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- PDB-7kzp: Structure of the human Fanconi anaemia Core complex -

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Basic information

Entry
Database: PDB / ID: 7kzp
TitleStructure of the human Fanconi anaemia Core complex
Components
  • (Fanconi anemia core complex-associated protein ...) x 2
  • (Fanconi anemia group ...) x 6
  • E3 ubiquitin-protein ligase FANCL
KeywordsLIGASE / Complex
Function / homology
Function and homology information


regulation of germ cell proliferation / regulation of CD40 signaling pathway / Fanconi anaemia nuclear complex / regulation of regulatory T cell differentiation / male meiotic nuclear division / gamete generation / neuronal stem cell population maintenance / replication-born double-strand break repair via sister chromatid exchange / brain morphogenesis / myeloid cell homeostasis ...regulation of germ cell proliferation / regulation of CD40 signaling pathway / Fanconi anaemia nuclear complex / regulation of regulatory T cell differentiation / male meiotic nuclear division / gamete generation / neuronal stem cell population maintenance / replication-born double-strand break repair via sister chromatid exchange / brain morphogenesis / myeloid cell homeostasis / female gonad development / protein monoubiquitination / germ cell development / spermatid development / negative regulation of double-strand break repair via homologous recombination / positive regulation of double-strand break repair via homologous recombination / interstrand cross-link repair / ovarian follicle development / removal of superoxide radicals / mitochondrion organization / TP53 Regulates Transcription of DNA Repair Genes / nucleotide-excision repair / Fanconi Anemia Pathway / RING-type E3 ubiquitin transferase / response to radiation / PKR-mediated signaling / ubiquitin-protein transferase activity / male gonad development / ubiquitin protein ligase activity / nuclear envelope / chromosome / regulation of cell population proliferation / cellular response to oxidative stress / regulation of inflammatory response / protein-containing complex assembly / damaged DNA binding / nuclear body / intracellular membrane-bounded organelle / DNA repair / centrosome / DNA damage response / ubiquitin protein ligase binding / chromatin / nucleolus / mitochondrion / DNA binding / nucleoplasm / nucleus / metal ion binding / plasma membrane / cytosol / cytoplasm
Similarity search - Function
Fanconi anaemia group C protein / Fanconi anemia-associated protein of 100kDa / Fanconi anemia group B protein / Fanconi anemia group G protein / Fanconi anaemia group C protein / Fanconi anemia-associated / Fanconi Anaemia group E protein, C-terminal / Fanconi anemia group F protein / FANCF, C-terminal domain superfamily / Fanconi anemia group E protein ...Fanconi anaemia group C protein / Fanconi anemia-associated protein of 100kDa / Fanconi anemia group B protein / Fanconi anemia group G protein / Fanconi anaemia group C protein / Fanconi anemia-associated / Fanconi Anaemia group E protein, C-terminal / Fanconi anemia group F protein / FANCF, C-terminal domain superfamily / Fanconi anemia group E protein / Fanconi anemia group F protein (FANCF) / Fanconi Anaemia group E protein FANCE / Fanconi anaemia group A protein / Fanconi anaemia group A protein, N-terminal domain / Fanconi anaemia group A protein / Fanconi anaemia group A protein N terminus / Fanconi anemia complex, subunit FancL, WD-repeat containing domain / E3 ubiquitin-protein ligase FANCL / FANCL C-terminal domain / FANCL, UBC-like domain 3 superfamily / FANCL, UBC-like domain 2 / FANCL, UBC-like domain 3 / FANCL UBC-like domain 1 / FANCL C-terminal domain / FANCL UBC-like domain 2 / FANCL UBC-like domain 3 / FANCL C-terminal domain / Ubiquitin-conjugating enzyme/RWD-like / Tetratricopeptide repeats / Tetratricopeptide repeat / Tetratricopeptide-like helical domain superfamily / Zinc finger, RING/FYVE/PHD-type
Similarity search - Domain/homology
Fanconi anemia group G protein / Fanconi anemia group A protein / Fanconi anemia group C protein / Fanconi anemia core complex-associated protein 100 / Fanconi anemia group B protein / Fanconi anemia group E protein / Fanconi anemia group F protein / E3 ubiquitin-protein ligase FANCL
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodELECTRON MICROSCOPY / single particle reconstruction / cryo EM / Resolution: 3.1 Å
AuthorsWang, S.L. / Pavletich, N.P.
Funding support United States, 1items
OrganizationGrant numberCountry
Howard Hughes Medical Institute (HHMI) United States
CitationJournal: Nat Struct Mol Biol / Year: 2021
Title: Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.
Authors: Shengliu Wang / Renjing Wang / Christopher Peralta / Ayat Yaseen / Nikola P Pavletich /
Abstract: The Fanconi anemia (FA) pathway is essential for the repair of DNA interstrand crosslinks. Central to the pathway is the FA core complex, a ubiquitin ligase of nine subunits that monoubiquitinates ...The Fanconi anemia (FA) pathway is essential for the repair of DNA interstrand crosslinks. Central to the pathway is the FA core complex, a ubiquitin ligase of nine subunits that monoubiquitinates the FANCI-FANCD2 (ID) DNA clamp. The 3.1 Å structure of the 1.1-MDa human FA core complex, described here, reveals an asymmetric assembly with two copies of all but the FANCC, FANCE and FANCF subunits. The asymmetry is crucial, as it prevents the binding of a second FANCC-FANCE-FANCF subcomplex that inhibits the recruitment of the UBE2T ubiquitin conjugating enzyme, and instead creates an ID binding site. A single active site then ubiquitinates FANCD2 and FANCI sequentially. We also present the 4.2-Å structures of the human core-UBE2T-ID-DNA complex in three conformations captured during monoubiquitination. They reveal the core-UBE2T complex remodeling the ID-DNA complex, closing the clamp on the DNA before ubiquitination. Monoubiquitination then prevents clamp opening after release from the core.
History
DepositionDec 10, 2020Deposition site: RCSB / Processing site: RCSB
Revision 1.0Mar 10, 2021Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2021Group: Database references / Category: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name
Revision 1.2Mar 6, 2024Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

