登録情報 | データベース: EMDB / ID: EMD-41233 |
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タイトル | Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381 |
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マップデータ | |
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試料 | - 複合体: Active complex of NPR1 ectodomain, ANP, and REGN5381 Fab
- タンパク質・ペプチド: Atrial natriuretic peptide receptor 1
- タンパク質・ペプチド: Atrial natriuretic peptide
- タンパク質・ペプチド: REGN5381 Fab heavy chain
- タンパク質・ペプチド: REGN5381 Fab light chain
- リガンド: 2-acetamido-2-deoxy-beta-D-glucopyranose
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キーワード | Atrial natriuretic peptide / antibody / activator / pulmonary hypertension / IMMUNE SYSTEM |
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機能・相同性 | 機能・相同性情報
positive regulation of delayed rectifier potassium channel activity / ANPR-A receptor complex / natriuretic peptide receptor activity / positive regulation of cGMP-mediated signaling / body fluid secretion / receptor guanylyl cyclase signaling pathway / positive regulation of renal sodium excretion / peptide receptor activity / neuropeptide receptor binding / regulation of high voltage-gated calcium channel activity ...positive regulation of delayed rectifier potassium channel activity / ANPR-A receptor complex / natriuretic peptide receptor activity / positive regulation of cGMP-mediated signaling / body fluid secretion / receptor guanylyl cyclase signaling pathway / positive regulation of renal sodium excretion / peptide receptor activity / neuropeptide receptor binding / regulation of high voltage-gated calcium channel activity / guanylate cyclase / positive regulation of potassium ion export across plasma membrane / cGMP biosynthetic process / regulation of atrial cardiac muscle cell membrane repolarization / guanylate cyclase activity / Physiological factors / regulation of vascular permeability / cardiac conduction system development / YAP1- and WWTR1 (TAZ)-stimulated gene expression / hormone binding / positive regulation of urine volume / negative regulation of JUN kinase activity / sodium ion export across plasma membrane / neuropeptide hormone activity / G protein-coupled peptide receptor activity / cardiac muscle hypertrophy in response to stress / negative regulation of systemic arterial blood pressure / hormone receptor binding / aortic valve morphogenesis / adenylate cyclase activity / regulation of calcium ion transmembrane transport via high voltage-gated calcium channel / positive regulation of heart rate / dopamine metabolic process / cGMP-mediated signaling / peptide hormone binding / neuropeptide signaling pathway / positive regulation of cardiac muscle contraction / response to muscle stretch / blood vessel diameter maintenance / negative regulation of angiogenesis / cell projection / female pregnancy / negative regulation of smooth muscle cell proliferation / hormone activity / negative regulation of cell growth / regulation of blood pressure / vasodilation / protein folding / perikaryon / collagen-containing extracellular matrix / cell surface receptor signaling pathway / receptor complex / protein kinase activity / Amyloid fiber formation / signaling receptor binding / GTP binding / protein-containing complex / extracellular space / extracellular region / ATP binding / plasma membrane / cytoplasm類似検索 - 分子機能 Natriuretic peptide, atrial type / Adenylyl cyclase class-4/guanylyl cyclase / Natriuretic peptides receptors signature. / Natriuretic peptide, conserved site / Atrial natriuretic peptide / Natriuretic peptides signature. / Natriuretic peptide / Natriuretic peptide / Adenylyl cyclase class-4/guanylyl cyclase, conserved site / Guanylate cyclase signature. ...Natriuretic peptide, atrial type / Adenylyl cyclase class-4/guanylyl cyclase / Natriuretic peptides receptors signature. / Natriuretic peptide, conserved site / Atrial natriuretic peptide / Natriuretic peptides signature. / Natriuretic peptide / Natriuretic peptide / Adenylyl cyclase class-4/guanylyl cyclase, conserved site / Guanylate cyclase signature. / Adenylyl- / guanylyl cyclase, catalytic domain / Adenylyl cyclase class-3/4/guanylyl cyclase / Adenylate and Guanylate cyclase catalytic domain / Guanylate cyclase domain profile. / Nucleotide cyclase / Receptor, ligand binding region / Receptor family ligand binding region / Periplasmic binding protein-like I / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 Natriuretic peptides A / Atrial natriuretic peptide receptor 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) / ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.08 Å |
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データ登録者 | Franklin MC / Romero Hernandez A |
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資金援助 | 1件 Organization | Grant number | 国 |
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Other private | | |
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引用 | ジャーナル: To Be Published タイトル: Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381 著者: Franklin MC / Romero Hernandez A |
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履歴 | 登録 | 2023年7月12日 | - |
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ヘッダ(付随情報) 公開 | 2024年7月17日 | - |
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マップ公開 | 2024年7月17日 | - |
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更新 | 2024年7月17日 | - |
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現状 | 2024年7月17日 | 処理サイト: RCSB / 状態: 公開 |
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