation of cell migration / positive regulation of apoptotic process / membrane raft / innate immune response / apoptotic process / ubiquitin protein ligase binding / protein-containing complex binding / protein kinase binding / enzyme binding / signal transduction / zinc ion binding / nucleoplasm / identical protein binding / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Park, Y.C. / Ye, H. / Hsia, C. / Segal, D. / Rich, R. / Liou, H.-C. / Myszka, D. / Wu, H. | ||||||
![]() | ![]() Title: A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Authors: Park, Y.C. / Ye, H. / Hsia, C. / Segal, D. / Rich, R.L. / Liou, H.C. / Myszka, D.G. / Wu, H. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 78.1 KB | Display | ![]() |
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PDB format | ![]() | 62.2 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 375.4 KB | Display | ![]() |
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Full document | ![]() | 383.5 KB | Display | |
Data in XML | ![]() | 9.1 KB | Display | |
Data in CIF | ![]() | 14.3 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 19412.998 Da / Num. of mol.: 1 / Fragment: N-TERMINAL DOMAIN Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
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#2: Protein | Mass: 19718.646 Da / Num. of mol.: 1 / Fragment: TRAF DOMAIN Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
#3: Water | ChemComp-HOH / |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.71 Å3/Da / Density % sol: 54.56 % | |||||||||||||||
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Crystal grow | Temperature: 293 K / Method: vapor diffusion / Details: VAPOR DIFFUSION, temperature 293K | |||||||||||||||
Crystal grow | *PLUS pH: 5.6 | |||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: ADSC / Detector: CCD / Date: Jun 1, 1999 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 0.9 Å / Relative weight: 1 |
Reflection | Resolution: 2→20 Å |
Reflection | *PLUS % possible obs: 96.9 % / Rmerge(I) obs: 0.036 |
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Processing
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Refinement | Resolution: 2→20 Å / σ(F): 2 /
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Refinement step | Cycle: LAST / Resolution: 2→20 Å
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Software | *PLUS Name: CNS / Classification: refinement | ||||||||||||
Refinement | *PLUS Highest resolution: 2 Å / Lowest resolution: 20 Å / σ(F): 2 / Rfactor obs: 0.229 | ||||||||||||
Solvent computation | *PLUS | ||||||||||||
Displacement parameters | *PLUS | ||||||||||||
Refine LS restraints | *PLUS
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