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Structure visualization

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  • Deposited structure unit
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  • Superimposition on EM map
  • EMDB-23085
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Structure viewerMolecule:
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Assembly

Deposited unit
A: Fanconi anemia group A protein
B: Fanconi anemia group B protein
C: Fanconi anemia group C protein
E: Fanconi anemia group E protein
F: Fanconi anemia group F protein
G: Fanconi anemia group G protein
H: Fanconi anemia group G protein
L: E3 ubiquitin-protein ligase FANCL
M: E3 ubiquitin-protein ligase FANCL
O: Fanconi anemia group B protein
P: Fanconi anemia core complex-associated protein 100
Q: Fanconi anemia core complex-associated protein 100
S: Fanconi anemia group A protein
W: Fanconi anemia core complex-associated protein 20
hetero molecules


Theoretical massNumber of molelcules
Total (without water)1,134,15217
Polymers1,133,95614
Non-polymers1963
Water00
1


  • Idetical with deposited unit
  • defined by author
  • Evidence: microscopy
TypeNameSymmetry operationNumber
identity operation1_5551

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Components

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Fanconi anemia group ... , 6 types, 9 molecules ASBOCEFGH

#1: Protein Fanconi anemia group A protein / Protein FACA


Mass: 165513.016 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCA, FAA, FACA, FANCH / Production host: Homo sapiens (human) / References: UniProt: O15360
#2: Protein Fanconi anemia group B protein / Protein FACB / Fanconi anemia-associated polypeptide of 95 kDa / FAAP95


Mass: 100640.172 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCB / Production host: Homo sapiens (human) / References: UniProt: Q8NB91
#3: Protein Fanconi anemia group C protein / Protein FACC


Mass: 66290.359 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCC, FAC, FACC / Production host: Homo sapiens (human) / References: UniProt: Q00597
#4: Protein Fanconi anemia group E protein / Protein FACE


Mass: 61026.086 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCE, FACE / Production host: Homo sapiens (human) / References: UniProt: Q9HB96
#5: Protein Fanconi anemia group F protein / Protein FACF


Mass: 45108.297 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCF / Production host: Homo sapiens (human) / References: UniProt: Q9NPI8
#6: Protein Fanconi anemia group G protein / Protein FACG / DNA repair protein XRCC9


Mass: 70873.727 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCG, XRCC9 / Production host: Homo sapiens (human) / References: UniProt: O15287

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Fanconi anemia core complex-associated protein ... , 2 types, 3 molecules PQW

#8: Protein Fanconi anemia core complex-associated protein 100 / Fanconi anemia-associated protein of 100 kDa


Mass: 96513.898 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FAAP100, C17orf70 / Production host: Homo sapiens (human) / References: UniProt: Q0VG06
#9: Protein/peptide Fanconi anemia core complex-associated protein 20


Mass: 4041.667 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human)

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Protein / Non-polymers , 2 types, 5 molecules LM

#10: Chemical ChemComp-ZN / ZINC ION


Mass: 65.409 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: Zn
#7: Protein E3 ubiquitin-protein ligase FANCL / Fanconi anemia group L protein / Fanconi anemia-associated polypeptide of 43 kDa / FAAP43 / RING- ...Fanconi anemia group L protein / Fanconi anemia-associated polypeptide of 43 kDa / FAAP43 / RING-type E3 ubiquitin transferase FANCL


Mass: 45203.953 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCL, PHF9 / Production host: Homo sapiens (human)
References: UniProt: Q9NW38, RING-type E3 ubiquitin transferase

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Details

Has ligand of interestN
Sequence detailsThe complete sequence of FAAP20 is MEAARRPRLGLSRRRPPPAGGPSGGRPWFLLGGDERERLWAELLRTVSPELILDHEVPSL ...The complete sequence of FAAP20 is MEAARRPRLGLSRRRPPPAGGPSGGRPWFLLGGDERERLWAELLRTVSPELILDHEVPSL PAFPGQEPRCGPEPTEVFTVGPKTFSWTPFPPDLWGPGRSYRLLHGAGGHLESPARSLPQ RPAPDPCRAPRVEQQPSVEGAAALRSCPMCQKEFAPRLTQLDVDSHLAQCLAESTEDVTW

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Experimental details

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Experiment

ExperimentMethod: ELECTRON MICROSCOPY
EM experimentAggregation state: PARTICLE / 3D reconstruction method: single particle reconstruction

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Sample preparation

ComponentName: Human Fanconi Anaemia Core complex / Type: COMPLEX / Entity ID: #1-#9 / Source: RECOMBINANT
Molecular weightValue: 1.1 MDa / Experimental value: NO
Source (natural)Organism: Homo sapiens (human)
Source (recombinant)Organism: Homo sapiens (human)
Buffer solutionpH: 8
Buffer component
IDConc.NameFormulaBuffer-ID
120 mMBicineC6H13NO41
2150 mMsodium chlorideNaCl1
31 mMDithiothreitolC4H10O2S21
SpecimenConc.: 1 mg/ml / Embedding applied: NO / Shadowing applied: NO / Staining applied: NO / Vitrification applied: YES
VitrificationCryogen name: ETHANE

