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Yorodumi- PDB-7aud: Structure of an engineered helicase domain construct for human Bl... -
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-Basic information
Entry | Database: PDB / ID: 7aud | |||||||||
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Title | Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM) | |||||||||
Components |
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Keywords | NUCLEAR PROTEIN / Helicase / RecQ / BLM / DNA Repair / Inhibitor / Allosteric | |||||||||
Function / homology | Function and homology information regulation of DNA-templated DNA replication / RecQ family helicase-topoisomerase III complex / telomeric G-quadruplex DNA binding / forked DNA-dependent helicase activity / resolution of DNA recombination intermediates / 8-hydroxy-2'-deoxyguanosine DNA binding / DNA/DNA annealing activity / telomeric D-loop binding / telomere maintenance via semi-conservative replication / cellular response to camptothecin ...regulation of DNA-templated DNA replication / RecQ family helicase-topoisomerase III complex / telomeric G-quadruplex DNA binding / forked DNA-dependent helicase activity / resolution of DNA recombination intermediates / 8-hydroxy-2'-deoxyguanosine DNA binding / DNA/DNA annealing activity / telomeric D-loop binding / telomere maintenance via semi-conservative replication / cellular response to camptothecin / t-circle formation / G-quadruplex DNA unwinding / telomeric D-loop disassembly / Y-form DNA binding / negative regulation of cell division / four-way junction helicase activity / G-quadruplex DNA binding / DNA double-strand break processing / cellular response to hydroxyurea / lateral element / negative regulation of DNA recombination / bubble DNA binding / Processive synthesis on the C-strand of the telomere / Impaired BRCA2 binding to PALB2 / DNA 3'-5' helicase / replisome / Defective homologous recombination repair (HRR) due to BRCA1 loss of function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function / Homologous DNA Pairing and Strand Exchange / Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) / Resolution of D-loop Structures through Holliday Junction Intermediates / DNA duplex unwinding / HDR through Single Strand Annealing (SSA) / Impaired BRCA2 binding to RAD51 / regulation of cyclin-dependent protein serine/threonine kinase activity / nuclear chromosome / replication fork processing / DNA unwinding involved in DNA replication / mitotic G2 DNA damage checkpoint signaling / 3'-5' DNA helicase activity / Presynaptic phase of homologous DNA pairing and strand exchange / response to X-ray / ATP-dependent activity, acting on DNA / SUMOylation of DNA damage response and repair proteins / four-way junction DNA binding / DNA helicase activity / isomerase activity / telomere maintenance / helicase activity / replication fork / molecular function activator activity / cellular response to ionizing radiation / double-strand break repair via homologous recombination / HDR through Homologous Recombination (HRR) / G2/M DNA damage checkpoint / protein homooligomerization / PML body / Meiotic recombination / nuclear matrix / p53 binding / protein complex oligomerization / chromosome / single-stranded DNA binding / Processing of DNA double-strand break ends / DNA recombination / DNA replication / Regulation of TP53 Activity through Phosphorylation / DNA repair / DNA damage response / nucleolus / positive regulation of DNA-templated transcription / protein homodimerization activity / ATP hydrolysis activity / protein-containing complex / DNA binding / zinc ion binding / nucleoplasm / ATP binding / identical protein binding / nucleus / cytoplasm / cytosol Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) synthetic construct (others) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.96 Å | |||||||||
Authors | Chen, X. / Oliver, A.W. | |||||||||
Funding support | United Kingdom, 2items
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Citation | Journal: Elife / Year: 2021 Title: Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. Authors: Chen, X. / Ali, Y.I. / Fisher, C.E. / Arribas-Bosacoma, R. / Rajasekaran, M.B. / Williams, G. / Walker, S. / Booth, J.R. / Hudson, J.J. / Roe, S.M. / Pearl, L.H. / Ward, S.E. / Pearl, F.M. / Oliver, A.W. #1: Journal: Biorxiv / Year: 2020 Title: Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein Authors: Chen, X. / Ali, Y. / Fisher, C.E.L. / Arribas-Bosacoma, R. / Rajasekaran, M.B. / Williams, G. / Walker, S. / Roe, S.M. / Pearl, L.H. / Ward, S.E. / Pearl, F.M.G. / Oliver, A.W. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7aud.cif.gz | 1.3 MB | Display | PDBx/mmCIF format |
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PDB format | pdb7aud.ent.gz | 1 MB | Display | PDB format |
PDBx/mmJSON format | 7aud.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7aud_validation.pdf.gz | 3.4 MB | Display | wwPDB validaton report |
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Full document | 7aud_full_validation.pdf.gz | 3.4 MB | Display | |
Data in XML | 7aud_validation.xml.gz | 109.8 KB | Display | |
Data in CIF | 7aud_validation.cif.gz | 144.4 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/au/7aud ftp://data.pdbj.org/pub/pdb/validation_reports/au/7aud | HTTPS FTP |
-Related structure data
Related structure data | 7aucC 4o3mS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
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-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
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