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- PDB-1aio: CRYSTAL STRUCTURE OF A DOUBLE-STRANDED DNA CONTAINING THE MAJOR A... -
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Open data
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Basic information
Entry | Database: PDB / ID: 1aio | |||||||||
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Title | CRYSTAL STRUCTURE OF A DOUBLE-STRANDED DNA CONTAINING THE MAJOR ADDUCT OF THE ANTICANCER DRUG CISPLATIN | |||||||||
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![]() | DNA / RIGHT HANDED DNA / DOUBLE HELIX / COMPLEXED WITH DRUG / MODIFIED | |||||||||
Function / homology | Cisplatin / DNA / DNA (> 10)![]() | |||||||||
Method | ![]() | |||||||||
![]() | Takahara, P.M. / Rosenzweig, A.C. / Frederick, C.A. / Lippard, S.J. | |||||||||
![]() | ![]() Title: Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin. Authors: Takahara, P.M. / Rosenzweig, A.C. / Frederick, C.A. / Lippard, S.J. #1: ![]() Title: Crystal Structure of the Anticancer Drug Cisplatin Bound to Duplex DNA Authors: Takahara, P.M. / Frederick, C.A. / Lippard, S.J. | |||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 39.7 KB | Display | ![]() |
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PDB format | ![]() | 26.1 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 350.8 KB | Display | ![]() |
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Full document | ![]() | 371.2 KB | Display | |
Data in XML | ![]() | 4.4 KB | Display | |
Data in CIF | ![]() | 6.3 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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1 | ![]()
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2 | ![]()
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Unit cell |
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Components
#1: DNA chain | Mass: 3630.186 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source #2: DNA chain | Mass: 3761.468 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source #3: Chemical | #4: Water | ChemComp-HOH / | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 3.32 Å3/Da / Density % sol: 62.94 % | ||||||||||||||||||||||||||||||||||||||||||||||||
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Crystal grow | Temperature: 277 K / Method: vapor diffusion, sitting drop / pH: 6.5 Details: pH 6.50, VAPOR DIFFUSION, SITTING DROP, temperature 277.00K | ||||||||||||||||||||||||||||||||||||||||||||||||
Components of the solutions |
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Crystal grow | *PLUS Temperature: 4 ℃ / pH: 6 | ||||||||||||||||||||||||||||||||||||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Diffraction | Mean temperature: 277 K |
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Detector | Type: MARRESEARCH / Detector: IMAGE PLATE / Date: Jan 1, 1995 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Relative weight: 1 |
Reflection | Resolution: 2.6→8 Å / Num. obs: 5797 / Observed criterion σ(I): 1 |
Reflection | *PLUS Highest resolution: 2.6 Å / Lowest resolution: 8 Å / % possible obs: 97 % / Rmerge(I) obs: 0.062 |
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Processing
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Refinement | Resolution: 2.6→8 Å / Cross valid method: THROUGHOUT / σ(F): 1
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Refinement step | Cycle: LAST / Resolution: 2.6→8 Å
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Refine LS restraints |
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Software | *PLUS Name: ![]() | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement | *PLUS Highest resolution: 2.6 Å / Lowest resolution: 8 Å / σ(F): 1 / % reflection Rfree: 10 % | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Solvent computation | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | *PLUS |