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- EMDB-45801: Cryo-EM structure of bovine Fallopian tube cilia doublet microtub... -

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Basic information

Entry
Database: EMDB / ID: EMD-45801
TitleCryo-EM structure of bovine Fallopian tube cilia doublet microtubule (48-nm periodicity)
Map data
Sample
  • Organelle or cellular component: bovine fallopian tube cilia
    • Protein or peptide: x 42 types
  • Ligand: x 3 types
Keywordsaxoneme / cilia / microtubule / dynein / Fallopian tube / doublet microtubule (DMT) / STRUCTURAL PROTEIN
Function / homology
Function and homology information


outer dynein arm docking complex / protein localization to motile cilium / Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane / Cilium Assembly / : / Sealing of the nuclear envelope (NE) by ESCRT-III / Kinesins / regulation of cilium movement / mucociliary clearance / Mitotic Prometaphase ...outer dynein arm docking complex / protein localization to motile cilium / Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane / Cilium Assembly / : / Sealing of the nuclear envelope (NE) by ESCRT-III / Kinesins / regulation of cilium movement / mucociliary clearance / Mitotic Prometaphase / outer acrosomal membrane / epithelial cilium movement involved in determination of left/right asymmetry / regulation of brood size / establishment of left/right asymmetry / 9+0 motile cilium / sperm flagellum assembly / manchette assembly / COPI-dependent Golgi-to-ER retrograde traffic / axonemal B tubule inner sheath / axonemal A tubule inner sheath / RHO GTPases activate IQGAPs / regulation of flagellated sperm motility / RHO GTPases Activate Formins / protein polyglutamylation / regulation of calcineurin-NFAT signaling cascade / Intraflagellar transport / positive regulation of feeding behavior / Resolution of Sister Chromatid Cohesion / EML4 and NUDC in mitotic spindle formation / outer dynein arm assembly / COPI-independent Golgi-to-ER retrograde traffic / COPI-mediated anterograde transport / cerebrospinal fluid circulation / inner dynein arm assembly / cilium-dependent cell motility / 9+2 motile cilium / regulation of cilium beat frequency involved in ciliary motility / 9+0 non-motile cilium / MHC class II antigen presentation / cilium movement involved in cell motility / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / The role of GTSE1 in G2/M progression after G2 checkpoint / acrosomal membrane / regulation of store-operated calcium entry / cilium movement / regulation of cilium assembly / axoneme assembly / Aggrephagy / Separation of Sister Chromatids / calcium ion sensor activity / Loss of Nlp from mitotic centrosomes / Recruitment of mitotic centrosome proteins and complexes / Loss of proteins required for interphase microtubule organization from the centrosome / Anchoring of the basal body to the plasma membrane / AURKA Activation by TPX2 / axonemal microtubule / Recruitment of NuMA to mitotic centrosomes / cilium organization / Regulation of PLK1 Activity at G2/M Transition / gamma-tubulin ring complex / Hedgehog 'off' state / ciliary rootlet / manchette / determination of left/right symmetry / 3'-5'-DNA exonuclease activity / UTP biosynthetic process / CTP biosynthetic process / motile cilium / DNA catabolic process / Neutrophil degranulation / nucleoside diphosphate kinase activity / single fertilization / positive regulation of cell motility / regulation of neuron projection development / GTP biosynthetic process / Hydrolases; Acting on ester bonds; Exodeoxyribonucleases producing 5'-phosphomonoesters / cerebral cortex cell migration / AMP binding / flagellated sperm motility / spermatid development / ciliary transition zone / ciliary base / intercellular bridge / microtubule organizing center / mitotic cytokinesis / cellular response to UV-C / regulation of signal transduction / regulation of cell division / cilium assembly / glial cell projection / axoneme / lung development / centriolar satellite / sperm flagellum / alpha-tubulin binding / beta-tubulin binding / cytoplasmic microtubule / ciliary tip / centriole / acrosomal vesicle
Similarity search - Function
Outer dynein arm-docking complex subunit 4 / Protein of unknown function DUF4541 / : / Cilia and flagella associated protein 90 / Protein of unknown function DUF4586 / Outer dynein arm-docking complex subunit 3 / Cilia-and flagella-associated protein 96 / FAM183 family / FAM183A and FAM183B related / : ...Outer dynein arm-docking complex subunit 4 / Protein of unknown function DUF4541 / : / Cilia and flagella associated protein 90 / Protein of unknown function DUF4586 / Outer dynein arm-docking complex subunit 3 / Cilia-and flagella-associated protein 96 / FAM183 family / FAM183A and FAM183B related / : / Echinoderm microtubule-associated protein first beta-propeller / Sperm-tail PG-rich repeat / Sperm-associated antigen 8 / Cilia- and flagella-associated protein 95 / NDPK7, first NDPk domain / Cilia- and flagella-associated protein 107 / : / : / : / Sperm-tail PG-rich repeat / Protein CFAP95 / ODAD1 central coiled coil region / Cilia- and flagella-associated protein 143 / Cilia and flagella associated protein 107 / Tektin / Cilia- and flagella-associated protein 276 / Sperm acrosome-associated protein 9 / : / Tektin family / Protein of unknown function (DUF3695) / Sperm acrosome-associated protein 9 / DJBP, EF-hand domain / EF-hand domain / Uncharacterised protein FAM166/UPF0605 / Cilia- and flagella-associated protein 77 / Protein Flattop / Ciliary microtubule inner protein 2B-like / Cilia- and flagella-associated protein 77 / Flattop / Nucleoside diphosphate kinase 7 / Piercer of microtubule wall 1/2 / Piercer of microtubule wall 1/2 / Cilia- and flagella-associated protein 141 / Cilia- and flagella-associated protein 141 / Cilia- and flagella-associated protein 161-like domain / : / : / EFHB C-terminal EF-hand domain / : / : / Nucleoside diphosphate kinase 7 N-terminal PH domain / Meiosis-specific nuclear structural protein 1 / Cilia- and flagella-associated protein 45 / NDPK7, second NDPk domain / Cilia- and flagella- associated protein 210 / CFAP53/TCHP / Trichohyalin-plectin-homology domain / Trichohyalin-plectin-homology domain / RIB43A / RIB43A / DM10 domain / EF-hand domain-containing protein EFHC1/EFHC2/EFHB / DM10 domain / DM10 domain profile. / Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases. / Enkurin domain / : / Calmodulin-binding / Enkurin domain profile. / : / CFA20 domain / Cilia- and flagella-associated protein 20/CFAP20DC / CFA20 domain / Recoverin family / Parkin co-regulated protein / Parkin co-regulated protein / EF hand / Nucleoside diphosphate kinase / Nucleoside diphosphate kinase (NDPK)-like domain profile. / Nucleoside diphosphate kinase-like domain / Nucleoside diphosphate kinase / NDK / Nucleoside diphosphate kinase-like domain superfamily / EF-hand domain pair / Armadillo/plakoglobin ARM repeat profile. / Armadillo/beta-catenin-like repeat / Armadillo/beta-catenin-like repeats / Armadillo / Tetratricopeptide repeat / TPR repeat region circular profile. / Alpha tubulin / Tubulin-beta mRNA autoregulation signal. / Beta tubulin, autoregulation binding site / Beta tubulin / TPR repeat profile. / Tubulin / Tubulin, C-terminal / Tubulin C-terminal domain / Tubulin, conserved site / Tubulin subunits alpha, beta, and gamma signature.
Similarity search - Domain/homology
Piercer of microtubule wall 2 protein / Cilia and flagella associated protein 77 / Cilia and flagella associated protein 90 / Sperm acrosome associated 9 / EF-hand domain-containing family member C2 / Ciliary microtubule associated protein 1C / EF-hand calcium binding domain 6 / Outer dynein arm-docking complex subunit 4 / Parkin coregulated gene protein / Tektin-3 ...Piercer of microtubule wall 2 protein / Cilia and flagella associated protein 77 / Cilia and flagella associated protein 90 / Sperm acrosome associated 9 / EF-hand domain-containing family member C2 / Ciliary microtubule associated protein 1C / EF-hand calcium binding domain 6 / Outer dynein arm-docking complex subunit 4 / Parkin coregulated gene protein / Tektin-3 / Outer dynein arm-docking complex subunit 3 / Cilia- and flagella-associated protein 144 / Enkurin / Outer dynein arm-docking complex subunit 2 / Cilia- and flagella-associated protein 276 / Cilia- and flagella- associated protein 210 / Cilia- and flagella-associated protein 52 / EF-hand domain-containing protein 1 / Sperm-associated antigen 8 / EF-hand domain-containing family member B / Outer dynein arm-docking complex subunit 1 / Cilia-and flagella-associated protein 96 / Cilia- and flagella-associated protein 53 / Cilia- and flagella-associated protein 161 / Tubulin alpha-1D chain / Meiosis-specific nuclear structural protein 1 / Tektin-2 / Cilia- and flagella-associated protein 107 / Tektin-4 / Ciliary microtubule inner protein 2B / Tektin-1 / Calaxin / Cilia- and flagella-associated protein 141 / Cilia- and flagella-associated protein 95 / RIB43A-like with coiled-coils protein 2 / Cilia- and flagella-associated protein 45 / Piercer of microtubule wall 1 protein / Tubulin beta-4B chain / Protein Flattop / Nucleoside diphosphate kinase 7 / Cilia- and flagella-associated protein 20
Similarity search - Component
Biological speciesBos taurus (domestic cattle)
Methodsingle particle reconstruction / cryo EM / Resolution: 3.52 Å
AuthorsSun C / Zhang R
Funding support United States, 1 items
OrganizationGrant numberCountry
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)1R01 GM138854 United States
CitationJournal: Nature / Year: 2025
Title: Structural diversity of axonemes across mammalian motile cilia.
Authors: Miguel Ricardo Leung / Chen Sun / Jianwei Zeng / Jacob R Anderson / Qingwei Niu / Wei Huang / Willem E M Noteborn / Alan Brown / Tzviya Zeev-Ben-Mordehai / Rui Zhang /
Abstract: Reproduction, development and homeostasis depend on motile cilia, whose rhythmic beating is powered by a microtubule-based molecular machine called the axoneme. Although an atomic model of the ...Reproduction, development and homeostasis depend on motile cilia, whose rhythmic beating is powered by a microtubule-based molecular machine called the axoneme. Although an atomic model of the axoneme is available for the alga Chlamydomonas reinhardtii, structures of mammalian axonemes are incomplete. Furthermore, we do not fully understand how molecular structures of axonemes vary across motile-ciliated cell types in the body. Here we use cryoelectron microscopy, cryoelectron tomography and proteomics to resolve the 96-nm modular repeat of axonemal doublet microtubules (DMTs) from both sperm flagella and epithelial cilia of the oviduct, brain ventricles and respiratory tract. We find that sperm DMTs are the most specialized, with epithelial cilia having only minor differences across tissues. We build a model of the mammalian sperm DMT, defining the positions and interactions of 181 proteins including 34 newly identified proteins. We elucidate the composition of radial spoke 3 and uncover binding sites of kinases associated with regeneration of ATP and regulation of ciliary motility. We discover a sperm-specific, axoneme-tethered T-complex protein ring complex (TRiC) chaperone that may contribute to construction or maintenance of the long flagella of mammalian sperm. We resolve axonemal dyneins in their prestroke states, illuminating conformational changes that occur during ciliary movement. Our results illustrate how elements of chemical and mechanical regulation are embedded within the axoneme, providing valuable resources for understanding the aetiology of ciliopathy and infertility, and exemplifying the discovery power of modern structural biology.
History
DepositionJul 18, 2024-
Header (metadata) releaseOct 30, 2024-
Map releaseOct 30, 2024-
UpdateMar 19, 2025-
Current statusMar 19, 2025Processing site: RCSB / Status: Released

