EMDB-11821: Intermediate assembly of the Large subunit from Leishmania major ...

Basic information

• Entry: Database: EMDB / ID: EMD-11821
• Title: Intermediate assembly of the Large subunit from Leishmania major mitochondrial ribosome

Sample

• Complex: Leishmania mitochondrial ribosome
  • Protein or peptide: x 73 types
  • RNA: x 4 types
• Ligand: x 2 types

• Keywords: RIBOSOME / Mitochondria / Kinetoplastid

Function / homology

Function:

pseudouridine synthesis / mitochondrial large ribosomal subunit assembly / pseudouridine synthase activity / negative regulation of ribosome biogenesis / kinetoplast / RNA methyltransferase activity / nuclear lumen / mitochondrial large ribosomal subunit / ciliary plasm / mitochondrial ribosome / mitochondrial translation / cyclosporin A binding / ribosomal large subunit binding / : / acyl binding / acyl carrier activity / RNA processing / chaperone-mediated protein folding / protein folding chaperone / peptidylprolyl isomerase / peptidyl-prolyl cis-trans isomerase activity / fatty acid biosynthetic process / unfolded protein binding / large ribosomal subunit / protein folding / ribosome biogenesis / protein-folding chaperone binding / large ribosomal subunit rRNA binding / nucleic acid binding / RNA helicase activity / negative regulation of translation / cytoskeleton / rRNA binding / hydrolase activity / ribosome / structural constituent of ribosome / mitochondrial matrix / translation / ribonucleoprotein complex / GTPase activity / mRNA binding / GTP binding / mitochondrion / RNA binding / ATP binding / membrane / nucleus / metal ion binding / cytosol / cytoplasm

Domain/homology:

Pseudouridine synthase, TruD, insertion domain / TRUD domain profile. / Pseudouridine synthase, TruD / Pseudouridine synthase, TruD, catalytic domain / EngB-type guanine nucleotide-binding (G) domain / GTP-binding protein EngA / : / : / GTPase Der, C-terminal KH-domain-like / : / KH-domain-like of EngA bacterial GTPase enzymes, C-terminal / Pseudouridine synthase, RsuA/RluA-like / RNA pseudouridylate synthase / PPR repeat family / tRNA/rRNA methyltransferase, SpoU type / SpoU rRNA Methylase family / Protein Iojap/ribosomal silencing factor RsfS / Ribosomal silencing factor during starvation / Pseudouridine synthase, catalytic domain superfamily / GTP-binding protein, orthogonal bundle domain superfamily / Pentatricopeptide (PPR) repeat profile. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / Pentatricopeptide repeat / DnaJ domain / 39S ribosomal protein L43/54S ribosomal protein L51 / Ribosomal protein L47, mitochondrial / MRP-L47 superfamily, mitochondrial / Mitochondrial 39-S ribosomal protein L47 (MRP-L47) / DnaJ molecular chaperone homology domain / dnaJ domain profile. / Chaperone J-domain superfamily / DnaJ domain / tRNA (guanine-N1-)-methyltransferase, N-terminal / Alpha/beta knot methyltransferases / 50S ribosome-binding GTPase / RNA helicase, DEAD-box type, Q motif / DEAD-box RNA helicase Q motif profile. / GTP binding domain / Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site / Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain profile. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain / Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD / Cyclophilin-like domain superfamily / Ribosomal protein/NADH dehydrogenase domain / Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain / Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain / Acyl carrier protein (ACP) / Phosphopantetheine attachment site / Nucleotidyltransferase superfamily / DEAD/DEAH box helicase domain / DEAD/DEAH box helicase / Phosphopantetheine attachment site. / Phosphopantetheine attachment site / Ribosomal protein L11, N-terminal / Ribosomal protein L11, N-terminal domain / Ribosomal protein L11/L12 / Ribosomal protein L11, C-terminal / Ribosomal protein L11, C-terminal domain superfamily / Ribosomal protein L11/L12, N-terminal domain superfamily / Ribosomal protein L11/L12 / Ribosomal protein L11, RNA binding domain / ACP-like superfamily / Carrier protein (CP) domain profile. / Phosphopantetheine binding ACP domain / Ribosomal protein L9, N-terminal / Ribosomal protein L9, N-terminal domain / Helicase conserved C-terminal domain / 50S ribosomal protein L30e-like / Ribosomal protein L28/L24 / : / Ribosomal protein L20 / Ribosomal protein L20, C-terminal / Ribosomal protein L21 / Ribosomal protein L17 / Ribosomal protein L17 superfamily / Ribosomal protein L17 / Ribosomal protein L21-like / L21-like superfamily / Ribosomal prokaryotic L21 protein / Ribosomal protein L24 / Ribosomal protein L3, bacterial/organelle-type / Ribosomal protein L15, bacterial-type / 50S ribosomal protein uL4 / K homology domain-like, alpha/beta / Small GTP-binding protein domain / Tetratricopeptide-like helical domain superfamily / Ribosomal protein L24 signature. / helicase superfamily c-terminal domain / Prokaryotic membrane lipoprotein lipid attachment site profile. / Ribosomal protein L24/L26, conserved site / Ribosomal protein L13 / Ribosomal protein L13 / Ribosomal protein L13 superfamily / Ribosomal protein L30, ferredoxin-like fold domain superfamily / Ribosomal protein L25/L23 / Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A

Component:

Flagellar attachment zone protein / Uncharacterized protein / Uncharacterized protein / Pseudouridylate synthase-like protein / Ribosomal protein L9 domain-containing protein / Rhodanese domain-containing protein / Large ribosomal subunit protein uL11m / Uncharacterized protein / Acyl carrier protein / Uncharacterized protein / Ribosomal protein L3-like protein / tRNA/rRNA methyltransferase SpoU type domain-containing protein / G domain-containing protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Large ribosomal subunit protein bL20c / Peptidyl-prolyl cis-trans isomerase / Uncharacterized protein / Putative ribosomal protein L14 / 50S ribosomal protein L13-like protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / G domain-containing protein / Large ribosomal subunit protein mL43 / Uncharacterized protein / Uncharacterized protein / 39S ribosomal protein L28, mitochondrial / Uncharacterized protein / DNAj-like protein / LIM zinc-binding domain-containing protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / GTPase Der / KOW domain-containing protein / Large ribosomal subunit protein uL23m / Uncharacterized protein / Uncharacterized protein / Peptidyl-prolyl cis-trans isomerase / Large ribosomal subunit protein uL22c / Mitochondrial RNA binding complex 1 subunit / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Putative 50S ribosomal protein L17 / Large ribosomal subunit protein uL15/eL18 domain-containing protein / Large ribosomal subunit protein bL21m / Uncharacterized protein / Uncharacterized protein / TRUD domain-containing protein / Large ribosomal subunit protein uL4m / DEAD/DEAH box helicase-like protein / Uncharacterized protein / Ribosomal protein L9 domain-containing protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein L5213T.03 / Ribosomal protein L30 ferredoxin-like fold domain-containing protein / Large ribosomal subunit protein uL29m

• Biological species: Leishmania tarentolae (eukaryote)
• Method: single particle reconstruction / cryo EM / Resolution: 3.4 Å
• Authors: Soufari H / Hashem Y

Funding support

France, 1 items

Organization	Grant number	Country
European Research Council (ERC)		France

• Citation: Journal: Proc Natl Acad Sci U S A / Year: 2020; Title: Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis.; Authors: Heddy Soufari / Florent Waltz / Camila Parrot / Stéphanie Durrieu-Gaillard / Anthony Bochler / Lauriane Kuhn / Marie Sissler / Yaser Hashem / ; Abstract: Kinetoplastids are unicellular eukaryotic parasites responsible for such human pathologies as Chagas disease, sleeping sickness, and leishmaniasis. They have a single large mitochondrion, essential for the parasite survival. In kinetoplastid mitochondria, most of the molecular machineries and gene expression processes have significantly diverged and specialized, with an extreme example being their mitochondrial ribosomes. These large complexes are in charge of translating the few essential mRNAs encoded by mitochondrial genomes. Structural studies performed in already highlighted the numerous peculiarities of these mitoribosomes and the maturation of their small subunit. However, several important aspects mainly related to the large subunit (LSU) remain elusive, such as the structure and maturation of its ribosomal RNA. Here we present a cryo-electron microscopy study of the protozoans and mitoribosomes. For both species, we obtained the structure of their mature mitoribosomes, complete rRNA of the LSU, as well as previously unidentified ribosomal proteins. In addition, we introduce the structure of an LSU assembly intermediate in the presence of 16 identified maturation factors. These maturation factors act on both the intersubunit and the solvent sides of the LSU, where they refold and chemically modify the rRNA and prevent early translation before full maturation of the LSU.

History

Deposition	Oct 7, 2020	-
Header (metadata) release	Apr 28, 2021	-
Map release	Apr 28, 2021	-
Update	Oct 9, 2024	-
Current status	Oct 9, 2024	Processing site: PDBe / Status: Released

Map

• File: Download / File: emd_11821.map.gz / Format: CCP4 / Size: 259.1 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
• Voxel size: X=Y=Z: 1.2 Å

Density

Contour Level	By AUTHOR: 0.04 / Movie #1: 0.04
Minimum - Maximum	-0.1202571 - 0.22247817
Average (Standard dev.)	-0.0003604588 (±0.012503493)

• Symmetry: Space group: 1

Details

EMDB XML:

Map geometry	Axis order X Y Z Origin 0 0 0 Dimensions 408 408 408 Spacing 408 408 408
Cell	A=B=C: 489.6 Å α=β=γ: 90.0 °

CCP4 map header:

mode	Image stored as Reals
Å/pix. X/Y/Z	1.2	1.2	1.2
M x/y/z	408	408	408
origin x/y/z	0.000	0.000	0.000
length x/y/z	489.600	489.600	489.600
α/β/γ	90.000	90.000	90.000
start NX/NY/NZ	72	72	65
NX/NY/NZ	157	157	169
MAP C/R/S	1	2	3
start NC/NR/NS	0	0	0
NC/NR/NS	408	408	408
D min/max/mean	-0.120	0.222	-0.000

Supplemental data

Sample components

Entire : Leishmania mitochondrial ribosome

• Entire: Name: Leishmania mitochondrial ribosome

Components

• Complex: Leishmania mitochondrial ribosome
  • Protein or peptide: Ribosomal protein L3-like protein
  • Protein or peptide: bL21m
  • Protein or peptide: uL22m
  • Protein or peptide: uL23m
  • Protein or peptide: uL24m
  • Protein or peptide: bL28m
  • Protein or peptide: uL29m
  • Protein or peptide: uL30m
  • Protein or peptide: bL32m
  • Protein or peptide: bL35m
  • Protein or peptide: mL41
  • Protein or peptide: uL4m
  • Protein or peptide: mL94
  • Protein or peptide: TRUD domain-containing protein
  • Protein or peptide: UA
  • Protein or peptide: mL95
  • Protein or peptide: RNA uridylyltransferase
  • Protein or peptide: mL67
  • Protein or peptide: mL71
  • Protein or peptide: mL81
  • Protein or peptide: mL98
  • Protein or peptide: Putative ribosomal protein L14
  • Protein or peptide: RIBOSOMAL_L9 domain-containing protein
  • Protein or peptide: mL86
  • Protein or peptide: mL87
  • Protein or peptide: mL53
  • Protein or peptide: mL63
  • Protein or peptide: mL68
  • Protein or peptide: mL80
  • Protein or peptide: mL74
  • Protein or peptide: L51_S25_CI-B8 domain-containing protein
  • Protein or peptide: mL42
  • Protein or peptide: mL52,mL52
  • Protein or peptide: Putative ribosomal protein L11
  • Protein or peptide: mL93
  • Protein or peptide: mL75
  • Protein or peptide: mL85
  • Protein or peptide: mL100
  • Protein or peptide: mL49
  • Protein or peptide: mL89
  • Protein or peptide: Peptidyl-prolyl cis-trans isomerase
  • Protein or peptide: mL72
  • Protein or peptide: mL84
  • Protein or peptide: mL76
  • Protein or peptide: 50S ribosomal protein L13-like protein
  • Protein or peptide: mL99
  • Protein or peptide: mL88
  • Protein or peptide: mL70
  • Protein or peptide: mL59/64
  • Protein or peptide: Peptidyl-prolyl cis-trans isomerase
  • Protein or peptide: LIM zinc-binding domain-containing protein
  • Protein or peptide: DNAj-like protein
  • Protein or peptide: SpoU_methylase domain-containing protein
  • Protein or peptide: Pseudouridylate synthase-like protein
  • Protein or peptide: Acyl carrier protein
  • Protein or peptide: Ribosomal_L18e/L15P domain-containing protein
  • Protein or peptide: L0R8F8
  • Protein or peptide: G domain-containing protein
  • Protein or peptide: GTPase Der
  • Protein or peptide: DEAD/DEAH box helicase-like protein
  • Protein or peptide: G domain-containing protein
  • Protein or peptide: mL78
  • Protein or peptide: U6
  • Protein or peptide: U1
  • Protein or peptide: U3
  • Protein or peptide: U4
  • Protein or peptide: Putative 50S ribosomal protein L17
  • Protein or peptide: U5
  • Protein or peptide: mL78
  • Protein or peptide: U2
  • RNA: Ribosomal RNA
  • RNA: R1
  • RNA: R2
  • RNA: R5
  • Protein or peptide: U8
  • Protein or peptide: bL19m
  • Protein or peptide: bL20m
• Ligand: GUANOSINE-5'-TRIPHOSPHATE
• Ligand: ADENOSINE-5'-TRIPHOSPHATE

