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- EMDB-45802: Cryo-EM structure of porcine brain ventricles cilia doublet micro... -

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Basic information

Entry
Database: EMDB / ID: EMD-45802
TitleCryo-EM structure of porcine brain ventricles cilia doublet microtubule (48-nm periodicity)
Map data
Sample
  • Organelle or cellular component: cilia from porcine brain ventricles
    • Protein or peptide: x 41 types
  • Ligand: x 2 types
Keywordsaxoneme / cilia / microtubule / dynein / brain ventricle / doublet microtubule (DMT) / STRUCTURAL PROTEIN
Function / homology
Function and homology information


regulation of cilium beat frequency / outer dynein arm docking complex / determination of heart left/right asymmetry / mucociliary clearance / outer acrosomal membrane / epithelial cilium movement involved in determination of left/right asymmetry / regulation of brood size / establishment of left/right asymmetry / 9+0 motile cilium / protein localization to motile cilium ...regulation of cilium beat frequency / outer dynein arm docking complex / determination of heart left/right asymmetry / mucociliary clearance / outer acrosomal membrane / epithelial cilium movement involved in determination of left/right asymmetry / regulation of brood size / establishment of left/right asymmetry / 9+0 motile cilium / protein localization to motile cilium / axonemal B tubule inner sheath / axonemal A tubule inner sheath / manchette / sperm axoneme assembly / inner dynein arm assembly / regulation of calcineurin-NFAT signaling cascade / positive regulation of feeding behavior / regulation of microtubule nucleation / outer dynein arm assembly / 9+0 non-motile cilium / cerebrospinal fluid circulation / sperm principal piece / regulation of cilium beat frequency involved in ciliary motility / epithelial cilium movement involved in extracellular fluid movement / regulation of store-operated calcium entry / 9+2 motile cilium / intraciliary transport / microtubule sliding / regulation of cilium assembly / ciliary transition zone / cilium movement / axoneme assembly / left/right axis specification / calcium ion sensor activity / axonemal microtubule / gamma-tubulin ring complex / ventricular system development / flagellated sperm motility / positive regulation of cilium assembly / UTP biosynthetic process / CTP biosynthetic process / determination of left/right symmetry / intermediate filament / motile cilium / nucleoside diphosphate kinase activity / GTP biosynthetic process / positive regulation of cell motility / regulation of neuron projection development / receptor clustering / ciliary base / beta-tubulin binding / spermatid development / cerebral cortex cell migration / microtubule organizing center / regulation of cell division / mitotic cytokinesis / sperm flagellum / axoneme / cilium assembly / single fertilization / alpha-tubulin binding / microtubule-based process / cytoplasmic microtubule / 3'-5' exonuclease activity / sperm midpiece / centriole / Hsp70 protein binding / cellular response to leukemia inhibitory factor / acrosomal vesicle / guanyl-nucleotide exchange factor activity / mitotic spindle organization / meiotic cell cycle / lung development / Hsp90 protein binding / G protein-coupled receptor binding / brain development / multicellular organism growth / SH3 domain binding / structural constituent of cytoskeleton / centriolar satellite / microtubule cytoskeleton organization / spindle pole / mitotic spindle / protein localization / nuclear envelope / mitotic cell cycle / actin binding / heart development / microtubule cytoskeleton / cell body / microtubule binding / spermatogenesis / gene expression / vesicle / microtubule / Ras protein signal transduction / cytoskeleton / hydrolase activity / protein kinase activity / calmodulin binding
Similarity search - Function
Outer dynein arm-docking complex subunit 4 / Protein of unknown function DUF4586 / Outer dynein arm-docking complex subunit 3 / Cilia-and flagella-associated protein 96 / FAM183 family / FAM183A and FAM183B related / Sperm-associated antigen 8 / Cilia- and flagella-associated protein 95 / NDPK7, first NDPk domain / Cilia- and flagella-associated protein 107 ...Outer dynein arm-docking complex subunit 4 / Protein of unknown function DUF4586 / Outer dynein arm-docking complex subunit 3 / Cilia-and flagella-associated protein 96 / FAM183 family / FAM183A and FAM183B related / Sperm-associated antigen 8 / Cilia- and flagella-associated protein 95 / NDPK7, first NDPk domain / Cilia- and flagella-associated protein 107 / : / : / : / Protein CFAP95 / ODAD1 central coiled coil region / Cilia- and flagella-associated protein 143 / Cilia and flagella associated protein 107 / Tektin / Cilia- and flagella-associated protein 276 / Sperm acrosome-associated protein 9 / : / Tektin family / Protein of unknown function (DUF3695) / Sperm acrosome-associated protein 9 / Uncharacterised protein FAM166/UPF0605 / Cilia- and flagella-associated protein 77 / Protein Flattop / Ciliary microtubule inner protein 2B-like / Cilia- and flagella-associated protein 77 / Flattop / Nucleoside diphosphate kinase 7 / Piercer of microtubule wall 1/2 / Piercer of microtubule wall 1/2 / Cilia- and flagella-associated protein 141 / Cilia- and flagella-associated protein 141 / Meiosis-specific nuclear structural protein 1 / Cilia- and flagella-associated protein 45 / NDPK7, second NDPk domain / Cilia- and flagella- associated protein 210 / CFAP53/TCHP / Trichohyalin-plectin-homology domain / Trichohyalin-plectin-homology domain / RIB43A / RIB43A / DM10 domain / EF-hand domain-containing protein EFHC1/EFHC2/EFHB / DM10 domain / DM10 domain profile. / Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases. / Enkurin domain / : / Calmodulin-binding / Enkurin domain profile. / : / CFA20 domain / Cilia- and flagella-associated protein 20/CFAP20DC / CFA20 domain / Recoverin family / Parkin co-regulated protein / Parkin co-regulated protein / EF hand / Nucleoside diphosphate kinase / Nucleoside diphosphate kinase-like domain / Nucleoside diphosphate kinase / NDK / Nucleoside diphosphate kinase-like domain superfamily / HEAT repeats / Armadillo/plakoglobin ARM repeat profile. / Armadillo/beta-catenin-like repeat / Armadillo/beta-catenin-like repeats / Armadillo / Tetratricopeptide repeat / Tubulin-beta mRNA autoregulation signal. / Alpha tubulin / Beta tubulin, autoregulation binding site / Beta tubulin / TPR repeat profile. / Tubulin / Tubulin, C-terminal / Tubulin C-terminal domain / Tubulin, conserved site / Tubulin subunits alpha, beta, and gamma signature. / Tubulin/FtsZ family, C-terminal domain / Tubulin/FtsZ-like, C-terminal domain / Tetratricopeptide repeats / Tubulin/FtsZ, C-terminal / Tubulin/FtsZ, 2-layer sandwich domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ, GTPase domain / Tubulin/FtsZ, GTPase domain superfamily / Tetratricopeptide repeat / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / Armadillo-like helical / EF-hand domain pair
Similarity search - Domain/homology
Cilia- and flagella-associated protein 53 / EF-hand domain containing 1 / Cilia- and flagella-associated protein 45 / Armadillo repeat-containing protein 4 isoform 1 / Sperm-associated antigen 8 isoform 1 / Tektin / Tektin / Chromosome 1 C15orf65 homolog / Meiosis-specific nuclear structural protein 1 / Enkurin ...Cilia- and flagella-associated protein 53 / EF-hand domain containing 1 / Cilia- and flagella-associated protein 45 / Armadillo repeat-containing protein 4 isoform 1 / Sperm-associated antigen 8 isoform 1 / Tektin / Tektin / Chromosome 1 C15orf65 homolog / Meiosis-specific nuclear structural protein 1 / Enkurin / EF-hand calcium binding domain 1 / Tektin / Cilia-and flagella-associated protein 96 / Tubulin beta chain / Tubulin alpha chain / Outer dynein arm docking complex subunit 3 / Cilia and flagella associated protein 161 / Parkin coregulated / Cilia and flagella associated protein 276 / Chromosome 1 C9orf135 homolog / Nucleoside diphosphate kinase homolog 7 / Cilia and flagella associated protein 141 / RIB43A-like with coiled-coils protein 1 / Sperm acrosome associated 9 / Tektin / Ciliary microtubule inner protein 2B / Protein Flattop / Uncharacterized protein / Ciliary microtubule inner protein 2B / Outer dynein arm-docking complex subunit 4 / Uncharacterized protein / EF-hand domain family member B / Cilia and flagella associated protein 77 / Cilia and flagella associated protein 210 / Cilia and flagella associated protein 144 / RIB43A domain with coiled-coils 2 / Cilia- and flagella-associated protein 52 / Cilia-and flagella-associated protein 20 / Coiled-coil domain-containing protein 114 isoform X2 / EF-hand domain-containing family member C2
Similarity search - Component
Biological speciesSus scrofa (pig)
Methodsingle particle reconstruction / cryo EM / Resolution: 3.65 Å
AuthorsSun C / Zhang R
Funding support United States, 1 items
OrganizationGrant numberCountry
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)1R01 GM138854 United States
CitationJournal: Nature / Year: 2025
Title: Structural diversity of axonemes across mammalian motile cilia.
Authors: Miguel Ricardo Leung / Chen Sun / Jianwei Zeng / Jacob R Anderson / Qingwei Niu / Wei Huang / Willem E M Noteborn / Alan Brown / Tzviya Zeev-Ben-Mordehai / Rui Zhang /
Abstract: Reproduction, development and homeostasis depend on motile cilia, whose rhythmic beating is powered by a microtubule-based molecular machine called the axoneme. Although an atomic model of the ...Reproduction, development and homeostasis depend on motile cilia, whose rhythmic beating is powered by a microtubule-based molecular machine called the axoneme. Although an atomic model of the axoneme is available for the alga Chlamydomonas reinhardtii, structures of mammalian axonemes are incomplete. Furthermore, we do not fully understand how molecular structures of axonemes vary across motile-ciliated cell types in the body. Here we use cryoelectron microscopy, cryoelectron tomography and proteomics to resolve the 96-nm modular repeat of axonemal doublet microtubules (DMTs) from both sperm flagella and epithelial cilia of the oviduct, brain ventricles and respiratory tract. We find that sperm DMTs are the most specialized, with epithelial cilia having only minor differences across tissues. We build a model of the mammalian sperm DMT, defining the positions and interactions of 181 proteins including 34 newly identified proteins. We elucidate the composition of radial spoke 3 and uncover binding sites of kinases associated with regeneration of ATP and regulation of ciliary motility. We discover a sperm-specific, axoneme-tethered T-complex protein ring complex (TRiC) chaperone that may contribute to construction or maintenance of the long flagella of mammalian sperm. We resolve axonemal dyneins in their prestroke states, illuminating conformational changes that occur during ciliary movement. Our results illustrate how elements of chemical and mechanical regulation are embedded within the axoneme, providing valuable resources for understanding the aetiology of ciliopathy and infertility, and exemplifying the discovery power of modern structural biology.
History
DepositionJul 18, 2024-
Header (metadata) releaseOct 23, 2024-
Map releaseOct 23, 2024-
UpdateMar 19, 2025-
Current statusMar 19, 2025Processing site: RCSB / Status: Released

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Structure visualization

Supplemental images

emd_45802.png

Downloads & links

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Map

FileDownload / File: emd_45802.map.gz / Format: CCP4 / Size: 512 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
Projections & slices

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AxesZ (Sec.)Y (Row.)X (Col.)
1.34 Å/pix.
x 512 pix.
= 686.08 Å		1.34 Å/pix.
x 512 pix.
= 686.08 Å		1.34 Å/pix.
x 512 pix.
= 686.08 Å

Surface

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Images are generated by Spider.

