|Entry||Database: PDB / ID: 1awo|
|Title||THE SOLUTION NMR STRUCTURE OF ABL SH3 AND ITS RELATIONSHIP TO SH2 IN THE SH(32) CONSTRUCT, 20 STRUCTURES|
|Components||ABL TYROSINE KINASE|
|Keywords||KINASE / SH3 DOMAIN / TRANSFERASE / PHOSPHOTRANSFERASE / PROTO-ONCOGENE / MULTIPLE DOMAIN / LEUKEMIA|
|Function / homology|
Function and homology information
mitochondrial depolarization / positive regulation of actin filament binding / transitional one stage B cell differentiation / DNA conformation change / negative regulation of phospholipase C activity / regulation of extracellular matrix organization / activation of protein kinase C activity / positive regulation of interleukin-2 production => GO:0032743 / nicotinate-nucleotide adenylyltransferase activity / positive regulation blood vessel branching ...mitochondrial depolarization / positive regulation of actin filament binding / transitional one stage B cell differentiation / DNA conformation change / negative regulation of phospholipase C activity / regulation of extracellular matrix organization / activation of protein kinase C activity / positive regulation of interleukin-2 production => GO:0032743 / nicotinate-nucleotide adenylyltransferase activity / positive regulation blood vessel branching / alpha-beta T cell differentiation / B cell proliferation involved in immune response / regulation of modification of synaptic structure / positive regulation of microtubule binding / positive regulation of Wnt signaling pathway, planar cell polarity pathway / microspike assembly / neuroepithelial cell differentiation / cerebellum morphogenesis / collateral sprouting / B-1 B cell homeostasis / actin filament branching / circulatory system development => GO:0072359 / positive regulation of oxidoreductase activity / activated T cell proliferation / neuropilin binding / neuropilin signaling pathway / bubble DNA binding / regulation of Cdc42 protein signal transduction / negative regulation of protein serine/threonine kinase activity / regulation of T cell differentiation / negative regulation of ubiquitin-protein transferase activity / regulation of microtubule polymerization / negative regulation of BMP signaling pathway / regulation of actin cytoskeleton reorganization / mitogen-activated protein kinase binding / proline-rich region binding / sequence-specific double-stranded DNA binding / syntaxin binding / positive regulation of interferon-gamma production => GO:0032729 / cellular response to dopamine / negative regulation of cell-cell adhesion / DNA damage induced protein phosphorylation / negative regulation of cellular senescence / positive regulation of osteoblast proliferation / regulation of response to DNA damage stimulus / regulation of axon extension / platelet-derived growth factor receptor-beta signaling pathway / positive regulation of cell migration involved in sprouting angiogenesis / cell leading edge / negative regulation of long-term synaptic potentiation / actin monomer binding / Bergmann glial cell differentiation / regulation of endocytosis / neuromuscular process controlling balance / positive regulation of focal adhesion assembly / positive regulation of actin cytoskeleton reorganization / positive regulation of substrate adhesion-dependent cell spreading / mismatch repair / regulation of hematopoietic stem cell differentiation / negative regulation of mitotic cell cycle / negative regulation of endothelial cell apoptotic process / regulation of cell adhesion / regulation of cell motility / endothelial cell migration / four-way junction DNA binding / positive regulation of stress fiber assembly / positive regulation of muscle cell differentiation / regulation of actin cytoskeleton organization / signal transduction in response to DNA damage / substrate adhesion-dependent cell spreading / positive regulation of endothelial cell migration / regulation of autophagy / cellular protein modification process / post-embryonic development / spleen development / SH2 domain binding / negative regulation