Entry | Database: PDB / ID: 6hk2 |
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Title | Crystal structure of ferric R-state human methemoglobin bound to maleimide-deferoxamine bifunctional chelator (DFO) |
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Components | (Hemoglobin subunit ...) x 2 |
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Keywords | OXYGEN TRANSPORT / DFO / COMPLEX / BETA CYS93 |
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Function / homology | Function and homology information
nitric oxide transport / hemoglobin alpha binding / cellular oxidant detoxification / hemoglobin binding / haptoglobin-hemoglobin complex / organic acid binding / renal absorption / hemoglobin complex / oxygen transport / Scavenging of heme from plasma ...nitric oxide transport / hemoglobin alpha binding / cellular oxidant detoxification / hemoglobin binding / haptoglobin-hemoglobin complex / organic acid binding / renal absorption / hemoglobin complex / oxygen transport / Scavenging of heme from plasma / endocytic vesicle lumen / blood vessel diameter maintenance / platelet aggregation / hydrogen peroxide catabolic process / oxygen carrier activity / Late endosomal microautophagy / Heme signaling / carbon dioxide transport / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / response to hydrogen peroxide / Cytoprotection by HMOX1 / oxygen binding / regulation of blood pressure / Chaperone Mediated Autophagy / positive regulation of nitric oxide biosynthetic process / tertiary granule lumen / Factors involved in megakaryocyte development and platelet production / ficolin-1-rich granule lumen / blood microparticle / iron ion binding / heme binding / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / membrane / metal ion binding / cytosolSimilarity search - Function Hemoglobin, pi / : / Hemoglobin, alpha-type / Hemoglobin, beta-type / Globin/Protoglobin / Globins / Globin domain profile. / Globin-like / Globin / Globin ...Hemoglobin, pi / : / Hemoglobin, alpha-type / Hemoglobin, beta-type / Globin/Protoglobin / Globins / Globin domain profile. / Globin-like / Globin / Globin / Globin-like superfamily / Orthogonal Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.55 Å |
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Authors | Cerutti, G. / Savino, C. / Montemiglio, L.C. / Boffi, A. |
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Funding support | Italy, 2items Organization | Grant number | Country |
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European Commission | 637295 | Italy | European Commission | 312284 | Italy |
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Citation | Journal: Int J Mol Sci / Year: 2020 Title: Biodistribution PET/CT Study of Hemoglobin-DFO-89Zr Complex in Healthy and Lung Tumor-Bearing Mice. Authors: Kiraga, L. / Cerutti, G. / Braniewska, A. / Strzemecki, D. / Sas, Z. / Boffi, A. / Savino, C. / Montemiglio, L.C. / Turnham, D. / Seaton, G. / Bonamore, A. / Clarkson, R. / Dabkowski, A.M. / ...Authors: Kiraga, L. / Cerutti, G. / Braniewska, A. / Strzemecki, D. / Sas, Z. / Boffi, A. / Savino, C. / Montemiglio, L.C. / Turnham, D. / Seaton, G. / Bonamore, A. / Clarkson, R. / Dabkowski, A.M. / Paisey, S.J. / Taciak, B. / Kucharzewska, P. / Rygiel, T.P. / Krol, M. |
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History | Deposition | Sep 5, 2018 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Sep 18, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 29, 2020 | Group: Database references / Derived calculations Category: citation / citation_author ...citation / citation_author / struct_conn / struct_conn_type Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_ptnr1_label_alt_id / _struct_conn.pdbx_ptnr2_label_alt_id / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn_type.id |
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Revision 1.2 | Jan 17, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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