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Structure visualization

Supplemental images

emd_45801.png

Downloads & links

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Map

FileDownload / File: emd_45801.map.gz / Format: CCP4 / Size: 512 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
Projections & slices

Image control

Size
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AxesZ (Sec.)Y (Row.)X (Col.)
1.34 Å/pix.
x 512 pix.
= 686.08 Å		1.34 Å/pix.
x 512 pix.
= 686.08 Å		1.34 Å/pix.
x 512 pix.
= 686.08 Å

Surface

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Images are generated by Spider.

Voxel sizeX=Y=Z: 1.34 Å
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Contour LevelBy AUTHOR: 0.3
Minimum - Maximum0.0 - 2.5421329
Average (Standard dev.)0.0112885395 (±0.07833449)
SymmetrySpace group: 1
Details

EMDB XML:

Map geometry
Axis orderXYZ
Origin000
Dimensions512512512
Spacing512512512
CellA=B=C: 686.08 Å
α=β=γ: 90.0 °

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Supplemental data

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Mask #1

Fileemd_45801_msk_1.map
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Half map: #2

Fileemd_45801_half_map_1.map
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Half map: #1

Fileemd_45801_half_map_2.map
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Sample components

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Entire : bovine fallopian tube cilia

EntireName: bovine fallopian tube cilia
Components
  • Organelle or cellular component: bovine fallopian tube cilia
    • Protein or peptide: Armadillo repeat containing 4
    • Protein or peptide: Coiled-coil domain containing 114
    • Protein or peptide: Coiled-coil domain containing 173
    • Protein or peptide: Uncharacterized protein C1orf158 homolog
    • Protein or peptide: Protein Flattop
    • Protein or peptide: CFAP141
    • Protein or peptide: Cilia and flagella associated protein 161
    • Protein or peptide: Cilia- and flagella-associated protein 20
    • Protein or peptide: EF-hand domain family member B
    • Protein or peptide: CFAP276
    • Protein or peptide: Cilia and flagella associated protein 45
    • Protein or peptide: Cilia and flagella associated protein 52
    • Protein or peptide: Methyl-CpG binding domain protein 1
    • Protein or peptide: Cilia and flagella associated protein 77
    • Protein or peptide: CFAP95
    • Protein or peptide: Cilia-and flagella-associated protein 96
    • Protein or peptide: EF-hand calcium-binding domain-containing protein 1
    • Protein or peptide: EF-hand calcium binding domain 6
    • Protein or peptide: EF-hand domain containing 1
    • Protein or peptide: EFHC2
    • Protein or peptide: Enkurin, TRPC channel interacting protein
    • Protein or peptide: Protein FAM166B
    • Protein or peptide: Cilia- and flagella-associated protein 144
    • Protein or peptide: Meiosis-specific nuclear structural protein 1
    • Protein or peptide: Nucleoside diphosphate kinase 7
    • Protein or peptide: Outer dynein arm-docking complex subunit 3
    • Protein or peptide: PACRG protein
    • Protein or peptide: Pierce1
    • Protein or peptide: Pierce2
    • Protein or peptide: RIB43A-like with coiled-coils protein 2
    • Protein or peptide: Sperm acrosome associated 9
    • Protein or peptide: Tektin-1
    • Protein or peptide: Tektin-2
    • Protein or peptide: Tektin-3
    • Protein or peptide: Tektin-4
    • Protein or peptide: TTC25 protein
    • Protein or peptide: Ciliary microtubule associated protein 1A
    • Protein or peptide: Ciliary microtubule associated protein 1C
    • Protein or peptide: Cilia and flagella associated protein 90
    • Protein or peptide: Sperm associated antigen 8
    • Protein or peptide: Tubulin beta-4B chain
    • Protein or peptide: Tubulin alpha-1D chain
  • Ligand: GUANOSINE-5'-DIPHOSPHATE
  • Ligand: MAGNESIUM ION
  • Ligand: GUANOSINE-5'-TRIPHOSPHATE

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Supramolecule #1: bovine fallopian tube cilia

SupramoleculeName: bovine fallopian tube cilia / type: organelle_or_cellular_component / ID: 1 / Parent: 0 / Macromolecule list: #1-#42
Source (natural)Organism: Bos taurus (domestic cattle)

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Macromolecule #1: Armadillo repeat containing 4

MacromoleculeName: Armadillo repeat containing 4 / type: protein_or_peptide / ID: 1 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 116.01707 KDa
SequenceString: MGVALTRSAQ WTAAGHGAKT LEVTPLNEAI VKEIIMFVES FIYKYPQEAN YVFVEPLEWK TNLDPSAFGS GYAVSGTTVK SEEADKNGE PLLYLSVPQI KIRSFGQLSR MLYIAKNMKL KEAQACIEAN RNPVAKILGL DYNIISEKIG NSFVSNILDK I TKDDDSES ...String:
MGVALTRSAQ WTAAGHGAKT LEVTPLNEAI VKEIIMFVES FIYKYPQEAN YVFVEPLEWK TNLDPSAFGS GYAVSGTTVK SEEADKNGE PLLYLSVPQI KIRSFGQLSR MLYIAKNMKL KEAQACIEAN RNPVAKILGL DYNIISEKIG NSFVSNILDK I TKDDDSES EIKMKIALQL KQLDLHLLNH SLKHISLEIR LNPGTVKNDI ELLKQFSGKG KQTVLESIEY TSDYEFSNGC RA PPWRQIK GEICYVLVKP HDAETLCVTC SKEGVFLNGG KTDDEGQINY ERKGEIYKDL VTLLKEKSAI FSENMSKQEI KFS EQPQKD QPNEAPKEEV AITHKASVTS RKSTQEKNRI NLGRSQLTKR LEPSLNWRTS VSSKDRNTLR DTQVEKHGGK LEKS RSSVS PGRAQLIRKS VEKIEEIISD SSSESEEDEE QPDHRQEANA DLPSEYWQIQ KLVKYLKGGN QTATVIALCS MKDFN LAQE TCQLAIRDVG GLEVLINLLE TDEVKCKIGS LKILKEISHN PQIRRNIVDL GGLPVMVNIL DSPHKSLKCL AAETIA NVA KFRRARRVVR RHGGITKLVA LLDCGKHSGE PAQSSLYETR DVEVARCGAL ALWSCSKSYA NKEAIRKAGG IPLLARL LK TSHENMLIPV VGTLQECASE ENYRAAIKAE RIIENLVKNL NSENEQLQEH CAMAIYQCAE DEETRDLVRL HGGLKPLA S LLNNTDNKER LAAVTGAIWK CSISKENVTK FREYKAIETL VGLLTDQPEE VLVNVVGALG ECCQEHENRV IIRRCGGIQ PLVNLLVGIN QALLVNVTKA VGACAVEPES MMIIDRLDGV RLLWSLLKNP HPDVKASAAW ALCPCIQNAK DAGEMVRSFV GGLELVVNL LKSDNKEVLA SVCAVITNIA KDQENLAVIT DHGVVPLLSK LANTNNDKLR RHLAETISRC CMWGRNRVAF G EHKAVAPL VRYLKSNDTN VHRATAQALY QLSEDADNCV TMHENGAVKL LLDMVGSPDE ELQEAAAGCI SNIRRLALAI EK ARYS

UniProtKB: Outer dynein arm-docking complex subunit 2

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Macromolecule #2: Coiled-coil domain containing 114

MacromoleculeName: Coiled-coil domain containing 114 / type: protein_or_peptide / ID: 2 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 77.675969 KDa
SequenceString: MPFGLSAGST RSEDGSEAFL EGMVDWELSR LQRQCKVMED ERRAYSKEVH QRINKQLEEI QRLEGVRHKL RVQISIAQSQ VRRLRDSER LESMGHLLKC QVRVQAEVKE LQAQNQALDR EIQEWESRNS AHSKNARSPG CVQHDKVKSQ RRIKSLENQL D KVICRFDI ...String:
MPFGLSAGST RSEDGSEAFL EGMVDWELSR LQRQCKVMED ERRAYSKEVH QRINKQLEEI QRLEGVRHKL RVQISIAQSQ VRRLRDSER LESMGHLLKC QVRVQAEVKE LQAQNQALDR EIQEWESRNS AHSKNARSPG CVQHDKVKSQ RRIKSLENQL D KVICRFDI QLAQNATLRE ELDLLRIERN RYLNVDRKLQ KEIQLLKDSV RNLMVSSTSA YTVREEAKAK LGMLRERAEK EV AQNETEV QILQRQIAHL EQLHHFLKLK NGDRQPDSAI VEKREQRARE VAEGLRKTSQ EKLVLRYEDA LNKLSQMTGE SDP DLLVEK YLELEERNFA EFNFINEQNS ELEHLQEEIK EMQEALVSGR RSEEDRRAQQ EQQRAELQQR VDDVHSEADD LEAR YHNFR EQLEKLKTNI QHLFTRAQCD STLINDLLGI KTHMRDRDIS LFLSLIEKRL VQLLTVQAFL ETQVVVMFNA ALMVL GQSS EDFPKKVAPP QPPDNLEDPP GFEAKDDYPL SKEELLSSVM KAEQHLKELV ESIKVESTPS MTSSTQKVSS SSRLVT QRP SQVPGSIMSH RTSGILVSSG GRATSSNVGH VTFGDSSATT GGLMSSRGSI PGRVTFRSPN SSSYLGSTGY VGSSRDH DS FEASKGPGSE SSGGLGSSPG PASSPGPASS TGQASSTSKD SQSNY

