Entry | Database: PDB / ID: 5yic |
---|
Title | Crystal Structure of KNI-10333 bound Plasmepsin II (PMII) from Plasmodium falciparum |
---|
Components | Plasmepsin II |
---|
Keywords | HYDROLASE / Plasmepsin / Plasmepsin II / KNI-10333 / Aspartic Protease / Plasmodium falciparum / Drug Development / inhibitor |
---|
Function / homology | Function and homology information
MHC class II antigen presentation / hemoglobin catabolic process / cytostome / plasmepsin II / Neutrophil degranulation / vacuolar lumen / food vacuole / vacuolar membrane / aspartic-type endopeptidase activity / proteolysisSimilarity search - Function Pepsin-like domain / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Eukaryotic aspartyl protease / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily ...Pepsin-like domain / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Eukaryotic aspartyl protease / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly BetaSimilarity search - Domain/homology |
---|
Biological species | ![](img/tx_eukaryote.gif) Plasmodium falciparum (malaria parasite P. falciparum) |
---|
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.9 Å |
---|
Authors | Mishra, V. / Rathore, I. / Bhaumik, P. |
---|
Funding support | India, 1items Organization | Grant number | Country |
---|
Department of Biotechnology, Government of India | Ramalingaswami Re-entry Fellowship | India |
|
---|
Citation | Journal: Febs J. / Year: 2018 Title: Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights. Authors: Mishra, V. / Rathore, I. / Arekar, A. / Sthanam, L.K. / Xiao, H. / Kiso, Y. / Sen, S. / Patankar, S. / Gustchina, A. / Hidaka, K. / Wlodawer, A. / Yada, R.Y. / Bhaumik, P. |
---|
History | Deposition | Oct 3, 2017 | Deposition site: PDBJ / Processing site: PDBJ |
---|
Revision 1.0 | Jul 11, 2018 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Jul 18, 2018 | Group: Data collection / Database references / Category: citation / Item: _citation.title |
---|
Revision 1.2 | May 29, 2019 | Group: Data collection / Database references / Category: citation Item: _citation.journal_abbrev / _citation.journal_id_ISSN ..._citation.journal_abbrev / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title |
---|
|
---|