登録情報 | データベース: PDB / ID: 6p2b |
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タイトル | Tethered PXR-LBD/SRC-1p bound to Garcinoic Acid |
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要素 | Nuclear receptor subfamily 1 group I member 2 |
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キーワード | TRANSCRIPTION / Garcinoic Acid / nuclear receptor |
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機能・相同性 | 機能・相同性情報
xenobiotic transport / intermediate filament cytoskeleton / steroid metabolic process / xenobiotic catabolic process / xenobiotic metabolic process / nuclear receptor binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / SUMOylation of intracellular receptors / Nuclear Receptor transcription pathway / nuclear receptor activity ...xenobiotic transport / intermediate filament cytoskeleton / steroid metabolic process / xenobiotic catabolic process / xenobiotic metabolic process / nuclear receptor binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / SUMOylation of intracellular receptors / Nuclear Receptor transcription pathway / nuclear receptor activity / sequence-specific double-stranded DNA binding / DNA-binding transcription activator activity, RNA polymerase II-specific / transcription regulator complex / cell differentiation / nuclear body / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of DNA-templated transcription / regulation of DNA-templated transcription / positive regulation of gene expression / chromatin / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm / nucleus類似検索 - 分子機能 : / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain ...: / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-NQD / Nuclear receptor subfamily 1 group I member 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.3 Å |
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データ登録者 | Walton, W.G. / Pellock, S.J. / Redinbo, M.R. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI) | CA222469 | 米国 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2020 タイトル: Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. 著者: Bartolini, D. / De Franco, F. / Torquato, P. / Marinelli, R. / Cerra, B. / Ronchetti, R. / Schon, A. / Fallarino, F. / De Luca, A. / Bellezza, G. / Ferri, I. / Sidoni, A. / Walton, W.G. / ...著者: Bartolini, D. / De Franco, F. / Torquato, P. / Marinelli, R. / Cerra, B. / Ronchetti, R. / Schon, A. / Fallarino, F. / De Luca, A. / Bellezza, G. / Ferri, I. / Sidoni, A. / Walton, W.G. / Pellock, S.J. / Redinbo, M.R. / Mani, S. / Pellicciari, R. / Gioiello, A. / Galli, F. |
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履歴 | 登録 | 2019年5月21日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年4月1日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年4月22日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.2 | 2023年10月11日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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