Supramolecule #1: Leishmania mitochondrial ribosome

• Supramolecule: Name: Leishmania mitochondrial ribosome / type: complex / ID: 1 / Parent: 0 ; Macromolecule list: #1, #10-#19, #2, #20-#29, #3, #30-#39, #4, #40-#49, #5, #50-#59, #6, #60-#69, #7, #70-#77, #8-#9
• Source (natural): Organism: Leishmania tarentolae (eukaryote)

Macromolecule #1: Ribosomal protein L3-like protein

• Macromolecule: Name: Ribosomal protein L3-like protein / type: protein_or_peptide / ID: 1 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 54.025246 KDa

Sequence

String:

MHRFRVCALG AAFCVARRWR SGGGPGDRRV RTDWYRCYPS LMEEKDRDMY HCYYPYLFDH GDKMSLYPKI PDNPREWQVE QLQTTYDAI REDKYDAFVR LRAKFPELYQ DTYAWDNPPP FGEFNMFYSV RFGMIGVKAF TCKDYDDLGN QFDCTAFWFP D NQIVKHST RNGDVGTDKV YVGAMNVPVE FHKPHVAAFY KAAGVPVKHV SAGFPVTPDA YAPVGTKLDV RHFKPGQEVT IT FQNTDYG YQGVMFRHGF DGGYVWLGDS KWQRRPGCMG AEGQKRIYPG HRMAGQTGAS AETYDGVPVW RIDYKNSLIY LPT LIDADV GTYVKFRDTI NTKGYTLWNE HRGTPPFPTF IPSEEEDLSK LATDEGQLTS PPLYMYFRDE FAAAQLVTQA DVED AKSAK PATAAPKKKV YDLKKYTEAR KKYRKNLQKA RKYKLMGVRT RAHEKQQEAR RAKILKYKRV KT

UniProtKB: Ribosomal protein L3-like protein

Macromolecule #2: uL4m

• Macromolecule: Name: uL4m / type: protein_or_peptide / ID: 2 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 50.000664 KDa

Sequence

String:

MYDSRSSGVH DVAPRDGVDF MYEGPQQVLP GAHPLPLFHP DNSVTRPPVS PYLPSPQRPH PYFTTELPEL PHFQTTRPIV YTVGTMKQR IVAPVFDLAN NVTHTRELDP FIFGFYPETE EMAKNLSYWL VRCQNFSSKW DYENREIWRK AKKNWPNTGM G MARVGDRK NHAHPWGAHS KPVKPWNLLM PTMDVKTWSK SNRMLVTLKM LQGKLQIVER LTLPEPTQEA YLQLCRTMGW DV RHKGGGA LFMDGGSRLT PSSEYDRAFF FGSFFNGRNK LVRPTLLCDE PYDYNRTSSK ARTKGPKGQK NPIPINRFNA YDA LTHDTL IITEGALLQL EDEMYTHKLA MLPPHIRAQL PERGFLDSEV LGDVPPALQT VQMEAAARTE EAEQAMYAPY YDNP YHPWQ DEGEASYAVD AVEGTVQRYI KSRKTSWAML S

UniProtKB: Large ribosomal subunit protein uL4m

Macromolecule #3: RIBOSOMAL_L9 domain-containing protein

• Macromolecule: Name: RIBOSOMAL_L9 domain-containing protein / type: protein_or_peptide / ID: 3 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 30.510725 KDa

Sequence

String:

MRRSAWVFVA PWVPPPRHDV KVTMPPPPGG EVGGSYGVST GYSDRLARTP YWKRMALSTY ALRMKENETR YPMSPHREGE YDLRYTVTA YPDHIKHRPL LEIGEAHQIP TIEIPVIFLV NLWDEERLTW FGRQYETVYV NRNVAREELL PQRYAIYATE E AYKLLGLP VVNHSIHEEI PKTPHAYKKL LEKQSYTEER WKYTIEYLFR KYEADPPELQ DKSEDGWDGV EELATSATAG GA GDSLAKR KGPVKQRKAR KIKLF

UniProtKB: Ribosomal protein L9 domain-containing protein

Macromolecule #4: Putative ribosomal protein L11

• Macromolecule: Name: Putative ribosomal protein L11 / type: protein_or_peptide / ID: 4 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 40.274641 KDa

Sequence

String:

MLRRSAVRYL KARPKTVNIE PGSNRFLDPN VEAKAKDIFA VPEFPNKAVL HNWRFFIKAG KAATGPPVGQ EFSKLGLKAM DFAKAFNDR TKPHFKDDIE LIVRIQVYFD KSYIFRIEPP PTAWFLLRAI RKKRGETGPV VLRGNYCAYL TLEMCYEIAK M KQMSWGKV EYPPIEVRVR RVVGQARRMG IAIIGIDTVH SSPVKGMTEK QYLEESEKHR KVHMIQYEAL KAKELESAPL IE RLHRPNM APLTNTQLEE GLKDANLLNA LWKSSHPKSL FTQDTRDREM ARRYLNTRGW FKEMTPEEMR VVFLNYRLPK QED HQRQLN MTNGQAQSQA YWSRDAASPQ

UniProtKB: Large ribosomal subunit protein uL11m

Macromolecule #5: 50S ribosomal protein L13-like protein

• Macromolecule: Name: 50S ribosomal protein L13-like protein / type: protein_or_peptide / ID: 5 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 20.500582 KDa

Sequence

String:

MSKQWLCREG ERWWLLDARG QQLPHVAKIA AQYMTGQHRP DFTPGMMTGD HVVITNIKDA VMTGDNWIRV PITWQTAYPG GKYRVRLSE MYERDPCMVM WWYLKDEVNR HFVRKLKTRT APLEKAWLYE DSVHPHAEKN PRPLVWTDTA TMGWRYKDPT F QRRWSPNQ FMS

UniProtKB: 50S ribosomal protein L13-like protein

Macromolecule #6: Ribosomal_L18e/L15P domain-containing protein

• Macromolecule: Name: Ribosomal_L18e/L15P domain-containing protein / type: protein_or_peptide / ID: 6 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 43.567301 KDa

Sequence

String:

MLSISAVQRR YRLFHPVHQT VPFHFNPVQS IFPLIYENNL LAKPRLSWKD YEGRKEFDAD HPLPVVGTRL NERTTTHKWS HWDQYINPQ ITQSWMYLTQ TPEYVGPRSG HNVIKMGWMK IGGSWKYSRS YNDARRGFAK GQWQERKMTP RFMLAPRVSA G GPRNRYEG KASFSRLSLS KLLWAVDTGR LNPNETITLY HLRNAKVIAD REVVWPGMVL LAGNVERVPY PLHIELQNAS AK AIQLLEE AGGSFTNVYM SHEGLYQELH PEEFPTFMEQ ELPERKGLEN FATNSRKRGW LAQWYEDESR YAHPGAGRRT AHY IRPPTD RDFPATIEEY ELAKHHQKWH LNQPGSATVL PWHSLNTADM ARRSAGRL

UniProtKB: Large ribosomal subunit protein uL15/eL18 domain-containing protein

Macromolecule #7: Putative 50S ribosomal protein L17

• Macromolecule: Name: Putative 50S ribosomal protein L17 / type: protein_or_peptide / ID: 7 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 35.8305 KDa

Sequence

String:

MLRWSRLLRG RPPPVMGHAK RMRFAGVDDN PSVTHKPWDT SEPLMADYGW ERGKLPKFRA RSPFHRQQIA RRMVTELIRK DYVIVGGAR APALRILADH VVELAKAGDT DSRQQLAYFL HDPLMVDKAF DEYPRRFRDM NAKYAMMTRL KGRRRSDNVA M YFVEYKNR DMSDNHKGED YTAGPERFFL PPRIIETEKG IQRPPHMQMA FDRWASKFKT EEFHHWWRLR HAKLRYWGVR NV PHPSDVD PLWTEKEEEE WHNEMLANTS DFEDFDLDDD SYEAAGEGGS QGGSSSLSGI GPEPQKKY

UniProtKB: Putative 50S ribosomal protein L17

Macromolecule #8: bL19m

• Macromolecule: Name: bL19m / type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 16.695305 KDa

Sequence

String:

MGYTRERTNR HFFVSRANAF FSRLPISRIQ RALAMEAIKK GSMKPWKHTK EQIIGSPITC NFEYNPRPVR LIGTVMDAHT EETSIKGGL KVYARSEEAN MMLWIPAGNP KLKYEVTAAK GSFEHYLDER SKWDEAWLTG RARMK

UniProtKB: Uncharacterized protein

Macromolecule #9: bL20m

• Macromolecule: Name: bL20m / type: protein_or_peptide / ID: 9 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 22.442826 KDa

Sequence

String:

MLRSTGVSLY YRATAELDRL RGMLRGRARL ERKVGLKRIT FLMRTQTRYR VEQKAHWERA IVRKNVDSAA HEHGSGWQHL RNDLARQNL MLLPRTQQQL AQYEPLAFRA VMELCASRVA PPPPPMTAQV PEEAYATRPE DPKVAHPAAR RQLEECVERM L CTGRSDVL QREGPRTTQA WMDAWKEYDL GSAAQK

UniProtKB: Large ribosomal subunit protein bL20c

Macromolecule #10: bL21m

• Macromolecule: Name: bL21m / type: protein_or_peptide / ID: 10 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 21.037311 KDa

Sequence

String:

MLRSANPTIA KALQPLIEGP KFAVVYCGNH QYKVSPGDVI AVQRLRAPIG SQIALKKVLM VGGPRFTAIG RPLLEHVRVT ADVEEQKRM RNVVSLFSTP GRRRLRWLDA QHAATILRIR EVVYEPTVVG ELDKYDGVLL KDFHADRHPN PVFTANDGYD L YYPKDWNK VEEASAFLEM MEAPPTEK

UniProtKB: Large ribosomal subunit protein bL21m

Macromolecule #11: uL22m

• Macromolecule: Name: uL22m / type: protein_or_peptide / ID: 11 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 32.278549 KDa

Sequence

String:

MPKPAPRYNI GLRPAPKRQN VGGQFLATQK HYARELWYKR QYYSTRPFAI QKHMGSTPRI LLDRTLWRSC WLTKSNLPDV NRWEKVVNS QRVTEDRWAL VEEDGVMYQV NWKMYCERLE TELQKAQDQL PQYSFMMKAV PSAWKKLDIE LSVLRGLSVR E AMAQCKLS PRKGHMAVFR ALEVAQQGAE GKGLDKEHLR IAYITCMPGP TDKQVDIRSR GYYAWKTKKS SHLLLTLAED PE MVLPDRT AIPYASLMTM KRAGLRTEPT MLDVPAITAE GI

UniProtKB: Large ribosomal subunit protein uL22c

Macromolecule #12: uL23m

• Macromolecule: Name: uL23m / type: protein_or_peptide / ID: 12 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 28.838916 KDa

Sequence

String:

MKRLSSHHAI VCGAASATAA STRFGDVVGG GSSCTATSPL FAAQRGRFYR PLVNQGINLW RSRMGRLHKG WTTWEYNRDV IPDPRPFPE PAVNNYFGRS RIWNPIAGKI GLVNRKAEEW GWPHQRPPPT GLRRSPEYFP FFFSRYFPDV EVRLVLDSVL N NETTRPIF HIPQDMSKQE LVNYLKNIYN IDNVVRIRVR NMRGRRFKNE VGEIKSLPDY KVAVVELDSP VSIVFKQIKG TE DTPDNKP AAQIT

UniProtKB: Large ribosomal subunit protein uL23m

Macromolecule #13: uL24m

• Macromolecule: Name: uL24m / type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 53.621793 KDa

Sequence

String:

MGCVRVRTGC RIRCVRASFT YTQAQMYARY RTRSRFYKRP EKMLKAYNVS PNLLRLPKVK PGLLKGIYTD EKIDLRDRER LELVESIRH PKERDFYQDH TYHNQWIARD LESHQKIQIA GRYPYFSPDY EIKPWIWYPG DTVEVVSGEG AGQRGAIIAV V KYKNEILV QNVNVQDVVI PASETRPEQV VQREHPISVL RVRHVDPSTN QLCHLEIVKV RNKETGELEE RRISLESGAL LP IPAPEET VEAGDPLKDT AIQDADEETY DREKEMPLLV VRRLQAMENY FVDSLQKSHE YHKALQMRNA QDMQTFQKDV LVR ATEKLA AAAAVAGHGA MAEAGSQAAS VATESSQAGD AEEDAVKGTI TVETVVAEVL KSEQRFRSDA AAPGVPGWWQ NMID AYVSV LEEEEATIEA EAAAQAQAAE ADRRAEQLMA DATAEAGQSM EEDGTMEGGD EDLDEQDGDL DEDASRSDRS K

UniProtKB: KOW domain-containing protein

Macromolecule #14: bL28m

• Macromolecule: Name: bL28m / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 27.222477 KDa

Sequence

String:

MLRQSSLLCF STFALNPETS RAPHGPPRGL INRYISMGLP PWAAWCNRVN RHALYRMSDV SPRSFLPKAP HEMDVIWMNE RVRERVRTS RQVQHVYRQL KYPFVKTGIH YSDTLDHWVQ VPMVEAAMFE IEKDGGFDNF ILKRSGPELR STYGERIRRH L LVRQKETQ KNFVLDQQAK ALAEVTQAEL MKATSEEELD AVLAKYGMDA EEFKRLMAKR VMEQRKSVAA AGLRSK

