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- PDB-7kzq: Structure of the human Fanconi anaemia Core-ID complex -

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Basic information

Entry
Database: PDB / ID: 7kzq
TitleStructure of the human Fanconi anaemia Core-ID complex
Components
  • (Fanconi anemia core complex-associated protein ...) x 2
  • (Fanconi anemia group ...) x 7
  • E3 ubiquitin-protein ligase FANCL
  • Fanconi anemia, complementation group I
KeywordsLIGASE / Complex
Function / homology
Function and homology information


regulation of germ cell proliferation / regulation of CD40 signaling pathway / Fanconi anaemia nuclear complex / regulation of regulatory T cell differentiation / homologous chromosome pairing at meiosis / double-strand break repair involved in meiotic recombination / male meiotic nuclear division / gamete generation / replication-born double-strand break repair via sister chromatid exchange / neuronal stem cell population maintenance ...regulation of germ cell proliferation / regulation of CD40 signaling pathway / Fanconi anaemia nuclear complex / regulation of regulatory T cell differentiation / homologous chromosome pairing at meiosis / double-strand break repair involved in meiotic recombination / male meiotic nuclear division / gamete generation / replication-born double-strand break repair via sister chromatid exchange / neuronal stem cell population maintenance / brain morphogenesis / DNA repair complex / mitotic intra-S DNA damage checkpoint signaling / myeloid cell homeostasis / negative regulation of double-strand break repair via homologous recombination / positive regulation of double-strand break repair via homologous recombination / female gonad development / protein monoubiquitination / spermatid development / germ cell development / interstrand cross-link repair / DNA polymerase binding / ovarian follicle development / condensed chromosome / removal of superoxide radicals / mitochondrion organization / nucleotide-excision repair / Fanconi Anemia Pathway / response to gamma radiation / TP53 Regulates Transcription of DNA Repair Genes / RING-type E3 ubiquitin transferase / response to radiation / PKR-mediated signaling / ubiquitin-protein transferase activity / male gonad development / ubiquitin protein ligase activity / nuclear envelope / cellular response to oxidative stress / chromosome / regulation of cell population proliferation / regulation of inflammatory response / protein-containing complex assembly / damaged DNA binding / nuclear body / DNA repair / intracellular membrane-bounded organelle / centrosome / DNA damage response / ubiquitin protein ligase binding / chromatin / nucleolus / mitochondrion / DNA binding / nucleoplasm / metal ion binding / nucleus / plasma membrane / cytosol / cytoplasm
Similarity search - Function
Fanconi anaemia group C protein / Fanconi anemia-associated protein of 100kDa / Fanconi anemia group B protein / Fanconi anemia group G protein / Fanconi anaemia group C protein / Fanconi anemia-associated / Fanconi Anaemia group E protein, C-terminal / Fanconi anemia group F protein / FANCF, C-terminal domain superfamily / Fanconi anemia group E protein ...Fanconi anaemia group C protein / Fanconi anemia-associated protein of 100kDa / Fanconi anemia group B protein / Fanconi anemia group G protein / Fanconi anaemia group C protein / Fanconi anemia-associated / Fanconi Anaemia group E protein, C-terminal / Fanconi anemia group F protein / FANCF, C-terminal domain superfamily / Fanconi anemia group E protein / Fanconi anemia group F protein (FANCF) / Fanconi Anaemia group E protein FANCE / Fanconi anaemia group A