UniProtKB: Outer dynein arm-docking complex subunit 1

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Macromolecule #3: Coiled-coil domain containing 173

MacromoleculeName: Coiled-coil domain containing 173 / type: protein_or_peptide / ID: 3 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 65.437598 KDa
SequenceString: MLVRFGRRSG QAKESAEMKN CEEDPVLYPP LLPTKVDLRQ VTIIPHNEWE RIRDSLDSLT REAACLRAER KAKKEMHLRS QEVVKHWTN TYAGMKEQKL EAKKKRDEEI EAERQILDIE EAIYKQGERK KAIELAKQYQ FYQTERVKNF HSGLLLSRVM K ERDAQIEF ...String:
MLVRFGRRSG QAKESAEMKN CEEDPVLYPP LLPTKVDLRQ VTIIPHNEWE RIRDSLDSLT REAACLRAER KAKKEMHLRS QEVVKHWTN TYAGMKEQKL EAKKKRDEEI EAERQILDIE EAIYKQGERK KAIELAKQYQ FYQTERVKNF HSGLLLSRVM K ERDAQIEF QKSKIKSDKK WEEQVKLNVE KAFKEEREKA EKQRRERVAL AKDHLKQIKE HEEEEERRRK EEEKDAEEIK RQ NSLYEIE MKKKQGKKKE EINESRRLFF EHLNDKHIIK AVEQQQQEEE DEKIRKFIKA KKRLTQMGKE KEAETHRLME ERR KRINNF LSKLMKEKFD NEDLIIARDI AEAEAEWEKR EREKYEKNKA ELKAIAEHRA LVMKNKEEEE RQRKIEATEQ MLAI LKADQ IFWEHEKEKK QKADKERREV QDAHIQQMAK HKFNALQAKQ AESEYCRLTE ALVAEKEKEF QDYAREVIES ESEST KKYI YPLVKAVQEG PGGGRGPVLV DRGGLRPSYQ ANDTTGVQLP FYNSPGSKYN NFQKSKGRLG FTW

UniProtKB: Cilia- and flagella- associated protein 210

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Macromolecule #4: Uncharacterized protein C1orf158 homolog

MacromoleculeName: Uncharacterized protein C1orf158 homolog / type: protein_or_peptide / ID: 4 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 23.271453 KDa
SequenceString: MQFLTAVSPQ SSSTPSWKIE TKYSTRVLTG NWTEERRKFI KATEKTPQTI YRKEYVPFPG HRPDQISRWY SKRTVEGLPY KYLITHHQE PSQRYLISTY DDHYNRHNYH PGLPELRTWN RHKLLWLPEK ADFPLLGPPT NYGLYEQLKQ KWLPPPEATL R ESIYTSSY ...String:
MQFLTAVSPQ SSSTPSWKIE TKYSTRVLTG NWTEERRKFI KATEKTPQTI YRKEYVPFPG HRPDQISRWY SKRTVEGLPY KYLITHHQE PSQRYLISTY DDHYNRHNYH PGLPELRTWN RHKLLWLPEK ADFPLLGPPT NYGLYEQLKQ KWLPPPEATL R ESIYTSSY PRPPAGAMSR REHAIPVPPP RLQPVPHF

UniProtKB: Cilia- and flagella-associated protein 107

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Macromolecule #5: Protein Flattop

MacromoleculeName: Protein Flattop / type: protein_or_peptide / ID: 5 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 21.214035 KDa
SequenceString: MATNYSANQY EKPFSPKYLQ NWSLAKPTKE RISSHEGYTQ IIANDRGHLL PSVPRSKASP WGSFMGTWQM PLKVPPARAT LTSRTAAGA ASLTRWIQKN PDLLKASNGL RPEIFGKPHD PDSQKKLRKS ITKTVQQAPS PTIIPSSPAS NLSSPDQLQS S HPSAGHTP ...String:
MATNYSANQY EKPFSPKYLQ NWSLAKPTKE RISSHEGYTQ IIANDRGHLL PSVPRSKASP WGSFMGTWQM PLKVPPARAT LTSRTAAGA ASLTRWIQKN PDLLKASNGL RPEIFGKPHD PDSQKKLRKS ITKTVQQAPS PTIIPSSPAS NLSSPDQLQS S HPSAGHTP GPQSPLNSPK CPPGSPCLPH AGRNLAEV

UniProtKB: Protein Flattop

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Macromolecule #6: CFAP141

MacromoleculeName: CFAP141 / type: protein_or_peptide / ID: 6 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 12.361437 KDa
SequenceString:
MSMEKMGKVE EHFQRALELK KMVHRWRNSH THCLWQITLS QRRNPYAILR MQDTMVQELA LANKQLLMVR QAALHQLFEK EHQQYQQEL NEKGKAFYME RL

UniProtKB: Cilia- and flagella-associated protein 141

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Macromolecule #7: Cilia and flagella associated protein 161

MacromoleculeName: Cilia and flagella associated protein 161 / type: protein_or_peptide / ID: 7 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 36.519594 KDa
SequenceString: MAQNLYGPRV RIGNWNEDVY LEEEIMKDFL AKRDKGQLLI QRNRRLKENL LRPMQLSVSE DGYIHYGDKV MLVSPDHPET EADLFLPGD LSLCMTPDEI KAHLSNELEV PCGLSAAQTK IPVGRNTFTI LCAAGEVIGQ VLRYGQNFRL GITGGFDDRM L YLSSDHRT ...String:
MAQNLYGPRV RIGNWNEDVY LEEEIMKDFL AKRDKGQLLI QRNRRLKENL LRPMQLSVSE DGYIHYGDKV MLVSPDHPET EADLFLPGD LSLCMTPDEI KAHLSNELEV PCGLSAAQTK IPVGRNTFTI LCAAGEVIGQ VLRYGQNFRL GITGGFDDRM L YLSSDHRT LLKSSKRSWL QEVFLTHEDS YLNCWQAAFP HPQLRLEYEG SPVPANTKIL ITHCHTNRGL VAHRHLFLRT YF GQEAEVA AHTYLDSHRV EKPKNHWMLV TGAPRKDLST MLDLPKPPAE DTRALEQERE QVSDPGARST PDARGCVPQC TLP M

UniProtKB: Cilia- and flagella-associated protein 161

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Macromolecule #8: Cilia- and flagella-associated protein 20

MacromoleculeName: Cilia- and flagella-associated protein 20 / type: protein_or_peptide / ID: 8 / Number of copies: 6 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 22.781389 KDa
SequenceString: MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEIE GTNVSTTYIT CPADPKKTLG IKLPFLVMII KNLKKYFTF EVQVLDDKNV RRRFRASNYQ STTRVKPFIC TMPMRLDDGW NQIQFNLSDF TRRAYGTNYI ETLRVQIHAN C RIRRVYFS ...String:
MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEIE GTNVSTTYIT CPADPKKTLG IKLPFLVMII KNLKKYFTF EVQVLDDKNV RRRFRASNYQ STTRVKPFIC TMPMRLDDGW NQIQFNLSDF TRRAYGTNYI ETLRVQIHAN C RIRRVYFS DRLYSEDELP AEFKLYLPVQ NKAKQ

UniProtKB: Cilia- and flagella-associated protein 20

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Macromolecule #9: EF-hand domain family member B

MacromoleculeName: EF-hand domain family member B / type: protein_or_peptide / ID: 9 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 97.960547 KDa
SequenceString: MCSFLRVPSP KGLEPSKGLG APLQPGTAYP SEMSALGPGM TVSGRKSPLS MEVGLAPEGK DDLEERRVFM GTTSPTELGL RVGLRKDFP CSKTYEERMA SPEIRSPSSK GLELRLKRQN ISRTVMDGSN LGVHRVSASQ ETKPPLSALP GRVGLEKERF L AGYCPGRV ...String:
MCSFLRVPSP KGLEPSKGLG APLQPGTAYP SEMSALGPGM TVSGRKSPLS MEVGLAPEGK DDLEERRVFM GTTSPTELGL RVGLRKDFP CSKTYEERMA SPEIRSPSSK GLELRLKRQN ISRTVMDGSN LGVHRVSASQ ETKPPLSALP GRVGLEKERF L AGYCPGRV TQPPLGQGCE SPQASGGRRC PVTGDPEGFG ASVSKLPALG MECRGELGGE SACVVMKPRA ETEPPVEVDM GL TRLEEPA EMESPEPQMG LVMEPPAWQL AQQPEEQREA ENTEPGVEPP DRIRPIYSGK FFDRMPCWPS AGKVLPIGYR AAT CLTERF PRLMTPPEAK KFFNFRYPPA GAERVFYGRA NDPQIAPSLT HGIRSKISIP AKVLINPQPI TTFQQKMKDK KESV YFSNQ RAPLGKSHDQ TPGLPKGLDI LNTTFGTAIV RETSARDMVN PPKPYKEVFE EAQAGHDLYV VSHNDYFVGE AKNRK YDPS SFHRFNLYGI PTPHFNDGRN MAKTLHWLHE LQMKRGAKIV SKRVDDFKEK FQHRLGRVLD PIAETMNVPP DYTFGA FLR PEDYGVGDLI HRRLPGEYLR GKDRQRGLVA AVRHHLKKVN YQNFDTLLAA FRHYDKKGDG VIDRAELQEA CDQACLH LD EKLLDQLFEY CDVDKDGLIN YLEFANFLTW KDKTPLKEYE ERVLIKGRKA DCANPAEANV EESEPALLLK PEDIVLKE P GSSEKTLRTL LRPSDKVSNH YKTTSSEISA VVGAVPSTCY PTYGVPTIRS DIPAPLIRRV SDRTSYGEEG NAYSLLHPT IFAQKGVFER DFFKTRSKQE ISEILCNIGV KLSEDEFENV WNLASKKHHR GEVCVENIRS VLDELQHADG AKCKAAT