Voxel sizeX=Y=Z: 1.34 Å
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Contour LevelBy AUTHOR: 0.35
Minimum - Maximum0.0 - 2.3817267
Average (Standard dev.)0.011283159 (±0.07916241)
SymmetrySpace group: 1
Details

EMDB XML:

Map geometry
Axis orderXYZ
Origin000
Dimensions512512512
Spacing512512512
CellA=B=C: 686.08 Å
α=β=γ: 90.0 °

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Supplemental data

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Mask #1

Fileemd_45802_msk_1.map
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Half map: #2

Fileemd_45802_half_map_1.map
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Half map: #1

Fileemd_45802_half_map_2.map
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Sample components

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Entire : cilia from porcine brain ventricles

EntireName: cilia from porcine brain ventricles
Components
  • Organelle or cellular component: cilia from porcine brain ventricles
    • Protein or peptide: Armadillo repeat-containing protein 4 isoform 1
    • Protein or peptide: Outer dynein arm-docking complex subunit 4
    • Protein or peptide: EF-hand calcium binding domain 1
    • Protein or peptide: Coiled-coil domain-containing protein 114 isoform X2
    • Protein or peptide: Outer dynein arm docking complex subunit 3
    • Protein or peptide: EFCAB6
    • Protein or peptide: Cilia- and flagella-associated protein 52
    • Protein or peptide: Cilia- and flagella-associated protein 45
    • Protein or peptide: Cilia and flagella associated protein 210
    • Protein or peptide: Cilia and flagella associated protein 276
    • Protein or peptide: Enkurin
    • Protein or peptide: Parkin coregulated
    • Protein or peptide: Cilia- and flagella-associated protein 20
    • Protein or peptide: Protein Flattop
    • Protein or peptide: Tektin
    • Protein or peptide: Tektin
    • Protein or peptide: Tektin
    • Protein or peptide: Tektin
    • Protein or peptide: RIB43A domain with coiled-coils 2
    • Protein or peptide: EF-hand domain containing 1
    • Protein or peptide: EF-hand domain-containing family member C2
    • Protein or peptide: Ciliary microtubule inner protein 2B
    • Protein or peptide: Ciliary microtubule inner protein 2B
    • Protein or peptide: Sperm-associated antigen 8 isoform 1
    • Protein or peptide: Nucleoside diphosphate kinase homolog 7
    • Protein or peptide: Cilia and flagella associated protein 161
    • Protein or peptide: Chromosome 1 C9orf135 homolog
    • Protein or peptide: Piercer of microtubule wall 1
    • Protein or peptide: Chromosome 1 C15orf65 homolog
    • Protein or peptide: EF-hand domain family member B
    • Protein or peptide: Cilia and flagella associated protein 141
    • Protein or peptide: Meiosis-specific nuclear structural protein 1
    • Protein or peptide: Cilia- and flagella-associated protein 53
    • Protein or peptide: CFAP107/C1orf158
    • Protein or peptide: Cilia and flagella associated protein 77
    • Protein or peptide: Cilia and flagella associated protein 144
    • Protein or peptide: Cilia-and flagella-associated protein 96
    • Protein or peptide: Sperm acrosome associated 9
    • Protein or peptide: Tubulin alpha chain
    • Protein or peptide: Tubulin beta chain
    • Protein or peptide: RIB43A-like with coiled-coils protein 1
  • Ligand: GUANOSINE-5'-TRIPHOSPHATE
  • Ligand: GUANOSINE-5'-DIPHOSPHATE

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Supramolecule #1: cilia from porcine brain ventricles

SupramoleculeName: cilia from porcine brain ventricles / type: organelle_or_cellular_component / ID: 1 / Parent: 0 / Macromolecule list: #1-#19, #21-#41, #20
Source (natural)Organism: Sus scrofa (pig)

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Macromolecule #1: Armadillo repeat-containing protein 4 isoform 1

MacromoleculeName: Armadillo repeat-containing protein 4 isoform 1 / type: protein_or_peptide / ID: 1 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 116.987055 KDa
SequenceString: MGVALTRSAQ WTAAGHGTRN LEITPLNEAI LKEIIIFVES FIYKHPQEAN YVFVEPLEWQ TKLDPSAFGS GYAVSETTVK SEEVDKNGE PLLFLSVPQI KIRSFGQLSR LLFIAKNTKL KEAQACIEAN RNPITKILGL DYNVINEINE DSTLLTILDK I TKDEDPES ...String:
MGVALTRSAQ WTAAGHGTRN LEITPLNEAI LKEIIIFVES FIYKHPQEAN YVFVEPLEWQ TKLDPSAFGS GYAVSETTVK SEEVDKNGE PLLFLSVPQI KIRSFGQLSR LLFIAKNTKL KEAQACIEAN RNPITKILGL DYNVINEINE DSTLLTILDK I TKDEDPES ETKVKIALLL KQLDLHLLNH SLRHISLEIR LNPRTVKNDI ELLKKFSGKG EQTVLESIDY TSDYEFSNGC RA PPWRQMQ GEICYVLVKP HDVEILCLTC SNEGVFLNGG KTDDEGEINY ERKGEIYKDL VTLLKEKSAV FSENMSKQEV RFS EEQQKE KDQLNEVPKE EEAAALHKAS NASHRSNLEK NQINLGKNQM TKRLEPSLNW KTTVDAKEKR RLQRDNLEEK RGGR LEKPR PSILPGRAQL IRRSIEKAEE VISESSSESE EDEEPPDHRQ EANADLPSEY WQIQKLVKYL KGGNQTATVI ALCSM KDFN LAQETCQLAI RDVGGLEVLI NLLETDEVKC QIGSLKILKE ISHNPQIRRN IVDLGGLPIM VNILDSPHKS LKCLAA ETI ANVAKFRRAR QAVRRHGGIT KLVALLDCGQ NLPEPAYLSL YETRDVEVAR CGALALWSCS KSYANKEAIR KAGGIPL LA RLLKTSHQDM LIPVVGTLQE CASEENYRAA IKAERIIENL VKNLNSENEQ LQEHCAMAIY QCAEDEETRD LVRLHGGL K PLASLLNNTD NKERLAAVTG AIWKCSISKE NVIKFREYKA IETLVGLLTD QPEEVLVNVV GALGECCQEH ENRVIVRRC GGIQPLVNLL VGINQALLVN VTKAVGACAV EPESMMIIDR LDGVRLLWSL LKNPHADVKA SAAWALCPCI QNAKDAGEMV RSFVGGLEL VVNLLKSDNK EVLASVCAAI TNIAKDEENL AVITDHGVVP LLSKLANTNN DKLRRHLAEA ISRCCMWGRN R VAFGEHKA VAPLVRYLKS SDTNVHRATA QALYQLSENA DNCITMHENG AVKLLLDMVG SPDQDLQEAA AGCISNIRRL AL ATEKARY T

UniProtKB: Armadillo repeat-containing protein 4 isoform 1

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Macromolecule #2: Outer dynein arm-docking complex subunit 4

MacromoleculeName: Outer dynein arm-docking complex subunit 4 / type: protein_or_peptide / ID: 2 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 78.707766 KDa
SequenceString: MAEQEANGLR STFPSYMAEG ERLYLCGEFA KAAHSFSNAL HLQNGDKNCL VARSKCFLKM GELEKSLADA EASLQGDPTF CKGILQKAE TLYTMGDFEF ALVFYHRGYK LRPDREFKVG IQKAQEAINN SVGSPASIKL ENREDLSFLS KQAERMQAQQ K AHPVRQFL ...String:
MAEQEANGLR STFPSYMAEG ERLYLCGEFA KAAHSFSNAL HLQNGDKNCL VARSKCFLKM GELEKSLADA EASLQGDPTF CKGILQKAE TLYTMGDFEF ALVFYHRGYK LRPDREFKVG IQKAQEAINN SVGSPASIKL ENREDLSFLS KQAERMQAQQ K AHPVRQFL YHPKRESKRK GSLKSEKIVR QLLGELYVDK EYLEKLLLDE DLIRGTIKHG LTVEDLIMTG INYLDTRSNF WR QQKPIYA RERDRKLMQE KWLRDRKRRP SQTAHYILKS LEDIDMLLTS GSAEGSLQKA EKVLKKVLEW SKEEVPNKDE LLG NLYSCI GNAQMELGQM VAALQSHRKD LEIAKEYDLP EAKSRALDNI GRVFARVGKF QQAIDTWEEK IPLARTTLEK TWLF HEIGR CYLELDQAWQ AQNYGEKSQQ CAEEEGDIEW QLNASVLVAQ AQVKLRDFES AVNNFEKALE RAKLVHSNEA QQAII SALD DANKGIIEEL KKTNYRDILK DKKEKEDVLD NTSAKEKEAT RRVRDEPEKV MKRWEHEQME NEKEMEGDLS KDTLGT AAS GQEGHEQRGA IEKASPLRRT EQAAMGRDPG EAAKEHLGEA GRTLSELKRG ETREIYRRPS DLDQNLSEEL STREPEV LE KKLSETGRGE SERLEKTESE EIGETENTEE MRKDEKEDEL ALE

UniProtKB: Outer dynein arm-docking complex subunit 4

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Macromolecule #3: EF-hand calcium binding domain 1

