登録情報 データベース : PDB / ID : 6au3 構造の表示 ダウンロードとリンクタイトル Crystal structure of SETDB1 Tudor domain with aryl triazole fragments 要素Histone-lysine N-methyltransferase SETDB1 詳細 キーワード TRANSFERASE / SETDB1 Tudor / fragment hits / epigenetics / methyllysine reader / Structural Genomics / Structural Genomics Consortium / SGC機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
[histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase / histone H3K9 trimethyltransferase activity / histone H3K9 monomethyltransferase activity / positive regulation of DNA methylation-dependent heterochromatin formation / heterochromatin organization / histone H3K9 methyltransferase activity / histone H3K9me2 methyltransferase activity / negative regulation of single stranded viral RNA replication via double stranded DNA intermediate / promoter-specific chromatin binding / PKMTs methylate histone lysines ... [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase / histone H3K9 trimethyltransferase activity / histone H3K9 monomethyltransferase activity / positive regulation of DNA methylation-dependent heterochromatin formation / heterochromatin organization / histone H3K9 methyltransferase activity / histone H3K9me2 methyltransferase activity / negative regulation of single stranded viral RNA replication via double stranded DNA intermediate / promoter-specific chromatin binding / PKMTs methylate histone lysines / chromosome / methylation / negative regulation of gene expression / intracellular membrane-bounded organelle / chromatin binding / DNA binding / zinc ion binding / nucleoplasm / nucleus / cytoplasm 類似検索 - 分子機能 Histone-lysine N-methyltransferase SETDB1 / Domain of unknown function DUF5604 / : / : / Domain of unknown function (DUF5604) / Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile. / Histone methyltransferase, Tudor domain 1 / Histone methyltransferase, Tudor domain 2 / Histone methyltransferase Tudor domain / Histone methyltransferase Tudor domain 1 ... Histone-lysine N-methyltransferase SETDB1 / Domain of unknown function DUF5604 / : / : / Domain of unknown function (DUF5604) / Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile. / Histone methyltransferase, Tudor domain 1 / Histone methyltransferase, Tudor domain 2 / Histone methyltransferase Tudor domain / Histone methyltransferase Tudor domain 1 / Pre-SET domain / Pre-SET motif / Pre-SET domain profile. / N-terminal to some SET domains / Tudor domain / Tudor domain / Post-SET domain / Post-SET domain profile. / SH3 type barrels. - #140 / Methyl-CpG binding domain / Methyl-CpG DNA binding / Methyl-CpG binding domain / Methyl-CpG-binding domain (MBD) profile. / DNA-binding domain superfamily / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / SET domain profile. / SET domain / SH3 type barrels. / Roll / Mainly Beta 類似検索 - ドメイン・相同性 Chem-BWM / Histone-lysine N-methyltransferase SETDB1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / フーリエ合成 / 解像度 : 1.8 Å 詳細データ登録者 MADER, P. / Mendoza-Sanchez, R. / IQBAL, A. / DONG, A. / DOBROVETSKY, E. / CORLESS, V.B. / LIEW, S.K. / TEMPEL, W. / SMIL, D. / DELA SENA, C.C. ...MADER, P. / Mendoza-Sanchez, R. / IQBAL, A. / DONG, A. / DOBROVETSKY, E. / CORLESS, V.B. / LIEW, S.K. / TEMPEL, W. / SMIL, D. / DELA SENA, C.C. / KENNEDY, S. / DIAZ, D. / HOLOWNIA, A. / VEDADI, M. / BROWN, P.J. / SANTHAKUMAR, V. / Bountra, C. / Edwards, A.M. / YUDIN, A.K. / Arrowsmith, C.H. / Structural Genomics Consortium (SGC) 引用ジャーナル : to be published タイトル : Crystal structure of SETDB1 Tudor domain with aryl triazole fragments著者: MADER, P. / Mendoza-Sanchez, R. / IQBAL, A. / DONG, A. / DOBROVETSKY, E. / CORLESS, V.B. / LIEW, S.K. / TEMPEL, W. / SMIL, D. / DELA SENA, C.C. / KENNEDY, S. / DIAZ, D. / HOLOWNIA, A. / ... 著者 : MADER, P. / Mendoza-Sanchez, R. / IQBAL, A. / DONG, A. / DOBROVETSKY, E. / CORLESS, V.B. / LIEW, S.K. / TEMPEL, W. / SMIL, D. / DELA SENA, C.C. / KENNEDY, S. / DIAZ, D. / HOLOWNIA, A. / VEDADI, M. / BROWN, P.J. / SANTHAKUMAR, V. / Bountra, C. / Edwards, A.M. / YUDIN, A.K. / Arrowsmith, C.H. / Structural Genomics Consortium (SGC) 履歴 登録 2017年8月30日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2017年9月27日 Provider : repository / タイプ : Initial release改定 1.1 2024年3月13日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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