of I-kappaB kinase/NF-kappaB signaling / positive regulation of mitotic cell cycle / positive regulation of release of sequestered calcium ion into cytosol / thymus development / negative regulation of ERK1 and ERK2 cascade / protein kinase C binding / phosphotyrosine residue binding / ephrin receptor binding / integrin-mediated signaling pathway / neural tube closure / peptidyl-tyrosine autophosphorylation / actin cytoskeleton organization / non-specific protein-tyrosine kinase / establishment of protein localization / non-membrane spanning protein tyrosine kinase activity / epidermal growth factor receptor signaling pathway / autophagy / SH3 domain binding / postsynapse / cell cycle arrest / cellular response to hydrogen peroxide / positive regulation of neuron death / intrinsic apoptotic signaling pathway in response to DNA damage / B cell receptor signaling pathway
Tyrosine-protein kinase, catalytic domain / F-actin binding / Protein kinase-like domain superfamily / Tyrosine-protein kinase ABL1/transforming protein Abl / Tyrosine-protein kinase ABL, SH2 domain / Tyrosine-protein kinase, active site / SH3 domain / SH3-like domain superfamily / SH2 domain superfamily / Protein kinase, ATP binding site ...Tyrosine-protein kinase, catalytic domain / F-actin binding / Protein kinase-like domain superfamily / Tyrosine-protein kinase ABL1/transforming protein Abl / Tyrosine-protein kinase ABL, SH2 domain / Tyrosine-protein kinase, active site / SH3 domain / SH3-like domain superfamily / SH2 domain superfamily / Protein kinase, ATP binding site / Serine-threonine/tyrosine-protein kinase, catalytic domain / SH3 domain / SH2 domain / Protein kinase domain / SH3 Domains / SH3 type barrels. / Roll / Mainly Beta
Tyrosine-protein kinase ABL1
|Biological species||Homo sapiens (human)|
|Method||SOLUTION NMR / VARIABLE TARGET FUNCTION TORSION ANGLE SIMULATED ANNEALING|
Journal: Structure / Year: 1995
Title: The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct.
Authors: Gosser, Y.Q. / Zheng, J. / Overduin, M. / Mayer, B.J. / Cowburn, D.
#1: Journal: Mol.Cell.Biol. / Year: 1994
Title: Mutagenic Analysis of the Roles of Sh2 and SH3 Domains in Regulation of the Abl Tyrosine Kinase
Authors: Mayer, B.J. / Baltimore, D.
#2: Journal: Nat.Struct.Biol. / Year: 1994
Title: High-Resolution Crystal Structures of Tyrosine Kinase SH3 Domains Complexed with Proline-Rich Peptides
Authors: Musacchio, A. / Saraste, M. / Wilmanns, M.
#3: Journal: Science / Year: 1993
Title: Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site
Authors: Ren, R. / Mayer, B.J. / Cicchetti, P. / Baltimore, D.
#4: Journal: Embo J. / Year: 1993
Title: Crystal Structure of the SH3 Domain in Human Fyn; Comparison of the Three-Dimensional Structures of SH3 Domains in Tyrosine Kinases and Spectrin
Authors: Noble, M.E. / Musacchio, A. / Saraste, M. / Courtneidge, S.A. / Wierenga, R.K.
#5: Journal: Cell(Cambridge,Mass.) / Year: 1992
Title: Three-Dimensional Solution Structure of the Src Homology 2 Domain of C-Abl
Authors: Overduin, M. / Rios, C.B. / Mayer, B.J. / Baltimore, D. / Cowburn, D.
SummaryFull reportAbout validation report
|Structure viewer||Molecule: |
Downloads & links
A: ABL TYROSINE KINASE
|#1: Protein|| |
Mass: 6637.299 Da / Num. of mol.: 1 / Fragment: SRC-HOMOLOGY 3 (SH3) DOMAIN / Mutation: N64S, N120S
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Description: EXPRESSED AS GST FUSIONS AND CLEAVED / Plasmid: PGEX / Production host: Escherichia coli (E. coli) / Strain (production host): NB42 / References: UniProt: P00519, EC: 22.214.171.124
|Experiment||Method: SOLUTION NMR|
|Sample conditions||pH: 7.5 / Temperature: 298 K|
*PLUSMethod: other / Details: NMR
|Refinement||Method: VARIABLE TARGET FUNCTION TORSION ANGLE SIMULATED ANNEALING|
Software ordinal: 1 / Details: USED REDAC STRATEGY
|NMR ensemble||Conformer selection criteria: LOWEST TARGET FUNCTION / Conformers calculated total number: 100 / Conformers submitted total number: 20|
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