MacromoleculeName: EF-hand calcium binding domain 1 / type: protein_or_peptide / ID: 3 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 29.379803 KDa
SequenceString: MNSVCLGKDT ALTLGRSQQL SVALMGVNLT MDACRRPGAA VCKLTCAELK LGIKDGLNAC CYICIFSFTV NKFEVKCLIS LFYNLVGDV TERQGVVVGL DRNAFRNILH VTFGMTDDMI MDRVFRGFDK DNDGCVSVSE WVYGLSVFLR GTLEEKMKYC F EVFDLNGD ...String:
MNSVCLGKDT ALTLGRSQQL SVALMGVNLT MDACRRPGAA VCKLTCAELK LGIKDGLNAC CYICIFSFTV NKFEVKCLIS LFYNLVGDV TERQGVVVGL DRNAFRNILH VTFGMTDDMI MDRVFRGFDK DNDGCVSVSE WVYGLSVFLR GTLEEKMKYC F EVFDLNGD GFISKEEMVH MLKNSLLKQP SEEDPDEGIK DLVEITLKKM DHDHDGKLSF PDYEAAVREE ALLLEAFGPC LP DPKSQKE FEAQVFKDPN EFGEV

UniProtKB: EF-hand calcium binding domain 1

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Macromolecule #4: Coiled-coil domain-containing protein 114 isoform X2

MacromoleculeName: Coiled-coil domain-containing protein 114 isoform X2 / type: protein_or_peptide / ID: 4 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 80.337516 KDa
SequenceString: MPLGLSAGST RSEDGSEAFL EGMVDWELSR LQRQCKVMEG ERRAYSKEVH QRINKQLGEI QRLEGVRDKL QVQISIAQSQ VKRLRDSER LENMGHLLKC RVQVQAEVKE LQEQTRALDR EIQEWETRIF AHSQDVKAPG CVLSQKVKVR QRIKILEDQL D RVTCRFDI ...String:
MPLGLSAGST RSEDGSEAFL EGMVDWELSR LQRQCKVMEG ERRAYSKEVH QRINKQLGEI QRLEGVRDKL QVQISIAQSQ VKRLRDSER LENMGHLLKC RVQVQAEVKE LQEQTRALDR EIQEWETRIF AHSQDVKAPG CVLSQKVKVR QRIKILEDQL D RVTCRFDI QLVRNATLRE ELDLLRIERN RYLNVDHKLQ KEIQHLRHAV SALMVSSTSA YTVREEAKNK ISMLRERAEK EV AQNETEV QILQRQVAHL EQLHRFLKLK NDDRQPDPAI LAKREQRARE VAEGLRKTSQ EKLVLRYEDA LNKLYQLTGE SDP DLMVEK YLELEERNFA EFNFINEQNS ELEHLQEEIK EMQEALVSRR RSEEDRRAQQ EQQRTELQQR VDEVHTEAEN LEAR FQDFR GQLEALKTAI QRLFTRAQCD STLINDLLGV KTQMRDRDIG LFLGLIEKRL VELLMVHAFL ETQSYPFTSL PSAAL MVLG QSPEELLKKV VLPLPPDNLE EPPGFEARDD YPLSKEELLS QVVKSLKVQE QAREQHLKEL AEAVKKVDST PSITFS QKA SSSTRLLPKS PSAIPGSIMS HRTSGILVAG GGRAPSSNVG HVTFGEPSSS AGRMTYGSTS ATGALASSRS STGGRVT FR SPSSSSYLGS TGYLESSRGH ESFGGLESRG PGSESSGGLG FSRGQVSSTG PASSTGQGST TSKDSRSNY

UniProtKB: Coiled-coil domain-containing protein 114 isoform X2

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Macromolecule #5: Outer dynein arm docking complex subunit 3

MacromoleculeName: Outer dynein arm docking complex subunit 3 / type: protein_or_peptide / ID: 5 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 72.117602 KDa
SequenceString: MTSPLCWAAS ANAMPSQDQV SASSKGRGNQ AQAKGHPQGK GSVQAWQSLH SKAGPFHASE GKSTVHTQVA ELQRKIQLLE GDRKAFYES TQWNIRKNQE TINQLREETR VLQLQLADLL QGDEKVVQAV IREWKSEKPY LKNRTGQQAL EHLDHQLSEK V KQLNALRH ...String:
MTSPLCWAAS ANAMPSQDQV SASSKGRGNQ AQAKGHPQGK GSVQAWQSLH SKAGPFHASE GKSTVHTQVA ELQRKIQLLE GDRKAFYES TQWNIRKNQE TINQLREETR VLQLQLADLL QGDEKVVQAV IREWKSEKPY LKNRTGQQAL EHLDHQLSEK V KQLNALRH QLGLRQKWLE ELQLQHSLRE LEMAEAQDRN TEVAKTMRNL ENRLEKALMK AEEAEHITNV YLQLKAYLQE ES LHLENRL DFMEAEVVRT KHELEELNVV NQEALNARDI AKNQLQDLEE TVLRERKKRD RYLTECKKRA EERKLQNERM ERK TQREDV LLHSDDTLQD SQRSKEEELR RRWSMYQMEV LFGKVKDATG VAETHAVVRR FLAQGETFTQ LETLKIENEQ MLLR LKQEK QRLQKELEDL KYSGEAMLMS EQKLQVELQE RIKAEEQRRA DVQDRLERTM RAMHMTKEAL EHLASKLDHI TVADS APEE APPRAPQDVR GSSTITQEAS GFAGKELDPK ASDYLPNLLG LVEEKLLKLQ AKLQNHNVPE MLRHIADREF FSTLEG KLP SYNTRIALPL AGHKDKFFDE EESEEEDNEV VTRAALKMRS QKLIESRSKR RGRSRKS

UniProtKB: Outer dynein arm docking complex subunit 3

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Macromolecule #6: EFCAB6

MacromoleculeName: EFCAB6 / type: protein_or_peptide / ID: 6 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 167.103703 KDa
SequenceString: MSTPSSTTAM ANPILSSLDV KRILFQSITN KGDDLKKAFH LLDTGNDRTV SKNELRRVIA DFLLPLTREQ FQDILAQIPL TRAGAVPYL EFLSRFGGTD LNVNAVKRGG ENAMNHCRTL RDLEAQVAEK IFKNIHTVAK AFKLLDVNKT GLVQARELRR V LETSVRGL ...String:
MSTPSSTTAM ANPILSSLDV KRILFQSITN KGDDLKKAFH LLDTGNDRTV SKNELRRVIA DFLLPLTREQ FQDILAQIPL TRAGAVPYL EFLSRFGGTD LNVNAVKRGG ENAMNHCRTL RDLEAQVAEK IFKNIHTVAK AFKLLDVNKT GLVQARELRR V LETSVRGL LDERFYFRFA KHYNVDKDTA VDYNVFLKNL GTNNDLNLKY DVGSQEVSWE EQRAKNPSRE CLPSSLSPED IR GNYSLDD LERVFCQELS RSHERVEKAL SAGDPSRGGY VSLNYLKIVL DTFVCRLPRR IFIQLMKRFG LKTTAKINWK QFL TSIYEP QWLETSNKIP MTKRNSINSR QPRQENIIPR LFSHEDHSTA LKEALLIINS KPGRQITGEE LRHTLNDMAV KISD SEFKE LMRTLDPGST GWVNVSTFVE LLEEKPRLSK PSPCEDPKAP LLLAWDSVEE IVHHSVTRNL (UNK)GFRRMLQSC D LGDTGLVG RQNFKKIMRA FCPCLTAEHL VKLCNKFQDI TSGRILYKKL LACLGINGPP TVSPVLVPKD QLFNEHFQKE DQ QQPDLSE RTEPTESKSA VTKKVTKEEV IEKLKDCIRQ RDPAFRKRFL DFSKEPNGKI NAHDFRKVLE EHGMPMDDDQ YAL LTAKIG YKKEGMSYLD FATGFEDAAM NGPEATPPQT PGLSKGTSDS SLITAKECLR QFPRRLKEFF RDPYAAFFNL DLDR DGLIS MHDLRRLLLH LRFNLKEEEF ERFLGLLGLR LSVTLNFREF RNLFEKRPFR SEDDAPQRLL RPKQKVADSE LACEQ AHQY LVTKAKTRWA DLSKNFIETD SEGNGILRRR DVKNALYGFD IPLTPREFEK LWLSYDTEGR GHVTYQEFLQ KLGISY SAD VHRPYANDHF NFMGHFTKQQ QMHEELRELQ QSAEKAVPPR DKLKDHYQDI SKALSKLDKP KNGSISFCKL QKLLQEC GC SLKQEELTDL LNSWGISWHD NSISYLDFLR AVENSKTTRP QPREKKERVP LDFATLNPEE VLKSIQEVVA ASGQALST A FSALDKEDTG FVKASDFGQV LKEFCYKLAD NQYHYFLRKL RLHLTPHINW KYFLQNFSSY LEETAAEWAE KMPKGPPPR SPKETANQAI LARLHKAVAS RYHAIAREFD GFDTAKTNTA SRDEFRSICT RHVQVLTDEQ FDRLWEEMPV NA(UNK)GRL KYL DFLSTFSSEK AATPPATDDS AKAQRGSSVP EVSEGGRSAG SSPTRNLRTG SKQQSHPCSP VGAALPLQNC ELIENKL RK RLQGCWRKFL RECKDRDAGK RGEIAPADFL ALAEKFNLDI NRDECQQLIV KYDLKNDGTF AYCSFIQSCV LLLRAKES S LLQRMKIQNA NKMKEAGAET SSFYCALLRI QPRIAHCWRP MRRAFKAHDQ GGTGFLSVAD FRKVLRQYSV ILSEEEFFH VLEHYDKTLS AKIPYNDFLR AFLQ

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Macromolecule #7: Cilia- and flagella-associated protein 52

