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基本情報
登録情報 | データベース: PDB / ID: 1bor | ||||||
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タイトル | TRANSCRIPTION FACTOR PML, A PROTO-ONCOPROTEIN, NMR, 1 REPRESENTATIVE STRUCTURE AT PH 7.5, 30 C, IN THE PRESENCE OF ZINC | ||||||
![]() | TRANSCRIPTION FACTOR PML | ||||||
![]() | TRANSCRIPTION REGULATION / PROTO-ONCOGENE / NUCLEAR BODIES (PODS) / LEUKEMIA | ||||||
機能・相同性 | ![]() regulation of calcium ion transport into cytosol / negative regulation of translation in response to oxidative stress / ubiquitin-like protein ligase activity / SUMO-modified protein reader activity / positive regulation of protein localization to chromosome, telomeric region / positive regulation of peptidyl-lysine acetylation / suppression of viral release by host / PML body organization / SUMO binding / fibroblast migration ...regulation of calcium ion transport into cytosol / negative regulation of translation in response to oxidative stress / ubiquitin-like protein ligase activity / SUMO-modified protein reader activity / positive regulation of protein localization to chromosome, telomeric region / positive regulation of peptidyl-lysine acetylation / suppression of viral release by host / PML body organization / SUMO binding / fibroblast migration / positive regulation of apoptotic process involved in mammary gland involution / : / regulation of double-strand break repair / myeloid cell differentiation / positive regulation of telomere maintenance / SMAD protein signal transduction / maintenance of protein location in nucleus / protein-containing complex localization / endoplasmic reticulum calcium ion homeostasis / 転移酵素; アシル基を移すもの; アミノアシル基を移すもの / positive regulation of extrinsic apoptotic signaling pathway / oncogene-induced cell senescence / Regulation of RUNX1 Expression and Activity / SUMO transferase activity / branching involved in mammary gland duct morphogenesis / negative regulation of interleukin-1 beta production / intrinsic apoptotic signaling pathway in response to oxidative stress / SUMOylation of ubiquitinylation proteins / cobalt ion binding / SMAD binding / entrainment of circadian clock by photoperiod / protein monoubiquitination / positive regulation of signal transduction by p53 class mediator / negative regulation of telomere maintenance via telomerase / protein sumoylation / negative regulation of mitotic cell cycle / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / retinoic acid receptor signaling pathway / cell fate commitment / protein targeting / cellular response to interleukin-4 / regulation of cell adhesion / SUMOylation of DNA damage response and repair proteins / response to UV / extrinsic apoptotic signaling pathway / positive regulation of defense response to virus by host / Regulation of TP53 Activity through Acetylation / DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / negative regulation of ubiquitin-dependent protein catabolic process / Regulation of PTEN localization / negative regulation of angiogenesis / transforming growth factor beta receptor signaling pathway / response to cytokine / cellular response to leukemia inhibitory factor / response to gamma radiation / circadian regulation of gene expression / regulation of circadian rhythm / negative regulation of cell growth / PML body / nuclear matrix / HCMV Early Events / Transcriptional regulation of granulopoiesis / protein import into nucleus / intrinsic apoptotic signaling pathway in response to DNA damage / Interferon gamma signaling / ubiquitin protein ligase activity / cellular senescence / positive regulation of fibroblast proliferation / early endosome membrane / protein-containing complex assembly / nuclear membrane / proteasome-mediated ubiquitin-dependent protein catabolic process / chromosome, telomeric region / molecular adaptor activity / transcription coactivator activity / protein stabilization / response to hypoxia / regulation of cell cycle / chromatin remodeling / protein heterodimerization activity / negative regulation of cell population proliferation / innate immune response / negative regulation of DNA-templated transcription / apoptotic process / ubiquitin protein ligase binding / regulation of DNA-templated transcription / endoplasmic reticulum membrane / nucleolus / protein homodimerization activity / DNA binding / zinc ion binding / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能 | ||||||
生物種 | ![]() | ||||||
手法 | 溶液NMR | ||||||
![]() | Borden, K.L.B. / Freemont, P.S. | ||||||
![]() | ![]() タイトル: The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML. 著者: Borden, K.L. / Boddy, M.N. / Lally, J. / O'Reilly, N.J. / Martin, S. / Howe, K. / Solomon, E. / Freemont, P.S. #1: ![]() タイトル: The Ring Finger. A Novel Protein Sequence Motif Related to the Zinc Finger 著者: Freemont, P.S. | ||||||
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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PDBx/mmCIF形式 | ![]() | 20 KB | 表示 | ![]() |
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-検証レポート
文書・要旨 | ![]() | 289.8 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 289.5 KB | 表示 | |
XML形式データ | ![]() | 3.9 KB | 表示 | |
CIF形式データ | ![]() | 4.9 KB | 表示 | |
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-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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NMR アンサンブル |
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要素
#1: タンパク質 | 分子量: 6113.134 Da / 分子数: 1 / 断片: RING FINGER DOMAIN, RESIDUES 49 - 104 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() |
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#2: 化合物 |
-実験情報
-実験
実験 | 手法: 溶液NMR |
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試料調製
試料状態 | pH: 7.5 / 温度: 303 K |
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結晶化 | *PLUS 手法: other / 詳細: NMR |
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解析
NMRアンサンブル | コンフォーマー選択の基準: REPRESENTATIVE STRUCTURE 登録したコンフォーマーの数: 1 |
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