UniProtKB: EF-hand domain-containing family member B

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Macromolecule #10: CFAP276

MacromoleculeName: CFAP276 / type: protein_or_peptide / ID: 10 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 19.387805 KDa
SequenceString:
MPLTRDPFQN PALDKDDSYL GKSRASKKLP YKNPTHLAQQ QEPWCRLSST PTITSMKRDG FFFYSEIPKD DLDFRLAALY NHHTGTFKN KSEILTHQET IQDTRRIKTQ FPGEFLPAPQ PPLITSRANI RHWINPKKES IHSIQGSIVS PHTAATNGGY S RKNDGGFF ST

UniProtKB: Cilia- and flagella-associated protein 276

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Macromolecule #11: Cilia and flagella associated protein 45

MacromoleculeName: Cilia and flagella associated protein 45 / type: protein_or_peptide / ID: 11 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 65.800328 KDa
SequenceString: MPLSTAGVLS SASTASNRSR NRPRYRTKAL SSEVDESLFG AIKPLTRSDS PIVLLRDKHA IRKTLTALGL DHKPETIQLI TRDMVRELI IPTKDPSGQS LIMSPEEFER IKWASHVLTK EELEAREQAF KKEKEAIVDT VTTRKKIMKQ KEMVWRNNRK L SDLEEVAK ...String:
MPLSTAGVLS SASTASNRSR NRPRYRTKAL SSEVDESLFG AIKPLTRSDS PIVLLRDKHA IRKTLTALGL DHKPETIQLI TRDMVRELI IPTKDPSGQS LIMSPEEFER IKWASHVLTK EELEAREQAF KKEKEAIVDT VTTRKKIMKQ KEMVWRNNRK L SDLEEVAK ERAQNLLQRA NQLRMEQEEE LKDMKKIILN AKCHAIRDAQ ILEKQLIQKE LDAEEKRLDQ MMEVERQKSV QR QEELDRK RREERIRGRR HIVEQMEKNQ EERSLLAEQR EQEKEQMLEY MEKLQEEDLR DLEQRHQQKL KMQAEIKRIN DEN QRQKAE LLAQEKLADQ MVMEFTKKKM AREAEFEAEQ ERIRREKEKE IARLRAMQEK AQDYQAEQDA LRAKRNQEVA DREW RRKEK ENAQKKMETE AKLRKSRLEQ VAFKEHTLAV QVQRDRDEFE RILRAQREQI EKERLEEEKK ATGRLQHANE LRRQV RENQ QKQVQARIAT FDEGRRLKEE AQKRRERIED IKRKKLEELR ATGLPEKYCI EAERKANIPV NTSVN

UniProtKB: Cilia- and flagella-associated protein 45

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Macromolecule #12: Cilia and flagella associated protein 52

MacromoleculeName: Cilia and flagella associated protein 52 / type: protein_or_peptide / ID: 12 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 68.719602 KDa
SequenceString: METQASPKDE VAEAVELELE AVIGFNGHVP TGLKCHPDQE HLVYPLGCTI LIQAINTQEQ NFLHGHGNNV SCVAISKSGL YIASGQVTF MGFKADIILW DYKKRELMAR LSLHKGKIEA LAFSPNDMYL VSLGGPDDGS VVVWSIAKRE AICGSPAAGL N VGNATTVI ...String:
METQASPKDE VAEAVELELE AVIGFNGHVP TGLKCHPDQE HLVYPLGCTI LIQAINTQEQ NFLHGHGNNV SCVAISKSGL YIASGQVTF MGFKADIILW DYKKRELMAR LSLHKGKIEA LAFSPNDMYL VSLGGPDDGS VVVWSIAKRE AICGSPAAGL N VGNATTVI FSKCRDEMFV TAGNGTIRVW ELDLPNRKIW PTECQTGQMK RIVMSISMAN DDSFFYLGTT TGDILKMNPR TK LLADTGP AKDKFSLGVS AICCLKMGGL LVGSGDGLLV FCKSPSYKPI KKIQLQGGIT SITLRGEGHQ FFVGTEESHI YRV NFTNFK ETLITTCHFE SVEDIVFPFG TAELFATCAK KDIRVWHTLT NRELLRITVP NMTCHGIDFM RDGKSIISAW DDGR IRAFA PETGRLMYVI NNAHRIGVTA IATTSDCKRV ISGGGEGEVR VWHIGHQTQK LEEALKEHKS SVSCIRVKKS NEECV TAST DGTCIIWDLV RLRRNQMILA NTLFQCVCYH PEEFQIITSG TDRKIAYWEV FDGSVIRELD GSLSGAVNGM DITVEG VHF VTGGNDHLVK VWDYNEGEVT HVGVGHSGNI TRIRISPGNQ YIVSVSADGA ILRWKYPFPS

UniProtKB: Cilia- and flagella-associated protein 52

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Macromolecule #13: Methyl-CpG binding domain protein 1

MacromoleculeName: Methyl-CpG binding domain protein 1 / type: protein_or_peptide / ID: 13 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 62.138992 KDa
SequenceString: MYSQRFGIVQ REVKGPTPKV VIVRAKPPKG QGAEHHLQRI QHSHQKHHAI LASIKSIERD RLKTEWDQHN DCKFVDSLVK ARVKDAMQG FIINTEERRN KLRELLASEE NEYFTEMQLK EETIEEKKDR MRDKIRLLRE KKEKERQDFV AEKLDQQFRE R CQELRAEL ...String:
MYSQRFGIVQ REVKGPTPKV VIVRAKPPKG QGAEHHLQRI QHSHQKHHAI LASIKSIERD RLKTEWDQHN DCKFVDSLVK ARVKDAMQG FIINTEERRN KLRELLASEE NEYFTEMQLK EETIEEKKDR MRDKIRLLRE KKEKERQDFV AEKLDQQFRE R CQELRAEL FCIHQKAVCE ERKAQIAFNE ELKRQKVVEE QMFSKLWEED RLAKERREAK EERRQKELVE NTRLGLNAQV TS IQAQRQA AQRLKEEEAL LVENENAQVK LENEQDKLKK QKTKQEIRAA LQKALQEKME RMQQEYREEQ DLNMKLMQNA LQS LQEETD KKKQKKEDMR REQKIYYQYL AQRHEEEKAQ EKELDRMLEK EKEKKFAEKD KELRLEKEAR KQLLNEVMCT RKLQ VQEKL QRKAKEQEER TMEQERINEG LKELNCEERE NFIRRCSLAQ EYRKQLQMQI CSQQQAREAE EEEERREFEA GIAAE KSFQ DKIQGILSTH QVVPRNIHPM RRACSTKLPP

UniProtKB: Cilia- and flagella-associated protein 53

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Macromolecule #14: Cilia and flagella associated protein 77

MacromoleculeName: Cilia and flagella associated protein 77 / type: protein_or_peptide / ID: 14 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 32.999203 KDa
SequenceString: MPEARNSCQD LTRWKKKKPP VRRTVSQICP PPRRPLTVAD IRPGMENERL GVVRDSMFQN PLIVKAELGK PRERSCSLPG INFNYGLYI RGLDGGVPEA IGHWNVFKQQ PTCPHELTRN YIAMNRGAVK AGLVTARENL HYRQLNDIRI SDQDDRRLKK E PPSLPPNM ...String:
MPEARNSCQD LTRWKKKKPP VRRTVSQICP PPRRPLTVAD IRPGMENERL GVVRDSMFQN PLIVKAELGK PRERSCSLPG INFNYGLYI RGLDGGVPEA IGHWNVFKQQ PTCPHELTRN YIAMNRGAVK AGLVTARENL HYRQLNDIRI SDQDDRRLKK E PPSLPPNM TFGIRARPST PFFDLLQHRY QQLWVQEQKD TQKAIKLEKK HKVILGKLYE TRSSQLRKYK PPMGLDTLWH MP HFQKVGP HLATFPTEAD RQRAFKAHRE ECAVRQGTLR MGNYTHP

UniProtKB: Cilia and flagella associated protein 77

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Macromolecule #15: CFAP95

MacromoleculeName: CFAP95 / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 26.661025 KDa
SequenceString: MDSSDSSCQE WCSHGQYWLE LGPTDLMERK GSLTLRSHHK KYSKPVLVYS WHRDRETYPK DYDIEGPEEV KKLCNSTYRR LGTSEPPVW ISETREKMAQ VCLNTKLAKI KSKALLNEET MNSGIIERDT GLPATGFGAL FTRHSPDWSK MCTLTTYAEE Y APPYEYQP ...String:
MDSSDSSCQE WCSHGQYWLE LGPTDLMERK GSLTLRSHHK KYSKPVLVYS WHRDRETYPK DYDIEGPEEV KKLCNSTYRR LGTSEPPVW ISETREKMAQ VCLNTKLAKI KSKALLNEET MNSGIIERDT GLPATGFGAL FTRHSPDWSK MCTLTTYAEE Y APPYEYQP LGDPCQDDDY SIVHRKCRSQ FTDLDGSKRV GINTWHDESG IYANSYVKRK LYSLTGGPIA PFLK

UniProtKB: Cilia- and flagella-associated protein 95

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Macromolecule #16: Cilia-and flagella-associated protein 96

MacromoleculeName: Cilia-and flagella-associated protein 96 / type: protein_or_peptide / ID: 16 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 34.554371 KDa
SequenceString: MPAEGGKTDM ERIGLFSEME YITVGDKYVS QFNRPFNESA SKNRQILPGG SKEMSNLQAG YFDPHFVRIF EGESYVNPNQ VRRRYMMEE AKKNLSKAFL PSNGEKKPCG LGSYYGTIGG PVPFFSAQSK PKEKYEPPGK NLYTNPGKKG TGYGYANITI G KQFSHSSD ...String:
MPAEGGKTDM ERIGLFSEME YITVGDKYVS QFNRPFNESA SKNRQILPGG SKEMSNLQAG YFDPHFVRIF EGESYVNPNQ VRRRYMMEE AKKNLSKAFL PSNGEKKPCG LGSYYGTIGG PVPFFSAQSK PKEKYEPPGK NLYTNPGKKG TGYGYANITI G KQFSHSSD LYDAAKLNNK KENEEHRRLL KGTAFKLNLY PREYFDTNPY MSEKPLPPIK KVEKKETVGN PFKPSSPGKK AG GMKAGTF DPYPSHSADP YVVKLKSPSS KSAKVFHPPG GPKSRPIESI MALNVKRALN MKNYKTASVQ SY

UniProtKB: Cilia-and flagella-associated protein 96

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Macromolecule #17: EF-hand calcium-binding domain-containing protein 1