MacromoleculeName: Cilia- and flagella-associated protein 52 / type: protein_or_peptide / ID: 7 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 68.199891 KDa
SequenceString: MENQIQPKAE VAKLELEAVI GFNGHVPTGL KCHPDQEHLI YPLGCTILIQ AIKTQEQNFL HGHSNNVSCV TISKSGVYIA SGQVTFMGF KADIILWDYK KRELMARLSL HKGKIEALAF SPNDLYLVSL GGPDDGSVVV WSIAKTEAIC GSPAAGLNVG N ATSVVFSQ ...String:
MENQIQPKAE VAKLELEAVI GFNGHVPTGL KCHPDQEHLI YPLGCTILIQ AIKTQEQNFL HGHSNNVSCV TISKSGVYIA SGQVTFMGF KADIILWDYK KRELMARLSL HKGKIEALAF SPNDLYLVSL GGPDDGSVVV WSIAKTEAIC GSPAAGLNVG N ATSVVFSQ CHDEMFVTAG NGTIRVWELD LPNRKIWPTE CQTGQMKRIV MSISMASDDS FFYLGTTTGD ILKMNPRTKL LA DTGPAKD KFSLGVSAIK CLKTGGLLVG SGAGLLVFCR SPSYKPIKKI QLQGGITSIS LRGEGHQFFV GTEESHIYRV NFT DFKETL VTTCHFEAVE DVVFPFGTAE LFATCAKKDI RVWHTLSNRE LLRITVPNMT CHGIDFMRDG KSLISAWDDG KIRA FAPET GRLMYVISNA HRIGVTAVAT TSDCTRVISG GGEGEVRVWQ IGHQTQKLEE ALKEHKSSVS CIRVKKNNEE CVTAS TDGT CIIWDLVRLR RNQMILANTL FQCVCYHPEE FQIITSGTDR KIAYWEVFDG SGIRELDGSL SGSINGMDIT PEGVHF VTG GNDHLVKVWD YNEGEVTHVG VGHSGNITRV RISPGNEYIV SVSADGAILR WKYPFPS

UniProtKB: Cilia- and flagella-associated protein 52

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Macromolecule #8: Cilia- and flagella-associated protein 45

MacromoleculeName: Cilia- and flagella-associated protein 45 / type: protein_or_peptide / ID: 8 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 65.621914 KDa
SequenceString: MPLSPAGVLS STSTASNRSR NRPRYRTKAL SSEVDESLFG GIKPLNQSDS PIVLLRDKHA IRKTLTALGL DHKPETIQLI TRDMVRELI IPTKDPSGES LIMSPEEFER IRWASHVPTR EELEAKEQAC KKEKEAIVDA VTTRKKIMKQ KEMVSRNNQK L SDLEEVAK ...String:
MPLSPAGVLS STSTASNRSR NRPRYRTKAL SSEVDESLFG GIKPLNQSDS PIVLLRDKHA IRKTLTALGL DHKPETIQLI TRDMVRELI IPTKDPSGES LIMSPEEFER IRWASHVPTR EELEAKEQAC KKEKEAIVDA VTTRKKIMKQ KEMVSRNNQK L SDLEEVAK ERAQNLLQRA SQLRMEQEEE LKDMKKIILN AKCHAIRDAQ ILEKQLIQKE LDAEEKRLDQ MMEVERQKSI QR QEELDKK RREERIRGRR HIVEQMEKNQ EERSLLAEQR EQEKEQMLEY MEQLQEEDLR DLERRHQQKL KMQAEIKRIN DEN QKQKAE LLAQEKLADQ MVMEFTKKKM AREAEFEAEQ ERIRREKEKE ISRLRALQEK VQDYQAEQDA LRAKRNQEVA DREW RRKEK ENAQKKMETE AQLRKSRLEQ VAFKEHSLAV QVQRDRDEFE RILRAQREQI EKEQQEEEKK AMERLQHANE LRRQV RENQ QKQVQDRIAI FEEGQRLKEE AQKRRERIEG IKKKKIEELR ATGLPEKYCI EAERKANIPT NTSVN

UniProtKB: Cilia- and flagella-associated protein 45

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Macromolecule #9: Cilia and flagella associated protein 210

MacromoleculeName: Cilia and flagella associated protein 210 / type: protein_or_peptide / ID: 9 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 66.292844 KDa
SequenceString: MGTSEVVVRF GRRCGRAKEI TEIKNYEEDQ VLYPPLLPDK VDLRQVTIIP HNEWERIRDS LDSLTREAAH LRAKRKAKKE MHFRSQEVV KHWTNTYAGM RKQKLEAKKK RDEEIEAERQ ILDVEEAIYK QGERKKAIEY AKQYQFYQTE RVKNFHSGLL L SRVMKERD ...String:
MGTSEVVVRF GRRCGRAKEI TEIKNYEEDQ VLYPPLLPDK VDLRQVTIIP HNEWERIRDS LDSLTREAAH LRAKRKAKKE MHFRSQEVV KHWTNTYAGM RKQKLEAKKK RDEEIEAERQ ILDVEEAIYK QGERKKAIEY AKQYQFYQTE RVKNFHSGLL L SRVMKERD AQIEFQKSKI KSDKKWEEQL KLNIEKGFKE EQEKAEKQRR DRLALAKDHL KQIKEHEEEE VRRRKQEEKD AE EIKQQNL LYEIEMKKKL GMKKEKINES RRLFFEHLND KNVIKAIERQ QQEEEDEKIR KFIKAKKRLT QMGKEKEAET HRL MEERRE RINNFLSKLM KEKFDNEDLI IARDIAEAEA EWEKREREKH EKNKAELKAI AEHRAVVMNN KEEEERRRKI EAKE QLLAI LKADQIFWEH EKEKKRKADK ERREVQDAHI QQMAKNKFKV KQAKQAELED CRLTEALIAE KEKEFQDYAR EVIEL ESKS TNKYMHPLVK AVQEGPGGGH GPVFVDRGGL RPSYQVNDIT GVQLPFYNSQ GSKYNNFQKS KGRLGFTW

UniProtKB: Cilia and flagella associated protein 210

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Macromolecule #10: Cilia and flagella associated protein 276

MacromoleculeName: Cilia and flagella associated protein 276 / type: protein_or_peptide / ID: 10 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 19.304631 KDa
SequenceString:
MPLTRDPFQH STLDNDDSYL GKIRASKKLP YKNPTHLAQQ QEPWCRLSST ATITSMRRDA CFFDPEIPKD DLDFRLSALY NHHSGTFKN KSEILIHQET IQDTHGIKIQ FPGESLPPPQ PPPITSQANI RHWINPKKES IHSIQGSIVS PHTAATNRGY S RKNDGGFF ST

UniProtKB: Cilia and flagella associated protein 276

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Macromolecule #11: Enkurin

MacromoleculeName: Enkurin / type: protein_or_peptide / ID: 11 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 29.949805 KDa
SequenceString: MDPTYSSESI YNLIPSDWKE PPQPPRYISI FKATVKDDMQ KFKTAMKTMG PAKLEVPSPK DFLKKHSKEK TLPPKKKFDR HEPKKPPVP LRTEHPVMGI QSEKNFINTN AANVIMGVAK KPKPVYVDKR TGDKHDLETS GLVPKYINKK DYGVTPEYIC K RNEEVKKA ...String:
MDPTYSSESI YNLIPSDWKE PPQPPRYISI FKATVKDDMQ KFKTAMKTMG PAKLEVPSPK DFLKKHSKEK TLPPKKKFDR HEPKKPPVP LRTEHPVMGI QSEKNFINTN AANVIMGVAK KPKPVYVDKR TGDKHDLETS GLVPKYINKK DYGVTPEYIC K RNEEVKKA QEEYDNYIQE NLRKAAMKRL SDEEREAVLQ GLKKNWEEVH KEFQSLSVFI DSIPKKMRKQ KLEEEMKQLE HD IAVLEKH KIIYIANKK

UniProtKB: Enkurin

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Macromolecule #12: Parkin coregulated

MacromoleculeName: Parkin coregulated / type: protein_or_peptide / ID: 12 / Number of copies: 6 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 29.412234 KDa
SequenceString: MVAEKETLSL SKCPDKMPKR TKLLAQQPLP VHQPHPLVSE GFTVKAMMKN SVVRGPPTAG AFKERPTKPT AFRKFYERGD FPIALEHDS KGNKIAWKVE IEKLDYHHYL PLFFDGLCEM TFPYEFFARQ GIHDMLEHGG NKILPVIPQL IIPIKNALNL R NRQVICVT ...String:
MVAEKETLSL SKCPDKMPKR TKLLAQQPLP VHQPHPLVSE GFTVKAMMKN SVVRGPPTAG AFKERPTKPT AFRKFYERGD FPIALEHDS KGNKIAWKVE IEKLDYHHYL PLFFDGLCEM TFPYEFFARQ GIHDMLEHGG NKILPVIPQL IIPIKNALNL R NRQVICVT LKVLQHLVVS AEMVGEALVP YYRQILPILN IFKNMNVNSG DGIDYSQQKR ENIGDLIQET LEAFERYGGE DA FINIKYM VPTYESCLLN

UniProtKB: Parkin coregulated

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Macromolecule #13: Cilia- and flagella-associated protein 20

MacromoleculeName: Cilia- and flagella-associated protein 20 / type: protein_or_peptide / ID: 13 / Number of copies: 5 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 22.781389 KDa
SequenceString: MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEIE GTNVSTTYIT CPADPKKTLG IKLPFLVMII KNLKKYFTF EVQVLDDKNV RRRFRASNYQ STTRVKPFIC TMPMRLDDGW NQIQFNLSDF TRRAYGTNYI ETLRVQIHAN C RIRRVYFS ...String:
MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEIE GTNVSTTYIT CPADPKKTLG IKLPFLVMII KNLKKYFTF EVQVLDDKNV RRRFRASNYQ STTRVKPFIC TMPMRLDDGW NQIQFNLSDF TRRAYGTNYI ETLRVQIHAN C RIRRVYFS DRLYSEDELP AEFKLYLPVQ NKAKQ

UniProtKB: Cilia-and flagella-associated protein 20

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Macromolecule #14: Protein Flattop

MacromoleculeName: Protein Flattop / type: protein_or_peptide / ID: 14 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 19.236705 KDa
SequenceString:
MATNYSANQY EKAFSPRYLQ NWSLAKPTKQ RISSHEGYTQ IIANDRGHLL PSVPRSKASP WGSFMGTWDM PLKVPPARVT LTSRTAAGA ASLTKWIQKN PNLLKASNGL RPEILGKPHD PDGQRKFGKS IIKTVQQAPR STIIPSSPGS NLNSPDHPQS S HPSAGHTP GPQSPANSK