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Electron microscopy imaging

Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company
MicroscopyModel: FEI TITAN KRIOS
Electron gunElectron source: FIELD EMISSION GUN / Accelerating voltage: 300 kV / Illumination mode: FLOOD BEAM
Electron lensMode: BRIGHT FIELD
Image recordingElectron dose: 65 e/Å2 / Detector mode: SUPER-RESOLUTION / Film or detector model: GATAN K2 SUMMIT (4k x 4k)

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Processing

SoftwareName: REFMAC / Version: 5.8.0267 / Classification: refinement
CTF correctionType: PHASE FLIPPING AND AMPLITUDE CORRECTION
3D reconstructionResolution: 3.1 Å / Resolution method: FSC 0.143 CUT-OFF / Num. of particles: 671972 / Symmetry type: POINT
RefinementResolution: 3.1→20 Å / Cor.coef. Fo:Fc: 0.876 / SU B: 24.192 / SU ML: 0.18 / ESU R: 0.235
Stereochemistry target values: MAXIMUM LIKELIHOOD WITH PHASES
Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
RfactorNum. reflection% reflection
Rwork0.30028 --
obs0.30028 1273223 99.63 %
Solvent computationIon probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1 Å / Solvent model: BABINET MODEL WITH MASK
Displacement parametersBiso mean: 58.035 Å2
Baniso -1Baniso -2Baniso -3
1--0.29 Å2-0.73 Å20.05 Å2
2---0.93 Å20.11 Å2
3---1.21 Å2
Refinement stepCycle: 1 / Total: 64462
Refine LS restraints
Refine-IDTypeDev idealDev ideal targetNumber
ELECTRON MICROSCOPYr_bond_refined_d0.0130.01365804
ELECTRON MICROSCOPYr_bond_other_d0.0340.01763715
ELECTRON MICROSCOPYr_angle_refined_deg1.5781.63289220
ELECTRON MICROSCOPYr_angle_other_deg2.271.571146650
ELECTRON MICROSCOPYr_dihedral_angle_1_deg8.3658134
ELECTRON MICROSCOPYr_dihedral_angle_2_deg32.45921.6123300
ELECTRON MICROSCOPYr_dihedral_angle_3_deg16.511511427
ELECTRON MICROSCOPYr_dihedral_angle_4_deg18.06515480
ELECTRON MICROSCOPYr_chiral_restr0.0910.28485
ELECTRON MICROSCOPYr_gen_planes_refined0.0070.0273261
ELECTRON MICROSCOPYr_gen_planes_other0.0070.0214951
ELECTRON MICROSCOPYr_nbd_refined
ELECTRON MICROSCOPYr_nbd_other
ELECTRON MICROSCOPYr_nbtor_refined
ELECTRON MICROSCOPYr_nbtor_other
ELECTRON MICROSCOPYr_xyhbond_nbd_refined
ELECTRON MICROSCOPYr_xyhbond_nbd_other
ELECTRON MICROSCOPYr_metal_ion_refined
ELECTRON MICROSCOPYr_metal_ion_other
ELECTRON MICROSCOPYr_symmetry_vdw_refined
ELECTRON MICROSCOPYr_symmetry_vdw_other
ELECTRON MICROSCOPYr_symmetry_hbond_refined
ELECTRON MICROSCOPYr_symmetry_hbond_other
ELECTRON MICROSCOPYr_symmetry_metal_ion_refined
ELECTRON MICROSCOPYr_symmetry_metal_ion_other
ELECTRON MICROSCOPYr_mcbond_it5.0110.12932788
ELECTRON MICROSCOPYr_mcbond_other5.00910.12932787
ELECTRON MICROSCOPYr_mcangle_it8.950.54740838
ELECTRON MICROSCOPYr_mcangle_other8.950.54840839
ELECTRON MICROSCOPYr_scbond_it4.90710.52933016
ELECTRON MICROSCOPYr_scbond_other4.90710.52933017
ELECTRON MICROSCOPYr_scangle_it
ELECTRON MICROSCOPYr_scangle_other9.08552.12648383
ELECTRON MICROSCOPYr_long_range_B_refined15.02873945
ELECTRON MICROSCOPYr_long_range_B_other15.02973946
ELECTRON MICROSCOPYr_rigid_bond_restr
ELECTRON MICROSCOPYr_sphericity_free
ELECTRON MICROSCOPYr_sphericity_bonded
LS refinement shellResolution: 3.1→3.179 Å / Total num. of bins used: 20
RfactorNum. reflection% reflection
Rfree0 0 -
Rwork0.626 92364 -
obs--100 %
Refinement TLS params.

