xenobiotic transport / labyrinthine layer morphogenesis / regulation of thyroid hormone receptor signaling pathway / positive regulation of transcription from RNA polymerase II promoter by galactose / positive regulation of female receptivity / intermediate filament cytoskeleton / hypothalamus development / male mating behavior / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / steroid metabolic process ...xenobiotic transport / labyrinthine layer morphogenesis / regulation of thyroid hormone receptor signaling pathway / positive regulation of transcription from RNA polymerase II promoter by galactose / positive regulation of female receptivity / intermediate filament cytoskeleton / hypothalamus development / male mating behavior / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / steroid metabolic process / cellular response to Thyroglobulin triiodothyronine / estrous cycle / Synthesis of bile acids and bile salts / Endogenous sterols / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / xenobiotic catabolic process / nuclear retinoid X receptor binding / response to retinoic acid / histone acetyltransferase activity / regulation of cellular response to insulin stimulus / Recycling of bile acids and salts / histone acetyltransferase / cellular response to hormone stimulus / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / positive regulation of adipose tissue development / peroxisome proliferator activated receptor signaling pathway / RORA activates gene expression / lactation / positive regulation of neuron differentiation / Regulation of lipid metabolism by PPARalpha / xenobiotic metabolic process / cerebellum development / BMAL1:CLOCK,NPAS2 activates circadian gene expression / SUMOylation of transcription cofactors / Activation of gene expression by SREBF (SREBP) / nuclear receptor coactivator activity / response to progesterone / hippocampus development / nuclear estrogen receptor binding / nuclear receptor binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / Heme signaling / SUMOylation of intracellular receptors / mRNA transcription by RNA polymerase II / Transcriptional activation of mitochondrial biogenesis / PPARA activates gene expression / Cytoprotection by HMOX1 / cerebral cortex development / Transcriptional regulation of white adipocyte differentiation / Nuclear Receptor transcription pathway / RNA polymerase II transcription regulator complex / nuclear receptor activity / male gonad development / sequence-specific double-stranded DNA binding / Circadian Clock / response to estradiol / HATs acetylate histones / DNA-binding transcription activator activity, RNA polymerase II-specific / Estrogen-dependent gene expression / transcription regulator complex / transcription coactivator activity / cell differentiation / nuclear body / protein dimerization activity / DNA-binding transcription factor activity, RNA polymerase II-specific / positive regulation of apoptotic process / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of DNA-templated transcription / chromatin binding / positive regulation of gene expression / regulation of DNA-templated transcription / chromatin / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / protein-containing complex / zinc ion binding / nucleoplasm / nucleus / plasma membrane / cytosol Similarity search - Function
A: NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 B: NUCLEAR RECEPTOR SUBFAMILY 1 GROUP I MEMBER 2 C: NUCLEAR RECEPTOR COACTIVATOR 1 D: NUCLEAR RECEPTOR COACTIVATOR 1 hetero molecules
Mass: 36136.738 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) HOMO SAPIENS (human) / Production host: ESCHERICHIA COLI (E. coli) / References: UniProt: O75469
#2: Protein/peptide
NUCLEARRECEPTORCOACTIVATOR1 / NCOA-1 / CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 74 / BHLHE74 / PROTEIN HIN-2 / RIP160 / RENAL ...NCOA-1 / CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 74 / BHLHE74 / PROTEIN HIN-2 / RIP160 / RENAL CARCINOMA ANTIGEN NY-REN-52 / STEROID RECEPTOR COACTIVATOR 1 / SRC-1 / STEROID RECEPTOR COACTIVATOR 1
Mass: 2022.333 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) HOMO SAPIENS (human) / Production host: ESCHERICHIA COLI (E. coli) / References: UniProt: Q15788, histone acetyltransferase
Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength
Wavelength: 0.9395 Å / Relative weight: 1
Reflection
Resolution: 2.25→45.74 Å / Num. obs: 37577 / % possible obs: 98 % / Observed criterion σ(I): 0 / Redundancy: 3.8 % / Biso Wilson estimate: 49.57 Å2 / Rmerge(I) obs: 0.06 / Net I/σ(I): 13.9
Reflection shell
Resolution: 2.25→2.31 Å / Redundancy: 3.8 % / Rmerge(I) obs: 0.55 / Mean I/σ(I) obs: 2.3 / % possible all: 100
-
Processing
Software
Name
Version
Classification
BUSTER
2.11.6
refinement
SCALA
datascaling
Refinement
Method to determine structure: MOLECULAR REPLACEMENT Starting model: NONE Resolution: 2.25→14.88 Å / Cor.coef. Fo:Fc: 0.9242 / Cor.coef. Fo:Fc free: 0.9175 / SU R Cruickshank DPI: 0.284 / Cross valid method: THROUGHOUT / σ(F): 0 / SU R Blow DPI: 0.297 / SU Rfree Blow DPI: 0.215 / SU Rfree Cruickshank DPI: 0.213 Details: IDEAL-DIST CONTACT TERM CONTACT SETUP. ALL ATOMS HAVE CCP4 ATOM TYPE FROM LIBRARY
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.2555
1877
5.01 %
RANDOM
Rwork
0.2306
-
-
-
obs
0.2319
37467
97.62 %
-
Displacement parameters
Biso mean: 58.84 Å2
Baniso -1
Baniso -2
Baniso -3
1-
0.6202 Å2
0 Å2
0 Å2
2-
-
-2.5639 Å2
0 Å2
3-
-
-
1.9436 Å2
Refine analyze
Luzzati coordinate error obs: 0.356 Å
Refinement step
Cycle: LAST / Resolution: 2.25→14.88 Å
Protein
Nucleic acid
Ligand
Solvent
Total
Num. atoms
4724
0
56
301
5081
Refine LS restraints
Refine-ID
Type
Dev ideal
Number
Restraint function
Weight
X-RAY DIFFRACTION
t_bond_d
0.008
4883
HARMONIC
2
X-RAY DIFFRACTION
t_angle_deg
0.9
6578
HARMONIC
2
X-RAY DIFFRACTION
t_dihedral_angle_d
1759
SINUSOIDAL
2
X-RAY DIFFRACTION
t_incorr_chiral_ct
X-RAY DIFFRACTION
t_pseud_angle
X-RAY DIFFRACTION
t_trig_c_planes
121
HARMONIC
2
X-RAY DIFFRACTION
t_gen_planes
687
HARMONIC
5
X-RAY DIFFRACTION
t_it
4883
HARMONIC
20
X-RAY DIFFRACTION
t_nbd
X-RAY DIFFRACTION
t_omega_torsion
2.23
X-RAY DIFFRACTION
t_other_torsion
19.3
X-RAY DIFFRACTION
t_improper_torsion
X-RAY DIFFRACTION
t_chiral_improper_torsion
613
SEMIHARMONIC
5
X-RAY DIFFRACTION
t_sum_occupancies
X-RAY DIFFRACTION
t_utility_distance
X-RAY DIFFRACTION
t_utility_angle
X-RAY DIFFRACTION
t_utility_torsion
X-RAY DIFFRACTION
t_ideal_dist_contact
5950
SEMIHARMONIC
4
LS refinement shell
Resolution: 2.25→2.31 Å / Total num. of bins used: 19
Rfactor
Num. reflection
% reflection
Rfree
0.3353
152
5.1 %
Rwork
0.3242
2826
-
all
0.3248
2978
-
obs
-
-
99.97 %
+
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