UniProtKB: Protein Flattop

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Macromolecule #15: Tektin

MacromoleculeName: Tektin / type: protein_or_peptide / ID: 15 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 48.432867 KDa
SequenceString: MAKLLQPPPK FLPSEWHIAN KNHYHRAEAQ RSRSERLVAE SQRLVDEIEK TTRKSQSDVN KKLEQRLEEV RFWKKELDDK LEQLVSATE DLLIYQTRLE KALESLKEPL HITEKCLEYR EKRVGIDLVR DEVEQELIKE AEVIQGVRAL LTRTLEETAE Q IRLNRSAK ...String:
MAKLLQPPPK FLPSEWHIAN KNHYHRAEAQ RSRSERLVAE SQRLVDEIEK TTRKSQSDVN KKLEQRLEEV RFWKKELDDK LEQLVSATE DLLIYQTRLE KALESLKEPL HITEKCLEYR EKRVGIDLVR DEVEQELIKE AEVIQGVRAL LTRTLEETAE Q IRLNRSAK YSLEKDLRDK FTALTIDDIC FSLNNNSPNI RYSENAVRIE PNSVSLEDWL DFSSTNVEKA DRQRNNSMTL KA LVDRILS QTASDLQRQC DVVDTAFRNG LKETKDARDK LAAHLAKVME EIASQEKNMT VLEKAILDQE GPAKVAHTRL ETR THRPNV ELCRDVAQYR LIKEVDEIAY NVARLKETLA QAQAELKGLN RRQLALQEEI QVKENSIYID EVLCVHMRRS IPPR DGDDR GQWAGGLRPD AVC

UniProtKB: Tektin

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Macromolecule #16: Tektin

MacromoleculeName: Tektin / type: protein_or_peptide / ID: 16 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 49.973676 KDa
SequenceString: MATLSVKPSQ RFRLPDWHTN SYLLSTNAER QRDASHQIRQ EARVLRNETN NQTIWDEHDN RTRLAERIDT VNRWKEMLDK CLTDLDAEI EALTQMKESA EQNLQAKNLP LDVAIECLTL RDCRRDIDVV KDPVEEELHK EVEVIEATKK ALQQKISQAF E KLCLLQEA ...String:
MATLSVKPSQ RFRLPDWHTN SYLLSTNAER QRDASHQIRQ EARVLRNETN NQTIWDEHDN RTRLAERIDT VNRWKEMLDK CLTDLDAEI EALTQMKESA EQNLQAKNLP LDVAIECLTL RDCRRDIDVV KDPVEEELHK EVEVIEATKK ALQQKISQAF E KLCLLQEA RQQLNADHRG KMETLDIDRG CLSLNLKSPN ISLKINPTRV PSGSTTLQQW DDFSQFNKNR AEAEMKGAVE LR EAIALTI AETNNELEAQ RVATEFAFRK RLREMEKVYS ELKWQEKNTL EEIAELQEDI RHLEEDLRRK LQNLKLCHTR LET RTYRPN VELCRDQAQF GLTDEVHQLE ATIAALKQKL AQAQDALDAL YKHLARLQAD IACKANSMLL DTKCMDTRRK LTVP AEKFV PEVDTFTRTT NRTLSPLKTC QLELT

UniProtKB: Tektin

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Macromolecule #17: Tektin

MacromoleculeName: Tektin / type: protein_or_peptide / ID: 17 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 56.55284 KDa
SequenceString: MELLGSTLTA TYAHPRPTPT SLLPAISTMA SSYRDRFPHY NLTHSLSLPW RPSTYYKAAS NWPALDPYCT RAQSVSQSAM LPFVSNRTT LFTRYTPDDW YRSNLTNYLE SNTSRHNSER LRVDTSRLIQ DKYQQTRKTQ ADSTQNLGER VNDIGFWKSE I THELDAMI ...String:
MELLGSTLTA TYAHPRPTPT SLLPAISTMA SSYRDRFPHY NLTHSLSLPW RPSTYYKAAS NWPALDPYCT RAQSVSQSAM LPFVSNRTT LFTRYTPDDW YRSNLTNYLE SNTSRHNSER LRVDTSRLIQ DKYQQTRKTQ ADSTQNLGER VNDIGFWKSE I THELDAMI GETNELTDVK KKLERALMET EAPLQVAREC LFHREKRMGI DLVHDEVETE LLTEVDIILC CQERMKLHLD KA IAQLAAS RASQHELEKD LSDKQAAYRI DDKCHHLRNT SDGISYFRGV ERVDATVSVP ESWAKFTDDN ILRSQSERAA SVK LRDDIQ NLLVVTANEM WNQFNKVNLA FTNRIAETAD AKNKMQIHLA KTLQEIFQTE TTIDSIKKAI RDKAAFLKVA QTRL DERTR RPNIELCRDM AQLRLVNEVY EVDDTIQTLQ QRLRDAEDTL QSLVHTKATL EHDLAVKANS LYIDQEKCMT MRKSF PSTM RLVGFC

UniProtKB: Tektin

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Macromolecule #18: Tektin

MacromoleculeName: Tektin / type: protein_or_peptide / ID: 18 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 52.015508 KDa
SequenceString: MAQTDILTTK QPAPQTVLAC QLPRKLYDVA QNTGAHTSSG LATAGFRTAK YLADEWFQNC YARYHQAFAD RDQSEQQRHE SQQLVAETE ALAQRTQKDS MKKVGEHLQD THCWKSELQR HVEELVAETD LLLAQKQRLE RALDATALPF SIATDNLQCQ E RRQHPDLV ...String:
MAQTDILTTK QPAPQTVLAC QLPRKLYDVA QNTGAHTSSG LATAGFRTAK YLADEWFQNC YARYHQAFAD RDQSEQQRHE SQQLVAETE ALAQRTQKDS MKKVGEHLQD THCWKSELQR HVEELVAETD LLLAQKQRLE RALDATALPF SIATDNLQCQ E RRQHPDLV RDWVEMELLK EAELIRNIQE LLKRTIMQAV NQIRLNREHK ETCEMGWSDK VEAYNIDEAC CRYHNQSTDV QF YPHSAKF EESASTPETW AKFTQDNLYG AERERLASVN LRELIECILQ DTAEDLRLQC DAVNLAFGRR CEELEDARHK LEY HLRKTL REITDQEHNV SVLKQAVKDK EAPLKVAQTR LYQRSHRPNV ELCRDTAQFR LVSEVEELNV SLATLREKLL EAEQ SLRNL EDTRMNLEKD LAVKTNSLFI NRQKCMTHRA CYPTVLQLAG YQ

UniProtKB: Tektin

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Macromolecule #19: RIB43A domain with coiled-coils 2

MacromoleculeName: RIB43A domain with coiled-coils 2 / type: protein_or_peptide / ID: 19 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 45.003449 KDa
SequenceString: MEVAQPKDLE EDFGQAKKRH AELCRQKRIF NARNRIFGGD IDAWNVQVCD QKIREATEKA RQETFAAEMR QNDKITCILE DRARRDRKT LCKAISDFQQ SFQKPETRRE FDLSDPLALK KDLPARQSDN DARNTVSGMQ KFMGEDLNFH QRRKFQEEQN R EWSLQQQR ...String:
MEVAQPKDLE EDFGQAKKRH AELCRQKRIF NARNRIFGGD IDAWNVQVCD QKIREATEKA RQETFAAEMR QNDKITCILE DRARRDRKT LCKAISDFQQ SFQKPETRRE FDLSDPLALK KDLPARQSDN DARNTVSGMQ KFMGEDLNFH QRRKFQEEQN R EWSLQQQR EWKIAREDQK HAEDLYLETR LQFDETAKHL QNLEGTTRKA VCAAVKEFNK NQALESAEKK RQERKQEQED NL AEITNLL RGDLLSEDPQ QAASSFGPHR VVPDRWKGMT QEQLEQIRLV QKQQVQEKLR LQEEERQRDM DWDRQRVQKA RAT LLSERQ LQRQQRALRR ALDGSNLSLA KEQLLQKKYM KEIYTNQPTE DYFTQFNTRS R

UniProtKB: RIB43A domain with coiled-coils 2

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Macromolecule #20: RIB43A-like with coiled-coils protein 1

MacromoleculeName: RIB43A-like with coiled-coils protein 1 / type: protein_or_peptide / ID: 20 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 44.590852 KDa
SequenceString: MFKTDLPPDP KEAAAIEARR NREKERQSRF LNVRTRVMGV DVEALNSQVE ERKLQEATEQ SKKAAYGTNQ VQYDVVAQML EKEQAERTR RLAKKVQEFR EQKQQLKNRS ELDLWDPHRL WKEFPPHLSN NDPYCGPASL QYFSGEDLNR STHLRMQQEQ F RYSLERQL ...String:
MFKTDLPPDP KEAAAIEARR NREKERQSRF LNVRTRVMGV DVEALNSQVE ERKLQEATEQ SKKAAYGTNQ VQYDVVAQML EKEQAERTR RLAKKVQEFR EQKQQLKNRS ELDLWDPHRL WKEFPPHLSN NDPYCGPASL QYFSGEDLNR STHLRMQQEQ F RYSLERQL QEQQQARIDY NCADMLNNQL RLAMDMRAAQ MAKLEESCRM AMMSAMANAN KFQVAEVAER QRREHQCQQE AN LTEIQNQ ITSDLLTENP QVAQNPVAPH RVLPYCWKGM TPEQRAAIRK VQEAQRHEKE AQRQAEQAMD SEWESQAERL ARA AQELEE QERELCAEFR RGLGSFNQQL AKEQKAQHNY LNSIIYTNQP TAQYHLQFNT SSR

UniProtKB: RIB43A-like with coiled-coils protein 1

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Macromolecule #21: EF-hand domain containing 1