UniProtKB: 39S ribosomal protein L28, mitochondrial

Macromolecule #15: uL29m

• Macromolecule: Name: uL29m / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 54.235465 KDa

Sequence

String:

MRCSARRANV AALYEFVDGN FLNNKRPAIP GGAWPLESLR RKSLADLQQI WLSLLKERNM LSTIKEHYLR HQEELGAMPA PSRLKMVEE SMENVKRVVK ERDAEATAEA VRIFKERLAK GIYRYPPGPP PPPGAHDPTS TVKLVLSRRV DEERLRELLG R FNVFEAHK GIVKLTMQLP EDVLTQKRDA EQLWQQYMAE RRNVEEYYKW PGSSTGSAES ASVYDHTVVE LAPGVYSGHR GT SAIESNC VDDSNDGAHG VVQAARLPVP PPKTRPPPPR NPLEHIKYQQ RSVLSKAVIQ LGYFPNITTT APRFTKADDV PRP VHPDEI EGPWEVRVTY DAKDGLAYVQ SLSLTSIDGA AVLSVEEEFP AAAQPYAAVD PVYQEAVRRE MAQEETLMKW PNVP KWKYQ YDLYTKKHLA QVVQYNYSNV VDYVDREVLL TGRSVWESPI DIDPTCGGMK SVPAHAKKPK RYMTHGLAEV GVTDI

UniProtKB: Large ribosomal subunit protein uL29m

Macromolecule #16: uL30m

• Macromolecule: Name: uL30m / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 45.564957 KDa

Sequence

String:

MRRCVMAKGE DPAHVAGWDD RQDAVEWWWT EANDSRGRQR LEAAAAVAAA AASSTVGLPL FPRFSPGRRR RRRPPAPPPP PPPLFLSRH LHSMPWLWCT CVKMQMYYTP TALTCPLSNS LAAHVGHIIV GVAALLPYSM LLFLTVMCNP RKHEPVLRAQ R IRWLTFHS LMFRLLRCIT ASPAVAASVA VAAAQTPTSL RPAAVCRRGV HLAPSVLAAS APPPPPQQQQ QPTSAAVPAS TA TSTTTIA AGPYRRVGNV FIVTCIDHPF KFSWEVNRML RELRLEFMGQ TTVVPDIPPV RKRIWRVRHV VRVDQLDLDE AKA LIGIPE HISFRDLAGQ IPPTFGRGGS VANPHMRSKM NFMRLRRMRL RDVMHRDQLE KRLLEERHHA LQQQQQQQQG GGEA AAAAA ATTA

UniProtKB: Ribosomal protein L30 ferredoxin-like fold domain-containing protein

Macromolecule #17: bL32m

• Macromolecule: Name: bL32m / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 9.865692 KDa

Sequence

String:

MLQRTTLRCY SALVGQATPV LLGSKGGTPK RKKNPMQLRR KTYGLHFKER YLKLEEWYFC PLCAEPKKQG EWCRREDCRQ IKP

UniProtKB: Uncharacterized protein

Macromolecule #18: bL35m

• Macromolecule: Name: bL35m / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 18.393578 KDa

Sequence

String:

MFRISLICFP KAGCEEITRQ GRRVVLKPQE YFAQHRMQVW QMRFKEMGPP FSRVWVALGG KMRRRRIGRQ IDVKDMRYYW RPIEPQYQR LYMSRLRIKD HSNKRVQPMR LRATNNDIGQ ASSLKEWERS SDRKYGAALA PPKKRDFEFR VF

UniProtKB: Uncharacterized protein

Macromolecule #19: mL41

• Macromolecule: Name: mL41 / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 22.673082 KDa

Sequence

String:

MLWCTGPRRI VFHNAPSVYP FTKPFHDTPY DQDRGRFDKT KNILRENKWP AWMDHGADGT GFGIGLNRTH PLSKLRGNLR RNPSEIPRV LNMMIQGVWH KSGNKLYFRG GKPPNPSTHP YLTGEPCPVY GWKVTDPGVI REFNLPQPED KTRYKPYVAL Q ERKIMGMQ APTKEHSAAS TSAASTDSKP LMKRLFFWK

UniProtKB: Uncharacterized protein

Macromolecule #20: mL94

• Macromolecule: Name: mL94 / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 17.88541 KDa

Sequence

String:

MAQWIPKTAW KVSNLNKRYG APYVAKGYAS LDPRCSLDAY SSFQQTVTSA DMKKALLSID STSSGALVID VRSEPERRLR PLLSPAIVA LHPHDILSGA ACPILPSNKE RAEMFVVASE AQRAVNACTA LRRWGFSRVT AVSVDAVSEA IAAVQKPADA A TSSSTKS

UniProtKB: Rhodanese domain-containing protein

Macromolecule #21: TRUD domain-containing protein

• Macromolecule: Name: TRUD domain-containing protein / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 68.396375 KDa

Sequence

String:

MKALGRGPIT RLANTAAPGG FAAPGAVYNR DDWNAGRDVS AEERQCGILT RLCTLAATAP REAASPACGL APLEAVIRVQ STDAHVTEV DANGGGAFLE KAPKGRWRKI SRSKTLLVED TATPFSNSDK SFSPRVQSYG EYVRRIGKLP EGRPLLRFAM F RDGYSLDS VCHRLRYEIG VPHDGVYLHE PPGGSFAAVT QFGVAVGVTR EQLPHASRHY NVHALIFDDR GYHALDELPR LS VAPQAYL HRILLRCVSG DEAAVAQRLR HLSSNGFINY FGLESFGIGS NTLFDMAAFA FRREPHRSVG AYLQTLAECS PLH HQPYLS YANAEESTVA GAVAEWLRVC ERAKLPRETR ELLRKLHCYH LSQCHPSDAT TISMEDVWKA CPIMHRAEQS AAAF VWNAM ASQRLLSFGS RPVKGDLVCR IGNRGAIEIA EVASDTDASH YTIDDVVLPI PCGGTPAAEL RYPTHSVNEA FFTQF AKKH SLSFLFNSGV DPTPRAAATL GPYRRLVSRP RNLQAAVLQD PSSCAALKSD LFLLQEHQPT EGWSLDYRQR VREPSN FNV SERFRERMSC IRKRRAGEHS VALAFVLPAG SSPWVALREA FHMHYGTFHD FYGVS

UniProtKB: TRUD domain-containing protein

Macromolecule #22: UA

• Macromolecule: Name: UA / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 14.446793 KDa

Sequence

String:

AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA A AAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAA

Macromolecule #23: mL95

• Macromolecule: Name: mL95 / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 18.694562 KDa

Sequence

String:

MLHRSCVLVD SFKEHYHRVH LPRRLALQRY IKREEARLSR HKGKAVAAAA AAGVQPGEVA YKYNRWWVSN DHEFVHQFAF VEDPDVTRE KRNTLPLVTK ENIWKEPQQT FFLPFAPFVR VVDYAKDPDT KFLKPVNIPR WKDYMQRTKP IVPRTWY

UniProtKB: Uncharacterized protein

Macromolecule #24: RNA uridylyltransferase

• Macromolecule: Name: RNA uridylyltransferase / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO / EC number: RNA uridylyltransferase
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 23.355764 KDa

Sequence

String:

MIARDPPQEG RLPDPSRLPY DDERFAEMLL EMEVNGVIDE TWQDAKKARM EDVKEIANIL SSLKVRDLCC VDVSEKTSNF DYMMFGTCE GARHIHLAAW AVQDADKVHR ISKIKRQQTD ELWEVVPVGR IVVNLMVESF REEMTLERKW AVTRSMDPLA A ANAPISEG RQVKAHGLWT LTLNLQDLED FEVDYCKDIL MRQM

UniProtKB: Uncharacterized protein L5213T.03

Macromolecule #25: mL67

• Macromolecule: Name: mL67 / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 97.698406 KDa

Sequence

String:

MRFDNAAPPP PPPPEAAGST TTSSSTAASA LPRVSYRTLP SSMYPKEVSS DFIPFPLPKH DASMGFGPVR LRNVPDIEEA RARMAKAAQ GPPRGSASTQ LQDADGDNAE AASALWAELS GETTATSVGL STTSVTGASP EDPEALSRPP DAQDEDLVGY H VHRHFPLL DVLGCDRSVN DLLAQFWNRP QREARTATVL DFAATLQRHS NEELTRVLYE LSSLFEWDGN GLQFIAAKVL KY GRSYTVS SELTKAFVQL VDAMTVAFVE EQPHRLAESP ALLAQVLHFL ALVKIMEPNK WYTLNPNAPQ NRADYTHPRG VNR TCGHVT TGRALLDFLE DMVTSGHNWT GEAAVDDQQG SLARSPVPQH ATNRFTEGWS EDDILDVMAG FSGVMPDGKA SSPV LYALL DELWMRWSKV GFVLSGSEQA VRLERLYMLL QVMDMQRDAV LDALLGGQLR AHSTAPSTST LPTLFCERDD TPPLT LAQS LTQTRGPDFF SAVSRDKRAM VKAAALRLLT ASLAKARDDS DAVLHQALVE SGTELLQSLT SKSAALSFAQ REQFDV ITL RAVPHMADVA ERLAEQRAEA PFFPLTASAG GLPDTAAVLA HLSSHPAPYI VLCKGRRVHP VRTLVSNLDH VAAVENV FL LHSSGVSKCV DALVAVARRL RSGKDALIVT ASCLRALQAA AQYGATEKRR ATADRALDIV SYELEAGRAI LMPVTDEL Y LHDAGTYCDE DLMLWTLAAY LARDVPLVKV HTIMSSRSRA RNPQHALRGE HSPLTSTDDL YNKSTPLLQA LRSKELRAV THHPVVQRPV RDPPQTLYNV NPIRARFVYR RDKALFDKYH VTARNLAPGF SQGALNSDLR ALGFYTPDHP QVPYTPLSEL KCHPVPANP PASQ

UniProtKB: Uncharacterized protein

Macromolecule #26: mL71

• Macromolecule: Name: mL71 / type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 49.368492 KDa

Sequence

String:

MLRRQCVVLS YQRGSWAPGS KHQKHMSLNP TMYLYRFAGP HGPGPYVMKY WWTLGCFPTG IERPFRLPEF LASYQQQHVP IEVEEWLQC FVKNPYEELK DATSSLLKCL EEVPIRENTR GYRSIESGVS SFAAPLAQFE RQLNVRVPSL AVRAALGSPA L RERLKDDL FEYNESLSAC GSTPHRRLAR LAFDEPLTLP GGINNSDDSE NLRGQISVPM SEAIGSYASP NPSTSDDEKK LI RLLTTFS EGCTLKEDYE SAFSLLSSSL GFSHDDNTDG VVHSNASAAA ILGGLYKEAE FHGRQAALLE PQAMSSRKSG GRG YVLWAT ATAYQEDFDR ASRIVEKGLE VFPDNADLKS IQEKLAGAVP AASSASPLCT RMVRSKGQQA RALLHGSGRS FDNE FDWVV FKNKLYPSKM NPSSNEMGSV FRRVGDFGGH ISTSRSLEPL

UniProtKB: Uncharacterized protein

Macromolecule #27: mL81

• Macromolecule: Name: mL81 / type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 37.743145 KDa

Sequence

String:

MRAAPTRLAP STVASLGRSH CGSQAYHLDA AGAAGWRRRR RLTGVSMTTT HTVAPAVSAL PFSLSTARRT YYWPYPENLV PEGATTSPF QSSPVPSVRE RIIREYALGP LFGSRTPCCV LGFAGTARDV AACKRDVRRW VARALGKSEA DVELGALVQA K EMLLHRSG TDESPRLGDG PGSRPDAEQR RVTRYARLPV QARTLLEVYL PGEEHGEVDA AADADATILA HGYFLQEQLH RH MTTTASS GSDPTGRRDS EDCQPEEPAR KMQSHCQGCS EPNDEADVKS SVAALHDVCG VIYCEVPVLD ESDFAFDQLC GKE VDDETT ERVTDRWTRR AMQQQPQL

UniProtKB: Uncharacterized protein

Macromolecule #28: mL98

• Macromolecule: Name: mL98 / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 13.262987 KDa

Sequence

String:

MLGGLRPLAA ATRRTVGGAL VSPALITPSR ALSVRTEDFF SKEAVSHARR VSWAPHTTEK KVGAFAKLSR SNFNDPLPVS FQSEPYFEE EIEAYRAHHR PDVYVYKYNV SPTHLSLRE

UniProtKB: Uncharacterized protein

Macromolecule #29: Putative ribosomal protein L14

• Macromolecule: Name: Putative ribosomal protein L14 / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 21.633137 KDa

Sequence

String:

MLRFFRARLA PTTTDAAAKL PAGNPVNKTW FRHNLIIRRK GSYRSRWGNG TEGYGAGVPL SDQVKLHCVD NTNCKHVRLI AKATAERFA HCRVFPAVAH RVSVQRFKGR GGGGEVSRHR VKPGNIYWVC LFTRRQTNTR MSGLQTNFDR NTCIIMNDQR V PLGTRVMY CAGRHVNHKY HLKAVVLANF FV

UniProtKB: Putative ribosomal protein L14

Macromolecule #30: mL86

• Macromolecule: Name: mL86 / type: protein_or_peptide / ID: 30 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 21.071691 KDa

Sequence

String:

MRPSALCLGG FTMKYKRGTG LWDEDHVNDF DANKYLSARS TMRWYYGMER LQTRNNMNAR RATQSYNNNM GLHHSGRGAF ERELERRGI QVDKYPLTTT TGAARVAEMV LLRRQELEAH AKKAMESQRQ ARRRDAPSEW YDETEGPLNP RFLASMQSNY T QVITELPS SPVTGRRELP GASFA

UniProtKB: Uncharacterized protein

Macromolecule #31: mL87

• Macromolecule: Name: mL87 / type: protein_or_peptide / ID: 31 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 22.265654 KDa

Sequence

String:

MMLQHTSLLC RKALQSYPVP PRARNYERRW SSSRTNPYNR MFWRTVLNED FARPSFWVSD FRHKYLAKHG MDYQGRVPAS PAPGMYQGF SDVHKILANH PKPQRESRHL PVMPMTPRVV FEHAQEKRID YAKKMHRDRR LVEQLRTHEF WGWYMKLQRV R GRWCKEHG VSSRGVYGPA VDAAELWG

UniProtKB: Uncharacterized protein

Macromolecule #32: mL53

• Macromolecule: Name: mL53 / type: protein_or_peptide / ID: 32 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 35.479988 KDa

Sequence

String:

MTAPASHYTF ANLKKLGLCA PQVALSRQPR LRPHVGHLNG LVYPLPYYAM WRGNHDKYTY NQATPARWGE GNTNTMYHQH YAHAKCPTD YGRGGREFQF LSVKRGKLKR KPLPTVQYVD PNSKPQWVFK SWHNPLSAPS MWEREVQYPE HTPAHTGAKR P LAVVAPKT SHKHLFLMHM EKVTVTVSPL LFGYGHTLQK AALDFYRRGL SARSPFPSDK MFLYYSIDHI TPKIEVTWLD GS VYVPPLI EGVKAQDLIQ MVMEQAWLAA DRMSAEGRVL NPIAIDDYKW EQLIAFKQKR AKGAEAAKGG AKKK

UniProtKB: Ribosomal protein L9 domain-containing protein

Macromolecule #33: mL63

• Macromolecule: Name: mL63 / type: protein_or_peptide / ID: 33 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 18.099469 KDa

Sequence

String:

MLRRSPVPRR YRTAWRELLH PLPVWARRQQ WLKRDTVEMN EAILREPYYR IKTFAQPAAF VSPRVSESAA HEPDTQQSSR YGVDRQLRG PRRAVSPERL QELREQLQFV GSIGPKVPPA AGAGTAYQDE YGTRLRPRYP QSWDTVPPHQ PSRSEI

UniProtKB: Uncharacterized protein

Macromolecule #34: mL68

• Macromolecule: Name: mL68 / type: protein_or_peptide / ID: 34 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 65.792461 KDa

Sequence

String:

MHLHISSIPH RNSNNSKGGV LDATGPMLSA KRGALLLQAY HRPGEVISYK AGDYHLVPKK FTVGKRIAVR SYLDRNRTEL SDRTFMPQK NWFRPYDLQD GCFDRDHERL SYRFYNLETK VIWKAFDTPE LIGMLLHDET VKGNSGMYAP DMLDAALHYT R EARYWRCI GITKPFYDRN TLRAHCWEDN GLQVGTLVMS QAMRHALMDL ERAVRRKELG LEPNYLWDRW GPIGFIDGAR AD YLPRFEH NPYVDPDGVD VTEIDVLPFN THEQIRERYR DFIEPDTAPF EEVFRSPSHG SLTTLADIPN ASVVALYKDL KLK AGTPVA GDAVELAPAD VRTLFYLSAN PEWRAVADGK ASWEEVVDAM QPVQAELDEK IDAARLLQNT RHNAERVRAF FEEK CGFHD FMYTPDKTIT AAVLCYLTEL RRICTETAWG AALAKCLTDM ERVQGMGRDA FLVYRHIEDA ILDKKRRLWA GRFAG ESHE ESTLDYLLEN FGRRAERPRN VGTTGVEFDR EQEPIGRQVQ RRVLDSDKAN KLAEIRRSRG KMWSKKRSVF DALHEK QLQ NFNYGVH

UniProtKB: Uncharacterized protein

Macromolecule #35: mL80

• Macromolecule: Name: mL80 / type: protein_or_peptide / ID: 35 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 27.945424 KDa

Sequence

String:

MQRCLARLFQ AGVHTPHGSR YNAARMKNWP VQEVPQNFNF TNEQRFKAKA VPRDTGKIPR DFLLSVLYRN QPCEVASLWE HCLHDPQIV LDSKRHLREV LQQARAEGFV SFEKDAVTDR WVCHLTRERF EEVRALVGAR AEAQDLYSGL RGASATETSA Y SESFREMN EDTKREHFRL LSEQVADTTT HLRKFQRMEM DYLPYTDLNG KVNFMWWYEM SDTRDATALP EAAAEGSPKL SE

UniProtKB: Uncharacterized protein

Macromolecule #36: mL74

• Macromolecule: Name: mL74 / type: protein_or_peptide / ID: 36 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 39.392641 KDa

Sequence

String:

MLSSAHRAAF ARPTATLWAS ARSFGAGPTR LLLGLEQVQD VPTSTDRKPT GMHRGPGKRQ TAPKEAAQYQ FIKKWDLQMR ETWDELEPF KGLPKPKVQF GNEAAEVIWP YALLLENVIK VHPYTKSIYV YYSQRQSTPL GELAARVAKR VSQAYLIPIT F HNSHVYVE AEMLLEYSET PWVVVHCLDG THKLIPVKPQ AGQTVKEGAE EVLNGIVSAC NEIGSAVKNP KEVMRLLSER PL QNQYVRV NYQWYGDTPE ERMSHLVKWD YEPEEVVPQL RNRTQHVLDW MNYDGNLPTH NSVRVNIHRE AARMRKPNVS AGP KTFFNS SGSRANARTA RFDNSRSSQS

UniProtKB: Uncharacterized protein

Macromolecule #37: L51_S25_CI-B8 domain-containing protein

• Macromolecule: Name: L51_S25_CI-B8 domain-containing protein / type: protein_or_peptide / ID: 37 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 31.231971 KDa

Sequence

String:

MSRNGELCLQ RIIVSYSPNK GNPAMRQFMA THLPEFHRQY PQVKIDIRPR QWPESSITGI YRDGSEKAYS IRFLSSMGIN VRFHRLVNE GNDYNHSFSA SHLHLQRRSV QGTWNPYLWN YEGTRARHKP PAQWSRKLTE KEWDYYVQQY GAQMKAEEDT I ADRVRRYT DIPEASTEEV NQRWKEHVMP RLQTDLEYNL SHWKKQHRTG AGRPAPPTLN EYSLFSVPDH SSLGQDAIDM LR RREAQRE EDWWRERKGQ LKPPE

UniProtKB: Large ribosomal subunit protein mL43

Macromolecule #38: mL42

• Macromolecule: Name: mL42 / type: protein_or_peptide / ID: 38 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 22.170172 KDa

Sequence

String:

MLRLTQAVLR VQSHQKKRAQ HPNAGTRFGR VYNRGFVRYG FGGFGMSVYS SKKDRTFKVM PVPPPPPATT AVEQRDDFAD NRGLSATTR TLSPTFRMFA LEDGGVLVSH PSHAQIMRWN QRVHTEEGKA ANSTVMDEYV NSRIQAIIAD NTIENTSLSQ W RKAHMWNV IKSHGKLQRR WGTPDFVMGA RSTLYNN

UniProtKB: Uncharacterized protein

Macromolecule #39: mL52,mL52

• Macromolecule: Name: mL52,mL52 / type: protein_or_peptide / ID: 39 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 29.196033 KDa

Sequence

String:

MRRRDWCGVC LPAATLHALA RRYSEYRSSY TGARSAPWAA PEAAPAYPSA RSPFPLERPR FRKTHIEWML HHGHGDRYGK YGPSREIAD FEYADGTPSS ISGKRFALKH HQDHLLVQLI RSAAIVERFE EEELLPRIPG TPEQRSWDPE IPLFLEDVDE F GRPPRPVA GNMVARVIEE RFAQESGRTP VNLANKHAGE VLEPNTMFAT YDPAAFVSDD IKKDVRRPFW SRRRWALSDN FM VPMSPKP KNTIKDE

UniProtKB: Uncharacterized protein

Macromolecule #40: mL93

• Macromolecule: Name: mL93 / type: protein_or_peptide / ID: 40 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 18.858525 KDa

Sequence

String:

MLRFTQVIRK NPVVFKQGQG MFSHQLKRIL NKKSLHKYNW DPLHMYDPRK LVHANRYVDH DTYEEKYDPH WEHNAHLVPD QQFYNIPVP KEYKDAYWWR DLQARRVQCP TEWVHFRMHT KDKLKYDFQD LAFRKKFEYS YEDVVANAKD MCS

UniProtKB: Uncharacterized protein

Macromolecule #41: mL75

• Macromolecule: Name: mL75 / type: protein_or_peptide / ID: 41 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 39.654387 KDa

Sequence

String:

MLRRTEIALK KGWTHNPGHT RRGGKNLAWR PKISDAKLSQ FVPLALVHPR RHPNNWQERQ FNALGYTKWP KDIGFYNAGD NFEVTPEAA WRLYVHARDE PYWGKLHCEK TIITLLPVVE KAPKENMERV LDVFRHYLKR YGADHYIYNA VMQAAAFAKN Y EQAEQLFK EMETLGLEPN AQSYVNMMLA AKLCGLPPEK SEAYFKRAVK DGAMQSVMRM DTEFRMWMDQ LDRLGSFTAS SG YLSVNEE GAKPMPRDMW AIWGWHRSES KFISRRDLIM QQVRARVHSG KELVGTVYTK TRRQPWAKFN GMLRHDYNGP SYR APTIFP DAPEYTNEAG HKAF

UniProtKB: Mitochondrial RNA binding complex 1 subunit

Macromolecule #42: mL85

• Macromolecule: Name: mL85 / type: protein_or_peptide / ID: 42 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 27.526311 KDa

Sequence

String:

MRRLPLFCRR PSRCCGATAS GSGSSSAAVL AASAAPSVLV LAARGIATSG RVTNEDRRWW LVHLECAPDV TPGTFVSWLD CCGTHTTKK LIERNIWTIE QVAELDSDRV DELKYKEGCL KMDVVWEHAR TIITPLKQRE VSGGVESQLQ SRILELRKKR E LERQRELL ARERATVSDK REETLRRLRE SVAAKKAALR KKLDEQHGEA TPAASESAST EAHRGTAEAA VEDEAVGNIV DR MSGGNPP RA

UniProtKB: Uncharacterized protein

Macromolecule #43: mL100

• Macromolecule: Name: mL100 / type: protein_or_peptide / ID: 43 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 146.807906 KDa

Sequence

String:

MLARYLDPSV HPLRVGQVVA YDYLHAAKTW QWTLGTVREI KDYTAVVQQW GLHTGDIDTL RSILLKEVDT ENGRMKNYHD MLAIAREKL ASIRRSNEDR VSHVRGHFDK AREKVELIDE VDLRKVTAQA APSPVAVAVL KAVWAVAKCD PTAVEFYEWA D VQLEYRKP AALDEIAKTD VLAKLYPSAE SLQQSLEQDP KLNYKAAARD SPVVASLHAW VITALAYQQA YNLLAHDKRI QE QNDAIAA AIAGMKACRA KIAKLKDELS SKDTAALPGQ VTSFTRTSVL VTIPLSAVIS PVNVDTDVKR CVLTKDEVEQ IPI DAKITR YAQKQKLAIT GSHLLDQYAA ATTTHIYVTE LEDRLFFFQH YMASALRDAQ TAAVDAHQRL AVSLHELEAF RQKR HDAKK ARAAEPELAD ADGVEPSSGP TSSRSPTGRA APRGQSAAPR GTASQQHKLL GPAYQSIDPA TIANEPLYAV TIEEY KAKD AAGERAMDEA ERMADEVQRL AVELEDAKAA ADKLAEELAA KDEELAAHRQ KRHDAQQARA SDPALAAADA VAPRSG KGA ASPHVGAVQR QAVDPATVPV APAVIAEEPL YVATAEELQH VRDFADQLAE ELEAFRQKRH DAKKARAAEP ELADADG VE PSSGPTSSRS PTGRAAPRGQ SAAPRGTASQ QHKLLGPAYQ SIDPATIANE PLYAVTIEEY KAKDAAGERA MDEAERMA D EVQRLAVELE DAKAAADKLA EELAAKDEEL AAHRQKRHDA QQARASDPAL AAADAVAPRS GKGAASPHVG AVQRQAVDP ATVPVAPAVI AEEPLYVATA EELQHVRDFA DQLAEELEAF RQKRHDAKKA RAAEPELADA DGVEPSSGPT SSRSPTGRAA PRGQSAAPR GTASQQHKLL GPAYQSIDPA TIANEPLYAV TIEEYKAKDA AGERAMDEAE RMADEVQRLA VELEDAKAAA D KLAEELAA KDEELAAHRQ KRHDAQQARA SDPALAAADA VAPRSGKGAA SPHVGAVQRQ AVDPATVPVA PAVIAEEPLY VA TAEELQH VRDFADQAAH DAATREAEVA GTVENLRNEL DDVREMNAKL EDEVFALKEQ LSDAEDAYKK LAGALVVAED ERQ ELCDDL EAALDELEQK KDEYDELLGN LEEVQGLLEA ADVAGRTAVE ALEQRNRDMA DLQGELANAL DASKENENLR ALLD AKERE IDRLKEYNSF WTDTVGTGKQ KVTHRLTKIF DGDWTRLMRH RPEALKAAFV IDSSNACHVP GDQIFLVSNS FTRRL LTRT DHCPKCDRLS TFRFMSVSGM VGRMPYKPVD TPGPSYATLY WRKQRSGKIA SQPLNEVCNK NEF

