登録情報 | データベース: EMDB / ID: EMD-41886 |
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タイトル | Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain |
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マップデータ | |
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試料 | - 複合体: Ternary complex of HER2/HER4/NRG1b
- タンパク質・ペプチド: Isoform JM-A CYT-1 of Receptor tyrosine-protein kinase erbB-4
- タンパク質・ペプチド: Receptor tyrosine-protein kinase erbB-2
- タンパク質・ペプチド: Isoform 6 of Pro-neuregulin-1, membrane-bound isoform
- リガンド: 2-acetamido-2-deoxy-beta-D-glucopyranose
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キーワード | Receptor Tyrosine Kinase / MEMBRANE PROTEIN / TRANSFERASE |
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機能・相同性 | 機能・相同性情報
ERBB3 signaling pathway / positive regulation of peptidyl-tyrosine autophosphorylation / sequestering of metal ion / establishment of planar polarity involved in nephron morphogenesis / ERBB4 signaling pathway / epidermal growth factor receptor activity / ERBB4-ERBB4 signaling pathway / olfactory bulb interneuron differentiation / central nervous system morphogenesis / ventricular cardiac muscle cell differentiation ...ERBB3 signaling pathway / positive regulation of peptidyl-tyrosine autophosphorylation / sequestering of metal ion / establishment of planar polarity involved in nephron morphogenesis / ERBB4 signaling pathway / epidermal growth factor receptor activity / ERBB4-ERBB4 signaling pathway / olfactory bulb interneuron differentiation / central nervous system morphogenesis / ventricular cardiac muscle cell differentiation / positive regulation of striated muscle cell differentiation / neuregulin receptor activity / negative regulation of secretion / cardiac muscle tissue regeneration / negative regulation of immature T cell proliferation in thymus / endocardial cell differentiation / animal organ development / ERBB3:ERBB2 complex / PLCG1 events in ERBB2 signaling / ERBB2-ERBB4 signaling pathway / GRB7 events in ERBB2 signaling / immature T cell proliferation in thymus / RNA polymerase I core binding / mitochondrial fragmentation involved in apoptotic process / ERBB2-EGFR signaling pathway / neural crest cell development / ERBB2 Activates PTK6 Signaling / cardiac muscle cell myoblast differentiation / cell communication / semaphorin receptor complex / protein tyrosine kinase activator activity / GABA receptor binding / transmembrane receptor protein tyrosine kinase activator activity / PI3K events in ERBB4 signaling / mammary gland epithelial cell differentiation / cardiac muscle cell differentiation / embryonic pattern specification / Signaling by ERBB4 / mammary gland development / chemorepellent activity / ventricular trabecula myocardium morphogenesis / regulation of microtubule-based process / positive regulation of protein localization to cell surface / ErbB-3 class receptor binding / ERBB2 Regulates Cell Motility / Sema4D induced cell migration and growth-cone collapse / regulation of postsynaptic neurotransmitter receptor internalization / motor neuron axon guidance / PI3K events in ERBB2 signaling / activation of transmembrane receptor protein tyrosine kinase activity / neural crest cell migration / ERBB signaling pathway / neurotransmitter receptor localization to postsynaptic specialization membrane / negative regulation of cardiac muscle cell apoptotic process / positive regulation of Rho protein signal transduction / epidermal growth factor receptor binding / neuromuscular junction development / Drug-mediated inhibition of ERBB2 signaling / Resistance of ERBB2 KD mutants to trastuzumab / Resistance of ERBB2 KD mutants to sapitinib / Resistance of ERBB2 KD mutants to tesevatinib / Resistance of ERBB2 KD mutants to neratinib / Resistance of ERBB2 KD mutants to osimertinib / Resistance of ERBB2 KD mutants to afatinib / Resistance of ERBB2 KD mutants to AEE788 / Resistance of ERBB2 KD mutants to lapatinib / Drug resistance in ERBB2 TMD/JMD mutants / cell fate commitment / enzyme-linked receptor protein signaling pathway / ERBB2-ERBB3 signaling pathway / positive regulation of transcription by RNA polymerase I / oligodendrocyte differentiation / cell surface receptor signaling pathway via JAK-STAT / Long-term potentiation / semaphorin-plexin signaling pathway / cellular response to epidermal growth factor stimulus / Signaling by ERBB2 / positive regulation of cell adhesion / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / SHC1 events in ERBB4 signaling / positive regulation of protein targeting to membrane / GABA-ergic synapse / mammary gland alveolus development / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / GRB2 events in ERBB2 signaling / transmembrane receptor protein tyrosine kinase activity / regulation of angiogenesis / neurogenesis / SHC1 events in ERBB2 signaling / coreceptor activity / regulation of ERK1 and ERK2 cascade / Schwann cell development / basal plasma membrane / Nuclear signaling by ERBB4 / positive regulation of epithelial cell proliferation / positive regulation of tyrosine phosphorylation of STAT protein / positive regulation of cardiac muscle cell proliferation / transcription coregulator activity / cell surface receptor protein tyrosine kinase signaling pathway / synapse assembly類似検索 - 分子機能 Neuregulin, C-terminal / Neuregulin-1 / Neuregulin / Neuregulin intracellular region / : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / Receptor L-domain ...Neuregulin, C-terminal / Neuregulin-1 / Neuregulin / Neuregulin intracellular region / : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain / Furin-like repeat / Furin-like repeats / EGF-like domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Growth factor receptor cysteine-rich domain superfamily / : / Epidermal growth factor-like domain. / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Immunoglobulin subtype / Immunoglobulin / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Immunoglobulin-like fold / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 Receptor tyrosine-protein kinase erbB-2 / Pro-neuregulin-1, membrane-bound isoform / Receptor tyrosine-protein kinase erbB-4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.31 Å |
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データ登録者 | Trenker R / Diwanji D / Bingham T / Verba KA / Jura N |
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資金援助 | ドイツ, 米国, 3件 Organization | Grant number | 国 |
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German Research Foundation (DFG) | TR 1668/1-1 | ドイツ | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM139636 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | CA274502 | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain 著者: Trenker R / Diwanji D / Bingham T / Verba KA / Jura N |
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履歴 | 登録 | 2023年9月10日 | - |
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ヘッダ(付随情報) 公開 | 2024年3月13日 | - |
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マップ公開 | 2024年3月13日 | - |
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更新 | 2024年3月13日 | - |
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現状 | 2024年3月13日 | 処理サイト: RCSB / 状態: 公開 |
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