MacromoleculeName: EF-hand domain containing 1 / type: protein_or_peptide / ID: 21 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 74.113344 KDa
SequenceString: MVSHPVHGLP FLPGTSFKDS TKTAFHRSQT LGYRNGYAVV RRPTVGIGGD RLQVNQLSQA ELDELANKAP VLTYGQLKRA PPAEFIPAH VAFDKKVLKF DAYFQEDVPG STEEHYRIRQ VNIYYYLEDD SMSVIEPVVE NSGIPQGKLI KRQRLPKNDR G DHYHWKDL ...String:
MVSHPVHGLP FLPGTSFKDS TKTAFHRSQT LGYRNGYAVV RRPTVGIGGD RLQVNQLSQA ELDELANKAP VLTYGQLKRA PPAEFIPAH VAFDKKVLKF DAYFQEDVPG STEEHYRIRQ VNIYYYLEDD SMSVIEPVVE NSGIPQGKLI KRQRLPKNDR G DHYHWKDL NRGINITIYG RTFRIVNCDK FTQVFLESQG IELNPPEKMA LDPYTELRKQ PLRKYVTPTD FDQLKQFLTF DK QVLRFYA IWDDTDSMFG ECRTYIIHYY LMDDTVEILE VHERNDGRDP FPLLMNRQRM PKVLVENAKN FPQCVLEISD QEV LEWYTA KDFIVGKPLT MLGRTFFIYD CDPFTRQYYK EKFGISDLPR IDVSKKEPPP VKQELPPYNG YGLIEDSAQN CLAL IPKAP KKDVIKMLMN DNKVLRYLAA LESPIPEDKG RRFVLSYFLA TDMISIFEPP VRNSGIIGGK YLGRTKVVKP DSSME NPIY YGPSDFFIGA VIEVFGHRFV ILDSDDYVLK YMESNPAQFS PEALLSIQNH IRRRDTPALE LDSQRTEKDP GTQELE VLI DTIQKQLKDH PCRDSIREAF RIYDTEASGY VDRETFFKIC DSLHLPVDDS LIKELVRMCS HGDDKMDYSS FVRAFSH

UniProtKB: EF-hand domain containing 1

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Macromolecule #22: EF-hand domain-containing family member C2

MacromoleculeName: EF-hand domain-containing family member C2 / type: protein_or_peptide / ID: 22 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 87.254148 KDa
SequenceString: MALPLLPGNS FNRNIGKEKF HKSQHWGFCN NVRMLVSEDK PGIGGELLLG QKMKPKYSVF PKEMGTGLPS WVAFDKQVLS FDAYLEDEV PDKSQENYRI RCYKIYFYLE DDTIQVNEPA LKNSGLPKGI FIRRHRISLP PPDEDQFYTV YHFNINVDIV L YGRTFKIY ...String:
MALPLLPGNS FNRNIGKEKF HKSQHWGFCN NVRMLVSEDK PGIGGELLLG QKMKPKYSVF PKEMGTGLPS WVAFDKQVLS FDAYLEDEV PDKSQENYRI RCYKIYFYLE DDTIQVNEPA LKNSGLPKGI FIRRHRISLP PPDEDQFYTV YHFNINVDIV L YGRTFKIY DCDTFTKNFL KKIGVKLNPP GQCPEDPYMK TRREKLDCVE PLRPYESFDT LKQFLEYDRK VLRFFCLWDD SG SLFGDRR ELILHYFLSD DTIEIKEVMP HNSGRDAMSL FLQRRKLPKY GPPGVYQPGQ IADRTVLNVY GGLSRRRVYS YLL DKYKLG NLDQEFYKDS DLSIGTTINV WGRKVLLCDC DEFTKTYYKT KYGIENFTSI SCKAPPPPKI ERKFPPYTGF GSEE DSLRS CIGLVPTPHR RNFKKFMEKD SYGNISNTLR FFAKLITHKC ADVERMFVIS YFLSDDTISV FEPIERNSGY TGGMF LKRT RVKKPGQEVF KSEFSEYVKA EELYVGAKVD VNGYLFLLLN ADEYTLNYME KNSDKFPRSN IKLALQKVKE EESKSR ELK QVFTAADCKH TKMVDYNTFR EIMMNLTVGK LTDQELITIA RHYRVPEEPC PDTCIVMAQA HEQLKKHAFE NFERLIA AC VYQDREKKKV LPSKDIKRLC KSSRLPFNDD LLGALLSKFE DSEKQINYES FFCALNWRAN PMPELEAVSY LKERCEDE W LGMPSPIPVK CISYLNLLKD VFGLEEE

UniProtKB: EF-hand domain-containing family member C2

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Macromolecule #23: Ciliary microtubule inner protein 2B

MacromoleculeName: Ciliary microtubule inner protein 2B / type: protein_or_peptide / ID: 23 / Number of copies: 5 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 30.596564 KDa
SequenceString: MTMASTFIPG LNPKNPHYIP GYTGHCPLLR FSMGQTYGQT TGQLLRGSPG LAWPPAHRTL LPPIRSPRSP EIPRRSLPVR RGHERLSSS MIPGYTGFVP QAQFIFAKNC NQVWAEALND FTQWYGGQGS QELPKEAKGE KDMEKDQQPK LEAEVEAENE P ELGQEVEQ ...String:
MTMASTFIPG LNPKNPHYIP GYTGHCPLLR FSMGQTYGQT TGQLLRGSPG LAWPPAHRTL LPPIRSPRSP EIPRRSLPVR RGHERLSSS MIPGYTGFVP QAQFIFAKNC NQVWAEALND FTQWYGGQGS QELPKEAKGE KDMEKDQQPK LEAEVEAENE P ELGQEVEQ ASPYSMDDRD PRKFFMSGFT GYVPRARFLF GSSFPVLSNQ ALQEFDQMKS QGRSQKDPKH LPPLSRTYPH NL GLLPKYG GYVPGYKFQF GRTYGHLTHD ALGAL

UniProtKB: Ciliary microtubule inner protein 2B

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Macromolecule #24: Ciliary microtubule inner protein 2B

MacromoleculeName: Ciliary microtubule inner protein 2B / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 28.407986 KDa
SequenceString: RFSMGQTYGQ TTGQLLRGSP GPAWPPAHRT LLPPIRSPRS PEIPRRSLPV RRGHERLSSS MIPGYTGFVP QAQFIFAKNC NQVWAEALN DFTQWYGGQG SQELPKEAKG EKDMEKDQQP KLEAEVEAEN EPELGQEVEQ ASPYSMDDRD PRKFFMSGFT G YVPRARFL ...String:
RFSMGQTYGQ TTGQLLRGSP GPAWPPAHRT LLPPIRSPRS PEIPRRSLPV RRGHERLSSS MIPGYTGFVP QAQFIFAKNC NQVWAEALN DFTQWYGGQG SQELPKEAKG EKDMEKDQQP KLEAEVEAEN EPELGQEVEQ ASPYSMDDRD PRKFFMSGFT G YVPRARFL FGSSFPVLSN QALQEFDQMK SQGRSQKDPK HLPPLSRTYP HNLGLLPKYG GYVPGYKFQF GRTYGHLTHD AL GALSTLQ KQLLA

UniProtKB: Ciliary microtubule inner protein 2B

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Macromolecule #25: Sperm-associated antigen 8 isoform 1

MacromoleculeName: Sperm-associated antigen 8 isoform 1 / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 50.53725 KDa
SequenceString: MVCRLYSNAV PSSECRKMET TDSTELSPSR SLDEQPSSEE LGTTSDPLPS LDGRHRSALA AATAAASAAA AATAAASTAK AAALSTQTP APYSERSLLL EPFSDNLTAA HHTTPRFTHK IGHGRLGFEP VQVSHIARNS YTANDPISSQ GPVPGSSSDP V PGSSSGPV ...String:
MVCRLYSNAV PSSECRKMET TDSTELSPSR SLDEQPSSEE LGTTSDPLPS LDGRHRSALA AATAAASAAA AATAAASTAK AAALSTQTP APYSERSLLL EPFSDNLTAA HHTTPRFTHK IGHGRLGFEP VQVSHIARNS YTANDPISSQ GPVPGSSSDP V PGSSSGPV PGSSSSPGPG TSSGPGGGSG PGPGGRSGEG TGPGPASDSR HSPGCGHDPG FSSSAPPGFR NPRADLVPNY AS WSHDSHW EPQKQPWKFL QVSEPGTRGH WKPSEVEGKS KIPSETLPRG QCLLYNWEEE RATNHLDQVP SMQDGSESFF FRH GHQGLL TLWPQSPMSS RTTQKDSYQP PGNHSQPVRG KREAMLEMFL RHQICKEVQA EQEATRKDSE VESVTHHDYR KELV HAGPP TPTRPHDYRT EQPETFWIQR APQLPGVSNI RTLDTPFRKN CSFSTPVPLS LGQPLPYEPE DYSH

UniProtKB: Sperm-associated antigen 8 isoform 1

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Macromolecule #26: Nucleoside diphosphate kinase homolog 7

MacromoleculeName: Nucleoside diphosphate kinase homolog 7 / type: protein_or_peptide / ID: 26 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 42.532766 KDa
SequenceString: MNHSERFVFI AEWYDPNASL FRRYELLFYP GDGSVEMHDV KNHRTFLKRT KYEDLHLEDL FIGNKVNVFS RQLVLIDYGD QYTARQLGS KKEKTLALIK PDAVSKAGEI IEIINKAGFT LTKLKMMTLS RKEATDFHID HQSRPFLNEL IQFITSGPII A MEILRDDA ...String:
MNHSERFVFI AEWYDPNASL FRRYELLFYP GDGSVEMHDV KNHRTFLKRT KYEDLHLEDL FIGNKVNVFS RQLVLIDYGD QYTARQLGS KKEKTLALIK PDAVSKAGEI IEIINKAGFT LTKLKMMTLS RKEATDFHID HQSRPFLNEL IQFITSGPII A MEILRDDA ICEWKKLLGP ANSGLARTDA PGSIRAVFGT DGIRNAAHGP DSLSCAAREM ELFFPSSGVC GPANTAKFTN CT TCCIVKP HAISEGLLGK ILMAIRDAGF EISAMQMFNM DRVNVEEFYE VYKGVVSEYN EMVTEMYSGP CVAMEIQQTN PTM TFREFC GPADPEIARH LRPGTLRAIF GKTKIQNAVH CTDLPEDGLL EVQYFFKILD N

UniProtKB: Nucleoside diphosphate kinase homolog 7

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Macromolecule #27: Cilia and flagella associated protein 161

MacromoleculeName: Cilia and flagella associated protein 161 / type: protein_or_peptide / ID: 27 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 35.381199 KDa
SequenceString: MAKNLYGPGV RMGNWNEDVY LEEERMRDFL AKRDEGQLLI QKNRRLKENL LRPMQLSVSE DGYIHYGDKV MLVNPDHPEV EADLFLGGD LSLCMTPDEI KAYLSDELEV PCGLSAAQTK IPVGRNTFTI LCAAGEVIGQ VVRYGQNFRL GIAGGFEGRM F YLSSDHRT ...String:
MAKNLYGPGV RMGNWNEDVY LEEERMRDFL AKRDEGQLLI QKNRRLKENL LRPMQLSVSE DGYIHYGDKV MLVNPDHPEV EADLFLGGD LSLCMTPDEI KAYLSDELEV PCGLSAAQTK IPVGRNTFTI LCAAGEVIGQ VVRYGQNFRL GIAGGFEGRM F YLSSDHRT LMKSSKRSWL QEVYLTDEDS YLNCWQAAFP DPQLRLEYEG FPIPANAKIL INHCHTNRGL VAHRHLFLST YF GKEVEVA AHTYLDSHRV EKPKNHWMLV TGNPRKNAPT VLDLPKPPAE GTRALEQVAE TPGSSTTPGA HACSHPL