protein / Fanconi anaemia group A protein, N-terminal domain / Fanconi anaemia group A protein / Fanconi anaemia group A protein N terminus / FANCL, UBC-like domain 2 / FANCL, UBC-like domain 3 / Fanconi anemia complex, subunit FancL, WD-repeat containing domain / E3 ubiquitin-protein ligase FANCL / FANCL C-terminal domain / FANCL, UBC-like domain 3 superfamily / FANCL UBC-like domain 1 / FANCL C-terminal domain / FANCL UBC-like domain 2 / FANCL UBC-like domain 3 / FANCL C-terminal domain / Fanconi anemia group I protein / FANCI solenoid 1 cap / FANCI solenoid 1 domain / FANCI helical domain 1 / FANCI helical domain 2 / FANCI solenoid 3 domain / FANCI solenoid 4 domain / FANCI solenoid 2 domain / FANCI solenoid 1 cap / FANCI solenoid 1 / FANCI solenoid 2 / FANCI solenoid 3 / FANCI solenoid 4 / FANCI helical domain 1 / FANCI helical domain 2 / Fanconi anaemia protein FANCD2 / Fanconi anaemia protein FancD2 nuclease / Ubiquitin-conjugating enzyme/RWD-like / Tetratricopeptide repeats / Tetratricopeptide repeat / Tetratricopeptide-like helical domain superfamily / Zinc finger, RING/FYVE/PHD-type
Similarity search - Domain/homology
Fanconi anemia, complementation group I / Fanconi anemia group G protein / Fanconi anemia group A protein / Fanconi anemia group C protein / Fanconi anemia core complex-associated protein 100 / Fanconi anemia group B protein / Fanconi anemia group D2 protein / Fanconi anemia group E protein / Fanconi anemia group F protein / E3 ubiquitin-protein ligase FANCL
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodELECTRON MICROSCOPY / single particle reconstruction / cryo EM / Resolution: 4.3 Å
AuthorsWang, S.L. / Pavletich, N.P.
Funding support United States, 1items
OrganizationGrant numberCountry
Howard Hughes Medical Institute (HHMI) United States
CitationJournal: Nat Struct Mol Biol / Year: 2021
Title: Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.
Authors: Shengliu Wang / Renjing Wang / Christopher Peralta / Ayat Yaseen / Nikola P Pavletich /
Abstract: The Fanconi anemia (FA) pathway is essential for the repair of DNA interstrand crosslinks. Central to the pathway is the FA core complex, a ubiquitin ligase of nine subunits that monoubiquitinates ...The Fanconi anemia (FA) pathway is essential for the repair of DNA interstrand crosslinks. Central to the pathway is the FA core complex, a ubiquitin ligase of nine subunits that monoubiquitinates the FANCI-FANCD2 (ID) DNA clamp. The 3.1 Å structure of the 1.1-MDa human FA core complex, described here, reveals an asymmetric assembly with two copies of all but the FANCC, FANCE and FANCF subunits. The asymmetry is crucial, as it prevents the binding of a second FANCC-FANCE-FANCF subcomplex that inhibits the recruitment of the UBE2T ubiquitin conjugating enzyme, and instead creates an ID binding site. A single active site then ubiquitinates FANCD2 and FANCI sequentially. We also present the 4.2-Å structures of the human core-UBE2T-ID-DNA complex in three conformations captured during monoubiquitination. They reveal the core-UBE2T complex remodeling the ID-DNA complex, closing the clamp on the DNA before ubiquitination. Monoubiquitination then prevents clamp opening after release from the core.
History
DepositionDec 10, 2020Deposition site: RCSB / Processing site: RCSB
Revision 1.0Mar 10, 2021Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2021Group: Database references / Category: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name
Revision 1.2Mar 6, 2024Group: Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / refine
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _refine.ls_d_res_high / _refine.ls_d_res_low

