登録情報 | データベース: PDB / ID: 6g0w |
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タイトル | Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor MCD72 |
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要素 | Poly [ADP-ribose] polymerase 14 |
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キーワード | TRANSFERASE / ADP-RIBOSYLATION / INHIBITOR COMPLEX / TRANSFERASE DOMAIN |
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機能・相同性 | 機能・相同性情報
positive regulation of interleukin-4-mediated signaling pathway / negative regulation of tyrosine phosphorylation of STAT protein / Nicotinamide salvaging / negative regulation of type II interferon-mediated signaling pathway / Maturation of nucleoprotein / Maturation of nucleoprotein / protein poly-ADP-ribosylation / NAD+-protein ADP-ribosyltransferase activity / NAD+-protein poly-ADP-ribosyltransferase activity / 転移酵素; グリコシル基を移すもの; 五炭糖残基を移すもの ...positive regulation of interleukin-4-mediated signaling pathway / negative regulation of tyrosine phosphorylation of STAT protein / Nicotinamide salvaging / negative regulation of type II interferon-mediated signaling pathway / Maturation of nucleoprotein / Maturation of nucleoprotein / protein poly-ADP-ribosylation / NAD+-protein ADP-ribosyltransferase activity / NAD+-protein poly-ADP-ribosyltransferase activity / 転移酵素; グリコシル基を移すもの; 五炭糖残基を移すもの / NAD+ binding / positive regulation of tyrosine phosphorylation of STAT protein / nucleotidyltransferase activity / transcription corepressor activity / negative regulation of gene expression / innate immune response / enzyme binding / membrane / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 PARP-14, RNA recognition motif 2 / : / WWE domain / WWE domain superfamily / WWE domain / WWE domain profile. / Phosphoenolpyruvate Carboxykinase; domain 3 - #10 / Phosphoenolpyruvate Carboxykinase; domain 3 / Poly(ADP-ribose) polymerase catalytic domain / Poly(ADP-ribose) polymerase, catalytic domain ...PARP-14, RNA recognition motif 2 / : / WWE domain / WWE domain superfamily / WWE domain / WWE domain profile. / Phosphoenolpyruvate Carboxykinase; domain 3 - #10 / Phosphoenolpyruvate Carboxykinase; domain 3 / Poly(ADP-ribose) polymerase catalytic domain / Poly(ADP-ribose) polymerase, catalytic domain / PARP catalytic domain profile. / Macro domain / Appr-1"-p processing enzyme / Macro domain / Macro domain profile. / Macro domain-like / Nucleotide-binding alpha-beta plait domain superfamily / Alpha-Beta Complex / Alpha Beta類似検索 - ドメイン・相同性 Chem-EGW / Protein mono-ADP-ribosyltransferase PARP14類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.34 Å |
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データ登録者 | Karlberg, T. / Thorsell, A.G. / Holechek, J. / Lease, R. / Ferraris, D. / Schuler, H. |
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引用 | ジャーナル: Bioorg. Med. Chem. Lett. / 年: 2018 タイトル: Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14. 著者: Holechek, J. / Lease, R. / Thorsell, A.G. / Karlberg, T. / McCadden, C. / Grant, R. / Keen, A. / Callahan, E. / Schuler, H. / Ferraris, D. |
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履歴 | 登録 | 2018年3月20日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2018年5月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年5月30日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.2 | 2024年1月17日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_special_symmetry Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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