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- SASDEN4: Protein tyrosine phosphatase SHP2 (Tyrosine-protein phosphatase n... -

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ID or keywords:

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Basic information

Entry
Database: SASBDB / ID: SASDEN4
SampleProtein tyrosine phosphatase SHP2
  • Tyrosine-protein phosphatase non-receptor type 11 (protein), SHP2, Homo sapiens
Function / homologyprotein-tyrosine-phosphatase / Isoform 1 of Tyrosine-protein phosphatase non-receptor type 11
Function and homology information
Biological speciesHomo sapiens (human)
CitationDate: 2018 Dec
Title: Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2
Authors: Pádua R / Sun Y / Marko I / Pitsawong W / Stiller J / Otten R
Contact author
  • RIcardo Padua (Howard Hughes Medical Institute, Department of Biochemistry, Brandeis University)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Models

Model #2376
Type: atomic / Chi-square value: 3.69978692451 / P-value: 0.000001
Search similar-shape structures of this assembly by Omokage search (details)

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Sample

SampleName: Protein tyrosine phosphatase SHP2 / Specimen concentration: 0.89-14.20
BufferName: 50 mM ADA, 2 mM TCEP / pH: 6.5
Entity #1286Name: SHP2 / Type: protein
Description: Tyrosine-protein phosphatase non-receptor type 11
Formula weight: 60.912 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: Q06124-2
Sequence: GSGMTSRRWF HPNITGVEAE NLLLTRGVDG SFLARPSKSN PGDFTLSVRR NGAVTHIKIQ NTGDYYDLYG GEKFATLAEL VQYYMEHHGQ LKEKNGDVIE LKYPLNCADP TSERWFHGHL SGKEAEKLLT EKGKHGSFLV RESQSHPGDF VLSVRTGDDK GESNDGKSKV ...Sequence:
GSGMTSRRWF HPNITGVEAE NLLLTRGVDG SFLARPSKSN PGDFTLSVRR NGAVTHIKIQ NTGDYYDLYG GEKFATLAEL VQYYMEHHGQ LKEKNGDVIE LKYPLNCADP TSERWFHGHL SGKEAEKLLT EKGKHGSFLV RESQSHPGDF VLSVRTGDDK GESNDGKSKV THVMIRCQEL KYDVGGGERF DSLTDLVEHY KKNPMVETLG TVLQLKQPLN TTRINAAEIE SRVRELSKLA ETTDKVKQGF WEEFETLQQQ ECKLLYSRKE GQRQENKNKN RYKNILPFDH TRVVLHDGDP NEPVSDYINA NIIMPEFETK CNNSKPKKSY IATQGCLQNT VNDFWRMVFQ ENSRVIVMTT KEVERGKSKC VKYWPDEYAL KEYGVMRVRN VKESAAHDYT LRELKLSKVG QGNTERTVWQ YHFRTWPDHG VPSDPGGVLD FLEEVHHKQE SIMDAGPVVV HCSAGIGRTG TFIVIDILID IIREKGVDCD IDVPKTIQMV RSQRSGMVQT EAQYRFIYMA VQHYIETLQR RI

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Experimental information

BeamInstrument name: Stanford Synchrotron Radiation Lightsource (SSRL) BL4-2
City: Stanford, CA / 国: USA / Type of source: X-ray synchrotron / Wavelength: 0.1127 Å / Dist. spec. to detc.: 1.65 mm
DetectorName: Rayonix MX225-HE
Scan
Title: Protein tyrosine phosphatase SHP2 / Measurement date: Mar 28, 2016 / Storage temperature: 4 °C / Cell temperature: 20 °C / Exposure time: 1 sec. / Number of frames: 10 / Unit: 1/A /
MinMax
Q0.0141 0.35
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 301 /
MinMax
Q0.0158844 0.297825
P(R) point1 301
R0 88.7
Result
Experimental MW: 55.6 kDa / Type of curve: merged
P(R)GuinierGuinier error
Forward scattering, I0121.1 121.13 0.25
Radius of gyration, Rg2.69 nm2.685 nm0.043

MinMax
D-8.87
Guinier point3 38

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