登録情報 | データベース: PDB / ID: 6o3c |
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タイトル | Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8 |
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要素 | |
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キーワード | SIGNALING PROTEIN / GPCR / Signaling / Hedgehog / Smoothened / Cholesterol / SAG |
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機能・相同性 | 機能・相同性情報
BBSome-mediated cargo-targeting to cilium / regulation of localization / ventral midline determination / mesenchymal to epithelial transition involved in metanephric renal vesicle formation / Activation of SMO / regulation of heart morphogenesis / contact inhibition / negative regulation of hair follicle development / negative regulation of hepatocyte proliferation / central nervous system neuron differentiation ...BBSome-mediated cargo-targeting to cilium / regulation of localization / ventral midline determination / mesenchymal to epithelial transition involved in metanephric renal vesicle formation / Activation of SMO / regulation of heart morphogenesis / contact inhibition / negative regulation of hair follicle development / negative regulation of hepatocyte proliferation / central nervous system neuron differentiation / 9+0 non-motile cilium / pancreas morphogenesis / regulation of somatic stem cell population maintenance / mesenchymal to epithelial transition / epithelial-mesenchymal cell signaling / myoblast migration / atrial septum morphogenesis / spinal cord dorsal/ventral patterning / Hedgehog 'on' state / determination of left/right asymmetry in lateral mesoderm / axon extension involved in axon guidance / midgut development / cell development / positive regulation of hepatic stellate cell activation / left/right axis specification / Hedgehog 'off' state / thalamus development / somite development / patched binding / forebrain morphogenesis / cellular response to cholesterol / type B pancreatic cell development / positive regulation of branching involved in ureteric bud morphogenesis / positive regulation of organ growth / dorsal/ventral neural tube patterning / smooth muscle tissue development / pattern specification process / cerebellar cortex morphogenesis / mammary gland epithelial cell differentiation / dentate gyrus development / dopaminergic neuron differentiation / commissural neuron axon guidance / oxysterol binding / positive regulation of multicellular organism growth / positive regulation of neural precursor cell proliferation / digestive tract development / positive regulation of smoothened signaling pathway / dorsal/ventral pattern formation / positive regulation of vascular associated smooth muscle cell migration / determination of left/right symmetry / neural crest cell migration / cell fate specification / cAMP-dependent protein kinase inhibitor activity / hair follicle development / anterior/posterior pattern specification / ciliary membrane / positive regulation of mesenchymal cell proliferation / negative regulation of epithelial cell differentiation / hair follicle morphogenesis / smoothened signaling pathway / positive regulation of neuroblast proliferation / heart looping / negative regulation of DNA binding / odontogenesis of dentin-containing tooth / dendritic growth cone / protein kinase A catalytic subunit binding / endoplasmic reticulum-Golgi intermediate compartment / protein localization to nucleus / developmental growth / epithelial cell differentiation / neuroblast proliferation / vasculogenesis / embryonic organ development / ossification / skeletal muscle fiber development / axonal growth cone / positive regulation of autophagy / heart morphogenesis / positive regulation of epithelial cell proliferation / homeostasis of number of cells within a tissue / epithelial cell proliferation / protein sequestering activity / centriole / astrocyte activation / negative regulation of protein phosphorylation / caveola / central nervous system development / G protein-coupled receptor activity / multicellular organism growth / cilium / cerebral cortex development / positive regulation of protein import into nucleus / osteoblast differentiation / protein import into nucleus / endocytic vesicle membrane / late endosome / regulation of gene expression / gene expression / in utero embryonic development / negative regulation of neuron apoptotic process類似検索 - 分子機能 Smoothened, transmembrane domain / Smoothened, cysteine-rich domain / Frizzled/Smoothened, transmembrane domain / Frizzled/Smoothened family membrane region / Frizzled/Smoothened family membrane region / Frizzled/secreted frizzled-related protein / Frizzled / Frizzled domain / Frizzled cysteine-rich domain superfamily / Fz domain ...Smoothened, transmembrane domain / Smoothened, cysteine-rich domain / Frizzled/Smoothened, transmembrane domain / Frizzled/Smoothened family membrane region / Frizzled/Smoothened family membrane region / Frizzled/secreted frizzled-related protein / Frizzled / Frizzled domain / Frizzled cysteine-rich domain superfamily / Fz domain / Frizzled (fz) domain profile. / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2.類似検索 - ドメイン・相同性 CHOLESTEROL / Chem-LKD / (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate / PHOSPHATE ION / Protein smoothened類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ)
![](img/tx_mammal.gif) Lama glama (ラマ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.8 Å |
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データ登録者 | Deshpande, I.S. / Liang, J. / Hedeen, D. / Roberts, K.J. / Zhang, Y. / Ha, B. / Latorraca, N.R. / Faust, B. / Dror, R.O. / Beachy, P.A. ...Deshpande, I.S. / Liang, J. / Hedeen, D. / Roberts, K.J. / Zhang, Y. / Ha, B. / Latorraca, N.R. / Faust, B. / Dror, R.O. / Beachy, P.A. / Myers, B.R. / Manglik, A. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/Office of the Director | DP5-OD023048-01 | 米国 |
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引用 | ジャーナル: Nature / 年: 2019 タイトル: Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. 著者: Deshpande, I. / Liang, J. / Hedeen, D. / Roberts, K.J. / Zhang, Y. / Ha, B. / Latorraca, N.R. / Faust, B. / Dror, R.O. / Beachy, P.A. / Myers, B.R. / Manglik, A. |
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履歴 | 登録 | 2019年2月26日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年7月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年7月17日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.name |
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改定 1.2 | 2019年7月24日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2020年7月29日 | Group: Data collection / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 1.4 | 2023年10月11日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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