MacromoleculeName: EF-hand calcium-binding domain-containing protein 1 / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 24.667131 KDa
SequenceString: MNRKKLQKLT DSLTKNCKHF SKFEVKCLIN LFYNLVGEVT ERQGVIIGLD RNAFRNILHM TFGMTDDMIM DRVFRGFDKD NDGCISVTE WVYGLSVFLR GTLEEKMKYC FEVFDLNGDS FISKEEMFHM LKNSLLKQPS EEDPDEGIKD LVEITLKKMD H DHDGKLSF ...String:
MNRKKLQKLT DSLTKNCKHF SKFEVKCLIN LFYNLVGEVT ERQGVIIGLD RNAFRNILHM TFGMTDDMIM DRVFRGFDKD NDGCISVTE WVYGLSVFLR GTLEEKMKYC FEVFDLNGDS FISKEEMFHM LKNSLLKQPS EEDPDEGIKD LVEITLKKMD H DHDGKLSF ADYEQAVREE TLLLEAFGPC LPDPKSQSEF EAQVFKDPNE FNEV

UniProtKB: Calaxin

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Macromolecule #18: EF-hand calcium binding domain 6

MacromoleculeName: EF-hand calcium binding domain 6 / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 162.942844 KDa
SequenceString: MTVTKSELRR VITTFLLPLT REQFQDVLAQ IPLTSSGAVP YLVFLSRFGG IDLNINVIKR GGENEMNGCR TLKDLEAQVG EKIFKNIKT VIKALMLIDV NTTGLVQPHE LRRVLETFCL KMKDEEYKKF AQHYNIDKDA AVDYNVFLKN LGSNNDLNLK Y NMGSQEVL ...String:
MTVTKSELRR VITTFLLPLT REQFQDVLAQ IPLTSSGAVP YLVFLSRFGG IDLNINVIKR GGENEMNGCR TLKDLEAQVG EKIFKNIKT VIKALMLIDV NTTGLVQPHE LRRVLETFCL KMKDEEYKKF AQHYNIDKDA AVDYNVFLKN LGSNNDLNLK Y NMGSQEVL WENQRVKSFK REEPPSSAVS DNIWKNYSLD EIETAFCLEL SKCYEKVEKA LSAGDPCTSG YVSLNYLKIV LD TFVYRLP RRIFIQLMKR FGLKTTTKVN WKQFLTSFYE PQYEASSKAP LTKRNSINFR NQVHKENVIT KLFRHEDHDS SLK KALLLI KSKPDGQITG QELQRILNCM VVKISDSEFR ELMRILDPGC TGCVNVSRFI ELIEESPKLH KIPAYKDTKM PLFL AWDSV EEIIHDSIAK NLSAFCNMLR SYDLGDTGLI GRNNFKKIMR VFCPFLTTEH LVKLCSKFQD IASGRILYKK LLACL GINR PPTVSPVSMP KGQLLNEHLQ KEEQPLPDHS ERATPAESQG AVTRNMTKDE VIEKLKSCIQ QQDPAFRKRF LDFTKE PNG KIHTHDFKKV LEDYGMPMDD DQYALLTTKL GYKKEGMSYL DFAAGFEDPK MNEPEVTPPQ TPVLPKGDVD SFFVTAE EC LRQFPRRLKE FFRDPYAAFF KMDTDRDGIL TMHDLHRLLQ HLLFNLKDEE FERLLGLLGL RLSITLNFRE FRNLCEKR S FSADDDAPQR LPRPKQKVAD SELACEQAHQ YLVTKAKTRW SDLSKNFIET DSEGNGILRR RDMKNALYGF DIPLTPREF EKLWMRYDSE GRGHITYQEF LQKLGINYSA DIHRPYAEEY FNFMGHFTKP QQVQEELKEL QQSTEKAMPA RDKLKDHDQD ISKALAKLD KSRTGYISLG RLQRLLQECG CSLKEEELID LLNSWGIAWH NNSINYLDFL RAVENNKLTR PQSQEKEESV P INFAALSP EEVLKNIQGV IAASSLALST AFSALDKEDT GFVKASDFGQ VLKDFCYKLT DNQYHYFLRK LRLHLTPYIN WK YFLQNFS SYVEETAVEW AEKMPRGPRP LSPKEMANQE LLARLHKAVT SHYHAIAQEF ENFDTMKTNT ASRDEFRSIC TRH VQVLTD EQFDRLWEEM PVNSKGRLRY LDFLSSFNVD KQATPLATSD SAKAQRGSSV PEVSDRGRSA GSSPTRDPKA GSKP RSHPC TPSSVSGTPP LQNCEPIETK LRKKVQGCWR ELLRECKERD FNKQGEIPGP EFLALVEKFN LDISRDECQQ LLIKY DLKN NGKFAYCSFI QSCVLLLKAK ETSLMQRMKI QNANKMKEAG AETCSFYSAL LRIQPKIVHC WRPMRRTFKA YDEGGT GLL SVADFRKVLR QYSINLSEEE FFHILEYYDK TLSSKISYND FLRAFLQ

UniProtKB: EF-hand calcium binding domain 6

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Macromolecule #19: EF-hand domain containing 1

MacromoleculeName: EF-hand domain containing 1 / type: protein_or_peptide / ID: 19 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 74.125344 KDa
SequenceString: MVSNPVHGLP FLPGTSFKDL TKTAFHRSQT LGYRNGYAVV RRPTVGIGGD RLQVNQLSQA DLDELASKIP ILTYGQARQA PPAAFVPAH VAFDKKVLKF DAYFQEDVPM SIEEHYRIRQ VHIYYYLEDD SMSVIEPVVE NSGIPQGKLI KRQRLSKNDR G DHYHWKDL ...String:
MVSNPVHGLP FLPGTSFKDL TKTAFHRSQT LGYRNGYAVV RRPTVGIGGD RLQVNQLSQA DLDELASKIP ILTYGQARQA PPAAFVPAH VAFDKKVLKF DAYFQEDVPM SIEEHYRIRQ VHIYYYLEDD SMSVIEPVVE NSGIPQGKLI KRQRLSKNDR G DHYHWKDL NRGINITIYG KTFRIVDCDK FTQVFLESQG IELNPPEKMA LDPYTELRKQ PLRKYVTPTD FDQLKQFLTF DK QVLRFYA IWDDTDSMFG ECRTYIIHYY LMDDTVEIRE VHERNDGRDP FPLLMNRQRM PKVLVENAKN FPRCVLEISD KEV LEWYTA KDFIVGKPLT ILGRTFFIYD CDPFTRQYYQ EKFGISDLPR IDMSKKEPPP MKQELPPYNG FGLIEDSAQN CFAL IPKAP QKDVIKMLMN ENKVLRYLAT LESPFPEDKG RRFVLSYFLA TDMISIFEPP VRNSGIIGGK YLGRTKVVKP GSSVE NPVY YGPSDFFIGA VIEVFGHRFV ILDTDDYVLK YMESNAAQYS PEALLSIQNH IRKQEAPAPE LDGQQAEEDP GVRDLE ALI DTIQKQLKDR PCRDNIREAF QIYDKEASGY VDRETFFKIC GSYQLPVDDS LIKELIRMCS HGEDKIDYYN FVRAFSN

UniProtKB: EF-hand domain-containing protein 1

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Macromolecule #20: EFHC2

MacromoleculeName: EFHC2 / type: protein_or_peptide / ID: 20 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 85.566766 KDa
SequenceString: MGKEKFHKSQ HWGFCNNVRM LVGEDKPGIG GELLFGQKIK PKYSVFPKGM GTDSPSWVAF DKQVLSFDAY LEDEVPDKSQ ENYRIRRYK IYFYLEDDTV EVNEPVLQNS GLPQGIFIRR HRISLPPPNE DQFYTVHHFN VNTDIVFYGR TFKVYDCDAF T KNFLTKIG ...String:
MGKEKFHKSQ HWGFCNNVRM LVGEDKPGIG GELLFGQKIK PKYSVFPKGM GTDSPSWVAF DKQVLSFDAY LEDEVPDKSQ ENYRIRRYK IYFYLEDDTV EVNEPVLQNS GLPQGIFIRR HRISLPPPNE DQFYTVHHFN VNTDIVFYGR TFKVYDCDAF T KNFLTKIG VKLNPPGQCP EDPYMKTRRE KLDCMEPICP YESFDTLKQF LEYDRKVLRF FCVWDDSGSV FGDRRELILH YF LSDDTIE IKEVLPHNSG RDAMSLFLQR RKLPKYGPPG VYQPGQLTDQ TVLNVYGGYS ETRVYGFLLD KYQLGKLDQE FYK DTDLSI GTTINVWGRK VLLCDCDDFT KTYYRTKYGI ENFTSIPCKA PSPPKIERKF PPYTGFGSEE DSLRSCIGLM PTPH QRNFK KFIEFDSYGN ISNTLRFFAK LITHKCADVE RMFVISYFLS DDTISVFEPI ERNSGYTGGM FLKRVRVKKP GQEVF KSEF SEYIKAEELY VGAKVNVNGY LFFLVNADEY TLNYMERNSD KFPLSSIELV IQKLKEEECK SRELKQVFTA ADCMHT KMV DFNTFREIMM NLTVGKLTDQ EVITIARRYR VPEDPCPHRN VLVAQAHEQL KKNAFENFER LIAMCVYEDR EKKKVLP SK DIKRLCKSSR LPLNEDLLGS LLSGFEDSEK QINYESFFCA LNWRVNPVPV LEVASYIKER CEDEWLGMPS PIPVKYIY Y LNLLKDVFGV DE

UniProtKB: EF-hand domain-containing family member C2

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Macromolecule #21: Enkurin, TRPC channel interacting protein

MacromoleculeName: Enkurin, TRPC channel interacting protein / type: protein_or_peptide / ID: 21 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 30.215129 KDa
SequenceString: MVAMDPTGPS ESIYNLIPSD WKEPPQPPRY VSIFKATVKD DMQKFKTAMK TMGPAKLEVP SPKDFLKKHS KEKILPPKKK FEWNERRKP PVPLRTDHPV MGIQSEKNFI NTNAADVIMG VAKKPKPIYV DKRTGDKHDL ETSGLVPKYI NKKDYGVTPE Y ICKRNEEV ...String:
MVAMDPTGPS ESIYNLIPSD WKEPPQPPRY VSIFKATVKD DMQKFKTAMK TMGPAKLEVP SPKDFLKKHS KEKILPPKKK FEWNERRKP PVPLRTDHPV MGIQSEKNFI NTNAADVIMG VAKKPKPIYV DKRTGDKHDL ETSGLVPKYI NKKDYGVTPE Y ICKRNEEV KKAQEEYDNY IQENLRKAAM KRLSDEEREA VLQGLKKNWE EVHKEFQSLS VFIDSIPKKI RKQKLEEEMK QL EHDIGVL EKHKVIYIAN KK