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Structure visualization

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Assembly

Deposited unit
A: Fanconi anemia group A protein
B: Fanconi anemia group B protein
C: Fanconi anemia group C protein
E: Fanconi anemia group E protein
F: Fanconi anemia group F protein
G: Fanconi anemia group G protein
H: Fanconi anemia group G protein
L: E3 ubiquitin-protein ligase FANCL
M: E3 ubiquitin-protein ligase FANCL
O: Fanconi anemia group B protein
P: Fanconi anemia core complex-associated protein 100
Q: Fanconi anemia core complex-associated protein 100
S: Fanconi anemia group A protein
W: Fanconi anemia core complex-associated protein 20
U: Fanconi anemia, complementation group I
V: Fanconi anemia group D2 protein
hetero molecules


Theoretical massNumber of molelcules
Total (without water)1,448,12121
Polymers1,447,79416
Non-polymers3275
Water0
1


  • Idetical with deposited unit
  • defined by author
  • Evidence: microscopy
TypeNameSymmetry operationNumber
identity operation1_5551

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Components

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Fanconi anemia group ... , 7 types, 10 molecules ASBOCEFGHV

#1: Protein Fanconi anemia group A protein / Protein FACA


Mass: 165513.016 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCA, FAA, FACA, FANCH / Production host: Homo sapiens (human) / References: UniProt: O15360
#2: Protein Fanconi anemia group B protein / Protein FACB / Fanconi anemia-associated polypeptide of 95 kDa / FAAP95


Mass: 100640.172 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCB / Production host: Homo sapiens (human) / References: UniProt: Q8NB91
#3: Protein Fanconi anemia group C protein / Protein FACC


Mass: 66290.359 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCC, FAC, FACC / Production host: Homo sapiens (human) / References: UniProt: Q00597
#4: Protein Fanconi anemia group E protein / Protein FACE


Mass: 61026.086 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCE, FACE / Production host: Homo sapiens (human) / References: UniProt: Q9HB96
#5: Protein Fanconi anemia group F protein / Protein FACF


Mass: 45108.297 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCF / Production host: Homo sapiens (human) / References: UniProt: Q9NPI8
#6: Protein Fanconi anemia group G protein / Protein FACG / DNA repair protein XRCC9


Mass: 70873.727 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCG, XRCC9 / Production host: Homo sapiens (human) / References: UniProt: O15287
#11: Protein Fanconi anemia group D2 protein / Protein FACD2


Mass: 164325.516 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCD2, FACD / Production host: Spodoptera frugiperda (fall armyworm) / References: UniProt: Q9BXW9

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Protein , 2 types, 3 molecules LMU

#7: Protein E3 ubiquitin-protein ligase FANCL / Fanconi anemia group L protein / Fanconi anemia-associated polypeptide of 43 kDa / FAAP43 / RING- ...Fanconi anemia group L protein / Fanconi anemia-associated polypeptide of 43 kDa / FAAP43 / RING-type E3 ubiquitin transferase FANCL


Mass: 45203.953 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCL, PHF9 / Production host: Homo sapiens (human)
References: UniProt: Q9NW38, RING-type E3 ubiquitin transferase
#10: Protein Fanconi anemia, complementation group I /


Mass: 149512.078 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FANCI / Production host: Spodoptera frugiperda (fall armyworm) / References: UniProt: B7ZMF2

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Fanconi anemia core complex-associated protein ... , 2 types, 3 molecules PQW

#8: Protein Fanconi anemia core complex-associated protein 100 / Fanconi anemia-associated protein of 100 kDa


Mass: 96513.898 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: FAAP100, C17orf70 / Production host: Homo sapiens (human) / References: UniProt: Q0VG06
#9: Protein/peptide Fanconi anemia core complex-associated protein 20


Mass: 4041.667 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human)

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Non-polymers , 1 types, 5 molecules

#12: Chemical
ChemComp-ZN / ZINC ION


Mass: 65.409 Da / Num. of mol.: 5 / Source method: obtained synthetically / Formula: Zn

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Details

Has ligand of interestN
Sequence detailsThe complete sequence of FAAP20 is MEAARRPRLGLSRRRPPPAGGPSGGRPWFLLGGDERERLWAELLRTVSPELILDHEVPSL ...The complete sequence of FAAP20 is MEAARRPRLGLSRRRPPPAGGPSGGRPWFLLGGDERERLWAELLRTVSPELILDHEVPSL PAFPGQEPRCGPEPTEVFTVGPKTFSWTPFPPDLWGPGRSYRLLHGAGGHLESPARSLPQ RPAPDPCRAPRVEQQPSVEGAAALRSCPMCQKEFAPRLTQLDVDSHLAQCLAESTEDVTW

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Experimental details

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Experiment

ExperimentMethod: ELECTRON MICROSCOPY
EM experimentAggregation state: PARTICLE / 3D reconstruction method: single particle reconstruction