UniProtKB: Flagellar attachment zone protein

Macromolecule #44: mL49

• Macromolecule: Name: mL49 / type: protein_or_peptide / ID: 44 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 26.212061 KDa

Sequence

String:

MQPRRMAGHF NPTPQANSLA ATHYAHTPEL RHMADGAAMS LSGQRIPLLK PTLSKWSRQL RSDIYDELLK LPLRYALHDF RTLQAHIHA VPATATNASC TAAAGERLPP GVYHASSGLS SASPDAPAYY AVAGRDSAVG YAPPLGPADP VDVIPFFVHR S SNGHLPGK VYSMNAKTLM PAFYMRIQNI EGDMFRFEEE LMKIFPTKKI FVRSHSVYVY NVNLDGRAVL HHWLLGLGF

UniProtKB: Uncharacterized protein

Macromolecule #45: mL89

• Macromolecule: Name: mL89 / type: protein_or_peptide / ID: 45 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 21.557305 KDa

Sequence

String:

MSSGAVGRGS FHSVVAGANP RRIPTYYNSA YELIQLHRAH REVTRNFLVR DKVFDNKFPG CSLANGLFKM VPNKRGNFHT RELTESIRH RTIWGQRIQQ QRTINAAILE DATKVLSPAQ MEDRFSYRTP DAAAYFSPQE YTAANNWPNY WQHPTEKHVV P KPRWRREP ELGGITRVRD AVATPIADY

UniProtKB: Uncharacterized protein

Macromolecule #46: Peptidyl-prolyl cis-trans isomerase

• Macromolecule: Name: Peptidyl-prolyl cis-trans isomerase / type: protein_or_peptide / ID: 46 / Number of copies: 1 / Enantiomer: LEVO / EC number: peptidylprolyl isomerase
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 25.314658 KDa

Sequence

String:

MWRLSRVALQ SNRAALYMPY TPVATNPVVY FDITAEGDAL GRVSVELFRD VVPRTSENFR SLCTGERGYG QCLLYYKGTP FHRIIPGFV MQGGDILTKD GRSNVSVFGY PFPDESFEGK AGKHLPGTVG MAHSGPNQNG SQFFFNLGRN EQLDRKFVVV G QVLGGWEI VNQVVKLCGS RCGTPVSRAW ISDCGQSGGY MAEETQEALQ GERAQHVIPG KEVLDLIQPR Y

UniProtKB: Peptidyl-prolyl cis-trans isomerase

Macromolecule #47: mL72

• Macromolecule: Name: mL72 / type: protein_or_peptide / ID: 47 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 56.554801 KDa

Sequence

String:

MCTRVFDVSQ RFILLVSLPP LSLSLRPSCC SRKAATRRRR STASVLLATD ALSLFVRTHY PSPLLFLLLP NFPLPIHSPR KQMRAAVGA VLQPSSSVGA LRCQARFITR LYTSYFKGEL FPNQLARPLE RLPRGVSLAA ARKGQQAAAP SSSGSGNPAT T ASLDVVTW GDVDSTDLVH ANEQSRAVAP QAGLAPRRPY VPLGEVAKLE LQGDYLTEGG LHQEALEYYG VVAKAYELAY PK DHPQVAG IRLKLAGAFR RTGRLTSSKA NCEAVLQMLD SAVQPPLELI VEALFELGLT SEAMSDAAAG TVFEEAVALV DMF HNSGQS HKMLRLLPRL GRRFNLNFEE KFVYFSPFDY DRVFALADQC LERAEVFYQA RNDRAGVMRV LQQRKELIDK KFFN MRDFA GRIHTMRGHW KRRAQVLTNA PTPDELLRYS PTIHQVYRDF KYELNAPIGR EKEVQPGVNR VVHDMGNPYR RSGVR SQRM FRDAEKNFEK YIRADAFEA

UniProtKB: Uncharacterized protein

Macromolecule #48: mL84

• Macromolecule: Name: mL84 / type: protein_or_peptide / ID: 48 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 24.621238 KDa

Sequence

String:

MLRWSRLLRE MAPELQLEYI PIIFTRTILG PQGGFAGEER LIKREVAQKY MSEGNAVTPS AEFHQGVWCY NPDSEQYDRF VERNAEFLD FAARKRQWLD VYWRVNTGYL LFGRQSWGQG WLLNCPLRKK DIAQKLWEQY KVRVDPRLIE FREKDRRTGI Q DLGHNWCW LYLPGAEELA IDREVYDNKR VKVRMHIRKM SSYGALY

UniProtKB: Uncharacterized protein

Macromolecule #49: mL76

• Macromolecule: Name: mL76 / type: protein_or_peptide / ID: 49 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 38.656633 KDa

Sequence

String:

MLQCTALVLK SQHKNVLRKG RPHMQKYKEL NRWQREAQGI TKWEQGHSHR PQPYVERFNP EGAGLTRGTS AYAWKWWHTQ YPWLPNVAP ADYVPPSPRG IRPAAWDDEF ADVVLSMSDE EIQSYLLDKL TEVIFAETQR DGYELRRLDF EGKPLTELPE R RIIENFVF EEETLRERVL DRVVEGVFRL VPTSTDRLEL KSVANIIDFV LTHVTVARKP LQHEIPEAAR TVMRSHPLQP QL GFVHALP TDNRDAVVQE WERMHHLDWQ FGKAVYEPRS AENERGNLTW LREVRHHEAR EAFQADVDSG EARRRHMAKI KAA AQVPHT GTTSQ

UniProtKB: Uncharacterized protein

Macromolecule #50: mL99

• Macromolecule: Name: mL99 / type: protein_or_peptide / ID: 50 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 13.048815 KDa

Sequence

String:

MRRTVRALYN SFERGWKDKT VHPLDRRGRF NLDEAAAELQ LDEAYVASLY KPLHYTYSMK GQRYPAEQGR TSRPGSLAAS RDRMFPLYR RNYKLNRELR VLDHRRISTD

UniProtKB: Uncharacterized protein

Macromolecule #51: mL88

• Macromolecule: Name: mL88 / type: protein_or_peptide / ID: 51 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 22.340785 KDa

Sequence

String:

MFQRTCTPRL LACTSALLKR SGKPSDLPDY KQVYLPYDTA PTKTELDRER RKFMHAYSGR MEHRKMVEVK DVPQNMYTYG KEGMSIPIS IFKDQADPVI GPEWTYPGIF ENKIVAQHWY MEELFDREKS NTFESPWQRQ VLDNQVKRRL GKVAWRMSML N IKTIDIFH KERGASKRPG AGDTKAPATP AGKK

UniProtKB: Uncharacterized protein

Macromolecule #52: mL70

• Macromolecule: Name: mL70 / type: protein_or_peptide / ID: 52 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 50.752273 KDa

Sequence

String:

MSVFPGLCGD VATTNYRVFL GTLPNLAVEE RFLRQVQPVF PWYASRKHVK EQASEFLEID LASCDPELLL RYTHVYYVRR QLYDELVDR QLTLMETGKA AKVADSALLT CLAQVNAAIT PRLQYELHLL QQAKKACRVP RRRELNPDAA LEAHDYLCMM R VVEEDVGG IPDAEMQARA YLPREVLEAK VKELAAMIFG DGGSATKGTG AALERKEQKL LQRMIPADYN KVGAVEKLRP VD VTALYRF TGERVCGRPA DKPFARALWG HVFRKVGSHP LYLQRASLYW ARHSGLDPQS ATSAMPADLA TAVCVQQALF PAL KYRCQY LYTSPDIARQ QWRTGHVVPL LRLFPLLGAP AAEDLAAQLV VEGEWAKLGI EADTNLLHDT VLRQLKDMVE QVSA LYESD AGAVLKRVED GAKVLCPSLS ERESLTMRGA PEDTSREVSA AAAARVANAA PA

UniProtKB: Uncharacterized protein

Macromolecule #53: mL59/64

• Macromolecule: Name: mL59/64 / type: protein_or_peptide / ID: 53 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 28.602615 KDa

Sequence

String:

MAFRGSSARL AATPGVGIAP ETTPVKYVPE MLNIQNAKWW NGRGKPVYRS TYNEKSWLEK ARWGAFTKGS RPVMRQRYSA AALKEALEM VPEGFETCDV PRPPQRIRAQ SEGVVGRWYT NYWTLHSVRY QCQLAGVEWQ FGERQRPRTN YDEPHMYTDF E ETKAIRDY RSRWINVNRS LVGMSRRMKE SEEEARYLHF KKVQDTFWSN RKVLVNRIKS MHNQGTLQSA KDLPIKTINI KA FLAE

UniProtKB: Uncharacterized protein

Macromolecule #54: Peptidyl-prolyl cis-trans isomerase

• Macromolecule: Name: Peptidyl-prolyl cis-trans isomerase / type: protein_or_peptide / ID: 54 / Number of copies: 1 / Enantiomer: LEVO / EC number: peptidylprolyl isomerase
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 28.924203 KDa

Sequence

String:

MRVWVLAPHS LPPASFRPIF EARPPSSPTH SFHLLPTPIY LYITCTDAVD LYVCAVTSLL AEWTTTMFAR STIRWAAGAG HAFMDIAIG SQPPHRVTFE LFTKRCPIAS ENFLKLCTGE NVLPQVSSID GIGEPSFRDQ FLPQLTYRNT TVHRVCKGYL V QGGDIVSG QGTGQLSIYG ESFDAPEEVK ASKFDRMGLL GTAVSAPHLN GSQFFILTAD KAPHLNGTCI CFGRVVDGWT VV KAIEAIP LTAAGEPAER VVVVECGKL

UniProtKB: Peptidyl-prolyl cis-trans isomerase

Macromolecule #55: LIM zinc-binding domain-containing protein

• Macromolecule: Name: LIM zinc-binding domain-containing protein / type: protein_or_peptide / ID: 55 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 25.173934 KDa

Sequence

String:

MYFYRRIPSL ASKMNHMRQF SLPRSSAAII MAASTAALAV PCRAMHGKPA SGHKVRTQHS RRWWMQSKAH HLTAVPHEEA RSRPHFPAY TEDVDQPMVV PDGVCCFNCD KPIDGDDINS YVWVPSGNAR VPTTQGYFFH VKCFKCWNCK YRIIHNQFYS K DSRAWCLS CALGRDIRVP TRRWHTSYVN THRTGSRLTG QFFPRHRHQM EFLFSPKE

UniProtKB: LIM zinc-binding domain-containing protein

Macromolecule #56: DNAj-like protein

• Macromolecule: Name: DNAj-like protein / type: protein_or_peptide / ID: 56 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 45.397457 KDa

Sequence

String:

MRGAPTYATA LGSACLPFAL DCDAILQASR RYSSTSAHGA RSSAAASTSK LNYYRNLGVD TDATPQEVKT AYRQLALKYH PDVVEETHR AHAEMLFRRV SEAYEVLSDP VRRRAHDAEL GIQTRRKQQP SATAPAGAPS AANAKAGTRA GSPAGGARPS S AFAERRKH TSSTASSTSS TTFQQQQQQQ RRRYRKPFVR GDANRVFSDA FDGKTLDEIL FDVQRRRRQE KAGRVAAERR HE KGGGAGH AASNGTTKSS SSPQPLMGES GPLDHDARLR HVMETAAELF AQRAQRQYGH GVLRHIRGVA GPLPDGPAPP PEV YMPFRP FVGMPVPPGV RTPPEPTLGK VLDSQEATVD SSSTPASRDA AWYEIPTQFH THTYADGTPQ SRSASLAKAT KYIH GMPHN MGQLYSYHRP Y

UniProtKB: DNAj-like protein

Macromolecule #57: SpoU_methylase domain-containing protein

• Macromolecule: Name: SpoU_methylase domain-containing protein / type: protein_or_peptide / ID: 57 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 63.872289 KDa

Sequence

String:

MGEQRSVARM SKSAYRHPLA PKDPSQRNVT IPIRASRAAA SASSSSASAA LSAEDLKKQA QKVLLLQMQQ KVLWEGTVID DVNHALVQH FLKLSTNDKY RQARQMLVIG GRAMIEELCR AGHRPRHLMV ECGKPIPEFL HDRRKTDVVL VDRSVSVAVT P GSDGYVGD FAIPTPPMKE KLIANHQRLN RVLVLDNIED PGVLGTLLRT ASGYQYDAII ATNHCADLYD HRVVRAARGA HF QTSVPIY TLKDEDGDDV YGLLNHIVER NNLLPLCYIA QADAAGVDGE TAGTQTGFVS SPEAPVGRVF RSSVVGAAPV PLP APRQSD SSYAASLSRE LASVSQAREE LLSDFCLDRF TGASSAEDDA RSGYILFAGP NHKRNMLRRL ERSLSRRSTR LLLD SLPSP SEAPSDLLIA MSVVLYTLRP RGNWDYLPVD TKHEHSTLDL QAKHASVDIG VNRLRVSVDD INLDEAEQQD RAHEA NEFM RWRRLARRRG SDYDHWMAAE QRRVQAMVRR ERQRRVAPWM PLRDAKTKPM PDWVPNIIDE YRQSLDRDAL ARERDI STS YQRPPR