UniProtKB: Enkurin

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Macromolecule #22: Protein FAM166B

MacromoleculeName: Protein FAM166B / type: protein_or_peptide / ID: 22 / Number of copies: 6 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 30.551627 KDa
SequenceString: MASTFIPGLN PQNPHYIPGY TGHCPLLRFS MGQTYGQMTG QLLRGSPGLA WPPAHRTLLP PIQPPRSPEP RRRSLPVRPG HERLSSSMV PGYTGFVPQA QFIFAKNCSQ VWAEALNGFT QRNGGQGSQE LPKEAKGEKD VEKDQEPKPE VEKEPELGQE A EQASPYSM ...String:
MASTFIPGLN PQNPHYIPGY TGHCPLLRFS MGQTYGQMTG QLLRGSPGLA WPPAHRTLLP PIQPPRSPEP RRRSLPVRPG HERLSSSMV PGYTGFVPQA QFIFAKNCSQ VWAEALNGFT QRNGGQGSQE LPKEAKGEKD VEKDQEPKPE VEKEPELGQE A EQASPYSM DDRDPRKFFM SGFTGYVPRA RFLFGSSFPV LSNQALQEFG EMKSPGRSQK DPKHLPALSR TYPQHLGLLP KY GGYVPGY KFQFGRTYGH LTQDALGLST LQKQLLV

UniProtKB: Ciliary microtubule inner protein 2B

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Macromolecule #23: Cilia- and flagella-associated protein 144

MacromoleculeName: Cilia- and flagella-associated protein 144 / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 16.178324 KDa
SequenceString:
MAGHQKEKAI ADEVHQNQIL RELYLKELRT QKLYTQYHVN PLRKVHTIAR KPMSWHDNLE EPADARFLNL IHHAAQGPRK KYPETQTEG QEIGWDSEPL VNPQRDDRRL NHFRVYKDIT LYKAKMWSLG EDDRHK

UniProtKB: Cilia- and flagella-associated protein 144

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Macromolecule #24: Meiosis-specific nuclear structural protein 1

MacromoleculeName: Meiosis-specific nuclear structural protein 1 / type: protein_or_peptide / ID: 24 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 60.538367 KDa
SequenceString: MASIRRTLSF SERHQKLVDI NYCKKLHVEA LQRLQNQTRD QMVQNENDDR AERKRFLRLL QDEQFELDME EAIQKAEENK RLRELQLAQ EEKLATELAK LKRESLKDEK LRQQVRENSA ELRELEKKLK AAYMNKERAA QIAEKDAIKY GQMKRDAEIA R TMMEEHER ...String:
MASIRRTLSF SERHQKLVDI NYCKKLHVEA LQRLQNQTRD QMVQNENDDR AERKRFLRLL QDEQFELDME EAIQKAEENK RLRELQLAQ EEKLATELAK LKRESLKDEK LRQQVRENSA ELRELEKKLK AAYMNKERAA QIAEKDAIKY GQMKRDAEIA R TMMEEHER LIKEESAAED KRNQAKAQYS HDLEKQLEEQ GKKKQEAYEQ LLKEKLMIDE IVRKIYEEDQ LERQQRLEKM NT TRRYIEE FQKEQALWRK KKREEMEEEN RKIIEFAKLQ QQREEDRMAK VQEKVKKKRL QLKNMLTQRL EEMLRQREDL EQV RQELYQ EEQAEIYKKK LEEEAEEKLR KQKELKQDFM DQMALKELIL QAAKEEEETF RKAMLAKFAE DDRIELMNAQ KPRM KQLEH KRAVEKLIEE RRNQFLADKQ RELEEWQWQQ RRQGCINAIV EEERLKLLKE HATKLLGYLP KGVFKNEDDI DMLGE EFRK AYQKRSEICE K

UniProtKB: Meiosis-specific nuclear structural protein 1

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Macromolecule #25: Nucleoside diphosphate kinase 7

MacromoleculeName: Nucleoside diphosphate kinase 7 / type: protein_or_peptide / ID: 25 / Number of copies: 2 / Enantiomer: LEVO / EC number: nucleoside-diphosphate kinase
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 42.650895 KDa
SequenceString: MNHSERFVFI AEWFDPNASL FRRYELLFYP GDGSVEMHDV KNHRTFLKRT KYEDLHLEDL FIGNKVNIFS RQLVLLDYGD QYTARQLGS KKEKTLALIK PDAVSKAGEI IEIINKAGFT LTKLKMMTLS RKEATDFHID HQSRPFLNEL IQFITSGPII A MEILRDDA ...String:
MNHSERFVFI AEWFDPNASL FRRYELLFYP GDGSVEMHDV KNHRTFLKRT KYEDLHLEDL FIGNKVNIFS RQLVLLDYGD QYTARQLGS KKEKTLALIK PDAVSKAGEI IEIINKAGFT LTKLKMMTLS RKEATDFHID HQSRPFLNEL IQFITSGPII A MEILRDDA VCEWKRLLGP ANSGLARTDA PESIRALFGT DGIKNAAHGP DSFACAAREM ELFFPSSGVC GPANTAKFTN CT TCCIVKP HAVSEGLLGK ILMTIRDAGF EISAMQMFNM DRINVEEFYE VYKGVVSEYN EMVTEMYSGP CVAMEIQQTN PTM TFREFC GPADPEIARH LRPGTLRAIF GKTKIQNAVH CTDLPEDGLL EVQYFFKILD N

UniProtKB: Nucleoside diphosphate kinase 7

+
Macromolecule #26: Outer dynein arm-docking complex subunit 3

MacromoleculeName: Outer dynein arm-docking complex subunit 3 / type: protein_or_peptide / ID: 26 / Number of copies: 3 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 72.163984 KDa
SequenceString: MTSPLCWAAA SNAMPSQDQI STPSKVKATQ VQLKPYRSRG KGLVPVWHSL HSKAGPLHAS EGKSAVNMQV AELQRKIQLL EGDRKAFYE STQWNIKKNQ ETINQLREET RVLQLQLTAL LQGDEKVVQA VIREWKSEKP YLKNRTGQQA LEHLDYRLNE K VKQLNALR ...String:
MTSPLCWAAA SNAMPSQDQI STPSKVKATQ VQLKPYRSRG KGLVPVWHSL HSKAGPLHAS EGKSAVNMQV AELQRKIQLL EGDRKAFYE STQWNIKKNQ ETINQLREET RVLQLQLTAL LQGDEKVVQA VIREWKSEKP YLKNRTGQQA LEHLDYRLNE K VKQLNALR HQLGLRQKWL EELQLQHSLR ELEIAEAQDS NTEVAKTMRN LENRLEKARM KAEEAEHITS VYLQLKAYLQ EE SLHLGNR LDFMEAEVVR TKHELEELHL VNQEALNARD IAKNQLQYLE ETVFRERKKR ERYLTECKKR AEEKKLQNER MER KTQREH VLLQSDDTLQ DSMYSKEEEL KRRWSMYQME VLFGKVKDAT GVAETHAVVR RFLAQGDTFT QLEMLKSENE QTLL RLKQE KQRLQQELED LKYSGEALLV SEQKRQAELQ GRLKMEEQRR ADAQNQLDRT MRALQITKEG LEHLAGKLNH IVVAG PTYE EGSPGASLDT KGSATPQPQE TGRSVGKMDP KVDDYLPNLL GLVEEKLLKL HSQLENHNVP EMLRHIVDLE FYATLE GKL PSYNTRIALP VAGHKDKFFD EEESEEDDSD VVTRAALKMR SQKLIESRSK RRGRSRRS

UniProtKB: Outer dynein arm-docking complex subunit 3

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Macromolecule #27: PACRG protein

MacromoleculeName: PACRG protein / type: protein_or_peptide / ID: 27 / Number of copies: 6 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 29.323059 KDa
SequenceString: MVAEKETLSL NKCPAKLPTR TKLLAQQPLP VHQPHSLVSE GFTVKAMMKN SVVRGPPSAG AFKERPTKPT AFRKFYERGD FPIALEHDS KGNKIAWKVE IEKLDYHHYL PLFFDGLCEM TFPYEFFARQ GIHDMLEHGG NKILPVIPQL IIPIKNALNL R NRQVICVT ...String:
MVAEKETLSL NKCPAKLPTR TKLLAQQPLP VHQPHSLVSE GFTVKAMMKN SVVRGPPSAG AFKERPTKPT AFRKFYERGD FPIALEHDS KGNKIAWKVE IEKLDYHHYL PLFFDGLCEM TFPYEFFARQ GIHDMLEHGG NKILPVIPQL IIPIKNALNL R NRQVICVT LKVLQHLVVS AEMVGEALVP YYRQILPILN IFKNKNVNSG DGIDYSQQKR ENIGDLIQET LEAFERYGGE DA FINIKYM VPTYESCLLN

UniProtKB: Parkin coregulated gene protein

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Macromolecule #28: Pierce1

MacromoleculeName: Pierce1 / type: protein_or_peptide / ID: 28 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 15.673458 KDa
SequenceString:
MSEEDPKACA EPEEPKAGPP PEKTSDWYRV SEDLPARFNN PAWFRGYRTK EPPSVYRTSN QAYGSRAPTV HEMPKVFYPN SYKFSRQVA VGGMFQNNTL NVYMEKSIVT GPDNYITSYD RLNFHPSYRV CRPSICD

UniProtKB: Piercer of microtubule wall 1 protein

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Macromolecule #29: Pierce2

MacromoleculeName: Pierce2 / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 13.784531 KDa
SequenceString:
MTECDWEKKS TSASNSDTEM KPELPPCVNP GNPVFSCMLD PKTLHTTTSL SKPKMIMYKT NSSNYGEFLP MPQFFPCYYT PREQVFSSH IRATGFYQNN TLNTAPDRTR TLDFPNFQHT L

UniProtKB: Piercer of microtubule wall 2 protein

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Macromolecule #30: RIB43A-like with coiled-coils protein 2

