+Open data
-Basic information
Entry | Database: PDB / ID: 7jty | ||||||
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Title | Co-crystal structure of alpha glucosidase with compound 1 | ||||||
Components |
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Keywords | HYDROLASE / Alpha Glucosidase II / Endoplasmic reticulum / Inhibitor complex | ||||||
Function / homology | Function and homology information glucan 1,3-alpha-glucosidase activity / glucosidase II complex / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / Post-translational protein phosphorylation / N-glycan processing / liver development / negative regulation of neuron projection development / carbohydrate binding / in utero embryonic development / carbohydrate metabolic process ...glucan 1,3-alpha-glucosidase activity / glucosidase II complex / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / Post-translational protein phosphorylation / N-glycan processing / liver development / negative regulation of neuron projection development / carbohydrate binding / in utero embryonic development / carbohydrate metabolic process / intracellular membrane-bounded organelle / calcium ion binding / protein-containing complex binding / endoplasmic reticulum / RNA binding Similarity search - Function | ||||||
Biological species | Mus musculus (house mouse) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.21 Å | ||||||
Authors | Karade, S.S. / Mariuzza, R.A. | ||||||
Funding support | United States, 1items
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Citation | Journal: J.Med.Chem. / Year: 2021 Title: N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum alpha-Glucosidases I and II with Antiviral Activity. Authors: Karade, S.S. / Hill, M.L. / Kiappes, J.L. / Manne, R. / Aakula, B. / Zitzmann, N. / Warfield, K.L. / Treston, A.M. / Mariuzza, R.A. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7jty.cif.gz | 431.9 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7jty.ent.gz | 329.1 KB | Display | PDB format |
PDBx/mmJSON format | 7jty.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7jty_validation.pdf.gz | 1.1 MB | Display | wwPDB validaton report |
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Full document | 7jty_full_validation.pdf.gz | 1.1 MB | Display | |
Data in XML | 7jty_validation.xml.gz | 71.4 KB | Display | |
Data in CIF | 7jty_validation.cif.gz | 103.9 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/jt/7jty ftp://data.pdbj.org/pub/pdb/validation_reports/jt/7jty | HTTPS FTP |
-Related structure data
Related structure data | 7k9nC 7k9oC 7k9qC 7k9tC 7kadC 7kb6C 7kb8C 7kbjC 7kbrC 7kryC 7l9eC 5f0eS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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