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- PDB-7aud: Structure of an engineered helicase domain construct for human Bl... -
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Basic information
Entry | Database: PDB / ID: 7aud | |||||||||
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Title | Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) | |||||||||
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![]() | NUCLEAR PROTEIN / Helicase / RecQ / BLM / DNA Repair / Inhibitor / Allosteric | |||||||||
Function / homology | ![]() regulation of DNA-templated DNA replication / RecQ family helicase-topoisomerase III complex / forked DNA-dependent helicase activity / telomeric G-quadruplex DNA binding / resolution of DNA recombination intermediates / 8-hydroxy-2'-deoxyguanosine DNA binding / DNA/DNA annealing activity / telomeric D-loop binding / telomere maintenance via semi-conservative replication / cellular response to camptothecin ...regulation of DNA-templated DNA replication / RecQ family helicase-topoisomerase III complex / forked DNA-dependent helicase activity / telomeric G-quadruplex DNA binding / resolution of DNA recombination intermediates / 8-hydroxy-2'-deoxyguanosine DNA binding / DNA/DNA annealing activity / telomeric D-loop binding / telomere maintenance via semi-conservative replication / cellular response to camptothecin / G-quadruplex DNA unwinding / t-circle formation / telomeric D-loop disassembly / Y-form DNA binding / negative regulation of cell division / four-way junction helicase activity / G-quadruplex DNA binding / cellular response to hydroxyurea / lateral element / negative regulation of DNA recombination / DNA double-strand break processing / bubble DNA binding / Processive synthesis on the C-strand of the telomere / Impaired BRCA2 binding to PALB2 / DNA 3'-5' helicase / Defective homologous recombination repair (HRR) due to BRCA1 loss of function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function / Homologous DNA Pairing and Strand Exchange / Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) / Resolution of D-loop Structures through Holliday Junction Intermediates / DNA duplex unwinding / HDR through Single Strand Annealing (SSA) / Impaired BRCA2 binding to RAD51 / 3'-5' DNA helicase activity / nuclear chromosome / regulation of cyclin-dependent protein serine/threonine kinase activity / DNA unwinding involved in DNA replication / replication fork processing / mitotic G2 DNA damage checkpoint signaling / Presynaptic phase of homologous DNA pairing and strand exchange / response to X-ray / ATP-dependent activity, acting on DNA / SUMOylation of DNA damage response and repair proteins / four-way junction DNA binding / DNA helicase activity / telomere maintenance / isomerase activity / Meiotic recombination / replication fork / helicase activity / molecular function activator activity / cellular response to ionizing radiation / G2/M DNA damage checkpoint / double-strand break repair via homologous recombination / protein homooligomerization / HDR through Homologous Recombination (HRR) / PML body / p53 binding / nuclear matrix / chromosome / Processing of DNA double-strand break ends / protein complex oligomerization / single-stranded DNA binding / DNA replication / Regulation of TP53 Activity through Phosphorylation / DNA recombination / DNA repair / DNA damage response / positive regulation of DNA-templated transcription / nucleolus / protein homodimerization activity / ATP hydrolysis activity / protein-containing complex / DNA binding / zinc ion binding / nucleoplasm / ATP binding / identical protein binding / nucleus / cytoplasm / cytosol Similarity search - Function | |||||||||
Biological species | ![]() synthetic construct (others) | |||||||||
Method | ![]() ![]() ![]() | |||||||||
![]() | Chen, X. / Oliver, A.W. | |||||||||
Funding support | ![]()
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![]() | ![]() Title: Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. Authors: Chen, X. / Ali, Y.I. / Fisher, C.E. / Arribas-Bosacoma, R. / Rajasekaran, M.B. / Williams, G. / Walker, S. / Booth, J.R. / Hudson, J.J. / Roe, S.M. / Pearl, L.H. / Ward, S.E. / Pearl, F.M. / Oliver, A.W. #1: ![]() Title: Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein Authors: Chen, X. / Ali, Y. / Fisher, C.E.L. / Arribas-Bosacoma, R. / Rajasekaran, M.B. / Williams, G. / Walker, S. / Roe, S.M. / Pearl, L.H. / Ward, S.E. / Pearl, F.M.G. / Oliver, A.W. | |||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 1.3 MB | Display | ![]() |
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PDB format | ![]() | 1 MB | Display | ![]() |
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-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 7aucC ![]() 4o3mS S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
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