MacromoleculeName: RIB43A-like with coiled-coils protein 2 / type: protein_or_peptide / ID: 30 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 44.773418 KDa
SequenceString: MEVAQPKDLK EDFVLAKRRH AELVRQKRIF NARNRIIGGD TTAWDAQVCD QNIKAATEKA RDEAFAAEMR QNDKIACLSE NRERRDRKN LCKAINDFQQ SFQRPETRRE FDLSDPLALK KDRPARQSDY DARNTISGMQ KFMGEDLNFH LRKKFQEEQN R EWSLQQQK ...String:
MEVAQPKDLK EDFVLAKRRH AELVRQKRIF NARNRIIGGD TTAWDAQVCD QNIKAATEKA RDEAFAAEMR QNDKIACLSE NRERRDRKN LCKAINDFQQ SFQRPETRRE FDLSDPLALK KDRPARQSDY DARNTISGMQ KFMGEDLNFH LRKKFQEEQN R EWSLQQQK EQMIGRENQK CAEDLYLKTR LQFDETAKHL QNLETATRKA VCATVKEFNK NQALESAEKK IQERKQEQED NL AEISNML RGDLLSENPQ QAASSFGPHR VVPDRWKGMS QEQLEEIRLV QRQQVQEKLR LQEEERQRDM DWDRRRIQKA RAT LLFEQQ QQRLQRGLRR ALDCSNLSLA REQLLQKKHM KELCTNHATE DYFTQFNTGS R

UniProtKB: RIB43A-like with coiled-coils protein 2

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Macromolecule #31: Sperm acrosome associated 9

MacromoleculeName: Sperm acrosome associated 9 / type: protein_or_peptide / ID: 31 / Number of copies: 7 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 19.345191 KDa
SequenceString:
MMNEVKESLR SVEQKYKIFQ QQQFTFIGAL EHCRENAHDK IRPISSIGQV QSYMEHHCSN STDRRILLMF LDICSELSKL CQHFEALHA GTPVTNNLLE KCKTLVSQSN DLSSLRAKYP HDVVNHLSCD EARNHYGGVV SLIPIILDLM KEWVAHSEKL P RKALQQGA T

UniProtKB: Sperm acrosome associated 9

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Macromolecule #32: Tektin-1

MacromoleculeName: Tektin-1 / type: protein_or_peptide / ID: 32 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 48.798375 KDa
SequenceString: MAKLLQQPPK FLRAEWQIAN KNQYHRAEAQ RSRSERLVAE SQRLVDEIEK TTRKSQSDVN KKLEQRLEEV RFWKKELDDK LEQLVYATE DLLLYQTRLQ KALESFKEPL HITEKCLEYR EKRVGIDLVH DEVEQELIKE HEIIRGVMTL LTRTLEETCE Q IRLNRSAK ...String:
MAKLLQQPPK FLRAEWQIAN KNQYHRAEAQ RSRSERLVAE SQRLVDEIEK TTRKSQSDVN KKLEQRLEEV RFWKKELDDK LEQLVYATE DLLLYQTRLQ KALESFKEPL HITEKCLEYR EKRVGIDLVH DEVEQELIKE HEIIRGVMTL LTRTLEETCE Q IRLNRSAK YNLEKDLRDK FTAITIDDIC FSLNNNSPNI KYSENVVRVE PNSVSLEDWL DFSNTNVEKA DKQRNNSLTL KA LVDRILF QTASDLRRQC DVVDTAFKNG LKETKDARDK LALHLDKVME EIASQEKNIV VLEKAILDQE GPAKVAHTRL ETR THRPNV ELCRDVAQYR LIKEVDEITH NVARLKETLA QAHVELKGLN RRQLALQEEI QIKENTIYID EVLCVPMRKS IPPR DGDDH GEWAGGSHPE AVC

UniProtKB: Tektin-1

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Macromolecule #33: Tektin-2

MacromoleculeName: Tektin-2 / type: protein_or_peptide / ID: 33 / Number of copies: 8 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 49.962656 KDa
SequenceString: MATLSVKPSP RFRLPDWQTN SYLLSTNAER QRDASHQIRQ EARVLRNETN NQTIWDEHDN RTRLAERIDT VSRWKEMLDK CLTDLDAEI DALAQMKESA EQNLQAKNLP LDVAIECLTL RESRRDIDVV KDPVEEELHK EVEVIEATKK ALQQKISQAF E KLFLLQEA ...String:
MATLSVKPSP RFRLPDWQTN SYLLSTNAER QRDASHQIRQ EARVLRNETN NQTIWDEHDN RTRLAERIDT VSRWKEMLDK CLTDLDAEI DALAQMKESA EQNLQAKNLP LDVAIECLTL RESRRDIDVV KDPVEEELHK EVEVIEATKK ALQQKISQAF E KLFLLQEA RQRLNSDHRG KMETLDIDRG CLSLNLTSPN ISLKINPTRV PNGSTSLQQW DDLSRFNKDH GEAEMKKAIE LR EAIALTI AETNNELEAQ RVATEFAFRK RLREMEKLYS ELKWQEKNTL EEIAELHEDI RHLEEDLRRK LQNLKLCHTR LEA RTYRPN VELCRDQAQY GLTDEVHQLE ATIAALKQKL AQAQDALDAL YKHLARLQAD IACKANSMLL DTKCMDTRRK LTVP AEKFV PEVDTFTRTT NRTLSPLKTC QLELA

UniProtKB: Tektin-2

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Macromolecule #34: Tektin-3

MacromoleculeName: Tektin-3 / type: protein_or_peptide / ID: 34 / Number of copies: 14 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 56.76091 KDa
SequenceString: MELLGSTLTA TYAHPRPTPT NFLPAISTMA STYRDRFPHY NLTHSLSLPW RPSTYYKAAS NWPTLDPYCT RSQRVSESTM LPFVSNRTT LFTRYTPDDW YRSNLTNFQE SNTSRHNSER LRVDTSRLIQ DKYQQTRKTQ ADSTQNLGER VNDIGFWKSE I IHELDAMI ...String:
MELLGSTLTA TYAHPRPTPT NFLPAISTMA STYRDRFPHY NLTHSLSLPW RPSTYYKAAS NWPTLDPYCT RSQRVSESTM LPFVSNRTT LFTRYTPDDW YRSNLTNFQE SNTSRHNSER LRVDTSRLIQ DKYQQTRKTQ ADSTQNLGER VNDIGFWKSE I IHELDAMI GETNELTDIK KRLERALMET EAPLQVAREC LFHREKRMGI DLVHDEVEKE LLTEVDTILC CQERMKLYLD KA IAQLAAN RAAQHELEKD LSDKQSAYRI DDKCHHLRNT SDGVSYFHGV ERVDATVSVP ESWAKFTDDN ILRSQSERAA SAK LRDDIQ NVLVVTANEM WNQFNKVNLA FTNRIAETAD AKNKIQTHLA KTLQEIFQTE MTIESIKKAI VEKSAFLKVA QTRL DERTR RPNIELCRDM AQLRLVNEVY EVDDTIQTLQ QRLRDAEDTL QSLAHTKATL EHDLAVKANS LYIDQDKCMS MRRSF PSTL RLVGFC

UniProtKB: Tektin-3

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Macromolecule #35: Tektin-4

MacromoleculeName: Tektin-4 / type: protein_or_peptide / ID: 35 / Number of copies: 8 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 52.025488 KDa
SequenceString: MAQTDILLTK EPAPQTVPAC QLPRKLYDVA RNTGAHTSSG LATSGFRTAK YLLDEWFQNC YARYHQAFAD RDQSERQRHE SQQLAAETE ALAQRTQQDS TRKVGERLQD MHGWKSELQR QVEELVSETE LLLAQKQRLE RALDATAGPF SIVTDNLQCR E RRQHPDLV ...String:
MAQTDILLTK EPAPQTVPAC QLPRKLYDVA RNTGAHTSSG LATSGFRTAK YLLDEWFQNC YARYHQAFAD RDQSERQRHE SQQLAAETE ALAQRTQQDS TRKVGERLQD MHGWKSELQR QVEELVSETE LLLAQKQRLE RALDATAGPF SIVTDNLQCR E RRQHPDLV RDCVEIELLK EAELIRNIQE LLKRTIKQAV SQIRLNWEHK ETCEMDWSDK VEAYNIDEAC CRYNNQSTDV QF YPHSAKF EESASTPETW AKFTQEHLYR AERERLASVN LRNLIDCILQ DTSEDLRLQC DAVNLAFGRR CEELEDARHK LEH HLRKTL REISDQEHNI AALKQAIKDK EAPLKVAQTR LYQRSHRPNV ELCRDAAQFR LASEVEELNL SLAALKEKLL EAEQ SLRNL EDTRMSLEKD IAIKTNSLFI DRHKCMAHRA HYPTVLQLAG YQ

UniProtKB: Tektin-4

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Macromolecule #36: TTC25 protein

MacromoleculeName: TTC25 protein / type: protein_or_peptide / ID: 36 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 78.492633 KDa
SequenceString: MADPENEVLR STFPSYMAEG ERLYLCGEFA KAAHSFSNAL HLQSGDKNCL VARSKCFLKM GELEKSLEDA EASLQGDPTF CKGILQKAE TLYTMGDFEF ALVFYHRGYK LRPDREFKVG IQKAQEAINN SVGSPSSIKL ENKGDLSFLS KQAESMRAQQ K PHPVRQLI ...String:
MADPENEVLR STFPSYMAEG ERLYLCGEFA KAAHSFSNAL HLQSGDKNCL VARSKCFLKM GELEKSLEDA EASLQGDPTF CKGILQKAE TLYTMGDFEF ALVFYHRGYK LRPDREFKVG IQKAQEAINN SVGSPSSIKL ENKGDLSFLS KQAESMRAQQ K PHPVRQLI HHPKRESKRK GSLKSEKIVR QLLGELYVDK EYLEKLLLDE DLIKGTIKHG LTVEDLIMTG INYLETRSDF WR QQKPIYA RERDRKLMQE KWLRDRKRRP SQTARYILKS LEDIDMLLTS GSAEGSLQKA EKVLKKVLEW NKEEVPNKDE LVG NLYSCI GNAQIELGQM VAALQSHRKD LEIAKEYDLP DAKSRALDNI GRVFARVGKF QQAIDTWEEK IPLAKTTLEK TWLF HEIGR CYLELDQAWE AQSYGEKSQQ CAEEEGDMEW QLNASVLVAQ AQVKLRDFES AVNNFEKALE RAKLVHNNEA QQAII NALD DANKGIIEEL KKTNYREILK EKKEKENATM LDGQTRTAKE KETRKTKDEP EKVMKQWVQE QTEKQLEGVL SKETLG VTA RQPEQRQRED PEKASWRKEL GAKERGPGDT AKGQFGEAGR TEQNREETRE IYRRPSELDQ NLSDESSPRE SEGLEKR LS KTDGGELEAL GKTESGEIKE MEITENSEKI EKDEKEDEPI E