Method: refined / Refine-ID: ELECTRON MICROSCOPY

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
125.5947-16.541211.178834.5945-0.94376.6858-0.3358-2.0929-1.01930.84760.01172.63050.0704-0.96420.32410.8946-0.24670.421.03450.31620.620760.0013216.778394.1245
26.2102-7.4574-3.044511.0331.45048.36520.0375-0.508-0.56090.15710.06020.92720.73990.1963-0.09780.4958-0.18720.13170.6070.18630.397471.7602211.626783.0579
310.7569-8.70265.672922.47392.270815.8541-0.70270.04420.58081.7062-0.22330.2346-0.0058-0.18040.9260.6483-0.17470.32460.45870.04990.326268.2148226.36294.3513
47.2983-5.16221.05567.45071.71779.38070.2035-0.3211-0.15780.2506-0.02220.4021-0.13990.0401-0.18130.549-0.20.22430.61810.08850.317974.3926220.794580.435
52.8802-1.6904-5.00992.31052.98578.73450.0022-0.41810.28360.45080.4139-0.4530.10250.7232-0.41610.4995-0.20410.0860.7619-0.09730.472885.8525229.274381.5899
61.01533.49221.035629.638513.29286.575-0.21960.13910.0554-0.44820.50320.0093-0.18990.3596-0.28360.4622-0.12050.05880.5295-0.15980.647385.1359210.793457.8505
729.7609-19.9089-38.779625.117231.044652.7405-0.8656-1.7644-0.31450.06950.6808-0.28080.91972.11420.18480.28650.041-0.17780.6338-0.04180.819489.1937196.459158.838
84.47540.65930.67610.58910.61291.3345-0.1554-0.11580.30740.1408-0.02350.0593-0.0863-0.04210.17890.532-0.04380.07820.4916-0.04630.519459.7642205.317859.0541
93.9396-0.9741-0.43380.2798-0.25643.51830.29530.9007-0.252-0.0641-0.26060.0602-0.08170.052-0.03460.57120.0380.18890.6179-0.05880.507243.4296197.406338.882
105.3806-7.57041.622627.3756-5.887310.78461.04110.2058-0.6795-0.63040.5381-1.50371.01910.085-1.57920.9015-0.0538-0.04780.2669-0.24831.093137.0747181.70546.5174
118.5708-0.5854-1.29698.5052-4.66029.7303-0.09370.1519-0.75150.32210.52230.2137-0.5717-0.246-0.42860.5471-0.11720.12140.4435-0.0790.547440.3554194.85650.1942
1218.8483-2.55610.98284.47920.03631.11010.1870.61020.4150.4055-0.2626-0.0122-0.0134-0.15740.07550.52010.06070.17530.6375-0.08380.336826.5681201.73141.9208
132.3934-0.9131-1.20412.1437-2.17485.1854-0.304-0.5592-0.20450.21120.30610.27850.0441-0.6967-0.00210.4711-0.05320.1680.9663-0.20780.599318.7985200.912250.7394
145.20671.5898-1.81175.6229-0.24224.983-0.1639-0.26410.49590.166-0.20930.2496-0.4582-0.47110.37320.55620.14630.29620.5009-0.16580.525527.8778215.303653.6315
1511.25080.1687.33653.11642.597818.99720.0723-0.34880.0276-0.1566-0.0463-0.23010.75570.3693-0.0260.47910.02550.11770.51150.0080.538283.427182.70750.3321
166.3009-2.4766-3.066614.76883.62829.6888-0.2517-0.14660.2055-0.19190.0579-0.0361-0.23880.46750.19380.483-0.0230.17660.5178-0.01050.397471.5847190.48943.899
172.56267.06164.173739.5747-7.299828.7890.06850.6703-0.6031-1.89831.6922-0.1110.94871.2019-1.76070.64990.0575-0.12490.7171-0.19490.556970.4934182.172433.7562
1814.0269-0.749113.67130.0787-0.180527.4534-0.15850.355-0.84940.110.03820.13161.26840.21470.12030.663-0.04150.10910.420.07780.430772.4945175.507950.938
1911.9562-0.471218.823123.691528.866766.751-1.2354-1.40490.22341.36540.75310.1627-0.2364-1.08050.48230.73150.1429-0.00410.97590.01930.436381.4001179.656669.3912
206.3171-6.69226.22557.4281-6.06167.1490.10320.0459-0.13360.1529-0.22920.19790.62920.01160.1260.5735-0.07220.07470.5583-0.00440.573969.8497186.177654.4193
2110.6409-1.2833.72075.44920.40822.86580.03820.0523-0.16510.142-0.29520.61451.0351-0.4770.2570.7374-0.23620.08960.497-0.06790.647460.6673177.377450.9699
2225.47773.6737-3.595819.1054.099940.49810.2326-1.1397-0.50571.7486-0.44040.40880.82090.40690.20790.6276-0.01720.2310.41210.06190.405465.5222182.95367.3613
232.09772.9892-1.996112.2260.12493.01230.083-0.10820.26120.6770.28080.15940.17720.2711-0.36380.6936-0.02410.01130.49710.04060.620358.6852186.335458.5067
242.00816.61956.420234.8113.72144.54930.8113-0.29130.14242.5929-0.10720.83412.8793-2.2919-0.70410.4683-0.31990.09840.5584-0.04050.909750.6768179.943859.8611
254.7521-1.32030.90542.26411.22886.0677-0.0923-1.0482-0.26370.2783-0.11610.2111-0.0007-0.24890.20840.7151-0.06690.30050.71780.00720.419243.1717196.599266.7309