UniProtKB: Cilia and flagella associated protein 161

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Macromolecule #28: Chromosome 1 C9orf135 homolog

MacromoleculeName: Chromosome 1 C9orf135 homolog / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 26.817912 KDa
SequenceString: MESSDSSCRD WCSGRQYRFE LGPTDLTERK GSLTLRSHHK KYSKPVLVYS WNHDREAYPK DYDIEGPEEV KKLCNSTYCR LGTHEPTVW KSETHEKMAQ VYLNTEFTEI KSKALLNEET ISSGIIERDT GLPATGFGAL FTKHPPDWRK MYTLTTYAEE Y APPYQYQP ...String:
MESSDSSCRD WCSGRQYRFE LGPTDLTERK GSLTLRSHHK KYSKPVLVYS WNHDREAYPK DYDIEGPEEV KKLCNSTYCR LGTHEPTVW KSETHEKMAQ VYLNTEFTEI KSKALLNEET ISSGIIERDT GLPATGFGAL FTKHPPDWRK MYTLTTYAEE Y APPYQYQP FDYPCQDDDY SVVHRKCRSQ FTDLNGSKRF GINTWHDESG IYANSYLKRK LYSLTTSPIA PF

UniProtKB: Chromosome 1 C9orf135 homolog

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Macromolecule #29: Piercer of microtubule wall 1

MacromoleculeName: Piercer of microtubule wall 1 / type: protein_or_peptide / ID: 29 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 15.692243 KDa
SequenceString:
MSEENPQECA EPEEPEATAS PEKTSDYYRV SEDLPARFNN PAWFRGYRTK EPPSVYRTSN QAYGSRAPTV HEMPKVFYPN SHKFSRQLA AGGMFQNNTF NVYMEKSIVT GPDNYITSYD RLNFHPSYRV NKPSICD

UniProtKB: Uncharacterized protein

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Macromolecule #30: Chromosome 1 C15orf65 homolog

MacromoleculeName: Chromosome 1 C15orf65 homolog / type: protein_or_peptide / ID: 30 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 13.888583 KDa
SequenceString:
MTECDWDKKS TSASNSDTEM KPEQRPSCVN PGNPVFSCML DPRSLHTATS LSKPKMIMYK TNSSNYGEFL PMPQFFPCYY TPKEQVFSG HIRATGFYQN NTLNTTPDRT RTLDFPNFQH TL

UniProtKB: Chromosome 1 C15orf65 homolog

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Macromolecule #31: EF-hand domain family member B

MacromoleculeName: EF-hand domain family member B / type: protein_or_peptide / ID: 31 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 98.40218 KDa
SequenceString: MEMCSFVRVP SPKVLGSSKA LGSSLQPGTA YPLEMSALGK VRVSERKSPL GMAVGFVQEG KGGLGERRVF MGTTSPTELG LRVRLGKED SSCTNKYEER IASSETKSPS SKGLEMRLKR PDISRTFMDG SNLGVNRVSA LQETKPSLSM LPGRVGLENE R FLAGCCPG ...String:
MEMCSFVRVP SPKVLGSSKA LGSSLQPGTA YPLEMSALGK VRVSERKSPL GMAVGFVQEG KGGLGERRVF MGTTSPTELG LRVRLGKED SSCTNKYEER IASSETKSPS SKGLEMRLKR PDISRTFMDG SNLGVNRVSA LQETKPSLSM LPGRVGLENE R FLAGCCPG RVKRPPLGMV CKSPQAVGSR RCPVAGDLEG LGASMGKQLV LDMEPRQELE KESTCVVMKP KAEMEPPVEV DM GLPQPED PDETNPTDLH MGLVIEPSEC QLAQLHEEQK VAENTELGVE PPDHIRPIYS GKFFDRTPCW PSAGKVLPIG YRV ATCLTE KLPRLMTPPE AKKFFNFRYP PAGAERVFYG RANDPQIAPY LTHGIRSKIS IPAKVLINPQ PITTFQQKIK DKKE SVYFS NQRAPLGKSH DQTPGLPKGL DVPNTTFGTA IIRELSLGDV VNPPKPYEEV FEEGQAGHDL YVVSHNDYFV GEAKN RKYN PSSFHRFNLY GVPTPHTNDG RNMAKTLHWL HELQMKRGAK IESKRADDFK EKFQHKLGRV LDPIAETMTV PPDHTF GAC LRPDEYGAGD LIHRRLPGEY LRGKDRERAL IAATRHHLKK VNYQNFDTLL AAFRHYDKKG DGAIDKAELQ EACNQAS LH LDEKLLDQLF EYCDVDNDGL INYLEFANFL NWKDKTPLKG YEERIIIKGR KPDCANPVET NAEESEPAFL IKPEDIIL K EPGSSEKTLR TLLRPSDKVS NYYKTTSSEI GADVGAVLST CHPIFGVPTI RSDIPAPRIR RISDRTNYGE DGNAYSLLY PTIFGQKGVF ERDFFKTRSK KEIAEILCNI GVNLSEDEFE NVWNLASKKH HRGEVCVENI RNVLDELQHA ERTKCKTAV

UniProtKB: EF-hand domain family member B

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Macromolecule #32: Cilia and flagella associated protein 141

MacromoleculeName: Cilia and flagella associated protein 141 / type: protein_or_peptide / ID: 32 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 12.197253 KDa
SequenceString:
MSMEKMVKVE ESFQRAVGLK KMVDRWQNSH THCLWQMTLS QRRNPYAILR MQNTVVQELA LANKQLLMVR QAALHQLFEK EHRQYQQEL NQMGKAFYVE RL

UniProtKB: Cilia and flagella associated protein 141

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Macromolecule #33: Meiosis-specific nuclear structural protein 1

MacromoleculeName: Meiosis-specific nuclear structural protein 1 / type: protein_or_peptide / ID: 33 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 60.768789 KDa
SequenceString: MASKRRTLSF SERHQKLVDA NYCKKLHVEA LKKLQNQVRN QMVRNENDDR AEHKRFLRLL QNEQFELDME EAIQKAEENR RLRECQLEQ EEKLALELAK LKHESLKDEK MRQQVRENSI ELRELEKKLQ AAYMNKERAA QIAEKDAIKY EQMKRDAEIA K TMMEEHER ...String:
MASKRRTLSF SERHQKLVDA NYCKKLHVEA LKKLQNQVRN QMVRNENDDR AEHKRFLRLL QNEQFELDME EAIQKAEENR RLRECQLEQ EEKLALELAK LKHESLKDEK MRQQVRENSI ELRELEKKLQ AAYMNKERAA QIAEKDAIKY EQMKRDAEIA K TMMEEHER LIKEENATED KRNKVKAQYN LDLEKQLEEQ EKKKQEAYEQ LLKEKLMIDE IVRKIYEEDQ LERQQKLEKM KT TQRYIEE FKKQQAVWRK KKREEMEEEN RRIIEFAKMQ QQREEDWMAK VQETEEKRLQ LQNTLSQRLE EMLRQREDLE QVR QELYLE EQAEIHKKKL EEEAEKKLRK QKELKQNFME QMALKELVLQ AAKEEEEIFR KAMLAKYAED DRIELMNAQK QRMK QLEHK KAVEKLIEER RNQFLADKQR ELEEWQLQQR RQGCVNEIIE EERLKLLKEH ATKLLGYLPK GVFKKVDDID MLGEE FRKA YQKRSEICEH K

UniProtKB: Meiosis-specific nuclear structural protein 1

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Macromolecule #34: Cilia- and flagella-associated protein 53

MacromoleculeName: Cilia- and flagella-associated protein 53 / type: protein_or_peptide / ID: 34 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 62.200133 KDa
SequenceString: MYSQRFGIVQ REVKGPTPKV VIMRAKPPKG QGAEQHLERI RHSHQKHHVI LASTKSNERD RLKAEWDQHN DRKFVDSLVK ARIKDAMQG FIINTEERRN KLRELLASEE NEYFTEMRLK EETIEEKKDR MKDKTRLLRE KKEKERQDFV AEKLDQQFRE C CEELRVEL ...String:
MYSQRFGIVQ REVKGPTPKV VIMRAKPPKG QGAEQHLERI RHSHQKHHVI LASTKSNERD RLKAEWDQHN DRKFVDSLVK ARIKDAMQG FIINTEERRN KLRELLASEE NEYFTEMRLK EETIEEKKDR MKDKTRLLRE KKEKERQDFV AEKLDQQFRE C CEELRVEL FCIHQKAVCE ERKAQIAFNE ELKRQKLVEE QMFLKLWEED RLAKEKREVE EARRQKELVE NTRLGLNAQI TS IQAQRQA ARQLKEEEAR LVENNKAQVK LENEQDKLKK QKTKQEIRAV LQKALQEKME QIQQEYREEQ DLNMKLTQNA LQN LQEEAD KKKQKREDMI REQKIYHQYL AQRHEEEKAQ EKELDRILEK EKEKKFAEKD KELRLQKEAR KQLVNEVMCT RKLQ VQEKL QRKAKEQEER AMEQERINEG LKELNREEQE NFARRSSLAQ EYRKQLQMQI CSRQQAREAE KEEERREFEA GIAAE KNFQ DKIEKILSTH QVLPRNIHPM RRACPSKLPP

UniProtKB: Cilia- and flagella-associated protein 53

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Macromolecule #35: CFAP107/C1orf158

