登録情報 | データベース: PDB / ID: 5wiv |
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タイトル | Structure of the sodium-bound human D4 Dopamine receptor in complex with Nemonapride |
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要素 | D(4) dopamine receptor, soluble cytochrome b562 chimera |
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キーワード | SIGNALING PROTEIN/ANTAGONIST / GPCR / dopamine receptor / antagonist / sodium / SIGNALING PROTEIN-ANTAGONIST complex |
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機能・相同性 | 機能・相同性情報
positive regulation of sodium:proton antiporter activity / positive regulation of dopamine uptake involved in synaptic transmission / dopamine neurotransmitter receptor activity, coupled via Gi/Go / epinephrine binding / response to histamine / dopamine neurotransmitter receptor activity / adenylate cyclase-inhibiting serotonin receptor signaling pathway / adenylate cyclase-inhibiting dopamine receptor signaling pathway / Dopamine receptors / negative regulation of voltage-gated calcium channel activity ...positive regulation of sodium:proton antiporter activity / positive regulation of dopamine uptake involved in synaptic transmission / dopamine neurotransmitter receptor activity, coupled via Gi/Go / epinephrine binding / response to histamine / dopamine neurotransmitter receptor activity / adenylate cyclase-inhibiting serotonin receptor signaling pathway / adenylate cyclase-inhibiting dopamine receptor signaling pathway / Dopamine receptors / negative regulation of voltage-gated calcium channel activity / dopamine binding / behavioral response to ethanol / regulation of dopamine metabolic process / fear response / serotonin binding / G protein-coupled serotonin receptor activity / inhibitory postsynaptic potential / positive regulation of kinase activity / regulation of postsynaptic neurotransmitter receptor internalization / norepinephrine binding / neurotransmitter receptor activity / arachidonate secretion / G protein-coupled dopamine receptor signaling pathway / dopamine metabolic process / behavioral response to cocaine / social behavior / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / behavioral fear response / negative regulation of protein secretion / potassium channel regulator activity / response to amphetamine / adult locomotory behavior / electron transport chain / positive regulation of MAP kinase activity / regulation of circadian rhythm / SH3 domain binding / intracellular calcium ion homeostasis / rhythmic process / G alpha (i) signalling events / chemical synaptic transmission / postsynapse / periplasmic space / electron transfer activity / iron ion binding / centrosome / glutamatergic synapse / dendrite / heme binding / identical protein binding / membrane / metal ion binding / plasma membrane類似検索 - 分子機能 Dopamine D4 receptor / Dopamine receptor family / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family)類似検索 - ドメイン・相同性 Nemonapride / OLEIC ACID / DI(HYDROXYETHYL)ETHER / PHOSPHATE ION / Soluble cytochrome b562 / D(4) dopamine receptor類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) Escherichia coli (大腸菌) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.143 Å |
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データ登録者 | Wacker, D. / Wang, S. / Levit, A. / Che, T. / Betz, R.M. / McCorvy, J.D. / Venkatakrishnan, A.J. / Huang, X.-P. / Dror, R.O. / Shoichet, B.K. / Roth, B.L. |
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資金援助 | 米国, 4件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of Mental Health (NIH/NIMH) | R01MH112205 | 米国 | National Institutes of Health/National Institute of Mental Health (NIH/NIMH) | HHSN-271-2013-00017-C | 米国 | National Institutes of Health/National Institute of Mental Health (NIH/NIMH) | U19MH082441 | 米国 | University of North Carolina | UNC Michael Hooker Chair for Protein Therapeutics and Translational Proteomics | 米国 |
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引用 | ジャーナル: Science / 年: 2017 タイトル: D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. 著者: Wang, S. / Wacker, D. / Levit, A. / Che, T. / Betz, R.M. / McCorvy, J.D. / Venkatakrishnan, A.J. / Huang, X.P. / Dror, R.O. / Shoichet, B.K. / Roth, B.L. |
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履歴 | 登録 | 2017年7月20日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年10月18日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年11月1日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name |
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改定 1.2 | 2018年1月17日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2019年11月27日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2023年10月4日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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