登録情報 | データベース: PDB / ID: 6eg2 |
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タイトル | Crystal structure of human BRM in complex with compound 16 |
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要素 | Maltose/maltodextrin-binding periplasmic protein,Probable global transcription activator SNF2L2 |
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キーワード | Hydrolase/Hydrolase Inhibitor / Helicase / ATPase / Chromatin remodeling / inhibitor / MBP fusion / Hydrolase-Hydrolase Inhibitor complex |
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機能・相同性 | 機能・相同性情報
bBAF complex / npBAF complex / nBAF complex / brahma complex / GBAF complex / regulation of G0 to G1 transition / Regulation of MITF-M-dependent genes involved in pigmentation / regulation of nucleotide-excision repair / regulation of mitotic metaphase/anaphase transition / SWI/SNF complex ...bBAF complex / npBAF complex / nBAF complex / brahma complex / GBAF complex / regulation of G0 to G1 transition / Regulation of MITF-M-dependent genes involved in pigmentation / regulation of nucleotide-excision repair / regulation of mitotic metaphase/anaphase transition / SWI/SNF complex / ATP-dependent chromatin remodeler activity / positive regulation of double-strand break repair / intermediate filament cytoskeleton / positive regulation of T cell differentiation / positive regulation of stem cell population maintenance / RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known / regulation of G1/S transition of mitotic cell cycle / negative regulation of cell differentiation / carbohydrate transmembrane transporter activity / spermatid development / maltose binding / maltose transport / maltodextrin transmembrane transport / positive regulation of myoblast differentiation / ATP-dependent activity, acting on DNA / ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing / helicase activity / positive regulation of cell differentiation / 加水分解酵素; 酸無水物に作用; 酸無水物に作用・細胞または細胞小器官の運動に関与 / negative regulation of cell growth / RMTs methylate histone arginines / nervous system development / outer membrane-bounded periplasmic space / histone binding / transcription coactivator activity / transcription cis-regulatory region binding / hydrolase activity / chromatin remodeling / negative regulation of cell population proliferation / intracellular membrane-bounded organelle / negative regulation of DNA-templated transcription / chromatin binding / positive regulation of cell population proliferation / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / ATP binding / nucleus類似検索 - 分子機能 BRK domain / BRK domain / BRK domain superfamily / domain in transcription and CHROMO domain helicases / Glutamine-Leucine-Glutamine, QLQ / QLQ / QLQ domain profile. / QLQ / domain in helicases and associated with SANT domains / Snf2, ATP coupling domain ...BRK domain / BRK domain / BRK domain superfamily / domain in transcription and CHROMO domain helicases / Glutamine-Leucine-Glutamine, QLQ / QLQ / QLQ domain profile. / QLQ / domain in helicases and associated with SANT domains / Snf2, ATP coupling domain / Snf2-ATP coupling, chromatin remodelling complex / Snf2-ATP coupling, chromatin remodelling complex / HSA domain / Helicase/SANT-associated domain / HSA domain profile. / : / SNF2-like, N-terminal domain superfamily / SNF2, N-terminal / SNF2-related domain / Maltose/Cyclodextrin ABC transporter, substrate-binding protein / Solute-binding family 1, conserved site / Bacterial extracellular solute-binding proteins, family 1 signature. / Bacterial extracellular solute-binding protein / Bacterial extracellular solute-binding protein / Helicase conserved C-terminal domain / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 ISOPROPYL ALCOHOL / Chem-J7J / Maltose/maltodextrin-binding periplasmic protein / Probable global transcription activator SNF2L2類似検索 - 構成要素 |
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生物種 | Escherichia coli O157:H7 (大腸菌) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.98 Å |
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データ登録者 | Zhu, X. / Kulathila, R. / Hu, T. / Xie, X. |
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引用 | ジャーナル: J. Med. Chem. / 年: 2018 タイトル: Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. 著者: Papillon, J.P.N. / Nakajima, K. / Adair, C.D. / Hempel, J. / Jouk, A.O. / Karki, R.G. / Mathieu, S. / Mobitz, H. / Ntaganda, R. / Smith, T. / Visser, M. / Hill, S.E. / Hurtado, F.K. / ...著者: Papillon, J.P.N. / Nakajima, K. / Adair, C.D. / Hempel, J. / Jouk, A.O. / Karki, R.G. / Mathieu, S. / Mobitz, H. / Ntaganda, R. / Smith, T. / Visser, M. / Hill, S.E. / Hurtado, F.K. / Chenail, G. / Bhang, H.C. / Bric, A. / Xiang, K. / Bushold, G. / Gilbert, T. / Vattay, A. / Dooley, J. / Costa, E.A. / Park, I. / Li, A. / Farley, D. / Lounkine, E. / Yue, Q.K. / Xie, X. / Zhu, X. / Kulathila, R. / King, D. / Hu, T. / Vulic, K. / Cantwell, J. / Luu, C. / Jagani, Z. |
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履歴 | 登録 | 2018年8月17日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年10月31日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年11月14日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_abbrev / _citation.journal_id_ISSN / _citation.title |
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改定 1.2 | 2018年12月5日 | Group: Data collection / Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / software Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _software.name |
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