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Yorodumi- PDB-7fqk: Crystal Structure of human Legumain in complex with (2S)-N-[(3S)-... -
+Open data
-Basic information
Entry | Database: PDB / ID: 7fqk | |||||||||
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Title | Crystal Structure of human Legumain in complex with (2S)-N-[(3S)-5-amino-1-(1,3-oxazol-2-yl)-5-oxopent-1-yn-3-yl]-1-[1-[4-(trifluoromethoxy)phenyl]cyclopropanecarbonyl]pyrrolidine-2-carboxamide | |||||||||
Components | Legumain | |||||||||
Keywords | HYDROLASE/INHIBITOR / CYSTEINE PROTEASE / ALLOSTERIC INHIBITOR / ASPARAGINYL ENDOPEPTIDASE / ALZHEIMER'S DISEASE / HYDROLASE / HYDROLASE-INHIBITOR complex | |||||||||
Function / homology | Function and homology information negative regulation of ERBB signaling pathway / legumain / vacuolar protein processing / renal system process / Vitamin D (calciferol) metabolism / receptor catabolic process / vitamin D metabolic process / self proteolysis / endolysosome lumen / response to acidic pH ...negative regulation of ERBB signaling pathway / legumain / vacuolar protein processing / renal system process / Vitamin D (calciferol) metabolism / receptor catabolic process / vitamin D metabolic process / self proteolysis / endolysosome lumen / response to acidic pH / activation of cysteine-type endopeptidase activity / dendritic spine organization / positive regulation of monocyte chemotaxis / Trafficking and processing of endosomal TLR / positive regulation of endothelial cell chemotaxis / negative regulation of multicellular organism growth / cellular response to hepatocyte growth factor stimulus / associative learning / protein maturation / endopeptidase activator activity / cellular response to calcium ion / MHC class II antigen presentation / positive regulation of mitotic cell cycle / lysosomal lumen / proteolysis involved in protein catabolic process / positive regulation of long-term synaptic potentiation / tau protein binding / memory / cellular response to amyloid-beta / antigen processing and presentation of exogenous peptide antigen via MHC class II / late endosome / apical part of cell / peptidase activity / negative regulation of neuron apoptotic process / lysosome / cysteine-type endopeptidase activity / negative regulation of gene expression / positive regulation of cell population proliferation / perinuclear region of cytoplasm / proteolysis / extracellular exosome / extracellular region / cytoplasm Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.97 Å | |||||||||
Authors | Ehler, A. / Benz, J. / Bartels, B. / Rudolph, M.G. | |||||||||
Funding support | Switzerland, 1items
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Citation | Journal: To be published Title: Crystal Structure of a human Legumain complex Authors: Bartels, B. / Kuhn, B. / Benz, J. / Rudolph, M.G. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7fqk.cif.gz | 454.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7fqk.ent.gz | 374.4 KB | Display | PDB format |
PDBx/mmJSON format | 7fqk.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7fqk_validation.pdf.gz | 2.2 MB | Display | wwPDB validaton report |
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Full document | 7fqk_full_validation.pdf.gz | 2.2 MB | Display | |
Data in XML | 7fqk_validation.xml.gz | 44.9 KB | Display | |
Data in CIF | 7fqk_validation.cif.gz | 62.6 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/fq/7fqk ftp://data.pdbj.org/pub/pdb/validation_reports/fq/7fqk | HTTPS FTP |
-Group deposition
ID | G_1002245 (5 entries) |
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Title | To be published |
Type | undefined |
Description | A set of AEP_Legumain crystal structures |
-Related structure data
Similar structure data | Similarity search - Function & homologyF&H Search |
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-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: _ / Refine code: _
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