261.0064-0.1954-1.02113.71121.23621.51160.3711-0.01450.2108-0.38110.2206-0.3592-0.57790.1768-0.59170.5619-0.15950.33790.5837-0.04190.629686.0495236.660567.1533
275.7988-5.3046-1.22424.95531.1830.34960.4724-0.05810.4626-0.454-0.1147-0.6096-0.08630.0737-0.35770.3489-0.01070.21350.6526-0.13980.8193115.2521212.519951.4037
284.09211.35951.11873.56050.1365.4851-0.1969-0.13660.14450.5083-0.2651-0.7746-0.3085-0.16920.4620.7395-0.0183-0.17130.18430.09520.611188.6311163.117469.5721
296.4539-4.06722.00295.8494-2.05664.1191-0.0146-0.0732-0.4713-0.2021-0.37490.79870.262-0.20530.38960.69050.28490.26150.5187-0.40730.819161.4756159.273639.3389
304.1967-0.9001-0.16356.8292-0.12043.92770.59680.5359-0.305-0.4056-0.3992-0.1647-0.24420.1581-0.19760.44930.17510.21930.6335-0.10980.295850.8411190.279826.1553
317.2489-0.64952.70112.05570.45226.48480.0961.44890.0043-0.5408-0.0801-0.74290.07590.8541-0.01590.568-0.1240.28830.87240.11880.547382.2069196.353333.8412
323.40061.05240.79894.8409-0.623.87820.3465-0.41790.051.0517-0.2883-0.1448-0.5019-0.5217-0.05811.02120.19710.20540.55150.46440.477555.967695.2817150.5264
330.44941.0611-0.76795.1178-2.82381.70370.16920.29240.10060.28750.10780.4914-0.2586-0.2598-0.2770.82180.0738-0.32431.0213-0.13540.591492.75988.5038172.6171
342.75961.05830.64920.44960.24810.15960.08960.62210.34150.1122-0.04920.05410.06920.1825-0.04041.3801-0.17820.30041.3750.15970.895595.988688.855205.4922
352.33210.5243-0.12254.559-1.46041.09570.2019-0.3505-0.48110.2558-0.1501-0.4720.4226-0.0181-0.05180.5599-0.0315-0.28630.45220.30070.5994153.0246132.131560.5568
362.6965-1.49270.36925.20880.68450.5669-0.0499-0.24150.36570.30690.0708-0.37730.02-0.0588-0.02090.35520.0210.04830.4804-0.00220.6827143.9382180.133350.862
376.36970.29494.24691.45020.22972.89920.03030.46090.0128-0.0050.00410.0795-0.01590.1242-0.03440.1068-0.0226-0.26670.68690.51220.9839196.0536147.965866.9948
384.3836-0.80390.47671.10080.86432.00420.1150.06040.1242-0.07470.3995-0.1539-0.05760.2206-0.51440.3497-0.1118-0.34050.46490.42150.9541235.4968147.23294.3708
397.5222-1.81911.43433.0836-1.85415.8548-0.6749-0.01690.56380.0542-0.19240.2349-0.3817-0.40990.86730.704-0.0258-0.22870.59940.44220.9266240.566160.3934156.8842
400.8478-0.64170.89621.4016-0.91933.2087-0.08130.06380.083800.0226-0.1204-0.0771-0.18960.05870.2647-0.1366-0.11570.66590.60180.7226224.918135.3642135.2204
412.5041.30930.38891.04740.48934.76760.3168-0.1247-0.19730.411-0.114-0.07770.20180.0856-0.20280.5386-0.148-0.07680.53690.6370.8121248.5366133.4664176.9128
425.34030.83670.12460.99221.34712.59920.27610.12760.14630.067-0.0067-0.1773-0.60940.0494-0.26950.8126-0.08720.07580.57350.61690.7235267.1414157.4318176.1694
431.18411.74290.64913.50350.49670.72560.0709-0.0823-0.00350.3057-0.0165-0.04340.13580.0083-0.05440.32290.0701-0.07360.68250.28170.5693122.80789.7969129.4082
448.54581.2506-1.10832.3914-0.4571.47650.15-0.3153-0.0979-0.0154-0.048-0.2123-0.2022-0.1506-0.1020.20190.0758-0.15090.8170.41660.4706163.6949106.2773156.5315
451.9687-0.04120.80435.3512.30211.8850.25530.69470.3557-0.3666-0.0157-1.179-0.22360.3301-0.23960.3851-0.04390.09160.60110.21670.7036134.6381136.7186121.0867
462.97931.2802-0.13241.131-0.12797.48280.1695-0.32670.33440.27740.216-0.4882-0.61980.1014-0.38540.69610.1008-0.59350.236-0.41641.0611138.856159.1401149.0714
470.7038-1.3430.81353.3817-2.48682.00710.6656-0.2927-0.0821-0.9054-0.21610.46470.37590.5615-0.44951.4102-0.3719-0.16430.9627-0.36910.3175144.7938171.9526174.8104
482.3105-1.13610.07413.20850.85760.4281-0.0231-0.28620.3657-0.2285-0.1482-0.1377-0.0984-0.09560.17120.4223-0.0429-0.24840.51440.41730.7371208.9447152.2446177.3834
493.38840.3181-1.09632.89231.26361.05580.0891-0.31550.09380.0817-0.0201-0.00860.1121-0.0138-0.06890.2468-0.1771-0.16770.73390.54760.7401222.9695107.2693166.4687
505.63890.9775-0.82092.1702-0.94121.0177-0.02930.0289-0.3174-0.30590.1370.20960.0971-0.0488-0.10770.2317-0.1178-0.2130.53420.60470.8325198.802793.4781155.0577
512.1842-0.4290.00954.4841.06071.5597-0.38630.2453-0.75490.53890.3497-0.2229-0.06870.04920.03670.43690.30950.34320.44490.18240.705698.7549110.03237.3759