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Sample preparation

ComponentName: Human Fanconi Anaemia Core-ID complex / Type: COMPLEX / Entity ID: #1-#11 / Source: RECOMBINANT
Molecular weightValue: 1.1 MDa / Experimental value: NO
Source (natural)Organism: Homo sapiens (human)
Source (recombinant)Organism: Homo sapiens (human)
Buffer solutionpH: 8
Buffer component
IDConc.NameFormulaBuffer-ID
120 mMBicineC6H13NO41
2150 mMsodium chlorideNaClSodium chloride1
31 mMDithiothreitolC4H10O2S21
SpecimenConc.: 1 mg/ml / Embedding applied: NO / Shadowing applied: NO / Staining applied: NO / Vitrification applied: YES
VitrificationCryogen name: ETHANE

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Electron microscopy imaging

Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company
MicroscopyModel: FEI TITAN KRIOS
Electron gunElectron source: FIELD EMISSION GUN / Accelerating voltage: 300 kV / Illumination mode: FLOOD BEAM
Electron lensMode: BRIGHT FIELDBright-field microscopy
Image recordingElectron dose: 65 e/Å2 / Detector mode: SUPER-RESOLUTION / Film or detector model: GATAN K2 SUMMIT (4k x 4k)

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Processing

SoftwareName: REFMAC / Version: 5.8.0267 / Classification: refinement
CTF correctionType: PHASE FLIPPING AND AMPLITUDE CORRECTION
3D reconstructionResolution: 4.3 Å / Resolution method: FSC 0.143 CUT-OFF / Num. of particles: 76111 / Symmetry type: POINT
RefinementResolution: 4.3→4.3 Å / Cor.coef. Fo:Fc: 0.845 / SU B: 97.213 / SU ML: 0.541 / ESU R: 0.753
Stereochemistry target values: MAXIMUM LIKELIHOOD WITH PHASES
Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
RfactorNum. reflection% reflection
Rwork0.33251 --
obs0.33251 637999 99.08 %
Solvent computationIon probe radii: 0.9 Å / Shrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: MASK
Displacement parametersBiso mean: 238.543 Å2
Baniso -1Baniso -2Baniso -3
1-0.94 Å2-2.13 Å2-2.8 Å2
2---0.1 Å2-2.9 Å2
3----0.84 Å2
Refinement stepCycle: 1 / Total: 85546
Refine LS restraints
Refine-IDTypeDev idealDev ideal targetNumber
ELECTRON MICROSCOPYr_bond_refined_d0.0130.01387256
ELECTRON MICROSCOPYr_bond_other_d0.0340.01784884
ELECTRON MICROSCOPYr_angle_refined_deg1.6651.632118207
ELECTRON MICROSCOPYr_angle_other_deg2.2671.571195513
ELECTRON MICROSCOPYr_dihedral_angle_1_deg8.19510761
ELECTRON MICROSCOPYr_dihedral_angle_2_deg33.82522.0844295
ELECTRON MICROSCOPYr_dihedral_angle_3_deg16.5781515505
ELECTRON MICROSCOPYr_dihedral_angle_4_deg16.98915570
ELECTRON MICROSCOPYr_chiral_restr0.0970.211333
ELECTRON MICROSCOPYr_gen_planes_refined0.0060.0296819
ELECTRON MICROSCOPYr_gen_planes_other0.0070.0219541
ELECTRON MICROSCOPYr_nbd_refined
ELECTRON MICROSCOPYr_nbd_other
ELECTRON MICROSCOPYr_nbtor_refined
ELECTRON MICROSCOPYr_nbtor_other
ELECTRON MICROSCOPYr_xyhbond_nbd_refined
ELECTRON MICROSCOPYr_xyhbond_nbd_other
ELECTRON MICROSCOPYr_metal_ion_refined
ELECTRON MICROSCOPYr_metal_ion_other
ELECTRON MICROSCOPYr_symmetry_vdw_refined
ELECTRON MICROSCOPYr_symmetry_vdw_other
ELECTRON MICROSCOPYr_symmetry_hbond_refined
ELECTRON MICROSCOPYr_symmetry_hbond_other
ELECTRON MICROSCOPYr_symmetry_metal_ion_refined
ELECTRON MICROSCOPYr_symmetry_metal_ion_other
ELECTRON MICROSCOPYr_mcbond_it5.24210.9343365
ELECTRON MICROSCOPYr_mcbond_other5.24210.92943364
ELECTRON MICROSCOPYr_mcangle_it8.73454019
ELECTRON MICROSCOPYr_mcangle_other8.73454020
ELECTRON MICROSCOPYr_scbond_it3.5410.98143891
ELECTRON MICROSCOPYr_scbond_other3.5410.98243892
ELECTRON MICROSCOPYr_scangle_it
ELECTRON MICROSCOPYr_scangle_other4.2764189
ELECTRON MICROSCOPYr_long_range_B_refined15.189103994
ELECTRON MICROSCOPYr_long_range_B_other15.189103995
ELECTRON MICROSCOPYr_rigid_bond_restr
ELECTRON MICROSCOPYr_sphericity_free
ELECTRON MICROSCOPYr_sphericity_bonded
LS refinement shellResolution: 4.2→4.304 Å / Total num. of bins used: 20
RfactorNum. reflection% reflection
Rfree0 0 -
Rwork0.419 45463 -
obs--100 %
Refinement TLS params.

