登録情報 データベース : PDB / ID : 6pdp 構造の表示 ダウンロードとリンクタイトル Human PIM1 bound to benzothiophene inhibitor 379 要素Peptide Serine/threonine-protein kinase pim-1 詳細キーワード TRANSFERASE/TRANSFERASE Inhibitor / PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1 / Structural Genomics / Structural Genomics Consortium / SGC / TRANSFERASE / TRANSFERASE-TRANSFERASE Inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of cardioblast proliferation / regulation of hematopoietic stem cell proliferation / vitamin D receptor signaling pathway / cellular detoxification / positive regulation of cyclin-dependent protein serine/threonine kinase activity / STAT5 activation downstream of FLT3 ITD mutants / transcription factor binding / ribosomal small subunit binding / positive regulation of cardiac muscle cell proliferation / Signaling by FLT3 fusion proteins ... positive regulation of cardioblast proliferation / regulation of hematopoietic stem cell proliferation / vitamin D receptor signaling pathway / cellular detoxification / positive regulation of cyclin-dependent protein serine/threonine kinase activity / STAT5 activation downstream of FLT3 ITD mutants / transcription factor binding / ribosomal small subunit binding / positive regulation of cardiac muscle cell proliferation / Signaling by FLT3 fusion proteins / positive regulation of TORC1 signaling / negative regulation of innate immune response / positive regulation of brown fat cell differentiation / protein serine/threonine kinase activator activity / regulation of transmembrane transporter activity / positive regulation of protein serine/threonine kinase activity / negative regulation of DNA-binding transcription factor activity / cellular response to type II interferon / manganese ion binding / Interleukin-4 and Interleukin-13 signaling / protein autophosphorylation / protein stabilization / non-specific serine/threonine protein kinase / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / positive regulation of DNA-templated transcription / negative regulation of apoptotic process / nucleolus / apoptotic process / nucleoplasm / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 Serine/threonine-protein kinase pim-1/2/3 / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain ... Serine/threonine-protein kinase pim-1/2/3 / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 Chem-OBY / Serine/threonine-protein kinase pim-1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)synthetic construct (人工物) 手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.5 Å 詳細データ登録者 Godoi, P.H.C. / Sriranganadane, D. / Santiago, A.S. / Fala, A.M. / Ramos, P.Z. / Mascarello, A. / Segretti, N. / Azevedo, H. / Guimaraes, C.R.W. / Arruda, P. ...Godoi, P.H.C. / Sriranganadane, D. / Santiago, A.S. / Fala, A.M. / Ramos, P.Z. / Mascarello, A. / Segretti, N. / Azevedo, H. / Guimaraes, C.R.W. / Arruda, P. / Elkins, J.M. / Counago, R.M. / Structural Genomics Consortium (SGC) 資金援助 ブラジル, 1件 詳細 詳細を隠す組織 認可番号 国 Sao Paulo Research Foundation (FAPESP) 13/50724-5 ブラジル
引用ジャーナル : To Be Published タイトル : Human PIM1著者 : Godoi, P.H.C. / Santiago, A.S. / Fala, A.M. / Ramos, P.Z. / Sriranganadane, D. / Mascarello, A. / Segretti, N. / Azevedo, H. / Guimaraes, C.R.W. / Arruda, P. / Elkins, J.M. / Counago, R.M. 履歴 登録 2019年6月19日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2019年7月24日 Provider : repository / タイプ : Initial release改定 1.1 2020年1月1日 Group : Author supporting evidence / カテゴリ : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization改定 1.2 2024年3月13日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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