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- PDB-1eit: NMR STUDY OF MU-AGATOXIN -

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Basic information

Entry
Database: PDB / ID: 1eit
TitleNMR STUDY OF MU-AGATOXIN
ComponentsMU-AGATOXIN-I
KeywordsNEUROTOXIN / EXCITATORY INSECT TOXIN
Function / homologyToxin 7 / Beta/delta-agatoxin family / Mu-agatoxin family signature. / host cell presynaptic membrane / sodium channel regulator activity / toxin activity / extracellular region / Mu-agatoxin-Aa1a
Function and homology information
Biological speciesAgelenopsis aperta (spider)
MethodSOLUTION NMR
AuthorsOmecinsky, D.O. / Reily, M.D.
Citation
Journal: Biochemistry / Year: 1996
Title: Three-dimensional structure analysis of mu-agatoxins: further evidence for common motifs among neurotoxins with diverse ion channel specificities.
Authors: Omecinsky, D.O. / Holub, K.E. / Adams, M.E. / Reily, M.D.
#1: Journal: J.Biomol.NMR / Year: 1995
Title: The Solution Structure of Omega-Aga-Ivb, a P-Type Calcium Channel Antagonist from the Venom of Agelenopsis Aperta
Authors: Reily, M.D. / Thanabal, V. / Adams, M.E.
#2: Journal: Nat.Struct.Biol. / Year: 1994
Title: Structure-Activity Relationships for P-Type Calcium Channel-Selective Omega-Agatoxins
Authors: Reily, M.D. / Holub, K.E. / Gray, W.R. / Norris, T.M. / Adams, M.E.
#3: Journal: Mol.Pharmacol. / Year: 1993
Title: Structure and Properties of Omega-Aga-Ivb, a New Antagonist of P-Type Calcium Channels
Authors: Adams, M.E. / Mintz, I.M. / Reily, M.D. / Thanabal, V. / Bean, B.P.
#4: Journal: J.Biol.Chem. / Year: 1989
Title: Purification and Characterization of Two Classes of Neurotoxins from the Funnel Web Spider, Agelenopsis Aperta
Authors: Skinner, W.S. / Adams, M.E. / Quistad, G.B. / Kataoka, H. / Cesarin, B.J. / Enderlin, F.E. / Schooley, D.A. / Bean, B.P.
History
DepositionDec 14, 1995Processing site: BNL
Revision 1.0Apr 3, 1996Provider: repository / Type: Initial release
Revision 1.1Mar 3, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 16, 2022Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_nmr_software / pdbx_struct_assembly / pdbx_struct_oper_list / struct_conn / struct_site
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site / _pdbx_nmr_software.name / _struct_conn.pdbx_leaving_atom_flag / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
Revision 1.4Oct 23, 2024Group: Data collection / Structure summary
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / pdbx_entry_details / pdbx_modification_feature

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: MU-AGATOXIN-I


Theoretical massNumber of molelcules
Total (without water)4,2761
Polymers4,2761
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Atom site foot note1: CIS PROLINE - PRO 28
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)10 / -
Representative

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Components

#1: Protein/peptide MU-AGATOXIN-I / MU-AGA-I


Mass: 4275.790 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Agelenopsis aperta (spider) / Tissue: VENOM / References: UniProt: P11057
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other

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Processing

NMR software
NameDeveloperClassification
DGIIHAVELrefinement
DiscoverBIOSYMrefinement
NMR ensembleConformers submitted total number: 10

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