登録情報 データベース : PDB / ID : 6s60 構造の表示 ダウンロードとリンクタイトル Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor 要素Transcriptional enhancer factor TEF-4 詳細 キーワード TRANSCRIPTION / TEAD2 / Inhibitor機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
TEAD-YAP complex / lateral mesoderm development / RUNX3 regulates YAP1-mediated transcription / notochord development / YAP1- and WWTR1 (TAZ)-stimulated gene expression / paraxial mesoderm development / hippo signaling / regulation of stem cell differentiation / Formation of axial mesoderm / embryonic heart tube morphogenesis ... TEAD-YAP complex / lateral mesoderm development / RUNX3 regulates YAP1-mediated transcription / notochord development / YAP1- and WWTR1 (TAZ)-stimulated gene expression / paraxial mesoderm development / hippo signaling / regulation of stem cell differentiation / Formation of axial mesoderm / embryonic heart tube morphogenesis / vasculogenesis / embryonic organ development / cellular response to retinoic acid / neural tube closure / transcription coactivator binding / disordered domain specific binding / sequence-specific double-stranded DNA binding / protein-containing complex assembly / transcription regulator complex / transcription by RNA polymerase II / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / intracellular membrane-bounded organelle / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytosol 類似検索 - 分子機能 : / TEA/ATTS domain / Transcriptional enhancer factor, metazoa / TEA/ATTS domain superfamily / TEA/ATTS domain / TEA domain signature. / TEA domain profile. / TEA domain / YAP binding domain / YAP binding domain 類似検索 - ドメイン・相同性 Chem-KX8 / MYRISTIC ACID / Transcriptional enhancer factor TEF-4 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2 Å 詳細データ登録者 Sturbaut, M. / Allemand, F. / Guichou, J.F. 引用ジャーナル : Eur.J.Med.Chem. / 年 : 2021タイトル : Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors.著者 : Sturbaut, M. / Bailly, F. / Coevoet, M. / Sileo, P. / Pugniere, M. / Liberelle, M. / Magnez, R. / Thuru, X. / Chartier-Harlin, M.C. / Melnyk, P. / Gelin, M. / Allemand, F. / Guichou, J.F. / Cotelle, P. 履歴 登録 2019年7月2日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2020年7月22日 Provider : repository / タイプ : Initial release改定 1.1 2022年2月2日 Group : Database references / カテゴリ : citation / citation_author / database_2Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession 改定 1.2 2024年1月24日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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