Method: refined / Refine-ID: ELECTRON MICROSCOPY

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
10.14610.75812.31424.076312.608639.949-0.4712-0.12550.0751-0.3214-0.72560.7296-0.7006-0.23961.19683.6573-0.3831.12693.16250.81193.928578.128210.665189.1453
27.4532-5.98582.88611.01924.37918.9540.0736-1.3666-1.05640.86840.51131.34361.5228-0.9232-0.58492.7438-0.33950.41133.40910.50032.295590.1917205.356178.3587
33.0582-4.4226-2.972232.21813.59846.6558-0.69311.71970.90643.64020.0445-0.03881.7861-0.96610.64862.98130.37770.46563.60080.19852.828486.1261220.591189.1671
43.1775-6.1229-5.069212.6119.34438.9368-0.0110.05920.42460.1534-0.0897-0.156-0.05030.70550.10062.2957-0.32020.30763.43240.50462.984892.7206214.508275.5948
51.0090.34720.50080.23830.20011.3224-0.0710.76980.70980.3130.4772-0.177-0.1455-0.4513-0.40632.8854-0.01620.28682.97690.1253.5711103.9704223.330376.4993
63.24676.13723.679961.701620.624613.74190.08310.32410.0585-2.81010.2106-2.156-1.09350.9819-0.29371.9875-0.16960.23442.60650.35793.0041103.8912204.11353.2644
75.8414-17.8466-10.495867.559639.344822.93591.372-1.7746-0.1998-1.24021.0223-4.0352-0.76810.8913-2.39432.5801-0.2158-0.74354.00010.463.7992108.3292189.772254.3781
815.05980.54371.29514.97624.81234.7526-0.4468-0.90290.5704-0.0803-0.3630.6382-0.4062-0.42820.80982.0757-0.06760.00262.72650.49242.558578.7605198.063954.0966
912.4257-1.6129-2.90870.4943-0.11532.64530.07240.1003-0.4714-0.5827-0.3329-0.15440.1313-0.29850.26052.69370.1278-0.3212.93550.11373.162362.8708189.127833.7159
104.314515.3944-2.349358.1105-2.58726.561-0.38290.1851-1.4924-0.77771.0857-3.08451.6413-0.6681-0.70292.7347-0.131-0.14782.8329-0.13014.61156.5381173.748142.0196
119.94498.0068-21.69739.8043-13.077253.3227-0.0606-0.09580.1478-0.8925-0.43431.275-0.7622-0.7960.49491.9528-0.3483-0.33892.96680.06963.625359.6295186.894545.2639
1220.4225-19.5056-3.983118.73423.79210.78130.47811.2352-0.2597-0.0174-0.7060.1182-0.1051-0.30470.2282.22040.0325-0.54233.8287-0.07273.164845.9877193.317936.448
131.974-5.3617-0.383822.50691.8284.6368-0.083-0.2439-0.64030.1850.30661.52660.1653-0.7605-0.22371.5866-0.02340.08722.96320.00413.662337.9669192.342445.5845
146.2956-4.53920.14197.4745-1.0160.37010.2949-0.70690.32720.236-0.14391.1106-0.6730.1037-0.15092.11480.08040.00453.2492-0.27573.317546.6972207.197447.9953
1513.5379-12.66386.684612.2973-2.884931.5875-1.20310.1983-0.45741.23380.3530.37632.3563.27940.85012.5265-0.0882-0.12492.93070.27322.7358102.8517175.93346.4603
