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- SASDDA5: Neurexin 1a L5L6 with ss6 insert (L5L6ss6) -

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ID or keywords:

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Basic information

Entry
Database: SASBDB / ID: SASDDA5
SampleNeurexin 1a L5L6 with ss6 insert
  • Neurexin 1a L5L6 with ss6 insert (protein), L5L6ss6, Homo sapiens
Function / homology
Function and homology information


gephyrin clustering involved in postsynaptic density assembly / neuroligin clustering involved in postsynaptic membrane assembly / postsynaptic density protein 95 clustering / postsynaptic membrane assembly / vocal learning / neuroligin family protein binding / positive regulation of synapse maturation / neuron cell-cell adhesion / vocalization behavior / neurotransmitter secretion ...gephyrin clustering involved in postsynaptic density assembly / neuroligin clustering involved in postsynaptic membrane assembly / postsynaptic density protein 95 clustering / postsynaptic membrane assembly / vocal learning / neuroligin family protein binding / positive regulation of synapse maturation / neuron cell-cell adhesion / vocalization behavior / neurotransmitter secretion / acetylcholine receptor binding / positive regulation of synapse assembly / Neurexins and neuroligins / adult behavior / social behavior / neuromuscular process controlling balance / Non-integrin membrane-ECM interactions / positive regulation of excitatory postsynaptic potential / calcium channel regulator activity / cell adhesion molecule binding / synapse assembly / positive regulation of synaptic transmission, glutamatergic / learning / axon guidance / cell projection / signaling receptor activity / presynaptic membrane / chemical synaptic transmission / nuclear membrane / vesicle / neuronal cell body / calcium ion binding / nucleolus / cell surface / endoplasmic reticulum / plasma membrane
Similarity search - Function
Syndecan/Neurexin domain / Syndecan domain / Neurexin/syndecan/glycophorin C / putative band 4.1 homologues' binding motif / : / Laminin G domain / Laminin G domain profile. / Laminin G domain / Laminin G domain / EGF-like domain ...Syndecan/Neurexin domain / Syndecan domain / Neurexin/syndecan/glycophorin C / putative band 4.1 homologues' binding motif / : / Laminin G domain / Laminin G domain profile. / Laminin G domain / Laminin G domain / EGF-like domain / EGF-type aspartate/asparagine hydroxylation site / Aspartic acid and asparagine hydroxylation site. / Epidermal growth factor-like domain. / EGF-like domain profile. / EGF-like domain / Concanavalin A-like lectin/glucanase domain superfamily
Similarity search - Domain/homology
Biological speciesHomo sapiens (human)
CitationDate: 2018 Sep
Title: Structural Plasticity of Neurexin 1α: Implications for its Role as Synaptic Organizer
Authors: Liu J / Misra A / Reddy S / White M / Ren G
Contact author
  • Mark White (University of Texas Medical Branch, Texas, USA)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Models

Model #1889
Type: mix / Radius of dummy atoms: 1.90 A / Symmetry: P1 / Chi-square value: 3.23 / P-value: 0.000001
Search similar-shape structures of this assembly by Omokage search (details)

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Sample

SampleName: Neurexin 1a L5L6 with ss6 insert / Specimen concentration: 2.00-4.00
BufferName: 20 mM HEPES pH 8, 150 mM NaCl, 0.5mM CaCl2 / pH: 8 / Comment: N1a Buffer
Entity #1015Name: L5L6ss6 / Type: protein / Description: Neurexin 1a L5L6 with ss6 insert / Formula weight: 45.5 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: Q9ULB1
Sequence: ADPVTFKTKS SYVALATLQA YTSMHLFFQF KTTSLDGLIL YNSGDGNDFI VVELVKGYLH YVFDLGNGAN LIKGSSNKPL NDNQWHNVMI SRDTSNLHTV KIDTKITTQI TAGARNLDLK SDLYIGGVAK ETYKSLPKLV HAKEGFQGCL ASVDLNGRLP DLISDALFCN ...Sequence:
ADPVTFKTKS SYVALATLQA YTSMHLFFQF KTTSLDGLIL YNSGDGNDFI VVELVKGYLH YVFDLGNGAN LIKGSSNKPL NDNQWHNVMI SRDTSNLHTV KIDTKITTQI TAGARNLDLK SDLYIGGVAK ETYKSLPKLV HAKEGFQGCL ASVDLNGRLP DLISDALFCN GQIERGCEVA LMKADLQGPS TTCQEDSCSN QGVCLQQWDG FSCDCSMTSF SGPLCNDPGT TYIFSKGGGQ ITYKWPPNDR PSTRADRLAI GFSTVQKEAV LVRVDSSSGL GDYLELHIHQ GKIGVKFNVG TDDIAIEESN AIINDGKYHV VRFTRSGGNA TLQVDSWPVI ERYPAGRQLT IFNSQATIII GGKEQGQPFQ GQLSGLYYNG LKVLNMAAEN DANIAIVGNV RLVGEVPSAS TSHHHHHH

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Experimental information

BeamInstrument name: Sealy Center For Structural Biology, UTMB-G Rigaku BioSAXS-1000
City: Galveston, TX / 国: USA / Type of source: X-ray in house / Wavelength: 0.15418 Å / Dist. spec. to detc.: 0.4838 mm
DetectorName: Rigaku BioSAXS-1000 / Type: Kratky-2D / Pixsize x: 0.001 mm
Scan
Title: Neurexin 1a L5L6 with ss6 insert / Measurement date: Sep 26, 2016 / Storage temperature: 10 °C / Cell temperature: 10 °C / Exposure time: 10 sec. / Number of frames: 3 / Unit: 1/A /
MinMax
Q0.018 0.6797
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 292 /
MinMax
Q0.017974 0.43297
P(R) point1 292
R0 124
Result
Type of curve: merged
ExperimentalStandardStandard errorPorod
MW33.4 kDa45.1 kDa0.1 44 kDa
Volume---70 nm3

P(R)P(R) errorGuinierGuinier error
Forward scattering, I045190 193 45109 137
Radius of gyration, Rg3.33 nm0.02 3.24 nm0.1

MinMaxError
D-12.4 0.5
Guinier point1 10 -

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