523.5626-0.4034-1.06553.07770.2655.7152-0.06980.09120.27470.4595-0.11060.91190.5430.10560.18030.44230.25210.38980.37730.12930.701384.3446124.323345.1041
534.5472-2.3045.89881.3274-3.32929.7481-0.03170.2660.28160.0752-0.3102-0.2658-0.31950.26790.34190.67450.13380.05030.41170.10320.550389.5343145.607658.853
5427.10114.63972.632819.19182.38368.57280.31061.0601-1.0483-0.2648-0.0387-0.9538-0.10840.376-0.2720.47920.18650.02920.37860.0860.182799.7382117.792588.7997
557.49480.5936-2.42381.1962-1.87743.49950.6486-1.33380.1830.0301-0.4423-0.1111-0.3861.065-0.20630.5446-0.18590.0070.7703-0.01830.8663110.581131.713398.7819
5636.44378.185634.814814.675211.502743.75630.2498-1.46350.44670.1476-1.07310.04320.7464-1.95490.82330.41640.02350.24160.27270.17230.339194.5014128.325591.781
5731.624112.2246-25.952221.32-6.352127.51910.37951.43412.0632-1.14960.96991.1534-0.1387-2.194-1.34940.8268-0.0267-0.2141.00130.01140.445580.1417127.995483.7594
5839.6818-16.454910.181715.6413-7.30335.95551.3448-1.3110.6587-0.5627-0.48390.310.5440.0164-0.86090.54210.0214-0.00490.2653-0.04910.363896.3874121.473397.629
5919.3616-14.12645.992947.1919-17.647615.88040.18160.27020.9971-0.6332-1.0379-2.78610.03450.71540.85630.12550.0172-0.03460.6847-0.02660.8412120.5497116.7999.4439
608.3081-0.01542.06045.7004-1.31583.80610.27860.18110.1229-0.4101-0.29270.35430.04660.10340.01410.51160.04780.11950.28080.17150.300693.7343122.488988.8893
6129.5587-19.370410.389414.5609-1.056421.4926-0.6759-2.2982.00220.38791.1162-1.6357-0.3088-1.7332-0.44030.7688-0.175-0.14970.6877-0.15030.6236103.125141.0235102.9494
620.48611.10971.753312.25574.48096.8906-0.01270.27590.0238-0.91780.1489-0.3659-0.31190.4768-0.13620.40390.13250.1190.68610.14050.477296.1078119.555782.6593
635.311110.92476.842822.641914.12338.8341-0.18630.4105-0.1238-0.20240.5074-0.6065-0.06580.4748-0.32111.46140.3263-0.02340.5950.56250.9124103.8087102.16188.157
643.0832-0.1996.08174.4858-5.298826.772-0.00110.14520.3220.0634-0.15190.0632-0.46711.20610.1530.34350.10750.04190.33840.13930.4429103.406111.1519101.9886
656.19140.5642-0.15915.494-0.16353.56980.17180.1136-0.4384-0.13530.0238-0.1480.82510.5061-0.19560.35820.1936-0.04370.58080.16390.6302112.3202100.0185107.8452
667.24420.66421.57072.7804-0.6998.91270.2789-0.3946-0.3643-0.1768-0.0151-0.24330.35460.1868-0.26370.32840.22630.0470.36480.14580.4644104.7324104.3182106.9992
671.48213.25251.764210.88985.01332.4909-0.2986-0.00820.0523-0.0830.3252-0.0507-0.12970.2217-0.02650.45760.0621-0.02050.56440.03590.4975107.9331119.6521120.5077
681.15072.60862.34376.01095.17545.3497-0.0930.571-0.239-0.10491.2277-0.31970.03421.1143-1.13470.5359-0.12030.10110.5333-0.27211.1615119.1858163.4947135.9423
696.15933.707-2.162720.17411.50011.43850.19620.8364-0.1377-0.176-0.2306-0.2226-0.2189-0.12750.03440.5663-0.0132-0.11270.53470.12540.3931103.5446136.0078120.2925
707.77370.77760.14082.6399-0.04691.42530.0010.3565-0.1414-0.01380.0171-0.40070.17740.0388-0.0180.24470.0220.07450.4092-0.05080.7539116.7712132.0135.8898
715.26592.1588-1.74039.6874-3.8162.467-0.1470.6624-0.5758-0.6550.0744-1.34820.12930.40740.07260.1997-0.01110.1090.5738-0.30180.9906129.182127.596234.7853
726.4239-1.24421.87138.6529-5.125725.63570.29760.2602-0.23840.78-0.0135-0.3742-0.3718-0.0828-0.28420.1803-0.0555-0.20210.3323-0.06390.7829132.034141.511748.0004
733.90380.0262-0.36326.9469-1.61361.48680.00750.2532-0.1198-0.00870.1021-0.4133-0.07110.1946-0.10960.1809-0.0025-0.19820.4751-0.08760.7682131.406143.574344.4235
746.98712.35470.29854.1587-1.49330.77570.1412-0.04640.06640.4073-0.08150.124-0.15390.091-0.05970.36130.041-0.12840.4646-0.11020.7107129.4547154.255149.9838
756.68393.121-1.39845.4347-1.00772.75630.03180.25850.88080.60840.27810.6706-0.11880.0703-0.30990.29150.03150.09350.4609-0.07470.8043113.3205157.690448.2896
766.26026.7209-3.57814.53842.11946.99690.21940.20050.32980.1410.01490.5137-0.3074-0.1928-0.23430.24520.0530.04750.4997-0.04460.7031105.0532147.379844.0492