1625.17979.5087-0.639221.8384.30113.21160.16091.48750.8886-1.5109-0.55190.4421-0.60761.31820.39092.35820.31490.23722.40580.42842.322590.9892183.107839.5264
1734.61-5.459533.4431.0738-5.37932.39890.45352.1884-1.9823-0.10360.94160.3026-0.07791.6154-1.39513.16030.16390.42554.5104-0.01483.186590.2733174.443329.3169
1827.314-9.787439.02957.4177-3.823382.36570.10621.4033-0.7771.8113-0.41770.87545.16531.56680.31152.71010.1118-0.06652.67760.61772.868192.1425168.287946.7344
199.07063.444523.519327.268165.1494182.9084-1.9856-2.43050.06-0.1788-0.67581.3393-3.7324-4.9752.66142.89070.37090.03413.8077-0.0172.9609100.2066172.747365.4939
2017.3827-0.2659-11.610114.2993-2.96678.5628-0.85080.1148-0.68071.36890.06240.33390.46620.3230.78832.06590.2256-0.09522.26980.46772.735889.2663178.98350.1055
218.2284-8.119112.509720.2252-8.849120.31681.2626-0.7826-0.2797-0.0425-1.50121.56551.4706-1.89750.23862.2546-0.3745-0.10013.0420.62623.429380.3135169.834646.4934
22106.82251.3385-7.64785.402421.337586.37252.1047-0.5413-2.6051.46350.4053-0.73774.48492.5392-2.513.3102-0.1489-0.36412.44890.84812.825184.8298175.890363.16
2310.1976-0.9568-20.69990.95631.859342.0795-1.327-1.3917-0.93370.8765-0.6011.76353.4233.07751.92812.6309-0.81730.52183.9443-0.52534.440778.0335178.978654.1601
2414.348717.3324-16.751844.436511.907864.1686-1.67891.02181.60872.3492-1.40966.34247.5051-5.87363.08852.12450.2020.39614.22630.39943.476770.5444172.328354.9831
259.9261-3.26092.531610.35056.29896.1393-0.1686-1.21581.11430.8569-0.53610.41940.6101-0.9960.70472.2095-0.35160.55553.3260.11272.958562.3031189.008361.7594
260.13-0.245-0.51315.19411.10912.29720.1437-0.24710.1097-0.21240.1168-0.5794-0.64110.1831-0.26052.3157-0.20920.21742.99980.07473.2737104.0814230.332161.9665
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1147.97845.75761.234114.00294.41989.42070.05870.31760.4541-0.20860.2404-0.6257-0.7266-0.2047-0.29922.67480.00660.11172.81710.63182.479792.8595128.9884188.704
1157.15520.26950.96594.95782.23415.60720.46620.31150.6622-0.2731-0.2070.5656-0.2197-0.36-0.25922.4466-0.1129-0.09292.87970.77052.758481.0189119.3692204.2026
1163.7021.3067-4.15714.9373-3.95866.1579-0.61910.43640.07780.20.1788-0.01640.5463-0.5890.44032.5228-0.9069-0.35673.12650.692.8864.752396.0162223.0433
1173.36123.40690.58376.6875-2.35193.0008-0.2544-0.1448-0.23120.4033-0.5908-0.3004-1.35590.6020.84522.6524-0.4425-0.64814.2155-0.06573.54330.283894.3126222.897