UniProtKB: tRNA/rRNA methyltransferase SpoU type domain-containing protein

Macromolecule #58: Pseudouridylate synthase-like protein

• Macromolecule: Name: Pseudouridylate synthase-like protein / type: protein_or_peptide / ID: 58 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 47.450383 KDa

Sequence

String:

MRRLFLLLAW QPSFAKHLSE LEPVPQRAPV EKRRRQHIPL SLQAREELSR KSNELQYHVV TQDWFGQRVD DFVTQHHPEW DYETVKRLV QQGHIYRYRK NGKKRYTRLT DRLEFDELVV VPTASFWERQ LAPPSGVELQ SSSTSQQQER RQKFHLSAKT R EMAQEMVL FKNEHVIVIN KPSGVPIMPT HDPLAMNITD LLPAWRYTNT QTPVICHNLD TETSGCVVLA RSANTHRMLG RM FVKRVVP NSVYWGFAVG KPPVNFGRIR MHFEVQKGQG GDVIVARPTP TADSKVGIAE FVVNASALEF GSFISFYPLT TRR HQERIM AAHALRAPLL GDAKYGGESA FPHSLSLFWD PARKDVPLHL HHRKIQLPYK NGAGEFVCVT APLPPHMEKT FKRL GWPVD ADDPLIPG

UniProtKB: Pseudouridylate synthase-like protein

Macromolecule #59: Acyl carrier protein

• Macromolecule: Name: Acyl carrier protein / type: protein_or_peptide / ID: 59 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 16.629881 KDa

Sequence

String:

MQRQVIRRLG NRSAFPLVAA VARSSQIRGA VRGDSGSRAR VIPSFMCSLR AYSGGHHEEP SSRSGQYLLD KSDVLTRVLE VVKNFEKVD ASKVTPESHF VKDLGLNSLD VVEVVFAIEQ EFILDIPDHD AEKIQSIPDA VEYIAQNPMA K

UniProtKB: Acyl carrier protein

Macromolecule #60: L0R8F8

• Macromolecule: Name: L0R8F8 / type: protein_or_peptide / ID: 60 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 14.783156 KDa

Sequence

String:

MPLCASPVRL QLCRTPSVLG AGGKWWKEGP PDYTRANRRR MELEQQRIES SQHLPPIEPT AEQACHLYRR LLKEGYKTLV VTDKDFYRR KVRYELEVTS RQTSSRVRGI MFEKGHWMLE NKLGGII

UniProtKB: Uncharacterized protein

Macromolecule #61: G domain-containing protein

• Macromolecule: Name: G domain-containing protein / type: protein_or_peptide / ID: 61 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 51.661969 KDa

Sequence

String:

MRATLRQCNV FDPAFMRKVK RTLSAYKGSM ETSAKKSMSR EAFVDIDEKG AAWYLGHMQS AANMLADKVK DADFILEIRD ARLPFTTEN PNIRKLTAGK PRLIIFNKAE LSNEDSNRAI QEYYERNGAF ALFTSARRCW RDVVEAVQRF TTHILPPLPY K TVAHVGLV VGMPNVGKST LINSLRLAHE YQFHREDFRR SRSPETVSIT PGTTRGMKLV PLSKDPPVVL YDTPGLTLPG CF TKESGLK LAACGIIPTN DVSLPQGMVA RYIYDILVAS GSSEHMAECL HLPRVPISFD DCVAMICERS GTSGQTEMGN LDP VRAHRF FVHDFIMGNL GKITLDVLPR RLLRSSQSSI PLLESGSSTA ATDGAQAAAG DDDGYAWTHH VETSDVVERY PDHM RDVLQ SLKGPLHHDG VPRRHQAPSV KNLDSPSDCT VISRKKGPIS RVTAFDEQLK RHTRLTPGR

UniProtKB: G domain-containing protein

Macromolecule #62: GTPase Der

• Macromolecule: Name: GTPase Der / type: protein_or_peptide / ID: 62 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 56.550797 KDa

Sequence

String:

MEDTARTDEQ RRRVAGWTPV VKTLGDHRLR VAIVGRMNSG KSSLFNLLCE DPTMPAKKNI VKDFNGITRD CVEAHAALDD LHFTVIDTP GLLGGKLVEE AFRTVETADA AIFVTAVDED VSAEEHDLIQ YLAAKKMPTC LLVNKMDLVP EEEEALVLDV Y NRLGLGKA VPFSARKREG LDMLSALLEP LYHIHAMRKV ENDWDIEDLA MAGDEAAMEE IRDRNCTDRY IRVAIVGRTN SG KTSLVNR LVGYERNRAA DESNTTRDPI EIACMYKGRK LKLIDTAGLA RQRYRTDREF LSRIHSLSLN EIRYAHVVIV VFD ATEGHP NKYDMSILHK VAQEGRPFVL CANKWDAVLD QSATAEAIDF KIKRQVQEVK YSNAVVVSAH TGMNLTLLMD QVLE LYDTW NKRVRRSELT KFWRKLEKSV IIPYHVARVG RITQISTRPP TFLLQLQTKK EESQLPKALQ EMMKNAITEE FGFRG VPLR LVQEVKDSNP DYI

UniProtKB: GTPase Der

Macromolecule #63: DEAD/DEAH box helicase-like protein

• Macromolecule: Name: DEAD/DEAH box helicase-like protein / type: protein_or_peptide / ID: 63 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 87.394422 KDa

Sequence

String:

MAVASTRLPT VGCSCSVATL AYSRTYVRSS NTRSTGSSSG SIISSSLPWS QHRCQVRTLI VPRQLKAYGG TFSQSIGERV DHAASHQVL QSLSPARTAQ SPLLAKPVKT KVVDNFADML VTPALQEALA DMGVSTPSPI QQTAIEAVLQ RKNTVIAAPH G EGKTLAYL LPLYQNMEKD RDVYKIPLRE RRPRMILLAP TKELVEQLQT VCARLDAATG LTSVCFTSRK RSKYHLSRML KN TMADVLV MDPKLILRLL RTRRLFIEDL RYFAVDEADA MMSSLHDHDA VQLLMKVQKR NQFKYLWPVQ TQYVFVTAYM TRK LEYIVG RKISDPVTCM FRQLMHRPQA RLRHRFYAIR REPEKFTVLM HLLRKNGHVP LPIDTDVAEV DVHTNPRKLS GSLA EWHEA VQRCAWKEQH EQEKSSGSGE AVTDDVVDVD EVAVRAPEEA SAAVPSVGLS ATENAAADDD YDHDSYARYT LERVR PLHW EHLTTVAAPF TCPIRRTVFA EGRRTIIFFR NIDATTAVFH QLRSAGFAVS LLHASLPYKV RKEMYADFAS GRTNIL CAT DVAARGLDLH VDMVINFDVP TNALAYLSRS GRTARMGREG QVLNLYNKHQ GVIVSAIKAF LKDNLPMEGL TNRKADM MQ PRYAEWRTHK INALARSYVS LITRKTIPAH LERTYVHHNA TWRPVFHPQK TGIHGGVAPR QQQKLMDRVR EQAVWFRR G QLARRKGGRA KFGSRTMKHG VWNDIGGVAS REVVNEAQNP SPAGPNFGPP SGPPQ

UniProtKB: DEAD/DEAH box helicase-like protein

Macromolecule #64: G domain-containing protein

• Macromolecule: Name: G domain-containing protein / type: protein_or_peptide / ID: 64 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 86.927453 KDa

Sequence

String:

MSFATSITCV LFYMLQLSLL LRGALCISYR ALKSAAAAPV AAAGVSAASS RLGGAWEGSI ERAEALENLS NEVFGRGNRH LKNVETLTA LPEGLHSFPE VCFIGKPGCG KSSLISCLLH NHRLGKAGAT AGTTRLLQFF NVGDALLLVD TPGYGGWRGR E VGQRLAEQ ANAFSILFRY LALRNGSNLK RVYWLMESSA PTPVSFQPRD EELLTFLSRE RIPFSVVLTK IDRHWRHYAE QQ RTADRVG NDGFVHPRHR RPETHDQGFF TRTSLPQDGV ARNMQEVYEF LGTDQVPILG VSANRLQPNR SRNLELLQHD IVH YCTQDL LHSEELSFRN MHKLSYAPPT ADRIHEIQLR YPVESFVVPE NNNMSLARMV EHHEEMKARF CENNVCARRL SAKD VAACH LESVAKLKAA CKHDTAERER AEKVRPTATY LFESTLAAAV TSLPLPGDVA GLLRASEAQG TATASVSRVG GLPER WKEC DDHNAEACAA DVCASRRFRV RPLLVGERQT SRDSLGDILE RALDEEEPRQ DFAGSIVDKG EKTANAASPP HCAHAE TTS SSHTLNPVPD EAPVPQPYRV DAVLLQEQPL EALPLPAMLD PDAHYVTAID GTPIPRSMIS VSVEQLAVSK DDELAHF AT KSGAGAYEEL IVADQEKSNA GADLFMETSD VAHLPEEVQT QLEEACARLT RSAARKQKER FLTKYVERKR KERSIYMQ A EGYMCPWLGR SEGRSVVQGF AGSCGTGKGG AVMRDLKQKG FGGKSYSART MKNRGRATKK TGFWAA

UniProtKB: G domain-containing protein

Macromolecule #65: mL78

• Macromolecule: Name: mL78 / type: protein_or_peptide / ID: 65 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 3.422209 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)

Macromolecule #66: U6

• Macromolecule: Name: U6 / type: protein_or_peptide / ID: 66 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 13.309536 KDa

Sequence

String:

AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA A AAAAAAAA AAAAAAAAAA AAAAAAAAA

Macromolecule #67: U1

• Macromolecule: Name: U1 / type: protein_or_peptide / ID: 67 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 3.287594 KDa

Sequence

String:

AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAA

Macromolecule #68: U3

• Macromolecule: Name: U3 / type: protein_or_peptide / ID: 68 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 5.348844 KDa

Sequence

String:

AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAA

Macromolecule #69: U4

• Macromolecule: Name: U4 / type: protein_or_peptide / ID: 69 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 9.684576 KDa

Sequence

String:

AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAA

Macromolecule #70: U5

• Macromolecule: Name: U5 / type: protein_or_peptide / ID: 70 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 6.699318 KDa

Sequence

String:

AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAA AAAAA

Macromolecule #71: mL78

• Macromolecule: Name: mL78 / type: protein_or_peptide / ID: 71 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 33.017754 KDa

Sequence

String:

MILITSNCAR VAAFARKAAC RGALCDRHRC ISGGGRGDLF TRHASAFKPP AFGVLRGLTH SSQTTHPQTG QLRARKLIQH AMHDRTLSG SGHHRTAVAT WSYLLPSLRQ NVEQAVPDTL YEKLLTDEVP LTPAESRQLA DAHRLLRFEL QKRIGLLEDS L ADAALPYL LQWPALFQRA WLRLPMDQGS ASVTDAKRDA VVPAPPSFVH APAALPITEW APTLSPASPS ACSNGLIGRG AL VPRLAQL TRHVIRCVEE DLGRLEHGSE PREDGAPRSR RQVTLEAAWR AQWASLLSWH AGTS

UniProtKB: Uncharacterized protein

Macromolecule #72: U2

• Macromolecule: Name: U2 / type: protein_or_peptide / ID: 72 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 2.647894 KDa

Sequence

String:

AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAA

Macromolecule #77: U8

• Macromolecule: Name: U8 / type: protein_or_peptide / ID: 77 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 4.211603 KDa

Sequence

String:

AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAA

Macromolecule #73: Ribosomal RNA

• Macromolecule: Name: Ribosomal RNA / type: rna / ID: 73 / Number of copies: 1
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 6.061920499999999 MDa

Sequence

String:

UUUCAAAAAU UGACUAAUUU UGAUAUUGUU UUGGCUCUGG ACUAAUUAAU UCUCCUUUAA UUUUAUUAUC UAAAAUUUGC AUACUUACA UAUUAAAGUA GUUAGUUUAG AUAUGAAAAU UAGUUAGAUU UCCAUUUGAA UUAGUUAUGU UAAAUAUAGA A UUAGUUAG GGUUGAUAAU GAAAUCAAUU AAGUUUAUAU AUAAAGUUAG UUAGUCAAUA UGAAUUUUUU UGCAAACAUU UC CGGUUGA CUUCAUGUGA UUACACGUAC UCCGUUUUGU UUUUAUGUGU CAUGAUUUGC AUUGAUUUUU UCGCAACCAC ACC AUAAAU CUAAUAUACU CAACAGCACC UACCAAGAGU UAAAAAUGAA AUUAAAUAAA AAUAAAAAAU AAAAUAAAAA UAAA AUAAA AAUAAAUUUA AAAAUAAAAA UAAGUUUAAA AAAUAAAUUA AAAUAAAAAA UUAUAAAAUG GAAAUUGAAA AAUAA AUUA CAAAUAAAAG AUUAAAUUUG AAUUAAUUAC AGAAAUUAGA CACAACACGC CCGAUCGAUU UCAUGCAUAC ACUUUU ACU UCGUUUUCGG UUUACGUUUU GUUGUUUGUA UUGGCUCGAU GGAUGAAUAU AAAAAGCUUA AAUACAAAAU UUCCAAC AA UUGGAUAAGC AAGAGUUAAA AAAUGAAAUU AAAUAAAAAU AAAAAAUAAA AUAAAAUAAA AUUAAAAUAA AAUAAAAA A UAAAAAAUUA AAAAUAAAAU UAAAAUAAAA AGUUAGAAAA UAAAAAAUUU AAAAAAUAUA AUUUGAAAAA UAAAUUACA AAUAAAAGAU UAAAUUUGAA UUAAUUGCAG ACACUAGACA CACAUUUCCG AUCGAUUUCA CGUAUACAUU UGUACUUCGU UUUUGGUUU AUGUUUUGUU GUUUGCACUG AUCGAGCAAA AUUUUUAUUU UAUAUAUAAU UUAAACUUUU GUUGUUGUUU G UUAGUAAG CAAAAAUAUU UAUGUCAUUU UAAUAUUAUU UAUGUACUUA CUAUUAUUUU GAUAAAUUUU AACUUUAAAU AG CAUAAAA ACUACAAUCA AUAAAGCAUA AAAAAAUUUA UUUAUGAUUA UAUUAAUAUA AAAUGACCUA AUAUAAUGAA AAU ACUUUA GUGUUAAGUU AUUUGUUUUA UUAUGAAAUA AGUUGCACUA UUUAUUGAAU UAAUAAAGAA AGAAUAGAAA UAAA UAAGU UAUAAUAUCU UUAAUUUAUU UAUAAUUUCU UUGCAUUUGU AUUUAGUGUG AGUUUACAUU UAAUUUUAUA UUAUU UUAG UGUUAGUAUA UAUUUAAAUU UAAUCAAAGU UAUUAUUAAA UAAUAUUGAU UUUGGAUGAA UUUAAUUUUU AAUUAU AUU UUUGAAUUUU AAUUUUAUUA UUUUGAUUUA AUAUUUUUAA AAUAUUAUAU AUUUUAGAUU UAAAUUUGUU GUUUUAU AU UUAGUUUAAU GUUUAUAAAU UGAUAAUUAA UUUGUUUUAU UUUAAAGUUU UUAUGAACUG UGAUUUAUAG UUUAUUAU U UUUAGUUUAA UGUUUAAAUA UUUAACUAGU GAUGGCACAG UUGUUCUAUA UGUACCUAUA AAAAAUAGUA AAAUUAUUU UAAUUAAAUU AAUAAAUAAU UAUUAAACUA AUUUUAUAUU AAUAUUAUGA AAAAUUUAAA AAUUAUUUUU UUUUUUUAAU UUUUAUAUA UUGAAGUAAU AUGUAUUGAA UUGAAUAUUA AAAAUACAAA UUUAAUUUGU AAUUAAUAAA UAUAUUUUAU U UUAAUAGA UGUUUAAUGU UAAUUAAUUU AUUAUUUUAA UAUUUAAUAU UUGUUUAUAC AAAAGUAACU UUUUUUGAAU AU AAAGAAU UAUUAUUAUA AAUAUUAUUU UAAAAAUAUA AAAAUAUUGU UAAUAAAAUU AUCAAGUUUC AAAAGCGUUU AUU AAAUGC GUCGGUCUAA GUAUUAUAUU UAAGAUUAUU CUUGUAUAUA GAUUUUUAUU UUAAUAAUUC UACAUAAUUA AAAA UUAAC CUCAAAUUAU AUUUAUUAGU AGCAUAGUAA UUUAUUAACU GAUUAUUAAA GCGUUCCAUA GAAAAUUUUA AAAUU AUAA CAAUCUAAAU AAAUAAUAAA UUAAAAUAAA AAUUUUAAAA AAAAUUAAAA AAUUAAAAUA GGGCAAGUCC UACUCU CCU UUACAAAGAG AACGUUUAUA UGUAAUUGUA UGUUUGAUUG GGGCAAUACU AUAUCUAUUU AUAUAGAAAA AGAACUA UA UUUAUUGAAA UAAUAAAAGG UUCGAGCAGG UUAACAAGCA UUAAUACUAA AUGUGUUUCA UCGUCUACUU AUUGCUAA A UUAUAAUUGA UUGUUCAUCA AAAAAGCAAU UCGUUAGUUG GGUUUUAAAA UCGUUGUAAA GCAGAUUUGU UUAUAUAUU UAAUUUUUGU AUAUAGUUAA AAAUUAAUAU UAGUACGCAA GGAUUCAUUA UUUGUAAUUU AAAUAUAUUA AAUGUUAUUU UAUUAAAUA AAAUAAAAUA AGUCAAUUGU UAUUAUUCAU AUUAAUUUUU UUAAAAGUUU UUUAAUUUUA UAUUAGUUUA U UUGUUUAA AAAGUAUCUA AUUAAUUCAU UAUUUAGGAA UAGUUAAUAA UAAUUUAUAA UUCUGAUUAG AUUUGUUUGU UA AUGCUAU UAAAGGGGUG UGGAAAAAGU GUUAAAUUUU UGAUAUAUUU AAAUAAUAAA UAAAAUAUAA CUUAUUAGUC AGA AAUGGA UGCCAGCCGU UGCGGUAAUU UCUAUGCUUU UAAAUAUUAU ACAUUUAUUU UAUAAAUUUG UUACUAUAUA UUUU UAGUC AAUAAAACUA AUAAUUAUUU UUAUUUGUUU UUAAACACCG UUUGGUAUAU GCAAAUAAAA AAUGACAUUA AUUAU UAAU UAUAUUAUAU UAUAUUUAUU CAUUUAAGUC AACAAUAUCU AUUUACUGUU UUUGACAACA UGAUAAGGAU UAUAAA UGG UAUUGCAAAU UUUAUAAUCA AAACUAAUUU AUUAUAUUAA AUUAGCAUGU UUAGAUAAAA CAAUAAAUUU AGAAGGU AU UGUUGCCCAC CAUUCUUUGU AAUAAAGACA ACGUGCAGUA AUUAAUGUAU UUAUAAAAAU AUAUUUUUUA AUGUUAAA U UUUCGUUGCC UUUUUUAUUA UUUAGAAAAU UUAUGAAUUU AUACAAAUCA AUAAUGAAAA UUAUAGUAUU AUUAUUUAU GAGGAGAAUU UUCGGAAGGA GGGAUUUUCG GACCAGGAAU GUCCAGAGAG GUUUCGGGCA UCAGCGAUUG AUUUUGGGAG AACGGAGCC GCCGAGUGAA AUUUGCCCAG AGCAGAGUCG GGAGAAGAGU GGAUCGACCG AAGAAAAGAC CGUUUUUCGG A AGGGGAGC AGGUCCAACC GAUUUUUUUG CCAACUUGCA CAGGAGGGAG CCAGAAGCGC ACUCAAAGUU AGUUUUGGGA GA UUUGAAG GGAGAAAUUU CCGAGUUUAU UCAUAUAUUU UUUAGUUUGU GUUAGCAAAU UUUGAAAUAC AACUUUUUUG CAA AUUGGA AGAAAACCUC CCAAAUGUAG CUUCCCAAUC UUCCUCUCUA AUCCAUUCCC AACGGUCUUU CCCCCAUCAU CCUC AGAUG UCUCUUCCCC CCCAAAAAAU CCUAAAAAUC CAAGUUCAUC UCGCUCUCUC UCCCCUCAAU UUCCUUAAAA ACUCG CUUC CUAAACUUAU CCCGAAAACC CCGCUCUUCU UCCCUCUAAA UCUUUAUCUC CUCCCCUCCA AAUCUCCCUC AAAUCU CUC CUCUCUUCUC CCGAAACUUU AAUCUUUUUA UUUUAUAAAU AAAUUUGGUA UUUAAAAUAU UAUAAUUAAA UAUUCUA AA UUAUUUAAUA AUAUUAGAAA UGAAUACUUU AUUAAAAUAA UAUUAAUGUG UAAUAUAUUU AAUCAUAUUA GAAUUCCG U UUAAAUUGAA AUAUAUUGAA UUGUAAUUAU CAAUACAAUA UAAGUUAUUA AAUAAUAAUU UAAUUUUAUA UGUUUUAUA AUUGUAAUUA UUUAGUUUUG AAAGUUUAUA UAUAAACAAG AUAUAACCUU UUUAUUUUUU AAUACAAUUU UAAAUGAAAU UUAUGAUUU AUUAUUAUUA AAUAUUACUG GCAGACUACA UGAAAAAUAU AAAAAGGCAU UUGUAUAGGU UUACUUUUGG A CCUCAACA UCCUGCAGCU CAUGGCGUUU UAUGUUGUUU AUUAUAUCUU UCUGGAGAAU AUAUAGUUUA UAUUGAUGUA AU AAUUGGU UAUUUGCAUC GUGGUACAGA AAAGUUAUGU GAAUAUAAAA CUGUAGAACA GUGUUUACCG AUGAAGACUG GAU UAUGUG AGUGUCGUUU GCAACGAGCA UUUACUGUCA UUGUGUUUUG AGUAUAUGUU GAGGUGUUGU CUUGCUAUUC GCUG UGCAU UUAUGCGUUU AUUAAUGUGU GAGUUUACGC GUUGUUUCAA UGGACUUCUU UGUUGCUCUU GUAUGGUUAU GGAUA UAGG AUCAUUGUCG CCAAUGCUUU GAUCGUUUGA AGAACGUGAU AAGUUGAUGA CUUUUUUUGA UUUGUGUUGU GGUUGU AGA AUGCAUUUAG CAUUUAUGUG CUUAUUAGGU UUACUUGAUG AUUUUGUAUU UGGGUUUAUA GAUUUUUUAU UGAUGUU GU GUAUAUCAUG UUUAUUUGUU UUAGAUUUAU AUGAUUUGCU UUUUAUUGGA AAUAGACUUU UAUAUUUGCG UUUGCGCG G GUUAGCAUUU UUUGAUGUUU UUGAUUUAUG UUUUAAUAGU AUAAGUGGUU GUUUGUCUAG AUCGUUGGGU AUGGUAUGA GAUGUUAGAU UAUAUAGUUG UUACGAAUUA UAUUUUAUGU UAGUUUUUGA UUAUUGUUUU UGUUAUUUAG GUGAUGCAUU UGAUAGACU UUUUUUGCGA CUUUUUGAUA UGCGUAUGAG UAUACUUCUA UGUAAACAAU GCUUUUUUGU AGGUUUUUUU G UCUUUGGA UUUGUGUGUU UAUUUGAUUA UAUGUAUGUU GAUGUAACUA UAGAAACUAU AAUUAGUUUA UUUUAUAGUU UA UGAUGUU GCAUAUUACC AGGAUGUUCA UUUGCUAAUG UUGAACAUCC UAAAGGCGAA UACAGUAUUU UUUUAUGUUU UUU AUAUGG AUUUAUAUCA CGUUUACGUA UACGUUGUGC AGAUUUUGUG CAUAUUUGUU UAUUAGAUGU GAUGAUGCGA GGGU UUAUG UUGCACGACU UAGUAGCAGU UAUUGGUAAU GUUGAUGUUG UUUUUGGUUC UGUAGAUCGA UAAGCUAUUU AUUUA UAUA CAAAAAUGAA AGAUGAAUCU AAAAAUUGGU GCGGAGGGGU UUGAUUUUUG UUGGGGUUCU GUCUUACCUG CUAUUU GUA UAGUUUAUUU AACUUUUUGU UUAUGUGGAU UAUUUUGUAU UAUGUUUGGU AGUUUUGUUU UUAUUGAUUA UUGUUUU AU UUGUUUUUUU UCUUGUCUUG UAUUUUGUUU AGUAUGCUUG UUGUGCGAUU UAUUUGUAGA UUCAUUACGG GGUUUGUU U GAUGUUUGUU GUUUUAUACG UUGUAUUCAA UAUUGUUUUG UAUGGUUUAU AAUUAGUGAA UUACUUCUUU UUUUAUCUU UAUUUUAUGU AGUUUUCAGU UUAGUUUUAU UUGUGAGUGU UGAAUUUGCA UUUGUAUUUG UUAUGCCUAU UAUGUUUAGU UGUUUAAUU UGUGAUUUUG GUUUUGUAUU UUAUUGAUAU UUUAUUGAUA UUUUUAAUUU AUUAAUUAAU ACAUUUUUAU U AUUUGUAA GUGGUUUAUU UGUUAAUUUU GUUUUAUUUU UAUUUUGAUU UCGUUUUUUU UUAUGUGUUU UAUUUAUGUU AU GAGUCGG UAUAUUAUUU GGCUUUUUGU UUAUGUGAAA UCAAGUUUGA GAGUUUUCAU UAUUAUUUGU GACUUGUAGU UGU GGCGUA UUUGGAUCAA UACUUUUUUU AAUCGAUUUA UUGCAUUUUA GUCAUGUCUU UUUAGGUAUA UUUUUGUUAU UUUU AUGUU UUAGUCGUUG UUUUAAUUUU UUAUGUAUGG AUACACGUUU UGUAUUUCUA UAUGUAGUGU GCCUAUAUUG GCAUU UUGU UGAUUGCGUU UGAUUUUUUU UAUUACGAUU UGUAUAUUUU GAUGUUUUAA GUGUGGUUUA CUUAUAUGCA UAAAGG CUC AAUUUUGAAU UUUUAAAUUU UAUUCUAAAA AGCGGAGAGG AAAGAAAAGG CUUUUAACUU CAGGUUGUUU AUUGCGU AU UUAUGGUGUG GGUUUUAGUU UAGGUUUUUU UAUUUGUAUG CAGAUAAUUU GUGGUGUGUG UUUAGCAUGA UUAUUUUU U AGUUGUUUUA UAUGUACUAA UUGAUAUUUU GUUUUAUUUU UGUGAGAUUU UGAUUUGGGA UUUGUAAUAC GAAGCACAC AUAUUUGUUU UACAUCGUUG UUAUUUUUUC UUCUUUAUGU UCAUAUAUUU AAGUGUAUAG UAUUAAUAAU UUUAUUUGAU ACACAUAUU UUAGUAUGGG UGGUAGGUUU UGUGAUAUAU AUAUUUAUAG UAAUAAUAGG UUUUAUUGGC UAUGUUUUAC C AUGUACAA UGAUGUCGUA UUGGGGUUUA ACAGUGUUCA GUAACAUUUU AGCAACUGUC CCAGUUAUUG GUACUUGACU UU GUUAUUG AAUAUGAGGU AGUGAGUAUA UUAAUGAUUU UACAUUGUUA AAAUUACAUG UGUUGCAUGU GCUAUUACCU UUU GUAUUA AUACUUGUAA UAUUUAUGCA UUUGUUUUGU UUACAUUAUU UUAUGAGUUC AGAUGGUUUU UGUGAUCGAU UUGC AUUUU AUUGCGAACG UUUAUGUUUU UGUAUGUGAU UUUAUUUACG AGAUAUGUUU UUGGCUUUUU UGAUAUUAUU UUUUG UAAU UUAUUUUAUU UUUAUAAAUU GAUAUUUUGU UUUUCAUGAA GAAUCUUGAG UUAUAGUUGA UACAUUAAAA ACAUCU GAU AAGAUUCUUC CUGAGUGAUU UUUUUUAUUU UUAUUUGGUU UUUUAAAAGC UGUACCAGAU AAAUUUACUG GUUUAUU AU UAAUGGUUAU UUUAUUAUUU UCCUUAUUUU UGUUUAUAUU AAAUUGCAUA UUAUGAUUUG UUUAUUGUAG AAGUUCAU U GUUGUGAUUU ACAUAUUCAU UAGUUUUAUU UUAUAGUAUA UUUAUGAGUG GUUUUUUAGC ACUGUAUGUU AUAUUAGCA UAUCCUAUAU GAAUGGAAUU ACAAUUUUGA GUGUUGCUUU UGUUUAUGUU AGUUGUAUGU AGAUUAGAUU AAAAAUUUAU AUAUUUUUU AUUAAGCGUU AAUAUAUUAA AUUUUAUUUA GAAUAGUAUU AAUAAUCAAA GGGUUGGAAG AAAUUUGCGA A AGAAAGGG AUCUUAGAAA GGAAAUUUUA GUUUAAGACC GAGAAGGGGA GAAGGGAGAG AGAGAUUCGU GUUAUUUAAU UU UUAUGGA UUAAUUGCGU AUUACUGUAU AACAUAUUUA AAUGUCUAUA UUUUAUUUUG UAUUGUAUUU AUGUAUUAUA UGG CUUUUU UAUUUUGUUU UUGCAUUUUA UUAGAUUUUA UAUUAUUUGG AAGUCUUUUA GUAGGAGAUG CGUUUAUGGA UGUU UUUUU UUUACGUUAU CUAUUAUGCU UUUUGGAGUG UUUUUCAUUA UUAUGUAGAU GUAUAUCUAC UUUUUUACGA AUGUU UUGU AAUCUUUUGU CUUCGCAUUU UUUGAUGCUU AUGUUUUGUG AUUUUGUAUA UUUUUUUAUU GUAUUUCUAU UAUUUU UUU UAAUGUGUGA UAUUAUUUAU UUUAUGAUAU UUUCAUUCGC CAUGCUAUUU UGCAUAAUAU UUUAUUUAUU UUUAUAU GC AUUAGAUAUG UUUUGCGCAU UAUUACAAAU AUUUAUAUUU UGUAAUAUGA UAAUGCAAUU AAUCAUGGAU UUUUUAUU G UUAUUAAUUU UUCAUUAAUU UAUAGAAUUA AAUCGAAUAA GUUAAUUAUA UCAAAAAAUA GUAUAAAUAU ACUACAACU UAAUAUAAAA AAUAGGUUUG AAAAUCGCAC AGUAUGUAAU CGUACAACUC AGAAUCCUAU AAAUUGAUAA GAAAAUAUAA AGAUGUUAA UUAUUAGUCU AAAAUAAAAA AUAUAAAUAA UAACCAACCA UAUUAUUGAA AAGAAAAUAA UACAAAUUCC C AUAUAACU UAAGUGAAGU AGUAAACAAA AUACUUUUAA AAAAAAACCA AAUACUAUUG GAAUAGCACC AAUACAUAAA AA AAUACUU GCUAAUAAUA CACUAAUUAA UAAAUUAUUA AAAAAGCUAA AAAAAAUAAA GUUAAUUAAA AAAUAAUUUU CAU UAUAUU UAAUAUCGAA CAUAUUAUAU ACUAUAAAAA AAUAAUAUAA AAUUAUUAAU AUAAUCAGAC UUAAUGAGUA AAUU AAAUG AAAAUUUAGA UACAUAUAAA AGAUGUAAUU UUUAUUAGAA AUAAAUAUUA AAAAUAAAAA ACUAAAAUUA UUAAC GCUA AGUACAAAUA AAAGACUUAC AAUUGCAAAA CUAUUUAAUC CAAUUAACAC GCAUGUAAUG CAUUGUAUUA UAAUAA GUU UUAUAAAUAU UAUAUAAAAG UAAAUAAAGC AAAUAAGCAA AAUAAUAAGU AUAAAGCAAA AUAAGACAUA AAAUGUU AG CAUGUAGAUA AAUAUAAACA CUCCAAGCCG AAUGUAUAAU UGUUCUAAAA AUAAAAUCAA UAUUGCAAUA UAUAAUUU A AAUAAUAUAA GUAAUAUAUA AAAUAAGCAU AAUAUACCUA AUCAUUCUUC AUCAAAUAUU AGAAAACAAA AAUCACAGA GAUAAAAACA GUAAUUUAGU AACAUAUAAU AUAGCAAGAC AAAUAAUAAU AUAAAGUUUA UUAAAUUUAU CAUAUAAUAA UAUCAUAAU AUUAGUAUUU UAUAACCGAA UCUACUUGAU AUUAAUAUAA GAAAAAGUAA UAAGCUAAAU AAUUCAAAUA G UAUUGAAA UAAAAAGUAU AUGUAUUACA UUUAAAAACA UAAAAAUUAU UAUAUAUUGU AUAAUUAUUA UCAUGAAUAC GA AUCUAGU AUCAAAGUUU AAAAAACAAA AAAGAAAAAA AAAGCAAAAU AAAAAAAGUA GUAAAAAGAU AAAGCAUAUA UAU GAGUCU AAAAUUGUUA GUAUUAUUAU GUUAAUAAUU ACAAUUCAUA UUAAAUCAAA UGAUAAAUAA AAAAGUGAAU UAUA AUCAC AUAAGAUAAU AAAACUAUAA AGUAAUAAAA AUAAUAUUAU AUGUAUUAAG UAUAGAAACA GAAGGAUUUC GAAAG GAGA GGACAGUUUA AGGAUUUUGA GGAGAAAUUU CGAGGGGAAA GGGGGGAACC AGAAGAACAU AGAAGUCAGU UUUCGA UAU UAAAAUAAUA UAGCAAUUAU UUUUGUAGUG AACAGUCAAA UAAAAGUAAG AACGCACAUG UAGAAUAAAA AAAUAAG UA UAAAUGCUUG CGCUGUUGUA AUUUUUAGUC UAUAACCAAU UACCCUUGGA UAAAAAAACC CAAUAAUUAA GAUAAUUA U AGCUUUAAAA CAUAUAAAUA AGCCCCCAAA ACAGAGACUG GCUAAUAAUA AUGUUGUCAG UAACACAUGA UUUAUUUCA AGAACGGAAU AUAAUAUAAA AAAGAAUCCU GAUAGUUCUG UAAUCAACCC AGCGACUAAU UCACUUUCAC AUUCCAUAUA GUCGAAUGG UAGUUUUAAU CCGUCUAGAA GCAUACUUAU UCAAAAUAUA CAUACAAAUA AGAUGCCGGC AAUAUAAAAG U UUGUAAUA UAAAUCUGCC CAACACAAAU GUCUUUAAUG CAAAAAAAGC UAAAGUAGUC UAACGAAUAU ACAGUUGUGU AU AAUAAAA AUAAGCCACU UUCAGAAAUA AUACUAAAAA ACAUAGUGCG CAUUGCAGAA AGAUAUACAA AGCAACUAGA GAA UAAAAA GCAACCUACA AAAAAUGUGC UAAACAUAUU ACUGAAAACA UGUACGCACA UCAUUAUUGU AAUAGUGAAU CCUG UGUCU AAUAACAGUA UAAAACCUAU AGGAAAAUAA AACCAACCAA UAAAAAUGCA GCAUGUAGUA AUUAACAUUG CACCU AUUA AGUAAAUGAU UUCAAAACUA AUUACAAAAA UGAUAAAUUU AAUAAAAAGU UUUAUUCCGU CAGUUAUUGG UGUUAA AAU UCCAAAAAAA CAAAGGGCCG GACCUAUUCG UAUUUGAACU AAAGCUAAAA UUCUUCUUUC ACAAAGACUU ACAAAGC CG GUCAAGACAA GAACAACUAA AAUGUCAAUA AUAAUAAUGA UAAUAAUAUC UAUAUUUAAC AUUUUUAAUU AUGGCUUU U AUUUUAUCAU UUUGAAUGAU UUUUUUACUG GAUUCUGUAA UUGUUUUAUU AUCUUUUGUG UGUUUUGUAU GUAUAUGGA UAUGCGCUUU AUUAUUUUCA GCAUGUUUAU UAGUGUCGAA AUUAAAUAAU GUUUAUUGUA CUUGGGAUUU CACGGCAUCU AAGUUUAUU GAUGUGUAUU GAUUCAUUAU UGGAGGUAUG UUUUCAUUAG GACUUUUACU UAGGUUAUGU UUGUUAUUAU A UUUUGGUC AUUUAAAUUU UGUUAGUUUU GAUUUAUGCA AAGUUGUUGG AUUUCAAUGG UAUUGAGUCU AUUUUAUUUU UG GAGAAAC AACAAUAUUU AGUAAUUUAA UUUUGGAAAG UGAUUAUAUG AUUGGUGAUU UACGUUUAUU ACAGUGUAAU CAU GUUUUA ACUUUAUUAA GUUUAGUUAU AUAUAAAUUA UGAUUAUCUG CUGUUGAUGU UAUACAUUCA 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AUAUU AUUA UUAUAUUAUU AUAUUAUCAU UAUUAUUAGA AUAUUUACUA AUAUAUAUAU AUAUCUAUAU CAAGCUUGUU AGAAAA AAC UAUGUUUUUU CUAACAAGAU UGAUACUCUC GGUAUGG