773.77572.7533-0.652111.03035.7397.5774-0.24480.40230.47450.00690.38080.2163-0.00510.0396-0.1360.09140.10590.01760.38590.07150.7355103.8018150.490942.4702
783.064-5.36572.120421.1701-11.240315.1188-0.11530.3464-0.07-0.5786-0.1523-0.33690.59380.77480.26760.2346-0.0046-0.00540.5109-0.03640.6865104.5091135.902735.8665
798.8988-4.0212-0.53311.83160.30962.48870.32371.0013-0.4314-0.2182-0.48190.1469-0.4082-0.17040.15820.64550.168-0.14890.7053-0.30610.807677.4289143.494229.1026
801.2954-0.19131.39360.13450.757715.4671-0.34790.0131-0.0062-0.027-0.1770.0315-0.6356-0.56290.5250.920.15090.06990.42690.06950.601283.3504145.277471.3949
812.3155-1.18730.03985.4012-6.1417.92740.2339-0.3386-0.0306-0.36630.22590.55020.1856-0.1799-0.45980.62810.1222-0.08250.5342-0.05050.676478.9218129.7688108.5445
820.1502-0.3966-0.74533.4492-0.81615.86910.10830.2152-0.0119-0.5609-0.21-0.17880.1235-0.41890.10170.4411-0.00550.00490.57470.07080.611985.1197139.418991.507
8334.6111-30.47833.887447.48923.88643.0323-0.6336-0.5964-1.60680.13041.0040.8408-0.28460.0405-0.37040.83470.1222-0.00290.80570.18170.4095103.7842124.3788109.6006
846.8181-0.451-6.17236.13151.22165.7513-0.10460.61630.6301-0.36960.54730.5990.1158-0.6645-0.44270.3402-0.05650.03940.74580.07410.490882.8081132.931996.7789
859.7458-2.95931.665615.328715.524218.09280.94290.9718-0.95640.36530.217-0.57430.91560.7615-1.161.1099-0.066-0.13710.68120.18480.83389.2772121.5228113.5778
866.00930.5444-3.85874.2011-12.963448.0344-1.5507-0.38021.35040.1483-0.2411-0.63190.1913-1.51831.79190.78350.0731-0.1290.7637-0.16880.641590.8074135.985498.9335
876.43076.88875.77388.91830.767324.6557-0.20230.0348-0.3797-0.75030.1777-0.42841.0732-0.06180.02451.0960.1321-0.05290.6560.10250.514493.2866135.650477.6823
885.29971.4207-6.88691.7142-6.378224.4761-0.0991-0.65830.4009-0.0361-0.0234-0.1093-0.13440.33270.12250.7798-0.05560.04810.24030.02170.593889.0089137.7402107.1914
893.2162-2.852-1.44058.15852.36780.8619-0.2054-0.1611-0.35891.3027-0.08920.73610.33710.00690.29450.5835-0.0354-0.02220.79630.21530.377690.9313120.1763125.976
909.40080.14843.37377.6954-2.74232.3009-0.3598-0.40731.15690.45140.09331.0431-0.3777-0.24580.26650.37660.2034-0.0520.6679-0.01710.791481.9666148.5565124.6571
918.29324.4425-2.52414.536110.212911.90020.0176-0.1917-0.02021.43150.0328-0.21971.4017-0.0869-0.05040.383-0.0238-0.13880.7276-0.00310.584884.7849132.6436127.8349
9244.147934.401916.173328.189113.06466.7286-0.82411.34221.74820.41210.95151.52430.04620.7537-0.12740.8430.08660.12270.8099-0.17121.036395.6336153.8809137.3497
936.34-1.5547-2.81077.26551.222810.51360.1284-0.44510.1869-0.91930.03450.19590.3629-0.5591-0.1630.3472-0.023-0.07260.52890.1220.48192.9367137.1643125.7487
949.19810.4895.13992.57780.44736.48570.2159-0.35561.3961-0.27030.2169-0.1342-0.2521-0.1071-0.43280.6023-0.0116-0.01320.2163-0.06690.94103.8765153.4964128.6353
957.3362-4.2692-0.18454.74551.00631.197-0.3856-0.94160.1130.38140.68660.06010.33270.2491-0.30090.58140.0445-0.2090.48720.04590.5059110.8227131.3387129.5844
963.0834-0.8045-1.31843.5085-1.21493.0675-0.22930.108-0.1125-0.09330.11470.27330.34350.40880.11460.24440.0275-0.25210.6940.2950.485191.792342.0498144.7778
973.8097-2.97242.54112.5655-2.1154.1805-0.1161-0.4903-0.22470.32640.4405-0.1218-0.30720.0405-0.32440.60930.2154-0.17430.78160.44790.854275.425686.2894143.1823
983.96661.814-0.19692.16580.64524.40750.0962-0.0953-0.3088-0.03740.06940.03750.4944-0.095-0.16560.50230.11680.10110.40010.25390.542973.634294.8445105.402
994.58361.12421.37796.2872-1.88184.2357-0.67550.2544-0.064-0.61880.58480.59250.26370.04430.09070.6676-0.08050.06260.39010.0640.476375.8446101.828679.5079
1005.61730.0556-1.77984.3193.01874.28890.00650.723-0.5107-0.3291-0.46140.64820.0964-0.39380.45490.414-0.0989-0.20730.58450.13420.550739.6987109.949387.4341
1013.0539-0.1949-0.83162.0170.49182.6037-0.21580.14280.00670.29250.05150.5166-0.1802-0.07080.16430.3130.1853-0.20250.41030.1851.040561.128558.303160.3199
1021.90830.3855-0.40184.8441-1.63152.9239-0.074-0.13450.31240.331-0.2780.1718-0.27510.1310.35190.35870.08030.09390.52070.09630.535164.9064114.0644111.8766