MacromoleculeName: CFAP107/C1orf158 / type: protein_or_peptide / ID: 35 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 23.449852 KDa
SequenceString: MQYFMAVNPQ SFSTPSWKVE TKYSTRVLTG NWVEERRKFT KATEK(UNK)PQSI YRKEYVPFPG HRPDQISRWY SKRRVE GLP YKHLITHHQE PSHHHLISTY DDHYNRHNYN PGLPLLRTWN KHKLLWLPEK ADFPLLAPPT NYGLYERLKQ RWLPPPE AT LRESMYTCSY ...String:
MQYFMAVNPQ SFSTPSWKVE TKYSTRVLTG NWVEERRKFT KATEK(UNK)PQSI YRKEYVPFPG HRPDQISRWY SKRRVE GLP YKHLITHHQE PSHHHLISTY DDHYNRHNYN PGLPLLRTWN KHKLLWLPEK ADFPLLAPPT NYGLYERLKQ RWLPPPE AT LRESMYTCSY PRPPSGAMSR REHAIPVPPP RLQPVPRF

UniProtKB: Uncharacterized protein

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Macromolecule #36: Cilia and flagella associated protein 77

MacromoleculeName: Cilia and flagella associated protein 77 / type: protein_or_peptide / ID: 36 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 32.726729 KDa
SequenceString: MPEASSSQDL MRWKKKPPVR RTVSQICPPP RRPLTVADIR PGMENDRLGV VRDSMFQNPL IVKAELGKPR ERSSSLPGID FNYGLYIRG LDGGVPEAIG HWNVFKQQPT CPHELTRNYI VMNRGAVKAG LVTARENFNY HQLKDIRISD QDDRRLKREP P SLPPNMTF ...String:
MPEASSSQDL MRWKKKPPVR RTVSQICPPP RRPLTVADIR PGMENDRLGV VRDSMFQNPL IVKAELGKPR ERSSSLPGID FNYGLYIRG LDGGVPEAIG HWNVFKQQPT CPHELTRNYI VMNRGAVKAG LVTARENFNY HQLKDIRISD QDDRRLKREP P SLPPNMTF GIRARPSTPF FDLLQHRYQQ LWVQEQKATQ KAIKLEKKHK VTLGPLYETR SSQLRKYKPP VRLDALWHMP HF QKVGPHL DTFPTEADRQ RAFKAHREEC AVRQGTLRMG NYTHP

UniProtKB: Cilia and flagella associated protein 77

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Macromolecule #37: Cilia and flagella associated protein 144

MacromoleculeName: Cilia and flagella associated protein 144 / type: protein_or_peptide / ID: 37 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 16.325543 KDa
SequenceString:
MAGRQKEKVI RDEVHQNQIL RELYLKELRT QILYTQYHVN PLRKVHTIAR KPMSWHDNLE EPEDARFLNL IHHAAQGPRK KYPETQTES QEIGWDSEPL VNPARDDRRL NHFRVYNDIT LYKAKMWSLG EKDRHK

UniProtKB: Cilia and flagella associated protein 144

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Macromolecule #38: Cilia-and flagella-associated protein 96

MacromoleculeName: Cilia-and flagella-associated protein 96 / type: protein_or_peptide / ID: 38 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 34.594367 KDa
SequenceString: MPGEGGKTDM ERIGLFSEME YVTVGDKYVS QFNRSFNEAA SKNRQMLPGG SKEMSSLQAG YFDPHFVRIF EGEGYVNLNQ VRRRHMMEE AKKNLGKAFL PSSGDKKPCG LGSYYGTIGG PVPFFSAQSK PKEKYEPPGK NLYTNPGKKG TGYGYANITI G NQFSHSTD ...String:
MPGEGGKTDM ERIGLFSEME YVTVGDKYVS QFNRSFNEAA SKNRQMLPGG SKEMSSLQAG YFDPHFVRIF EGEGYVNLNQ VRRRHMMEE AKKNLGKAFL PSSGDKKPCG LGSYYGTIGG PVPFFSAQSK PKEKYEPPGK NLYTNPGKKG TGYGYANITI G NQFSHSTD FYDAAKLNYK KENEEHRRLL KGTAFKLNLY PREYFDANPY FFEKPLPPIK KAEKKETLAN PFKPSSPGKK AG GMKAGTF DPYPSHSADP YVVKLTSPIS SKGAKIFHPP GGPKSRPIES VMTLNVKRAL NMKNYKTASV QSY

UniProtKB: Cilia-and flagella-associated protein 96

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Macromolecule #39: Sperm acrosome associated 9

MacromoleculeName: Sperm acrosome associated 9 / type: protein_or_peptide / ID: 39 / Number of copies: 7 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 25.335152 KDa
SequenceString: MTMNEVKESL RSVEQKYRLF QQQQFTFIAA LEHCREDAHD KIRPISSIGQ VQSYMEHHCH NATDRRILLM FLDICTELSK LCQHFEALH AGTPVTNNLL EKCKSLVSHS NDLSSLRAKY PHDVVNHLSC DEARNHYGGV VSLIPVVLDL MKEWVAHSEK L PRKALQHV ...String:
MTMNEVKESL RSVEQKYRLF QQQQFTFIAA LEHCREDAHD KIRPISSIGQ VQSYMEHHCH NATDRRILLM FLDICTELSK LCQHFEALH AGTPVTNNLL EKCKSLVSHS NDLSSLRAKY PHDVVNHLSC DEARNHYGGV VSLIPVVLDL MKEWVAHSEK L PRKALQHV SEPQGAPQAA AHAPCGTQPW LRKHKCWQLT RDGLKPGAGD KRCSKPPWRP PGGKL

UniProtKB: Sperm acrosome associated 9

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Macromolecule #40: Tubulin alpha chain

MacromoleculeName: Tubulin alpha chain / type: protein_or_peptide / ID: 40 / Number of copies: 136 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 49.797035 KDa
SequenceString: QRECISVHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK HVPRAVFVDL EPTVIDEVRT GTYRQLFHP EQLITGKEDA ANNYARGHYT IGKELIDLVL DRIRKLADQC TGLQGFLIFH SFGGGTGSGF TSLLMERLSV D YGKKSKLE ...String:
QRECISVHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK HVPRAVFVDL EPTVIDEVRT GTYRQLFHP EQLITGKEDA ANNYARGHYT IGKELIDLVL DRIRKLADQC TGLQGFLIFH SFGGGTGSGF TSLLMERLSV D YGKKSKLE FSIYPAPQVS TAVVEPYNSI LTTHTTLEHS DCAFMVDNEA IYDICRRNLD IERPTYTNLN RLISQIVSSI TA SLRFDGA LNVDLTEFQT NLVPYPRIHF PLATYAPVIS AEKAYHEQLS VAEITNACFE PANQMVKCDP RHGKYMACCL LYR GDVVPK DVNAAIAAIK TKRSIQFVDW CPTGFKVGIN YQPPTVVPGD LAKVQRAVCM LSNTTAIAEA WARLDHKFDL MYAK RAFVH WYVGEGMEEG EFSEAREDMA ALEKDYEEVG MDSVEGEGEE EE

UniProtKB: Tubulin alpha chain

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Macromolecule #41: Tubulin beta chain

MacromoleculeName: Tubulin beta chain / type: protein_or_peptide / ID: 41 / Number of copies: 133 / Enantiomer: LEVO
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 49.798211 KDa
SequenceString: MREIVHLQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY YNEATGGKYV PRAVLVDLEP GTMDSVRSGP FGQIFRPDN FVFGQSGAGN NWAKGHYTEG AELVDSVLDV VRKEAESCDC LQGFQLTHSL GGGTGSGMGT LLISKIREEY P DRIMNTFS ...String:
MREIVHLQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY YNEATGGKYV PRAVLVDLEP GTMDSVRSGP FGQIFRPDN FVFGQSGAGN NWAKGHYTEG AELVDSVLDV VRKEAESCDC LQGFQLTHSL GGGTGSGMGT LLISKIREEY P DRIMNTFS VVPSPKVSDT VVEPYNATLS VHQLVENTDE TYCIDNEALY DICFRTLKLT TPTYGDLNHL VSATMSGVTT CL RFPGQLN ADLRKLAVNM VPFPRLHFFM PGFAPLTSRG SQQYRALTVP ELTQQMFDAK NMMAACDPRH GRYLTVAAVF RGR MSMKEV DEQMLNVQNK NSSYFVEWIP NNVKTAVCDI PPRGLKMSAT FIGNSTAIQE LFKRISEQFT AMFRRKAFLH WYTG EGMDE MEFTEAESNM NDLGNPVVTR GACLWLGGGE GPQPPSPLRS GLSP

UniProtKB: Tubulin beta chain

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Macromolecule #42: GUANOSINE-5'-TRIPHOSPHATE

MacromoleculeName: GUANOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 42 / Number of copies: 136 / Formula: GTP
Source (natural)Organism: Sus scrofa (pig)
Molecular weightTheoretical: 523.18 Da
Chemical component information

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

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Macromolecule #43: GUANOSINE-5'-DIPHOSPHATE

MacromoleculeName: GUANOSINE-5'-DIPHOSPHATE / type: ligand / ID: 43 / Number of copies: 133 / Formula: GDP
Molecular weightTheoretical: 443.201 Da
Chemical component information

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

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Experimental details

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Structure determination

Methodcryo EM
Processingsingle particle reconstruction
Aggregation statefilament

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Sample preparation

BufferpH: 7.4
VitrificationCryogen name: ETHANE

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Electron microscopy

MicroscopeTFS KRIOS
Image recordingFilm or detector model: GATAN K3 BIOQUANTUM (6k x 4k) / Average electron dose: 50.0 e/Å2
Electron beamAcceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
Electron opticsIllumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD / Nominal defocus max: 2.5 µm / Nominal defocus min: 0.5 µm
Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company

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Image processing

Startup modelType of model: EMDB MAP
EMDB ID:

40619

Final reconstructionResolution.type: BY AUTHOR / Resolution: 3.65 Å / Resolution method: FSC 0.143 CUT-OFF / Number images used: 113809
Initial angle assignmentType: MAXIMUM LIKELIHOOD
Final angle assignmentType: MAXIMUM LIKELIHOOD

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About Yorodumi

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News

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Feb 9, 2022. New format data for meta-information of EMDB entries

New format data for meta-information of EMDB entries

  • Version 3 of the EMDB header file is now the official format.
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Related info.:EMDB header

External links:wwPDB to switch to version 3 of the EMDB data model

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Aug 12, 2020. Covid-19 info

Covid-19 info

URL: https://pdbj.org/emnavi/covid19.php

New page: Covid-19 featured information page in EM Navigator.

Related info.:Covid-19 info / Mar 5, 2020. Novel coronavirus structure data

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Mar 5, 2020. Novel coronavirus structure data

Novel coronavirus structure data

Related info.:Yorodumi Speices / Aug 12, 2020. Covid-19 info

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