1180.06120.0115-0.02350.0706-0.00050.01430.42750.2402-0.0750.2192-0.37790.172-0.1351-0.2104-0.04962.85630.4382-0.27185.65670.67243.514432.6179112.4138199.4817
1190.01110.0147-0.02830.0416-0.06270.14910.1424-0.1730.0283-0.0005-0.4430.10130.07040.8210.30063.36210.28251.58035.4291-0.10644.019731.167138.9489200.017
1200.1044-0.14730.02850.3209-0.06020.01640.2507-0.4846-0.1907-0.389-0.21350.4030.2170.0224-0.03724.8274-1.52711.99838.5868-0.02332.099545.7455157.4779202.1811
Refinement TLS group
IDRefine-IDRefine TLS-IDAuth asym-IDAuth seq-ID
1ELECTRON MICROSCOPY1C1 - 14
2ELECTRON MICROSCOPY2C15 - 49
3ELECTRON MICROSCOPY3C50 - 70
4ELECTRON MICROSCOPY4C71 - 94
5ELECTRON MICROSCOPY5C95 - 144
6ELECTRON MICROSCOPY6C145 - 169
7ELECTRON MICROSCOPY7C170 - 178
8ELECTRON MICROSCOPY8C179 - 326
9ELECTRON MICROSCOPY9C327 - 378
10ELECTRON MICROSCOPY10C379 - 390
11ELECTRON MICROSCOPY11C391 - 400
12ELECTRON MICROSCOPY12C401 - 425
13ELECTRON MICROSCOPY13C426 - 483
14ELECTRON MICROSCOPY14C484 - 558
15ELECTRON MICROSCOPY15E12 - 25
16ELECTRON MICROSCOPY16E26 - 47
17ELECTRON MICROSCOPY17E48 - 59
18ELECTRON MICROSCOPY18E60 - 72
19ELECTRON MICROSCOPY19E73 - 83
20ELECTRON MICROSCOPY20E84 - 104
21ELECTRON MICROSCOPY21E105 - 120
22ELECTRON MICROSCOPY22E121 - 130
23ELECTRON MICROSCOPY23E131 - 142
24ELECTRON MICROSCOPY24E143 - 154
25ELECTRON MICROSCOPY25E155 - 181
26ELECTRON MICROSCOPY26F1 - 183
27ELECTRON MICROSCOPY27F184 - 355
28ELECTRON MICROSCOPY28L1 - 103
29ELECTRON MICROSCOPY29L104 - 197
30ELECTRON MICROSCOPY30L198 - 296
31ELECTRON MICROSCOPY31L297 - 402
32ELECTRON MICROSCOPY32M1 - 103
33ELECTRON MICROSCOPY33M104 - 197
34ELECTRON MICROSCOPY34M198 - 296
35ELECTRON MICROSCOPY35M297 - 402
36ELECTRON MICROSCOPY36G12 - 342
37ELECTRON MICROSCOPY36S32 - 55
38ELECTRON MICROSCOPY37G343 - 611
39ELECTRON MICROSCOPY37S19 - 31
40ELECTRON MICROSCOPY38S56 - 246
41ELECTRON MICROSCOPY39S265 - 524
42ELECTRON MICROSCOPY40S542 - 627
43ELECTRON MICROSCOPY41S648 - 1033
44ELECTRON MICROSCOPY42S1043 - 1215
45ELECTRON MICROSCOPY43S1216 - 1443
46ELECTRON MICROSCOPY44H12 - 386
47ELECTRON MICROSCOPY44A29 - 55
48ELECTRON MICROSCOPY45H387 - 611
49ELECTRON MICROSCOPY45A19 - 28
50ELECTRON MICROSCOPY46A56 - 248
51ELECTRON MICROSCOPY47A262 - 401
52ELECTRON MICROSCOPY48A402 - 524
53ELECTRON MICROSCOPY49A648 - 1034
54ELECTRON MICROSCOPY49A2001 - 2107
55ELECTRON MICROSCOPY50A1043 - 1215
56ELECTRON MICROSCOPY51A1216 - 1443
57ELECTRON MICROSCOPY52B7 - 254
58ELECTRON MICROSCOPY53B255 - 369
59ELECTRON MICROSCOPY54B385 - 476
