登録情報 | データベース: EMDB / ID: EMD-41884 |
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タイトル | Structure of the HER4/BTC Homodimer Extracellular Domain |
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マップデータ | |
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試料 | - 複合体: HER4/BTC homodimer
- タンパク質・ペプチド: Receptor tyrosine-protein kinase erbB-4
- タンパク質・ペプチド: Betacellulin
- リガンド: 2-acetamido-2-deoxy-beta-D-glucopyranose
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キーワード | Receptor Tyrosine Kinase / MEMBRANE PROTEIN / TRANSFERASE |
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機能・相同性 | 機能・相同性情報
establishment of planar polarity involved in nephron morphogenesis / ERBB4 signaling pathway / epidermal growth factor receptor activity / ERBB4-ERBB4 signaling pathway / olfactory bulb interneuron differentiation / central nervous system morphogenesis / Inhibition of Signaling by Overexpressed EGFR / neuregulin receptor activity / EGFR interacts with phospholipase C-gamma / cardiac muscle tissue regeneration ...establishment of planar polarity involved in nephron morphogenesis / ERBB4 signaling pathway / epidermal growth factor receptor activity / ERBB4-ERBB4 signaling pathway / olfactory bulb interneuron differentiation / central nervous system morphogenesis / Inhibition of Signaling by Overexpressed EGFR / neuregulin receptor activity / EGFR interacts with phospholipase C-gamma / cardiac muscle tissue regeneration / ERBB2-ERBB4 signaling pathway / mitochondrial fragmentation involved in apoptotic process / ERBB2-EGFR signaling pathway / ERBB2 Activates PTK6 Signaling / GABA receptor binding / Signaling by EGFR / transmembrane receptor protein tyrosine kinase activator activity / positive regulation of urine volume / PI3K events in ERBB4 signaling / negative regulation of epithelial cell apoptotic process / mammary gland epithelial cell differentiation / embryonic pattern specification / Signaling by ERBB4 / positive regulation of protein localization to cell surface / ERBB2 Regulates Cell Motility / PI3K events in ERBB2 signaling / neural crest cell migration / epithelial cell apoptotic process / neurotransmitter receptor localization to postsynaptic specialization membrane / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / epidermal growth factor receptor binding / cell fate commitment / GAB1 signalosome / cell surface receptor signaling pathway via JAK-STAT / Long-term potentiation / positive regulation of cell division / cellular response to epidermal growth factor stimulus / Signaling by ERBB2 / SHC1 events in ERBB4 signaling / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / GABA-ergic synapse / mammary gland alveolus development / GRB2 events in ERBB2 signaling / transmembrane receptor protein tyrosine kinase activity / neurogenesis / SHC1 events in ERBB2 signaling / basal plasma membrane / Nuclear signaling by ERBB4 / positive regulation of tyrosine phosphorylation of STAT protein / positive regulation of cardiac muscle cell proliferation / cell surface receptor protein tyrosine kinase signaling pathway / synapse assembly / Downregulation of ERBB4 signaling / lactation / regulation of cell migration / positive regulation of mitotic nuclear division / EGFR downregulation / Signaling by ERBB2 TMD/JMD mutants / clathrin-coated endocytic vesicle membrane / Signaling by ERBB2 KD Mutants / epidermal growth factor receptor signaling pathway / receptor protein-tyrosine kinase / positive regulation of cell differentiation / Downregulation of ERBB2 signaling / positive regulation of receptor signaling pathway via JAK-STAT / postsynaptic density membrane / growth factor activity / neuromuscular junction / peptidyl-tyrosine phosphorylation / Constitutive Signaling by Aberrant PI3K in Cancer / positive regulation of fibroblast proliferation / Cargo recognition for clathrin-mediated endocytosis / PIP3 activates AKT signaling / Clathrin-mediated endocytosis / cell migration / nervous system development / presynaptic membrane / heart development / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / basolateral plasma membrane / protein tyrosine kinase activity / postsynaptic membrane / Estrogen-dependent gene expression / protein autophosphorylation / Extra-nuclear estrogen signaling / transcription cis-regulatory region binding / receptor complex / cell population proliferation / positive regulation of ERK1 and ERK2 cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor ligand activity / mitochondrial matrix / positive regulation of protein phosphorylation / negative regulation of cell population proliferation / positive regulation of cell population proliferation / glutamatergic synapse / positive regulation of DNA-templated transcription / negative regulation of apoptotic process類似検索 - 分子機能 : / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain ...: / Epidermal growth factor receptor transmembrane-juxtamembrane segment / Tyrosine protein kinase, EGF/ERB/XmrK receptor / Growth factor receptor domain 4 / Growth factor receptor domain IV / Receptor L-domain / Furin-like cysteine-rich domain / Receptor L-domain superfamily / Furin-like cysteine rich region / Receptor L domain / Furin-like repeat / Furin-like repeats / Growth factor receptor cysteine-rich domain superfamily / : / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 Probetacellulin / Receptor tyrosine-protein kinase erbB-4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.7 Å |
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データ登録者 | Trenker R / Diwanji D / Bingham T / Verba KA / Jura N |
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資金援助 | ドイツ, 米国, 3件 Organization | Grant number | 国 |
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German Research Foundation (DFG) | TR 16681/1 | ドイツ | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM139636 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | CA274502 | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Structure of the HER4/BTC Homodimer Extracellular Domain 著者: Trenker R / Diwanji D / Bingham T / Verba KA / Jura N |
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履歴 | 登録 | 2023年9月10日 | - |
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ヘッダ(付随情報) 公開 | 2024年3月13日 | - |
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マップ公開 | 2024年3月13日 | - |
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更新 | 2024年3月13日 | - |
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現状 | 2024年3月13日 | 処理サイト: RCSB / 状態: 公開 |
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