Macromolecule #74: R1

• Macromolecule: Name: R1 / type: rna / ID: 74 / Number of copies: 1
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 896.58 Da

Sequence

String:

AUU

Macromolecule #75: R2

• Macromolecule: Name: R2 / type: rna / ID: 75 / Number of copies: 1
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 10.670844 KDa

Sequence

String:

UUUUUUUUUU UUUUUUUUUU UUUUUUUUUU UUUUU

Macromolecule #76: R5

• Macromolecule: Name: R5 / type: rna / ID: 76 / Number of copies: 1
• Source (natural): Organism: Leishmania tarentolae (eukaryote)
• Molecular weight: Theoretical: 1.485872 KDa

Sequence

String:

UUUUU

Macromolecule #78: GUANOSINE-5'-TRIPHOSPHATE

• Macromolecule: Name: GUANOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 78 / Number of copies: 1 / Formula: GTP
• Molecular weight: Theoretical: 523.18 Da

Chemical component information

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

Macromolecule #79: ADENOSINE-5'-TRIPHOSPHATE

• Macromolecule: Name: ADENOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 79 / Number of copies: 1 / Formula: ATP
• Molecular weight: Theoretical: 507.181 Da

Chemical component information

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

Experimental details

Structure determination

• Method: cryo EM
• Processing: single particle reconstruction
• Aggregation state: particle

Sample preparation

• Buffer: pH: 7
• Grid: Model: Quantifoil R2/2 / Material: COPPER / Support film - Material: CARBON / Support film - topology: CONTINUOUS / Support film - Film thickness: 2
• Vitrification: Cryogen name: ETHANE / Instrument: FEI VITROBOT MARK IV

Electron microscopy

• Microscope: FEI TALOS ARCTICA
• Image recording: Film or detector model: FEI FALCON III (4k x 4k) / Detector mode: INTEGRATING / Average electron dose: 60.0 e/Ų
• Electron beam: Acceleration voltage: 200 kV / Electron source: FIELD EMISSION GUN
• Electron optics: Illumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD
• Experimental equipment: Model: Talos Arctica / Image courtesy: FEI Company

Image processing

• Startup model: Type of model: PDB ENTRY
• Final reconstruction: Resolution.type: BY AUTHOR / Resolution: 3.4 Å / Resolution method: FSC 0.143 CUT-OFF / Number images used: 59200
• Initial angle assignment: Type: MAXIMUM LIKELIHOOD / Software - Name: RELION
• Final angle assignment: Type: MAXIMUM LIKELIHOOD / Software - Name: RELION