ribonuclease P activity / tRNA 5'-leader removal / ribosomal small subunit binding / translational termination / translational initiation / ribosome biogenesis / small ribosomal subunit / tRNA binding / oxidoreductase activity / rRNA binding ...ribonuclease P activity / tRNA 5'-leader removal / ribosomal small subunit binding / translational termination / translational initiation / ribosome biogenesis / small ribosomal subunit / tRNA binding / oxidoreductase activity / rRNA binding / ribosome / structural constituent of ribosome / ribonucleoprotein complex / iron ion binding / translation / ATP hydrolysis activity / zinc ion binding / ATP binding / cytoplasm 類似検索 - 分子機能
Ribosomal protein L7Ae, prokaryotes / : / Small zinc finger protein HVO_2753-like, zinc-binding pocket / Small zinc finger protein HVO_2753-like / Small zinc finger protein HVO_2753-like, Zn-binding pocket / Ribosomal protein S27ae / Ribosomal protein S9, archaeal / Ribosomal protein S13, archaeal / Ribosomal protein S17, archaeal / Ribosomal protein S6e, archaeal ...Ribosomal protein L7Ae, prokaryotes / : / Small zinc finger protein HVO_2753-like, zinc-binding pocket / Small zinc finger protein HVO_2753-like / Small zinc finger protein HVO_2753-like, Zn-binding pocket / Ribosomal protein S27ae / Ribosomal protein S9, archaeal / Ribosomal protein S13, archaeal / Ribosomal protein S17, archaeal / Ribosomal protein S6e, archaeal / Ribosomal protein S4, archaeal / Ribosomal protein S12, archaea / Ribosomal protein S3, archaeal / 30S ribosomal protein S3Ae / Ribosomal protein S7, archaeal / Ribosomal protein S19e, archaeal / Ribosomal protein S11, archaeal / Ribosomal protein S2, archaeal / Ribosomal protein S14, type Z, archaeal / RLI1 / Ribosomal protein S8e, archaeal / RNase L inhibitor RLI-like, possible metal-binding domain / Possible Fer4-like domain in RNase L inhibitor, RLI / Ribosomal protein L7Ae, archaea / 4Fe-4S binding domain / Ribosomal protein S5, eukaryotic/archaeal / Ribosomal protein S19e, conserved site / Ribosomal protein S19e signature. / S27a-like superfamily / Ribosomal protein S10, eukaryotic/archaeal / Ribosomal protein S27a / Ribosomal protein S2, eukaryotic/archaeal / Ribosomal protein S27a / Ribosomal protein S27a / Ribosomal protein S17e, conserved site / Ribosomal protein S17e signature. / 40S ribosomal protein S29/30S ribosomal protein S14 type Z / Ribosomal protein S3, eukaryotic/archaeal / Ribosomal protein S19e / Ribosomal protein S3Ae, conserved site / Ribosomal protein S19e / Ribosomal protein S3Ae signature. / Ribosomal_S19e / Ribosomal protein S27e signature. / Ribosomal protein S4e, N-terminal, conserved site / Ribosomal protein S4e signature. / Ribosomal protein S19A/S15e / Ribosomal protein S8e, conserved site / Ribosomal protein S8e signature. / Ribosomal protein S17e / Ribosomal protein S17e-like superfamily / Ribosomal S17 / Ribosomal protein S4e, N-terminal / RS4NT (NUC023) domain / Ribosomal S24e conserved site / Ribosomal protein S24e signature. / Ribosomal protein S4, KOW domain / Ribosomal protein S4e / Ribosomal protein S4e, central region / Ribosomal protein S4e, central domain superfamily / Ribosomal family S4e / Ribosomal protein S27, zinc-binding domain superfamily / Ribosomal protein S24e / Ribosomal protein S23, eukaryotic/archaeal / Ribosomal protein S24e / Ribosomal protein S27 / Ribosomal protein S27 / Ribosomal protein S8e / Ribosomal protein S17, archaeal/eukaryotic / Ribosomal protein S3Ae / Ribosomal protein S28e conserved site / Ribosomal S3Ae family / Ribosomal protein S28e signature. / Ribosomal S3Ae family / Ribosomal protein S28e / Ribosomal protein S28e / Ribosomal protein S6e / Ribosomal protein S5/S7, eukaryotic/archaeal / Ribosomal protein S6e / Ribosomal protein S6e / Ribosomal protein S13/S15, N-terminal / Ribosomal protein S15P / Ribosomal S13/S15 N-terminal domain / Ribosomal S13/S15 N-terminal domain / Ribosomal protein S4/S9, eukaryotic/archaeal / Ribosomal protein L7Ae conserved site / Ribosomal protein L7Ae signature. / Ribosomal protein S8e/ribosomal biogenesis NSA2 / Ribosomal protein S8e / 4Fe-4S ferredoxin, iron-sulphur binding, conserved site / 4Fe-4S ferredoxin-type iron-sulfur binding region signature. / 4Fe-4S ferredoxin-type iron-sulfur binding domain profile. / 4Fe-4S ferredoxin-type, iron-sulphur binding domain / Ribosomal protein L7Ae/L8/Nhp2 family / Ribosomal protein S14/S29 / Ribosomal protein L7Ae/L30e/S12e/Gadd45 / Ribosomal protein L7Ae/L30e/S12e/Gadd45 family / Ribosomal protein S19, bacterial-type / ABC transporter / ABC transporter-like, ATP-binding domain 類似検索 - ドメイン・相同性
ATPase / 30S ribosomal protein S2 / 30S ribosomal protein S27e / 30S ribosomal protein S9 / 30S ribosomal protein S13 / 30S ribosomal protein S8 / 30S ribosomal protein S11 / 30S ribosomal protein S3 / 30S ribosomal protein S4 / 30S ribosomal protein S14 type Z ...ATPase / 30S ribosomal protein S2 / 30S ribosomal protein S27e / 30S ribosomal protein S9 / 30S ribosomal protein S13 / 30S ribosomal protein S8 / 30S ribosomal protein S11 / 30S ribosomal protein S3 / 30S ribosomal protein S4 / 30S ribosomal protein S14 type Z / 30S ribosomal protein S4e / 30S ribosomal protein S17 / RNA-binding protein / 30S ribosomal protein S27ae / 30S ribosomal protein S24e / 30S ribosomal protein S15 / 30S ribosomal protein S3Ae / 30S ribosomal protein S28e / 50S ribosomal protein L7Ae / 30S ribosomal protein S17e / LSU ribosomal protein L41E / 30S ribosomal protein S6e / 30S ribosomal protein S10 / 30S ribosomal protein S8e / 30S ribosomal protein S12 / 30S ribosomal protein S7 / 30S ribosomal protein S19P / 30S ribosomal protein S5 / 30S ribosomal protein S19e / RNase L inhibitor 類似検索 - 構成要素
ジャーナル: EMBO J / 年: 2020 タイトル: Molecular analysis of the ribosome recycling factor ABCE1 bound to the 30S post-splitting complex. 著者: Elina Nürenberg-Goloub / Hanna Kratzat / Holger Heinemann / André Heuer / Peter Kötter / Otto Berninghausen / Thomas Becker / Robert Tampé / Roland Beckmann / 要旨: Ribosome recycling by the twin-ATPase ABCE1 is a key regulatory process in mRNA translation and surveillance and in ribosome-associated protein quality control in Eukarya and Archaea. Here, we ...Ribosome recycling by the twin-ATPase ABCE1 is a key regulatory process in mRNA translation and surveillance and in ribosome-associated protein quality control in Eukarya and Archaea. Here, we captured the archaeal 30S ribosome post-splitting complex at 2.8 Å resolution by cryo-electron microscopy. The structure reveals the dynamic behavior of structural motifs unique to ABCE1, which ultimately leads to ribosome splitting. More specifically, we provide molecular details on how conformational rearrangements of the iron-sulfur cluster domain and hinge regions of ABCE1 are linked to closure of its nucleotide-binding sites. The combination of mutational and functional analyses uncovers an intricate allosteric network between the ribosome, regulatory domains of ABCE1, and its two structurally and functionally asymmetric ATP-binding sites. Based on these data, we propose a refined model of how signals from the ribosome are integrated into the ATPase cycle of ABCE1 to orchestrate ribosome recycling.