登録情報 | データベース: PDB / ID: 7k2u |
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タイトル | DHODH IN COMPLEX WITH LIGAND 13 |
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要素 | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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キーワード | OXIDOREDUCTASE / DIHYDROOROTATE DEHYDROGENASE / DHODH / INHIBITOR |
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機能・相同性 | 機能・相同性情報
pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane ...pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane / mitochondrion / nucleoplasm / cytosol類似検索 - 分子機能 Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / : / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase-type TIM barrel類似検索 - ドメイン・相同性 ACETATE ION / FLAVIN MONONUCLEOTIDE / OROTIC ACID / TRIETHYLENE GLYCOL / Chem-VU7 / Dihydroorotate dehydrogenase (quinone), mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.73 Å |
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データ登録者 | Shaffer, P.L. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2020 タイトル: A carboxylic acid isostere screen of the DHODH inhibitor Brequinar. 著者: DeRatt, L.G. / Christine Pietsch, E. / Tanner, A. / Shaffer, P. / Jacoby, E. / Wang, W. / Kazmi, F. / Zhang, X. / Attar, R.M. / Edwards, J.P. / Kuduk, S.D. |
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履歴 | 登録 | 2020年9月9日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年10月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年3月6日 | Group: Advisory / Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_unobs_or_zero_occ_atoms Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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