Entry | Database: PDB / ID: 6r66 |
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Title | Crystal structure of transthyretin in complex with CHF5075, a flurbiprofen analogue |
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Components | Transthyretin |
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Keywords | TRANSPORT PROTEIN / Amyloidosis / tetramer / binding protein |
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Function / homology | Function and homology information
Retinoid cycle disease events / thyroid hormone binding / The canonical retinoid cycle in rods (twilight vision) / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation ...Retinoid cycle disease events / thyroid hormone binding / The canonical retinoid cycle in rods (twilight vision) / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / identical protein bindingSimilarity search - Function Transthyretin, conserved site / Transthyretin signature 2. / Transthyretin, thyroxine binding site / Transthyretin signature 1. / Transthyretin / Transthyretin/hydroxyisourate hydrolase / Transthyretin/hydroxyisourate hydrolase domain / Transthyretin/hydroxyisourate hydrolase domain superfamily / HIUase/Transthyretin familySimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.3 Å |
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Authors | Loconte, V. / Menozzi, I. / Ferrari, A. / Berni, R. / Zanotti, G. |
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Citation | Journal: J.Struct.Biol. / Year: 2019 Title: Structure-activity relationships of flurbiprofen analogues as stabilizers of the amyloidogenic protein transthyretin. Authors: Loconte, V. / Menozzi, I. / Ferrari, A. / Folli, C. / Imbimbo, B.P. / Zanotti, G. / Berni, R. |
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History | Deposition | Mar 26, 2019 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Sep 11, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Nov 6, 2019 | Group: Data collection / Database references / Category: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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Revision 1.2 | May 15, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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