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- PDB-1agt: SOLUTION STRUCTURE OF THE POTASSIUM CHANNEL INHIBITOR AGITOXIN 2:... -

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Basic information

Entry
Database: PDB / ID: 1agt
TitleSOLUTION STRUCTURE OF THE POTASSIUM CHANNEL INHIBITOR AGITOXIN 2: CALIPER FOR PROBING CHANNEL GEOMETRY
ComponentsAGITOXIN 2
KeywordsNEUROTOXIN / POTASSIUM CHANNEL BLOCKER
Function / homologyScorpion short toxins signature. / Scorpion short chain toxin, potassium channel inhibitor / Scorpion short toxin, BmKK2 / Knottin, scorpion toxin-like superfamily / ion channel inhibitor activity / potassium channel regulator activity / toxin activity / extracellular region / Potassium channel toxin alpha-KTx 3.2
Function and homology information
Biological speciesLeiurus quinquestriatus hebraeus (scorpion)
MethodSOLUTION NMR
AuthorsKrezel, A.M. / Kasibhatla, C. / Hidalgo, P. / Mackinnon, R. / Wagner, G.
CitationJournal: Protein Sci. / Year: 1995
Title: Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry.
Authors: Krezel, A.M. / Kasibhatla, C. / Hidalgo, P. / MacKinnon, R. / Wagner, G.
History
DepositionApr 14, 1995Processing site: BNL
Revision 1.0Jul 10, 1995Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Nov 29, 2017Group: Derived calculations / Other
Category: pdbx_database_status / pdbx_struct_assembly ...pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_conf / struct_conf_type
Item: _pdbx_database_status.process_site
Revision 1.4Nov 20, 2024Group: Data collection / Database references / Structure summary
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature / pdbx_nmr_software
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: AGITOXIN 2


Theoretical massNumber of molelcules
Total (without water)4,1051
Polymers4,1051
Non-polymers00
Water00
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_5551
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)17 / -
Representative

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Components

#1: Protein/peptide AGITOXIN 2


Mass: 4104.978 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Leiurus quinquestriatus hebraeus (scorpion)
Species: Leiurus quinquestriatus / Strain: hebraeus / Gene: AGTX2 / Plasmid: PCSP105 / Gene (production host): AGTX2 / Production host: Escherichia coli (E. coli) / References: UniProt: P46111
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

NMR software
NameVersionDeveloperClassification
NMRCHITECT2.3BIOSYM TECHNOLOGIESrefinement
Discover2.9BIOSYM TECHNOLOGIESrefinement
NMR ensembleConformers submitted total number: 17

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