+Open data
-Basic information
Entry | Database: PDB / ID: 1ain | ||||||
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Title | CRYSTAL STRUCTURE OF HUMAN ANNEXIN I AT 2.5 ANGSTROMS RESOLUTION | ||||||
Components | ANNEXIN I | ||||||
Keywords | CALCIUM/PHOSPHOLIPID BINDING / CALCIUM-PHOSPHOLIPID BINDING complex | ||||||
Function / homology | Function and homology information regulation of interleukin-1 production / myoblast migration involved in skeletal muscle regeneration / regulation of leukocyte migration / granulocyte chemotaxis / positive regulation of T-helper 1 cell differentiation / phospholipase A2 inhibitor activity / regulation of hormone secretion / positive regulation of vesicle fusion / neutrophil clearance / negative regulation of T-helper 2 cell differentiation ...regulation of interleukin-1 production / myoblast migration involved in skeletal muscle regeneration / regulation of leukocyte migration / granulocyte chemotaxis / positive regulation of T-helper 1 cell differentiation / phospholipase A2 inhibitor activity / regulation of hormone secretion / positive regulation of vesicle fusion / neutrophil clearance / negative regulation of T-helper 2 cell differentiation / positive regulation of neutrophil apoptotic process / negative regulation of interleukin-8 production / cadherin binding involved in cell-cell adhesion / neutrophil activation / peptide cross-linking / cornified envelope / neutrophil homeostasis / calcium-dependent phospholipid binding / Formyl peptide receptors bind formyl peptides and many other ligands / motile cilium / negative regulation of exocytosis / cellular response to glucocorticoid stimulus / vesicle membrane / alpha-beta T cell differentiation / arachidonate secretion / positive regulation of cell migration involved in sprouting angiogenesis / positive regulation of wound healing / positive regulation of G1/S transition of mitotic cell cycle / phosphatidylserine binding / monocyte chemotaxis / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / phagocytic cup / lateral plasma membrane / Smooth Muscle Contraction / cellular response to vascular endothelial growth factor stimulus / phagocytosis / positive regulation of T cell proliferation / keratinocyte differentiation / positive regulation of interleukin-2 production / adherens junction / phospholipid binding / sarcolemma / calcium-dependent protein binding / regulation of inflammatory response / early endosome membrane / regulation of cell shape / basolateral plasma membrane / G alpha (i) signalling events / actin cytoskeleton organization / G alpha (q) signalling events / Interleukin-4 and Interleukin-13 signaling / collagen-containing extracellular matrix / adaptive immune response / vesicle / endosome / cell surface receptor signaling pathway / apical plasma membrane / inflammatory response / innate immune response / focal adhesion / signaling receptor binding / lipid binding / calcium ion binding / negative regulation of apoptotic process / cell surface / signal transduction / extracellular space / extracellular exosome / extracellular region / nucleoplasm / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / Resolution: 2.5 Å | ||||||
Authors | Kim, S.-H. | ||||||
Citation | Journal: Protein Sci. / Year: 1993 Title: Crystal structure of human annexin I at 2.5 A resolution. Authors: Weng, X. / Luecke, H. / Song, I.S. / Kang, D.S. / Kim, S.H. / Huber, R. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1ain.cif.gz | 22.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1ain.ent.gz | 10.6 KB | Display | PDB format |
PDBx/mmJSON format | 1ain.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1ain_validation.pdf.gz | 286.3 KB | Display | wwPDB validaton report |
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Full document | 1ain_full_validation.pdf.gz | 286.2 KB | Display | |
Data in XML | 1ain_validation.xml.gz | 883 B | Display | |
Data in CIF | 1ain_validation.cif.gz | 3.5 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ai/1ain ftp://data.pdbj.org/pub/pdb/validation_reports/ai/1ain | HTTPS FTP |
-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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Unit cell |
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-Components
#1: Protein | Mass: 35093.121 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / References: UniProt: P04083 |
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#2: Chemical | ChemComp-CA / |
-Experimental details
-Experiment
Experiment | Method: X-RAY DIFFRACTION |
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-Sample preparation
Crystal | Density Matthews: 2.82 Å3/Da / Density % sol: 56.4 % | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Crystal grow | *PLUS pH: 6.5 / Method: other | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Radiation | Scattering type: x-ray |
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Radiation wavelength | Relative weight: 1 |
Reflection | *PLUS Highest resolution: 2.5 Å / Num. obs: 13945 / % possible obs: 97.3 % / Rmerge(I) obs: 0.0535 / Num. measured all: 76668 |
-Processing
Software |
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Refinement | Rfactor Rwork: 0.163 / Highest resolution: 2.5 Å | ||||||||||||
Refinement step | Cycle: LAST / Highest resolution: 2.5 Å
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Refine LS restraints |
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Refinement | *PLUS Highest resolution: 2.5 Å / Lowest resolution: 10 Å / Rfactor obs: 0.177 | ||||||||||||
Solvent computation | *PLUS | ||||||||||||
Displacement parameters | *PLUS | ||||||||||||
Refine LS restraints | *PLUS
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