登録情報 | データベース: PDB / ID: 5v54 |
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タイトル | Crystal structure of 5-HT1B receptor in complex with methiothepin |
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要素 | 5-hydroxytryptamine receptor 1B,OB-1 fused 5-HT1b receptor,5-hydroxytryptamine receptor 1B |
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キーワード | ELECTRON TRANSPORT / 5-hydroxytryptamine / GPCR antagonist / OB1 |
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機能・相同性 | 機能・相同性情報
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels / negative regulation of gamma-aminobutyric acid secretion / serotonergic synapse / G protein-coupled serotonin receptor complex / adenylate cyclase-inhibiting serotonin receptor signaling pathway / regulation of behavior / negative regulation of synaptic transmission, GABAergic / response to mineralocorticoid / Serotonin receptors / negative regulation of serotonin secretion ...voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels / negative regulation of gamma-aminobutyric acid secretion / serotonergic synapse / G protein-coupled serotonin receptor complex / adenylate cyclase-inhibiting serotonin receptor signaling pathway / regulation of behavior / negative regulation of synaptic transmission, GABAergic / response to mineralocorticoid / Serotonin receptors / negative regulation of serotonin secretion / drinking behavior / cellular response to temperature stimulus / bone remodeling / serotonin binding / negative regulation of synaptic transmission, glutamatergic / vasoconstriction / G protein-coupled serotonin receptor activity / : / G protein-coupled receptor internalization / neurotransmitter receptor activity / regulation of synaptic vesicle exocytosis / regulation of dopamine secretion / cellular response to alkaloid / calyx of Held / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / positive regulation of vascular associated smooth muscle cell proliferation / presynaptic modulation of chemical synaptic transmission / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / response to cocaine / cellular response to xenobiotic stimulus / presynaptic membrane / G alpha (i) signalling events / chemical synaptic transmission / response to ethanol / dendrite / endoplasmic reticulum / plasma membrane類似検索 - 分子機能 5-Hydroxytryptamine 1B receptor / 5-hydroxytryptamine receptor family / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family)類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト)
![](img/tx_arthropod.gif) Spodoptera frugiperda (ツマジロクサヨトウ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.9 Å |
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データ登録者 | Yin, W.C. / Zhou, X.E. / Yang, D. / de Waal, P. / Wang, M.T. / Dai, A. / Cai, X. / Huang, C.Y. / Liu, P. / Yin, Y. ...Yin, W.C. / Zhou, X.E. / Yang, D. / de Waal, P. / Wang, M.T. / Dai, A. / Cai, X. / Huang, C.Y. / Liu, P. / Yin, Y. / Liu, B. / Caffrey, M. / Melcher, K. / Xu, Y. / Wang, M.W. / Xu, H.E. / Jiang, Y. |
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資金援助 | 中国, 米国, 16件 組織 | 認可番号 | 国 |
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National Natural Science Foundation | 31300607 | 中国 | Outstanding Young Scientist Foundation | | 中国 | Jay and Betty Van Andel Foundation | | 米国 | Ministry of Science and Technology of China | 2012ZX09301001 | 中国 | Ministry of Science and Technology of China | 2012CB910403 | 中国 | Ministry of Science and Technology of China | 2013CB9106010 | 中国 | Ministry of Science and Technology of China | XDB08020303 | 中国 | Ministry of Science and Technology of China | 2013ZX09507001 | 中国 | National Institutes of Health | DK071662 | 米国 | National Institutes of Health | GM102545 | 米国 | National Institutes of Health | GM104212 | 米国 | Shanghai Science and Technology Development Fund | 15DZ2291600 | 中国 | Shanghai Science and Technology Development Fund | 14431901200 | 中国 | National Natural Science Foundation | 81373463 | 中国 | CAS-Novo Nordisk Research Fund | | 中国 | Youth Innovation Promotion Association of CAS | | 中国 |
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引用 | ジャーナル: Cell Discov / 年: 2018 タイトル: A common antagonistic mechanism for class A GPCRs revealed by the structure of the human 5-HT1B serotonin receptor bound to an antagonist 著者: Yin, W.C. / Zhou, X.E. / Yang, D. / De Waal, P. / Wang, M.T. / Dai, A. / Cai, X. / Huang, C.Y. / Liu, P. / Yin, Y. / Liu, B. / Caffrey, M. / Melcher, K. / Xu, Y. / Wang, M.W. / Xu, H.E. / Jiang, Y. |
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履歴 | 登録 | 2017年3月13日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2018年2月7日 | Provider: repository / タイプ: Initial release |
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