60ELECTRON MICROSCOPY55B477 - 493
61ELECTRON MICROSCOPY56B494 - 502
62ELECTRON MICROSCOPY57B503 - 511
63ELECTRON MICROSCOPY58B512 - 518
64ELECTRON MICROSCOPY59B519 - 531
65ELECTRON MICROSCOPY60B532 - 574
66ELECTRON MICROSCOPY61B575 - 601
67ELECTRON MICROSCOPY62B602 - 612
68ELECTRON MICROSCOPY63B613 - 634
69ELECTRON MICROSCOPY64B635 - 644
70ELECTRON MICROSCOPY65B645 - 663
71ELECTRON MICROSCOPY66B664 - 687
72ELECTRON MICROSCOPY67B688 - 735
73ELECTRON MICROSCOPY68B736 - 770
74ELECTRON MICROSCOPY69B771 - 837
75ELECTRON MICROSCOPY70B838 - 859
76ELECTRON MICROSCOPY71P5 - 86
77ELECTRON MICROSCOPY72P87 - 130
78ELECTRON MICROSCOPY73P131 - 155
79ELECTRON MICROSCOPY74P156 - 217
80ELECTRON MICROSCOPY75P218 - 280
81ELECTRON MICROSCOPY76P281 - 346
82ELECTRON MICROSCOPY77P347 - 371
83ELECTRON MICROSCOPY78P372 - 418
84ELECTRON MICROSCOPY79P419 - 433
85ELECTRON MICROSCOPY80P434 - 457
86ELECTRON MICROSCOPY81P458 - 509
87ELECTRON MICROSCOPY82P510 - 531
88ELECTRON MICROSCOPY83P532 - 548
89ELECTRON MICROSCOPY84P549 - 593
90ELECTRON MICROSCOPY85P594 - 605
91ELECTRON MICROSCOPY86P606 - 636
92ELECTRON MICROSCOPY87P637 - 654
93ELECTRON MICROSCOPY88P655 - 709
94ELECTRON MICROSCOPY89P710 - 754
95ELECTRON MICROSCOPY90P755 - 768
96ELECTRON MICROSCOPY91P769 - 784
97ELECTRON MICROSCOPY92P785 - 808
98ELECTRON MICROSCOPY93P809 - 836
99ELECTRON MICROSCOPY94P837 - 881
100ELECTRON MICROSCOPY95O7 - 369
101ELECTRON MICROSCOPY96O391 - 432
102ELECTRON MICROSCOPY96Q449 - 500
103ELECTRON MICROSCOPY97O471 - 655
104ELECTRON MICROSCOPY98O656 - 749
105ELECTRON MICROSCOPY98Q669 - 685
106ELECTRON MICROSCOPY99O750 - 859
107ELECTRON MICROSCOPY99Q823 - 881
108ELECTRON MICROSCOPY100Q5 - 435
109ELECTRON MICROSCOPY101Q501 - 668
110ELECTRON MICROSCOPY102Q701 - 822
111ELECTRON MICROSCOPY103U1 - 169
112ELECTRON MICROSCOPY104U170 - 305
113ELECTRON MICROSCOPY105U306 - 398
114ELECTRON MICROSCOPY106U411 - 684
115ELECTRON MICROSCOPY107U696 - 791
116ELECTRON MICROSCOPY108U801 - 934
117ELECTRON MICROSCOPY109U949 - 1039
118ELECTRON MICROSCOPY110U1040 - 1154
119ELECTRON MICROSCOPY111U1155 - 1280
120ELECTRON MICROSCOPY112V45 - 187
121ELECTRON MICROSCOPY113V188 - 254
122ELECTRON MICROSCOPY114V255 - 311
123ELECTRON MICROSCOPY115V337 - 465
124ELECTRON MICROSCOPY116V466 - 623
125ELECTRON MICROSCOPY117V624 - 839
126ELECTRON MICROSCOPY118V916 - 1145
127ELECTRON MICROSCOPY119V1150 - 1250
128ELECTRON MICROSCOPY120V1251 - 1376

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