+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 1bld | ||||||
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タイトル | BASIC FIBROBLAST GROWTH FACTOR (FGF-2) MUTANT WITH CYS 78 REPLACED BY SER AND CYS 96 REPLACED BY SER, NMR | ||||||
要素 | BASIC FIBROBLAST GROWTH FACTOR | ||||||
キーワード | GROWTH FACTOR | ||||||
機能・相同性 | 機能・相同性情報 growth factor dependent regulation of skeletal muscle satellite cell proliferation / positive regulation of inner ear auditory receptor cell differentiation / positive regulation of lens fiber cell differentiation / positive regulation of neuroepithelial cell differentiation / regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of endothelial cell chemotaxis to fibroblast growth factor / TGFBR3 regulates FGF2 signaling / positive regulation of cell fate specification / regulation of retinal cell programmed cell death / Formation of intermediate mesoderm ...growth factor dependent regulation of skeletal muscle satellite cell proliferation / positive regulation of inner ear auditory receptor cell differentiation / positive regulation of lens fiber cell differentiation / positive regulation of neuroepithelial cell differentiation / regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of endothelial cell chemotaxis to fibroblast growth factor / TGFBR3 regulates FGF2 signaling / positive regulation of cell fate specification / regulation of retinal cell programmed cell death / Formation of intermediate mesoderm / regulation of cell migration involved in sprouting angiogenesis / FGFRL1 modulation of FGFR1 signaling / corticotropin hormone secreting cell differentiation / thyroid-stimulating hormone-secreting cell differentiation / chemokine binding / chondroblast differentiation / lymphatic endothelial cell migration / negative regulation of fibroblast growth factor receptor signaling pathway / POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation / positive regulation of cerebellar granule cell precursor proliferation / cerebellar granule cell precursor proliferation / positive regulation of stem cell differentiation / positive regulation of epithelial tube formation / Formation of the nephric duct / receptor-receptor interaction / FGFR2b ligand binding and activation / regulation of endothelial cell chemotaxis to fibroblast growth factor / paracrine signaling / hyaluronan catabolic process / inner ear auditory receptor cell differentiation / glial cell differentiation / negative regulation of wound healing / FGFR2c ligand binding and activation / Activated point mutants of FGFR2 / Phospholipase C-mediated cascade; FGFR2 / Signaling by activated point mutants of FGFR3 / FGFR3c ligand binding and activation / stem cell development / Phospholipase C-mediated cascade; FGFR3 / embryonic morphogenesis / fibroblast growth factor receptor binding / angiogenesis involved in coronary vascular morphogenesis / FGFR4 ligand binding and activation / FGFR1b ligand binding and activation / mammary gland epithelial cell differentiation / Phospholipase C-mediated cascade; FGFR4 / Signaling by activated point mutants of FGFR1 / organ induction / FGFR1c ligand binding and activation / Downstream signaling of activated FGFR1 / Phospholipase C-mediated cascade: FGFR1 / negative regulation of fibroblast migration / cell migration involved in sprouting angiogenesis / embryo development ending in birth or egg hatching / endothelial cell proliferation / Signaling by FGFR2 IIIa TM / positive regulation of vascular endothelial cell proliferation / positive regulation of endothelial cell chemotaxis / Syndecan interactions / branching involved in ureteric bud morphogenesis / positive regulation of cell migration involved in sprouting angiogenesis / positive regulation of DNA biosynthetic process / PI-3K cascade:FGFR2 / PI-3K cascade:FGFR3 / positive regulation of neuroblast proliferation / PI-3K cascade:FGFR4 / positive regulation of sprouting angiogenesis / chemoattractant activity / positive regulation of stem cell proliferation / PI-3K cascade:FGFR1 / positive regulation of cell division / negative regulation of blood vessel endothelial cell migration / PI3K Cascade / Non-integrin membrane-ECM interactions / neuroblast proliferation / fibroblast growth factor receptor signaling pathway / response to axon injury / positive regulation of blood vessel endothelial cell migration / canonical Wnt signaling pathway / regulation of angiogenesis / SHC-mediated cascade:FGFR2 / positive regulation of osteoblast differentiation / SHC-mediated cascade:FGFR3 / SHC-mediated cascade:FGFR4 / SHC-mediated cascade:FGFR1 / negative regulation of stem cell proliferation / positive regulation of cardiac muscle cell proliferation / FRS-mediated FGFR2 signaling / FRS-mediated FGFR3 signaling / positive regulation of vascular associated smooth muscle cell proliferation / Signaling by FGFR2 in disease / FRS-mediated FGFR4 signaling / Signaling by FGFR3 in disease / release of sequestered calcium ion into cytosol / FRS-mediated FGFR1 signaling / positive regulation of endothelial cell proliferation / substantia nigra development / Signaling by FGFR1 in disease / regulation of cell migration / ERK1 and ERK2 cascade 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) | ||||||
手法 | 溶液NMR | ||||||
データ登録者 | Powers, R. / Seddon, A.P. / Bohlen, P. / Moy, F.J. | ||||||
引用 | ジャーナル: Biochemistry / 年: 1996 タイトル: High-resolution solution structure of basic fibroblast growth factor determined by multidimensional heteronuclear magnetic resonance spectroscopy. 著者: Moy, F.J. / Seddon, A.P. / Bohlen, P. / Powers, R. #1: ジャーナル: J.Biomol.NMR / 年: 1995 タイトル: 1H, 15N, 13C and 13Co Assignments and Secondary Structure Determination of Basic Fibroblast Growth Factor Using 3D Heteronuclear NMR Spectroscopy 著者: Moy, F.J. / Seddon, A.P. / Campbell, E.B. / Bohlen, P. / Powers, R. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 1bld.cif.gz | 1.4 MB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb1bld.ent.gz | 1.2 MB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 1bld.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
文書・要旨 | 1bld_validation.pdf.gz | 341.1 KB | 表示 | wwPDB検証レポート |
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文書・詳細版 | 1bld_full_validation.pdf.gz | 575.5 KB | 表示 | |
XML形式データ | 1bld_validation.xml.gz | 101.7 KB | 表示 | |
CIF形式データ | 1bld_validation.cif.gz | 125.8 KB | 表示 | |
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/bl/1bld ftp://data.pdbj.org/pub/pdb/validation_reports/bl/1bld | HTTPS FTP |
-関連構造データ
-リンク
-集合体
登録構造単位 |
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NMR アンサンブル |
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-要素
#1: タンパク質 | 分子量: 17349.805 Da / 分子数: 1 / 変異: C78S, C96S / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: CDNA / 発現宿主: Escherichia coli (大腸菌) / 参照: UniProt: P09038 |
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-実験情報
-実験
実験 | 手法: 溶液NMR |
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-試料調製
結晶化 | *PLUS 手法: other / 詳細: NMR |
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-解析
NMRアンサンブル | 登録したコンフォーマーの数: 30 |
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