1035.94070.08721.30352.51741.45243.7167-0.5306-0.18530.8527-0.2403-0.12340.643-0.7819-0.35360.6540.61240.1074-0.23770.21040.20750.834743.3612126.6871100.6721
Refinement TLS group
IDRefine-IDRefine TLS-IDAuth asym-IDAuth seq-ID
1ELECTRON MICROSCOPY1C1 - 14
2ELECTRON MICROSCOPY2C15 - 49
3ELECTRON MICROSCOPY3C50 - 70
4ELECTRON MICROSCOPY4C71 - 94
5ELECTRON MICROSCOPY5C95 - 144
6ELECTRON MICROSCOPY6C145 - 169
7ELECTRON MICROSCOPY7C170 - 178
8ELECTRON MICROSCOPY8C179 - 326
9ELECTRON MICROSCOPY9C327 - 378
10ELECTRON MICROSCOPY10C379 - 390
11ELECTRON MICROSCOPY11C391 - 400
12ELECTRON MICROSCOPY12C401 - 425
13ELECTRON MICROSCOPY13C426 - 483
14ELECTRON MICROSCOPY14C484 - 558
15ELECTRON MICROSCOPY15E12 - 25
16ELECTRON MICROSCOPY16E26 - 47
17ELECTRON MICROSCOPY17E48 - 59
18ELECTRON MICROSCOPY18E60 - 72
19ELECTRON MICROSCOPY19E73 - 83
20ELECTRON MICROSCOPY20E84 - 104
21ELECTRON MICROSCOPY21E105 - 120
22ELECTRON MICROSCOPY22E121 - 130
23ELECTRON MICROSCOPY23E131 - 142
24ELECTRON MICROSCOPY24E143 - 154
25ELECTRON MICROSCOPY25E155 - 181
26ELECTRON MICROSCOPY26F1 - 183
27ELECTRON MICROSCOPY27F184 - 355
28ELECTRON MICROSCOPY28L1 - 103
29ELECTRON MICROSCOPY29L104 - 197
30ELECTRON MICROSCOPY30L198 - 296
31ELECTRON MICROSCOPY31L297 - 402
32ELECTRON MICROSCOPY32M1 - 103
33ELECTRON MICROSCOPY33M104 - 197
34ELECTRON MICROSCOPY34M198 - 296
35ELECTRON MICROSCOPY35G12 - 342
36ELECTRON MICROSCOPY35S32 - 55
37ELECTRON MICROSCOPY36G343 - 610
38ELECTRON MICROSCOPY36S19 - 31
39ELECTRON MICROSCOPY37S56 - 246
40ELECTRON MICROSCOPY38S265 - 524
41ELECTRON MICROSCOPY39S542 - 627
42ELECTRON MICROSCOPY40S648 - 1033
43ELECTRON MICROSCOPY41S1043 - 1215
44ELECTRON MICROSCOPY42S1216 - 1443
45ELECTRON MICROSCOPY43H12 - 386
46ELECTRON MICROSCOPY43A29 - 55
47ELECTRON MICROSCOPY44H387 - 610
48ELECTRON MICROSCOPY44A19 - 28
49ELECTRON MICROSCOPY45A56 - 248
50ELECTRON MICROSCOPY46A249 - 401
51ELECTRON MICROSCOPY47A402 - 524
52ELECTRON MICROSCOPY48A648 - 1034
53ELECTRON MICROSCOPY49A1043 - 1215
54ELECTRON MICROSCOPY50A1216 - 1443
55ELECTRON MICROSCOPY51B7 - 254
56ELECTRON MICROSCOPY52B255 - 369
57ELECTRON MICROSCOPY53B385 - 476
58ELECTRON MICROSCOPY54B477 - 493
59ELECTRON MICROSCOPY55B494 - 502
60ELECTRON MICROSCOPY56B503 - 511
61ELECTRON MICROSCOPY57B512 - 518
62ELECTRON MICROSCOPY58B519 - 531
63ELECTRON MICROSCOPY59B532 - 574
64ELECTRON MICROSCOPY60B575 - 601
65ELECTRON MICROSCOPY61B602 - 612
66ELECTRON MICROSCOPY62B613 - 634
67ELECTRON MICROSCOPY63B635 - 644
68ELECTRON MICROSCOPY64B645 - 663
69ELECTRON MICROSCOPY65B664 - 687
70ELECTRON MICROSCOPY66B688 - 735
71ELECTRON MICROSCOPY67B736 - 770
72ELECTRON MICROSCOPY68B771 - 837
73ELECTRON MICROSCOPY69B838 - 859
74ELECTRON MICROSCOPY70P5 - 86
75ELECTRON MICROSCOPY71P87 - 130
76ELECTRON MICROSCOPY72P131 - 155
77ELECTRON MICROSCOPY73P156 - 217
78ELECTRON MICROSCOPY74P218 - 280
79ELECTRON MICROSCOPY75P281 - 346
80ELECTRON MICROSCOPY76P347 - 371
81ELECTRON MICROSCOPY77P372 - 418
82ELECTRON MICROSCOPY78P419 - 433
83ELECTRON MICROSCOPY79P434 - 457
84ELECTRON MICROSCOPY80P458 - 509
85ELECTRON MICROSCOPY81P510 - 531
86ELECTRON MICROSCOPY82P532 - 548
87ELECTRON MICROSCOPY83P549 - 557
88ELECTRON MICROSCOPY84P558 - 584
89ELECTRON MICROSCOPY85P585 - 593
90ELECTRON MICROSCOPY86P594 - 605
91ELECTRON MICROSCOPY87P606 - 636
92ELECTRON MICROSCOPY88P637 - 654
93ELECTRON MICROSCOPY89P655 - 709
94ELECTRON MICROSCOPY90P710 - 754
95ELECTRON MICROSCOPY91P755 - 768
96ELECTRON MICROSCOPY92P769 - 784
97ELECTRON MICROSCOPY93P785 - 808
98ELECTRON MICROSCOPY94P809 - 836
99ELECTRON MICROSCOPY95P837 - 881
100ELECTRON MICROSCOPY96O7 - 369
101ELECTRON MICROSCOPY97O391 - 432
102ELECTRON MICROSCOPY97Q449 - 500
103ELECTRON MICROSCOPY98O471 - 655
104ELECTRON MICROSCOPY99O656 - 749
105ELECTRON MICROSCOPY99Q669 - 685
106ELECTRON MICROSCOPY100O750 - 859
107ELECTRON MICROSCOPY100Q823 - 881
108ELECTRON MICROSCOPY101Q5 - 435
109ELECTRON MICROSCOPY102Q501 - 668
110ELECTRON MICROSCOPY103Q701 - 822

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