UniProtKB: Outer dynein arm-docking complex subunit 4

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Macromolecule #37: Ciliary microtubule associated protein 1A

MacromoleculeName: Ciliary microtubule associated protein 1A / type: protein_or_peptide / ID: 37 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 27.684936 KDa
SequenceString: MAEEVWVGTW RPHRPRGPIM ALYSSPGPKY LIPPTTGFVK HTPTKLRAPA YSFRGAPMLL AENCSPGPRY SVNPKILRTG KDLGPAYSI LGRYHTKTTL TPGPGDYFPE KSTKHVFDSA PSHSISARTK TFRVDSTPGP AAYMLPMVMG PHTIGKVSQP S FSIKGRSK ...String:
MAEEVWVGTW RPHRPRGPIM ALYSSPGPKY LIPPTTGFVK HTPTKLRAPA YSFRGAPMLL AENCSPGPRY SVNPKILRTG KDLGPAYSI LGRYHTKTTL TPGPGDYFPE KSTKHVFDSA PSHSISARTK TFRVDSTPGP AAYMLPMVMG PHTIGKVSQP S FSIKGRSK LGSFSDDLHK TPGPAAYRQT DVQVTKFKAP QYTMAARVEP PGDKTLKPGP GAHSPEKVTM TRPCAPVVSF GI KHSDYMT PLVVDVD

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Macromolecule #38: Ciliary microtubule associated protein 1C

MacromoleculeName: Ciliary microtubule associated protein 1C / type: protein_or_peptide / ID: 38 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 30.860854 KDa
SequenceString: MKLPKGVKNP VFYGQQPEKK VPMSSGHEIK QTPVVLAMLK GPGPAKYLRP SCTGYIDHDV SMFQEPAYTL HAWHPEKRIM DIRSPGPCY FLDPKITRFG MVSCPQVPMA EHISNLRLSP TPAPCHYHLE KTHLPGERRA PGYSFGFRCP YRVMDPNPGP N RYQMPLLL ...String:
MKLPKGVKNP VFYGQQPEKK VPMSSGHEIK QTPVVLAMLK GPGPAKYLRP SCTGYIDHDV SMFQEPAYTL HAWHPEKRIM DIRSPGPCY FLDPKITRFG MVSCPQVPMA EHISNLRLSP TPAPCHYHLE KTHLPGERRA PGYSFGFRCP YRVMDPNPGP N RYQMPLLL GPNLPANKAA PCYSLAPLDK NWFYKNMSRG PGPAAHTRPE PSVYQNRSPV YSMAKRFGYP VDHTPRPGPG SH NVQQVRA HKPRPPAFTM GIKHSPHLCP LIVDIRD

UniProtKB: Ciliary microtubule associated protein 1C

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Macromolecule #39: Cilia and flagella associated protein 90

MacromoleculeName: Cilia and flagella associated protein 90 / type: protein_or_peptide / ID: 39 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 16.820848 KDa
SequenceString:
MEDDEEEITA AALRGKPRPL PISALSAFSY IPPRRQDPKE HSYYYRQGWT GIISLYDCVF KRDPGYNQKL HRDDREHAKS LGLRINEEE CERPVGVLSS SVYGRRIDQP VEPLNRDHGR AGHVKADFYR KNDITSIKAP GFGHISPA

UniProtKB: Cilia and flagella associated protein 90

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Macromolecule #40: Sperm associated antigen 8

MacromoleculeName: Sperm associated antigen 8 / type: protein_or_peptide / ID: 40 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 51.604398 KDa
SequenceString: METSESTDRS QSRCLDLQPS SDGLGSSSDP FSSWDGRHRS ALVAATAAAS AAATAASTAR AAALWTKSPA PYSHGNLLTE PSSDSLTER YTGPRFTHKI SHGRLGFQPA YFSHIAWNPY TTNDLSSSRG PIPGSSSGPV PGSSSSPGPD SSSDPGPSSS S GPGGSPGG ...String:
METSESTDRS QSRCLDLQPS SDGLGSSSDP FSSWDGRHRS ALVAATAAAS AAATAASTAR AAALWTKSPA PYSHGNLLTE PSSDSLTER YTGPRFTHKI SHGRLGFQPA YFSHIAWNPY TTNDLSSSRG PIPGSSSGPV PGSSSSPGPD SSSDPGPSSS S GPGGSPGG SGRGPGHGPG PGGGSGQGPG GGSGQGTDLG PAIDSRHSPG HGHGPRFNFS APVGFRNPRG DLIPNYTGCK HH CHWEPQK QSWKFLKVSE PGARGLWKPP EVEGKSTVLS ETLPRGQCLL YNWEEERATN YLDQVPVMQD GSESFFFRHG HRG LLTLQP QSPTSSCTTQ KDSYQPPKSH CQPIRGKREA ILEMLLRQQI CKEVQAEQEP TRKDSEVESV THHDYKKELV QAGP PAPTK IHDYHTEQPE TFWLERAPQL PGVSNIRTLD TPFRKNCSFS TPVPLSLEQP LPFEPESYSQ HGEISSLACQ GGGQG GGGG

UniProtKB: Sperm-associated antigen 8

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Macromolecule #41: Tubulin beta-4B chain

MacromoleculeName: Tubulin beta-4B chain / type: protein_or_peptide / ID: 41 / Number of copies: 130 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 49.877824 KDa
SequenceString: MREIVHLQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY YNEATGGKYV PRAVLVDLEP GTMDSVRSGP FGQIFRPDN FVFGQSGAGN NWAKGHYTEG AELVDSVLDV VRKEAESCDC LQGFQLTHSL GGGTGSGMGT LLISKIREEY P DRIMNTFS ...String:
MREIVHLQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY YNEATGGKYV PRAVLVDLEP GTMDSVRSGP FGQIFRPDN FVFGQSGAGN NWAKGHYTEG AELVDSVLDV VRKEAESCDC LQGFQLTHSL GGGTGSGMGT LLISKIREEY P DRIMNTFS VVPSPKVSDT VVEPYNATLS VHQLVENTDE TYCIDNEALY DICFRTLKLT TPTYGDLNHL VSATMSGVTT CL RFPGQLN ADLRKLAVNM VPFPRLHFFM PGFAPLTSRG SQQYRALTVP ELTQQMFDAK NMMAACDPRH GRYLTVAAVF RGR MSMKEV DEQMLNVQNK NSSYFVEWIP NNVKTAVCDI PPRGLKMSAT FIGNSTAIQE LFKRISEQFT AMFRRKAFLH WYTG EGMDE MEFTEAESNM NDLVSEYQQY QDATAEEEGE FEEEAEEEVA

UniProtKB: Tubulin beta-4B chain

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Macromolecule #42: Tubulin alpha-1D chain

MacromoleculeName: Tubulin alpha-1D chain / type: protein_or_peptide / ID: 42 / Number of copies: 134 / Enantiomer: LEVO
Source (natural)Organism: Bos taurus (domestic cattle)
Molecular weightTheoretical: 50.335594 KDa
SequenceString: MRECISVHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK HVPRAVFVDL EPTVIDEVRT GTYRQLFHP EQLITGKEDA ANNYARGHYT IGKELIDLVL DRIRKLADQC TGLQGFLIFH SFGGGTGSGF TSLLMERLSV D YGKKSKLE ...String:
MRECISVHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK HVPRAVFVDL EPTVIDEVRT GTYRQLFHP EQLITGKEDA ANNYARGHYT IGKELIDLVL DRIRKLADQC TGLQGFLIFH SFGGGTGSGF TSLLMERLSV D YGKKSKLE FSIYPAPQVS TAVVEPYNSI LTTHTTLEHS DCAFMVDNEA IYDICRRNLD IERPTYTNLN RLIGQIVSSI TA SLRFDGA LNVDLTEFQT NLVPYPRIHF PLATYAPVIS AEKAYHEQLS VAEITNACFE PANQMVKCDP RHGKYMACCL LYR GDVVPK DVNAAIATIK TKRTIQFVDW CPTGFKVGIN YQPPTVVPGG DLAKVQRAVC MLSNTTAIAE AWARLDHKFD LMYA KRAFV HWYVGEGMEE GEFSEAREDM AALEKDYEEV GMDSVEGEGE EEEGDEY

UniProtKB: Tubulin alpha-1D chain

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Macromolecule #43: GUANOSINE-5'-DIPHOSPHATE

MacromoleculeName: GUANOSINE-5'-DIPHOSPHATE / type: ligand / ID: 43 / Number of copies: 130 / Formula: GDP
Molecular weightTheoretical: 443.201 Da
Chemical component information

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

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Macromolecule #44: MAGNESIUM ION

MacromoleculeName: MAGNESIUM ION / type: ligand / ID: 44 / Number of copies: 106 / Formula: MG
Molecular weightTheoretical: 24.305 Da

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Macromolecule #45: GUANOSINE-5'-TRIPHOSPHATE

MacromoleculeName: GUANOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 45 / Number of copies: 134 / Formula: GTP
Molecular weightTheoretical: 523.18 Da
Chemical component information

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

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Experimental details

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Structure determination

Methodcryo EM
Processingsingle particle reconstruction
Aggregation statefilament

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Sample preparation

BufferpH: 7.4
VitrificationCryogen name: ETHANE

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Electron microscopy

MicroscopeTFS KRIOS
Image recordingFilm or detector model: GATAN K3 BIOQUANTUM (6k x 4k) / Average electron dose: 50.0 e/Å2
Electron beamAcceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
Electron opticsIllumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD / Nominal defocus max: 2.5 µm / Nominal defocus min: 0.5 µm
Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company

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Image processing

Startup modelType of model: EMDB MAP
EMDB ID:

40619

Final reconstructionResolution.type: BY AUTHOR / Resolution: 3.52 Å / Resolution method: FSC 0.143 CUT-OFF / Number images used: 153589
Initial angle assignmentType: MAXIMUM LIKELIHOOD
Final angle assignmentType: MAXIMUM LIKELIHOOD
FSC plot (resolution estimation)

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